MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dabrafenib Mesylate | Dabrafenib Mesylate is a potent and selective Raf kinase inhibitor with IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK2118436 Mesylate; GSK 2118436B. CAS No. 1195768-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-14660A. |  |
| Dabuzalgron | Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 115-1240. CAS No. 219311-44-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117071. | |
| DACA | DACA (XR 5000) is a potential and blood-brain barrier-penetrating topoisomerase I and II inhibitor. DACA can be used in the research of colorectal cancer, leukemia and lung cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89459-25-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100777. | |
| Dacarbazine | Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Imidazole Carboxamide. CAS No. 4342-3-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-B0078. | |
| Dacetuzumab | Dacetuzumab (SGN-40) is a humanized IgG1, anti-CD40 monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab ((SGN-40) can be used for multiple myeloma research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 880486-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99015. | |
| Dacinostat | Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NVP-LAQ824; LAQ824. CAS No. 404951-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-13606. | |
| Daclatasvir | Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 μM and 3.27 μM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-790052; EBP 883. CAS No. 1009119-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10466. | |
| Daclizumab | Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 24-7375. CAS No. 152923-56-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108738. | |
| DACM | DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-directed fluorescent dye (Ex=396 nm, Em=468 nm)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide. CAS No. 55145-14-7. Pack Sizes: 1 mg. Product ID: HY-121030. | |
| Dacomitinib | Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-00299804; PF-299804. CAS No. 1110813-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13272. | |
| Dactolisib | Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC50s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively. Dactolisib (BEZ235) inhibits both mTORC1 and mTORC2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BEZ235; NVP-BEZ235. CAS No. 915019-65-7. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50673. | |
| Dactolisib hydrochloride | Dactolisib (BEZ235) hydrochloride is an orally active, dual pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR with IC50 of 4 nM/5 nM/7 nM/75 nM and 20.7 nM, respectively. Dactolisib hydrochloride (BEZ235) inhibits mTORC1 and mTORC2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BEZ235 hydrochloride; NVP-BEZ235 hydrochloride. CAS No. 2319647-83-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-50673A. | |
| Dactolisib Tosylate | Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BEZ235 Tosylate; NVP-BEZ 235 Tosylate. CAS No. 1028385-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15174. | |
| Dactylorhin A | Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 256459-34-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125531. | |
| DAF-2DA | DAF-2DA (5,6-Diaminofluorescein diacetat) is most widely probe for NO measurement. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5,6-Diaminofluorescein diacetat. CAS No. 205391-02-2. Pack Sizes: 100 μg; 250 μg; 500 μg. Product ID: HY-D0032. | |
| Dafadine-A | Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Dafadine-A inhibits the mammalian ortholog of DAF-9 (CYP27A1). Dafadine-A does not inhibits DAF-12 and sterol- and oxysterol-metabolizing P450s[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1065506-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-16670. | |
| DAF-FM | DAF-FM is a cell-impermeant diaminofluorescein, which can be used as fluorescent indicator for nitric oxide (NO) with good pH tolerance[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 254109-20-1. Pack Sizes: 1 mg. Product ID: HY-126774. | |
| DAF-FM DA | DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Diaminofluorescein-FM diacetate. CAS No. 254109-22-3. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-D0717. | |
| DAF-FM DA (solution) | DAF-FM DA (Diaminofluorescein-FM diacetate) (solution) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) [1].Solvent and concentration: DMSO: 2 mM. Uses: Scientific research. Category: Signaling pathways. CAS No. 254109-22-3. Pack Sizes: 20 μL; 50 μL. Product ID: HY-DY1048. | |
| Dagrocorat | Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-00251802. CAS No. 1044535-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16718. | |
| Daidzein | Daidzein is a soy isoflavone, which acts as a PPAR activator. Uses: Scientific research. Category: Signaling pathways. CAS No. 486-66-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-N0019. | |
| Daidzein-d4 | Daidzein-d4 is the deuterium labeled Daidzein. Daidzein is a soy isoflavone, which acts as a PPAR activator. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219803-57-2. Pack Sizes: 1 mg. Product ID: HY-N0019S. | |
| Daidzein (Standard) | Daidzein (Standard) is the analytical standard of Daidzein. This product is intended for research and analytical applications. Daidzein is a soy isoflavone, which acts as a PPAR activator. Uses: Scientific research. Category: Signaling pathways. CAS No. 486-66-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-N0019R. | |
| Daidzin | Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Daidzoside; NPI-031D; Daidzein 7-O-glucoside. CAS No. 552-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0018. | |
| Daidzin (Standard) | Daidzin (Standard) is the analytical standard of Daidzin. This product is intended for research and analytical applications. Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Daidzoside (Standard); NPI-031D (Standard); Daidzein 7-O-glucoside (Standard). CAS No. 552-66-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0018R. | |
| [D-Ala2]-GIP (human) | [D-Ala2]-GIP (human) is a GIP receptor agonist (EC50 = 630 pM). [D-Ala2]-GIP (human) improves glucose tolerance. [D-Ala2]-GIP (human) shows neuroprotective activity in MPTP (HY-W114750)-induced Parkinson's disease model. [D-Ala2]-GIP (human) also improves cognitive function and hippocampal synaptic plasticity in obese diabetic rats. [D-Ala2]-GIP (human) can be used for research of type 2 diabetes, Parkinson's disease, etc[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 444073-04-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3247. | |
| D-Ala-Lys-AMCA hydrochloride | D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2703746-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111956B. | |
| D-Alanine | D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Alanine; Ba 2776; D-α-Alanine. CAS No. 338-69-2. Pack Sizes: 10 mM * 1 mL in Water; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-41700. | |
| Dalazatide | Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ShK-186. CAS No. 1081110-69-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3507. | |
| Dalbavancin | Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDL-63397; BI-397. CAS No. 171500-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17586A. | |
| Dalbavancin hydrochloride | Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDL-63397 hydrochloride; BI-397 hydrochloride. CAS No. 2227366-51-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17586. | |
| Dalbergin | Dalbergin is a composition of the extract from the Dalbergia Sissoo Linn. knot wood. Dalbergin demonstrats notable antioxidant ability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 482-83-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N8347. | |
| Dalfopristin | Dalfopristin (RP54476) is a semisynthetic sulfone antibiotic. Dalfopristin alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP54476. CAS No. 112362-50-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0241. | |
| D-Allose | D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities[1][2][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2595-97-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg. Product ID: HY-128741. | |
| Dalmelitinib | Dalmelitinib is an orally active selective c-Met kinase inhibitor (IC50: 2.9 nM) that binds to the ATP-binding region of c-Met. Dalmelitinib induces the phosphorylation of MET, partially or completely inhibits the phosphorylation of AKT and ERK. Dalmelitinib potently inhibits cancer cell (c-Met oncogene amplification) proliferation, and is used for the research of cancers like human non-small cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637658-98-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147259. | |
| Dalotuzumab | Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0646; h7C10. CAS No. 1005389-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99284. | |
| D-α-Hydroxyglutaric acid | D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid. CAS No. 13095-47-1. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113038. | |
| D-α-Hydroxyglutaric acid-13C5 disodium | D-α-Hydroxyglutaric acid-13C5 disodium is the 13C-labeled D-α-Hydroxyglutaric acid (HY-113038). D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1648909-80-1. Pack Sizes: 1 mg. Product ID: HY-W779800. | |
| D-α-Hydroxyglutaric acid disodium | D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disodium (R)-2-hydroxyglutarate. CAS No. 103404-90-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100542. | |
| D-α-Tocopherol acetate | D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Vitamin E acetate. CAS No. 58-95-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B1278. | |
| Dalpiciclib | Dalpiciclib (SHR-6390) is an orally active and highly selective inhibitor of CDK4 and 6 with IC50 values of 12.4 nM and 9.9 nM, respectively[1][2]. Dalpiciclib shows antitumor activity against breast cancer and esophageal squamous cell carcinoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SHR-6390. CAS No. 1637781-04-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114338. | |
| DAMGO | DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78123-71-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0210. | |
| DAMGO TFA | DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 950492-85-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-P0210B. | |
| Daminozide | Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1596-84-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-13643. | |
| Dammarenediol II | Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14351-29-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3677. | |
| Damnacanthal | Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 477-84-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-108485. | |
| Damulin A | Damulin A is a saponin found in G. pentaphyllum with anti-cancer activities[1]. Uses: Scientific research. Category: Natural products. CAS No. 1202868-74-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16941. | |
| Damulin B | Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum. Damulin B can inhibit cancer cell apoptosis, decrease mitochondrial membrane potential, inhibit ROS production and cause G0/G1 phase arrest. Damulin B can prevent Cisplatin (HY-17394)-induced acute kidney injury and induce hair growth. Damulin B shows anti-inflammation anti-diabetic and anti-obesity effect. Damulin B can be used for the researches of cancer, inflammation, metabolic disease, such as lung cancer, osteoarthritis and diabetes[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1202868-75-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16942. | |
| Danavorexton | Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-925. CAS No. 2114324-48-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133898. | |
| Danazol | Danazol inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC50 of 65 μg/mL and 31 μg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17230-88-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg. Product ID: HY-B1029. | |
| Danegaptide Hydrochloride | Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GAP-134 Hydrochloride; ZP 1609 Hydrochloride. CAS No. 943133-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10913A. | |
| Danicamtiv | Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MYK-491. CAS No. 1970972-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109128. | |
| Danicopan | Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACH-4471. CAS No. 1903768-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117930. | |
| Danirixin | Danirixin is a selective, and reversible CXCR2 antagonist, with IC50?of?12.5 nM for CXCL8. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK1325756. CAS No. 954126-98-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19768. | |
| Danoprevir | Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM)[1][2]. Danoprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 0.05 μM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITMN-191; R7227; RO5190591; RG7227. CAS No. 850876-88-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10238. | |
| Danshenol A | Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189308-08-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122917. | |
| Danshensu | Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97?μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dan shen suan A; Salvianic acid A. CAS No. 76822-21-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1913. | |
| Dansylcadaverine | Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Monodansyl cadaverine. CAS No. 10121-91-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-D1027. | |
| Dansyl chloride | Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DNSCl. CAS No. 605-65-2. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-D0017. | |
| Dansyl glutathione | Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DNS-glutathione. CAS No. 75017-02-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101131. | |
| Dansyl-Tyr-Val-Gly | Dansyl-Tyr-Val-Gly is a substrate of peptidylglycine monooxygenase (PHM), with a KD of 22 μM for PHM. Dansyl-Tyr-Val-Gly can be used to investigate the catalytic mechanism, kinetics and inactivation characteristics of PHM[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 113527-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138126. | |
| Dantrolene | Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: F 368. CAS No. 7261-97-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-12542. | |
| Dantrolene sodium | Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: F 440. CAS No. 14663-23-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-14657. | |
| Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dantrolene sodium hydrate. CAS No. 24868-20-0. Pack Sizes: 100 mg; 500 mg. Product ID: HY-12542A. | |
| Danuglipron | Danuglipron (PF-06882961) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron has the potential for type 2 diabetes research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06882961. CAS No. 2230198-02-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125824. | |
| Danusertib | Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PHA-739358. CAS No. 827318-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10179. | |
| Danvatirsen | Danvatirsen (AZD9150) is an antisense oligonucleotide targeting STAT3. Danvatirsen reduces the viability and promotes apoptosis of leukemia cell lines. Danvatirsen inhibits the expression of endogenous STAT3 and its downstream target genes, and reduces the proliferation and tumorigenicity of neuroblastoma and lymphoma cells. Danvatirsen inhibited tumor growth in mouse models of neuroblastoma, lymphoma, and non-small cell lung cancer. Danvatirsen achieves STAT3 mRNA and protein depletion in a mouse model of epidermoid carcinoma. Danvatirsen can be used in research related to lymphoma, myelodysplastic syndrome, acute myeloid leukemia, neuroblastoma and non-small cell lung cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD9150. CAS No. 1402357-06-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-145729. | |
| DAO-IN-1 | DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51856-25-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-W037417. | |
| DAOS | DAOS, a Trinder's reagent, is a novel highly water-soluble aniline derivative; are widely used in diagnostic tests and biochemical tests. Uses: Scientific research. Category: Signaling pathways. CAS No. 83777-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-15913. | |
| D-AP5 | D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-APV; D-2-Amino-5-phosphonovaleric acid. CAS No. 79055-68-8. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100714A. | |
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