MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Decursinol angelate | Decursinol angelate acts as a PKC activator and GDH inhibitor, with an IC50 of 1.432 μM against human GDH. Decursinol angelate activates PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130848-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N4322. |  |
| Decyl β-D-maltopyranoside | Decyl β-D-maltopyranoside is an epithelial permeability enhancer. Decyl β-D-maltopyranoside regulates the paracellular transport pathway and increases the permeability of molecules and proteins transported via the paracellular route. Decyl β-D-maltopyranoside enhances the transepithelial paracellular permeability of EPO across cell monolayers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 82494-09-5. Pack Sizes: 100 mg. Product ID: HY-W040203. | |
| Decylubiquinone | Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55486-00-5. Pack Sizes: 5 mg (77.53 mM * 200 μL in Ethanol); 10 mg (77.53 mM * 400 μL in Ethanol). Product ID: HY-121134. | |
| Defactinib | Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VS-6063; PF-04554878. CAS No. 1073154-85-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12289. | |
| Defactinib hydrochloride | Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VS-6063 hydrochloride; PF 04554878 hydrochloride. CAS No. 1073160-26-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12289A. | |
| Defensin HNP-1 human | Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 148093-65-6. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-P2310. | |
| Deferasirox | Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICL 670. CAS No. 201530-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17359. | |
| Deferiprone | Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone can inhibit KDM. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 30652-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0568. | |
| Deferiprone-d3 | Deferiprone-d3 is the deuterium labeled Deferiprone (HY-B0568). Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone can inhibit KDM. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346601-82-8. Pack Sizes: 1 mg. Product ID: HY-B0568S. | |
| Deferiprone (Standard) | Deferiprone (Standard) is the analytical standard of Deferiprone. This product is intended for research and analytical applications. Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 30652-11-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0568R. | |
| Deferitrin | Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GT-56-252. CAS No. 239101-33-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108260. | |
| Deferoxamine | Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deferoxamine B; Deferriferrioxamine B; Deferrioxamine. CAS No. 70-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1625. | |
| Deferoxamine-DBCO | Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as 89Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DFO-DBCO. CAS No. 2359695-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-158067. | |
| Deferoxamine mesylate | Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Desferrioxamine B mesylate; DFOM. CAS No. 138-14-7. Pack Sizes: 20 mg; 100 mg; 500 mg. Product ID: HY-B0988. | |
| Defibrotide sodium | Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83712-60-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108746. | |
| Deflazacort | Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14484-47-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-13609. | |
| DEG-77 | DEG-77 is a molecular glue targeting IKZF2 and CK1α, with DC50 values of 15.3 nM and 10 nM, respectively. DEG-77 exhibits significant anti-tumor activity, inducing increased transcriptional levels of the pro-apoptotic protein Bax and the cell cycle arrest protein p21. DEG-77 is applicable to the research of acute myeloid leukemia (AmL), diffuse large B-cell lymphoma and ovarian cancer. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032265-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157334. | |
| Degarelix | Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC50 = 3 nM). Degarelix acetate Degarelix acetate (FE 200486) is used for the research of prostate cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FE 200486 free base. CAS No. 214766-78-6. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16168A. | |
| Degrasyn | Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WP1130. CAS No. 856243-80-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13264. | |
| Deguelin | Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Deguelin; (-)-cis-Deguelin. CAS No. 522-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-13425. | |
| Deguelin (Standard) | Deguelin (Standard) is the analytical standard of Deguelin. This product is intended for research and analytical applications. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Deguelin (Standard); (-)-cis-Deguelin (Standard). CAS No. 522-17-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13425R. | |
| DEHP | DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82. CAS No. 117-81-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1945. | |
| DEHP-d4 | DEHP-d4 is the deuterium labeled DEHP. DEHP (Bis(2-ethylhexyl) phthalate) is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bis(2-ethylhexyl) phthalate-d4; Ergoplast FDO-d4; ESBO-D 82-d4. CAS No. 93951-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1945S. | |
| Dehydroabietic acid | Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1740-19-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N6869. | |
| Dehydroaripiprazole | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole (HY-14546) and dopamine D2/D3 receptor partial agonist. Dehydroaripiprazole also has certain affinity for serotonin 5-HT1A, 5-HT2A and 5-HT2B receptors. Dehydroaripiprazole has antipsychotic activity equivalent to Aripiprazole[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-14857; DM-14857. CAS No. 129722-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100665. | |
| Dehydroascorbic acid | Dehydroascorbic acid is an oxidized form of vitamin C that can cross the blood-brain barrier (BBB). Dehydroascorbic acid clears cytotoxic reactive oxygen species (ROS) produced after ischemic stroke by converting to ascorbic acid (AA), thereby reducing neuronal and glial cell damage and stabilizing cerebral microvascular NO signaling to maintain perfusion in the ischemic area. Dehydroascorbic acid can be used in research on ischemic stroke[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 490-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-110281. | |
| Dehydroascorbic acid (Standard) | Dehydroascorbic acid (Standard) is the analytical standard of Dehydroascorbic acid. This product is intended for research and analytical applications. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Uses: Scientific research. Category: Signaling pathways. CAS No. 490-83-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110281R. | |
| Dehydrocholic acid | Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dehydrocholate. CAS No. 81-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-B1393. | |
| Dehydrocorydaline nitrate | Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 13-Methylpalmatine nitrate. CAS No. 13005-09-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4238. | |
| Dehydrocostus Lactone | Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 μg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Dehydrocostus lactone; Epiligulyl oxide. CAS No. 477-43-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0591. | |
| Dehydroemetine | Dehydroemetine is an orally active antiparasitic agent. Dehydroemetine can inhibit parasites such as Entamoeba histolytica, and it can also be used in the research of parasitic diseases like visceral leishmaniasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4914-30-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-121241. | |
| Dehydroepiandrosterone sulfate | Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHEA sulfate; Prasterone sulfate. CAS No. 651-48-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113416. | |
| Dehydroepiandrosterone sulfate sodium | Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHEA sulfate sodium; Prasterone sulfate sodium. CAS No. 1099-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg. Product ID: HY-B0765. | |
| Dehydroepiandrosterone sulfate sodium-d6 | Dehydroepiandrosterone sulfate sodium salt-d6 (DHEA sulfate sodium salt-d6; Prasterone sulfate sodium salt-d6) is the deuterium labeled Dehydroepiandrosterone sulfate sodium salt (HY-B0765). Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHEA sulfate sodium-d6; Prasterone sulfate sodium-d6. CAS No. 1261254-41-4. Pack Sizes: 1 mg. | |
| Dehydromiltirone | Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,2-Didehydromiltirone. CAS No. 116064-77-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122961. | |
| Dehydronitrosonisoldipine | Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 87375-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-Z0816. | |
| Dehydrovomifoliol | Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD). Uses: Scientific research. Category: Signaling pathways. CAS No. 39763-33-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-137996. | |
| Dehydro-ZINC39395747 | Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC50 of 9.14 μM and a Kd of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 433248-87-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103061. | |
| DEL-22379 | DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 181223-80-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18932. | |
| Delafloxacin | Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RX-3341; WQ-3034; ABT492. CAS No. 189279-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14814. | |
| Delamanid | Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-67683. CAS No. 681492-22-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10846. | |
| Delamanid-d4 | Delamanid-d4 is the deuterium labeled Delamanid. Delamanid, a newer?mycobacterial cell wall synthesis ?inhibitor, inhibits the synthesisi of mucolic acids[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-67683-d4. CAS No. 2747917-54-8. Pack Sizes: 1 mg. Product ID: HY-10846S. | |
| Delanzomib | Delanzomib (CEP-18770) is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC50 of 3.8 nM. Delanzomib inhibits NF-κB activity, induces cancer cell apoptotic, and has strong antiangiogenic and anti-cancer activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CEP-18770. CAS No. 847499-27-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10454. | |
| Delavirdine | Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: U 90152; BHAP-U 90152. CAS No. 136817-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10571. | |
| Delavirdine mesylate | Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: U 90152 mesylate; BHAP-U 90152 mesylate. CAS No. 147221-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10571A. | |
| Delgocitinib | Delgocitinib (JTE-052) is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JTE-052. CAS No. 1263774-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109053. | |
| Delocamten | Delocamten is the inhibitor for cardiac myosin with an IC50 of 1.1 μM. Delocamten can be used in researchs of hypertrophic cardiomyopathy, left ventricular hypertrophy and diastolic dysfunction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2417411-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172424. | |
| Delpacibart | Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AOC-1001 Antibody; AOC-1044 Antibody. CAS No. 2653183-66-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990051. | |
| Delpazolid | Delpazolid is a novel oxazolidinone antibiotic agent which can inhibit the growth of MSSA and MRSA with a MIC90 of 2 μg/mL for both of them. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LCB01-0371. CAS No. 1219707-39-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100180. | |
| Delphinidin 3-glucoside chloride | Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL)[1]. Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM[2]. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 μM[3]. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction[4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride. CAS No. 6906-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-108052. | |
| Delphinidin-3-O-galactoside chloride | Delphinidin-3-O-galactoside chloride is an anthocyanin found in abbiteye blueberry. Delphinidin-3-O-galactoside chloride show inhibitory activitiesagainst α-glucosidase with an IC50 of 68.33 μM, and tyrosinase with an IC50 of 34.14 μM. Delphinidin-3-O-galactoside chloride attenuates HO-1 and HSP70 messenger RNA down-regulation, suppresses cytotoxicity, reduces endoplasmic reticulum stress responses, scavenges free radicals, reduces intracellular triglyceride levels and lipid droplet accumulation. Delphinidin-3-O-galactoside chloride can be used for the researches of diabesity, melanoma and inflammation[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28500-00-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6606. | |
| Delphinidin-3-sambubioside chloride | Delphinidin-3-sambubioside (Dp3?Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L.[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dp3?Sam chloride. CAS No. 53158-73-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129143. | |
| Delphinidin chloride | Delphinidin chloride is an anthocyanin isolated from berries and red wine. Delphinidin chloride exhibits endothelium-dependent vasodilation and anticancer activity. Delphinidin chloride also modulates JAK/STAT3 and MAPK signaling, thereby inducing apoptosis in HCT116 cells. Delphinidin chloride is also a potent inhibitor of EGFR (IC50: 1.3 μM), shutting down downstream signaling cascades[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 528-53-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2409. | |
| Δ5-?Avenasterol | Δ5-Avenasterol, belongs to the components of oat grain , exhibits propounding antioxidant effectiveness[1]. Uses: Scientific research. Category: Natural products. CAS No. 18472-36-1. Pack Sizes: 5 mg; 10 mg; 1 mg. Product ID: HY-N4103A. | |
| Δ7-Avenasterol | Δ7-Avenasterol (Delta-7-avenasterol) is a phytosterol that binds to prostaglandin E2 receptor (prostaglandin E2 receptor) and cyclooxygenase-2 (COX-2). Δ7-Avenasterol is applicable to research related to gastric ulcer, anti-inflammation and antioxidation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Delta-7-avenasterol. CAS No. 7212-91-1. Pack Sizes: 500 μg. Product ID: HY-165131. | |
| Deltamethrin | Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Decamethrin. CAS No. 52918-63-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-B1971. | |
| Delta (Phospho) Sleep Inducing Peptide | Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats[1][2][3]. Uses: Scientific research. Category: Peptides. Alternative Names: DSIP-P. CAS No. 70754-23-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P3819. | |
| Deltasonamide 1 | Deltasonamide 1 is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2088485-33-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122641. | |
| Deltasonamide 2 hydrochloride | Deltasonamide 2 hydrochloride is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2448341-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122641C. | |
| Deltasonamide 2 TFA | Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2235358-74-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122641B. | |
| Delta-Tocopherol | Delta-Tocopherol is an isomer of Vitamin E[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 119-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-113026. | |
| δ-Tocotrienol | δ-Tocotrienol is a Vitamin E in vegetables, fruits, seeds, nuts, grains and oils. Vitamin E has become well known for its role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection. Uses: Scientific research. Category: Signaling pathways. CAS No. 25612-59-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122778. | |
| delta-Valerobetaine | delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO). Uses: Scientific research. Category: Signaling pathways. CAS No. 6778-33-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114202. | |
| Deltorphin I | Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deltorphin 1; Deltorphin C; [D-Ala2] Deltorphin I. CAS No. 122752-15-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1336. | |
| Demcizumab | Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OMP 21M18. CAS No. 1243262-17-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99261. | |
| Demecolcine | Demecolcine is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 477-30-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0282. | |
| Demethoxycurcumin | Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin. CAS No. 22608-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0006. | |
| Demethoxycurcumin (Standard) | Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Curcumin II (Standard); Desmethoxycurcumin (Standard); Monodemethoxycurcumin (Standard). CAS No. 22608-11-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0006R. | |
| Demethyl-lurbinectedin-cyanide | Demethyl-lurbinectedin-cyanide is an ecteinascidin compound with anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 497871-20-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-186039. | |
| Demethyl-sapanisertib-C2-amide-PEG7-C2-N3 | Demethyl-sapanisertib-C2-amide-PEG7-C2-N3 (Compound 10c) is an azide group linker used for coupling, which can be employed in the synthesis of "Rapa-Link" compounds, such as M-1111 (HY-176948), an mTOR inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1887095-85-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-176947. | |
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