MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dapaconazole | Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1269726-67-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16719. |  |
| Dapagliflozin | Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin induces HIF1 expression and attenuates renal IR injury[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-512148. CAS No. 461432-26-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-10450. | |
| Dapagliflozin ((2S)-1,2-propanediol, hydrate) | Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-512148 (2S)-1,2-propanediol, hydrate. CAS No. 960404-48-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10450A. | |
| Dapagliflozin-3-O-β-D-glucuronide | Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2, that can be used to improve glycemic control and attenuate type 2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-801576. CAS No. 1351438-75-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-125156. | |
| Dapagliflozin-d5 | Dapagliflozin-d5 is a deuterium labeled Dapagliflozin (HY-10450). Dapagliflozin is a competitive SGLT2 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-512148-d5. CAS No. 1204219-80-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-10450S. | |
| Dapagliflozin impurity | Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 960404-86-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-128723. | |
| Dapagliflozin (Standard) | Dapagliflozin (Standard) is the analytical standard of Dapagliflozin. This product is intended for research and analytical applications. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin induces HIF1 expression and attenuates renal IR injury[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-512148 (Standard). CAS No. 461432-26-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10450R. | |
| Dapansutrile | Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 54863-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-17629. | |
| Daphnetin | Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7,8-Dihydroxycoumarin. CAS No. 486-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0281. | |
| DAPI | DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells[1]. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment[2] (Ex/Em = 356/451 nm). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4',6-Diamidino-2-phenylindole. CAS No. 47165-04-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D2868. | |
| DAPI dihydrochloride | DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells[1]. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment[2] (Ex/Em = 356/451 nm). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4',6-Diamidino-2-phenylindole dihydrochloride. CAS No. 28718-90-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D0814. | |
| DAPI dihydrochloride (solution) | DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride (solution) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells[1]. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment[2] (Ex/Em = 356/451 nm).Solvent and concentration: ddH2O: 5 mg/mL. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4',6-Diamidino-2-phenylindole dihydrochloride (solution). CAS No. 28718-90-3. Pack Sizes: 500 μL; 1 mL. Product ID: HY-DY1081. | |
| Dapiglutide | Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZP7570. CAS No. 2296814-85-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3291. | |
| D-Apiose (10% in water) | D-Apiose (10% in water) is a branched pentose found in rhamnogalacturonan-II (RG-II) in the cell walls of higher plants and in apigalacturonan in the cell walls of aquatic monocots. D-Apiose (10% in water) increases cell wall stability by participating in interstrand RG-II crosslinking via boronate esters[1].Size denotes the total mass of the entire solution, with the D-Apiose content of 10% (w/w). Uses: Scientific research. Category: Signaling pathways. CAS No. 639-97-4. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N9689. | |
| Dapirolizumab | Dapirolizumab is an antibody targeting CD40L (CD154). Dapirolizumab can be used in research related to systemic lupus erythematosus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416147-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99842A. | |
| DAPK1-IN-1 | DAPK1-IN-1 (compound 10) is a death-associated protein kinase 1 (DAPK1) inhibitor with a Kd value of 0.63 μM. DAPK1-IN-1 can be used in Alzheimers disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429522-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169109. | |
| Daporinad | Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²? pool, ultimately weakening the mitogen-induced Ca²? signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FK866; APO866. CAS No. 658084-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50876. | |
| Dapoxetine hydrochloride | Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY-210448 hydrochloride. CAS No. 129938-20-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0304A. | |
| Daprodustat | Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK1278863. CAS No. 960539-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17608. | |
| Dapsone | Dapsone (4,4-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4,4-Diaminodiphenyl sulfone; DDS. CAS No. 80-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-B0688. | |
| DAPT | DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSI-IX. CAS No. 208255-80-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13027. | |
| DAPTA | DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Ala-peptide T-amide; Adaptavir. CAS No. 106362-34-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1034. | |
| Daptomycin | Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY146032. CAS No. 103060-53-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0108. | |
| D-Arabinose | D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10323-20-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 250 g; 500 g. Product ID: HY-N0059. | |
| D-Arabitol | D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488-82-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-N3686. | |
| D-Arabitol (Standard) | D-Arabitol (Standard) is the analytical standard of D-Arabitol. This product is intended for research and analytical applications. D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 488-82-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N3686R. | |
| Darapladib | Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor (IC50=0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB-480848. CAS No. 356057-34-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10521. | |
| Daratumumab | Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414. CAS No. 945721-28-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9915. | |
| Daratumumab (Anti-CD38) | Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human CD38, Human Antibody (PBS). CAS No. 945721-28-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9915A. | |
| Daraxonrasib | Daraxonrasib (RMC-6236) is an orally active, non-covalent RAS (ON) inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RMC-6236; RAS-IN-2. CAS No. 2765081-21-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148439. | |
| Darglitazone | Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally active PPAR-γ agonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-86325. CAS No. 141200-24-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-120160. | |
| Darifenacin | Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin inhibits tumor growth in colorectal cancer cells and has anti-tumor effects[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK-88525. CAS No. 133099-04-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0033. | |
| Darifenacin hydrobromide | Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK-88525 hydrobromide. CAS No. 133099-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0012. | |
| Darigabat | Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06372865; CVL-865. CAS No. 1614245-70-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120874. | |
| Darizmetinib | Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HRX-0215. CAS No. 2369583-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-152860. | |
| Darolutamide | Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist. Darolutamide has a Ki of 11 nM for rat wild-type AR (wtAR) and IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation[1]. Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation[1]. Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants[1]. Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ODM-201; BAY-1841788. CAS No. 1297538-32-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16985. | |
| Darovasertib | Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LXS196; IDE196. CAS No. 1874276-76-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101569. | |
| Darunavir | Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMC114; UIC-94017. CAS No. 206361-99-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-17040. | |
| DAS-5-oCRBN | DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3044084-97-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163144. | |
| DASA-58 | DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1203494-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19330. | |
| Dasabuvir | Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-333. CAS No. 1132935-63-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13998. | |
| Dasatinib | Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib also induces apoptosis and autophagy, and can cross the blood-brain barrier[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-354825. CAS No. 302962-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10181. | |
| Dasatinib-d8 | Dasatinib-d8 (BMS-354825-d8) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-354825-d8. CAS No. 1132093-70-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-10181S. | |
| Dasatinib hydrochloride | Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively[1]. Dasatinib hydrochloride also induces apoptosis and autophagy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-354825 hydrochloride. CAS No. 854001-07-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10181A. | |
| Dasatinib monohydrate | Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively[1]. Dasatinib monohydrate also induces apoptosis and autophagy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-354825 monohydrate. CAS No. 863127-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-10181B. | |
| Dasatinib (Standard) | Dasatinib (Standard) is the analytical standard of Dasatinib. This product is intended for research and analytical applications. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively[1]. Dasatinib also induces apoptosis and autophagy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-354825 (Standard). CAS No. 302962-49-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10181R. | |
| Dasminapant | Dasminapant (APG-1387), a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APG-1387. CAS No. 1570231-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-125593. | |
| Dasotraline hydrochloride | Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SEP-225289 hydrochloride. CAS No. 675126-08-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12850A. | |
| Datiscetin | Datiscetin (compound 5) is a natural compound isolated from the cultivar Roland, and shows fungitoxic activity towards F. oxysporum f. sp. dianthi.[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 480-15-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8722. | |
| Datopotamab | Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 (TROP2) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2267989-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99843. | |
| Datopotamab deruxtecan (solution) | Datopotamab deruxtecan (DS-1062) solution is a TROP2-targeted antibody-drug conjugate (ADC) with human TROP2 Kd of 0.74 nmol/L. Datopotamab deruxtecan solution consists of the antibody Datopotamab (HY-P99843) and the toxic molecule-linker conjugate Deruxtecan (HY-13631E). Datopotamab deruxtecan solution binds TROP2, triggers internalization and lysosomal trafficking and releases DXd topoisomerase I inhibitor payload. Datopotamab deruxtecan solution disrupts DNA function, induces DNA damage, apoptosis, and bystander killing of tumor microenvironment cells. Datopotamab deruxtecan solution can be used in research related to triple-negative breast cancer, gastric cancer, and non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DS-1062 (solution); Dato-DXd (solution). CAS No. 2238831-60-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141598. | |
| Daucosterol | Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Eleutheroside A; β-Sitosterol β-D-glucoside. CAS No. 474-58-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N0410. | |
| DAUDA | DAUDA (11-(dansylamino) undecanoic acid) is an environment-sensitive fluorescent fatty acid analogue. DAUDA alters its intensities and fluorescent emission spectra on entry into binding proteins. DAUDA is used to determine the relative affinity of natural fatty acids for polymorphs of the Schistosoma mansoni Sm14 fatty acid-binding protein[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73025-02-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-120959. | |
| Daun02 | Daun02 is a proagent of the topoisomerase inhibitor Daunorubicin. Uses: Scientific research. Category: Signaling pathways. CAS No. 290304-24-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13061. | |
| Daunomycinone | Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC-109351. CAS No. 21794-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114658. | |
| Daunorubicin | Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor[1][2][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Daunomycin; RP 13057; Rubidomycin. CAS No. 20830-81-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13062A. | |
| Daunorubicin hydrochloride | Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor[1][2][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride. CAS No. 23541-50-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13062. | |
| dAurAB5 | dAurAB5 is a dual Aurora-A (DC50 = 8.8 nM) and Aurora-B (DC50 = 6.1 nM) PROTAC degrader. dAurAB5 induces degradation of Aurora-A and Aurora-B, reduces N-Myc levels, and decreases viability in IMR32 neuroblastoma cells. dAurAB5 downregulates the levels of AAK1, PTK2, GAK, and TTK. dAurAB5 can be used to study cancers such as neuroblastoma. (Pink: TTK ligand 2: HY-168542, Blue: Thalidomide-O-COOH: HY-103597, Black: 6-Aminocaproic acid: HY-B0236)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3115765-45-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-171770. | |
| Davalintide | Davalintide is an Amylin (HY-P1464)-mimetic peptide with greater potency and longer-lasting effects. Davalintide is a potent agonist of amylin receptor (IC50 = 0.04 nM), calcitonin receptor (IC50 = 0.06 nM) and calcitonin related peptide receptor (CGRP receptor) (IC50 = 3.1 nM). Davalintide shows stronger potency to Amylin to activate cyclic AMP production through the calcitonin receptor (EC50 = 1.4 nM). Davalintide regulates blood sugar and weight through various mechanisms such as delaying gastric emptying, inhibiting glucagon secretion, and reducing food intake. Davalintide can be used for the studies of anti-obesity and anti-diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 863919-85-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P11320. | |
| Davidigenin | Davidigenin is an antidiabetic compound with antitumor, antispasmodic, and antioxidant activities. Davidigenin inhibits duodenal contractions induced by acetylcholine or histamine. Uses: Scientific research. Category: Signaling pathways. CAS No. 23130-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W983015. | |
| Davutamig | Davutamig (REGN-5093) is a human IgG4-kappa, anti-MET bispecific antibody. Davutamig binds 2 distinct epitopes of MET, blocking ligand binding and inducing MET internalization and degradation. Davutamig is applicable to the research of advanced non-small cell lung cancer with MET gene abnormalities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN-5093. CAS No. 2648058-48-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990073. | |
| Daxdilimab | Daxdilimab is an anti-ILT7 monoclonal antibody, ILT7 is a cell surface molecule specific to the pDC type of dendritic cells. Daxdilimab can be used in acute lung injury (ALI) in patients with COVID-19 infection research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI7734; VIB7734. CAS No. 2245966-28-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99226. | |
| DAz-2 | DAz-2 is a sulfonic acid probe for living cells, which can directly detect sulfonic acid-modified proteins in living cells and is cell-permeable[1]. Uses: Scientific research. Category: Fluorescent dyes. CAS No. 1176905-54-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-132278. | |
| Dazodalibep | Dazodalibep (MEDI 4920; VIB 4920) is a non-antibody fusion protein that targets CD40L. Dazodalibep inhibits the co-stimulatory signals between immune cells (such as T cells, B cells, and antigen-presenting cells), thereby enabling the inhibition of a broader range of cellular and humoral responses. Dazodalibep can be used for research on rheumatoid arthritis and Sjögren's syndrome[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI 4920; VIB 4920. CAS No. 2245953-10-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99845. | |
| Dazostinag disodium | Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-676. CAS No. 2553413-93-5. Pack Sizes: 10 mM * 1 mL in Water; 100 μg; 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-148029. | |
| Dazoxiben hydrochloride | Dazoxiben hydrochloride is a potent and orally active thromboxane (TX) synthase inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK 37248. CAS No. 74226-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106067A. | |
| Dazucorilant | Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ?1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CORT113176. CAS No. 1496508-34-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-132811. | |
| Dazukibart | Dazukibart (PF-06823859) is a potent, selective humanized IgG1 neutralizing monoclonal antibody that targets interferon β (IFNβ). Dazukibart can be used in the study of moderate to severe dermatomyositis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06823859. CAS No. 2639474-65-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990036. | |
| DB008 | DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively[1]. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2991637-98-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-150221. | |
| DB04760 | DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 544678-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-125166. | |
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