MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Desloratadine | Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sch34117. CAS No. 100643-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0539. |  |
| Desmethyl cariprazine | Desmethyl cariprazine is a major active metabolite of cariprazine, with activities at human dopamine receptors and serotonin receptors, showing a pEC50 of 8.90 at human D2 receptors, a pEC50 of 8.09 at D3 receptors, and a pEC50 of 6.28 at 5-HT1A receptors. Desmethyl cariprazine inhibits forskolin-induced cAMP production at D2, D3 and 5-HT1A receptors, and suppresses serotonin-induced Ca2+ release at 5-HT2B receptors. Desmethyl cariprazine is applicable to research related to schizophrenia, bipolar disorder type I and bipolar disorder.[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 839712-15-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100656. | |
| Desmethylcitalopram hydrochloride | Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6, -2C19 with IC50s of 39.5 and 53.5 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCIT hydrochloride. CAS No. 97743-99-2. Pack Sizes: 1 mg. Product ID: HY-113739. | |
| Desmethyl-QCA276 | Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1]. Desmethyl-QCA276 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC BRD4-binding moiety 4. CAS No. 2126819-55-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-44103. | |
| Desmorpholinyl Navitoclax-NH-Me | Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Desmorpholinyl ABT-263-NH-Me. CAS No. 2365172-82-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131232. | |
| Desmosterol | Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 313-04-2. Pack Sizes: 10 mM * 1 mL in DMF; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113224. | |
| Desmosterol-d6 | Desmosterol-d6 is the deuterium labeled Desmosterol. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1246298-67-8. Pack Sizes: 500 μg; 1 mg. Product ID: HY-113224S. | |
| Desonide | Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 638-94-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0248. | |
| Desoxyrhaponticin | Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 30197-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N2486. | |
| Desoxyrhaponticin (Standard) | Desoxyrhaponticin (Standard) is the analytical standard of Desoxyrhaponticin. This product is intended for research and analytical applications. Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 30197-14-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2486R. | |
| Desthiobiotin-Iodoacetamide | Desthiobiotin-Iodoacetamide can be used as an ADC Linker. Desthiobiotin-Iodoacetamide also acts as a probe used to label the the Oridonin (HY-N0004)-treated cell lysis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924824-04-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150230. | |
| Desthiobiotin-NHS ester | Desthiobiotin-NHS ester is a biotinylated biochemical assay reagent that reacts with amine groups (such as lysine residues) of proteins or other biomolecules to form stable amide bonds. Desthiobiotin-NHS ester can be used as probes for metalloproteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80750-24-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-W437745. | |
| (Des-Thr7)-Glucagon | (Des-Thr7)-Glucagon is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Peptides. CAS No. 1802078-28-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4504. | |
| Desvenlafaxine | Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: O-Desmethylvenlafaxine. CAS No. 93413-62-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0602. | |
| DETA NONOate | DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Diethylamine NONOate; NOC-18. CAS No. 146724-94-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136278. | |
| Deucravacitinib | Deucravacitinib (BMS-986165) is an orally active allosteric inhibitor of tyrosine kinase 2 (TYK2), with an IC50 of 0.2 nM and a Ki of 0.02 nM against the JH2 domain of TYK2, and it exhibits selectivity over other JAK subtypes and most of the kinome. Deucravacitinib blocks IL-23, IL-12, p-STAT1/3 and Type I IFN signaling, and inhibits Th17/Th1-mediated psoriasis inflammation. Deucravacitinib can be used in research related to moderate-to-severe plaque psoriasis, inflammatory bowel disease and systemic lupus erythematosus[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-986165. CAS No. 1609392-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-117287. | |
| Deuruxolitinib | Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), is an orally active JAK1 and JAK2 inhibitor. Deuruxolitinib demonstrates significant hair regrowth effects. Deuruxolitinib can be used for the research of alopecia areata[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CTP-543; Ruxolitinib d8; Deuterated Ruxolitinib. CAS No. 1513883-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-50856S. | |
| Devazepide | Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-364,718; MK-329. CAS No. 103420-77-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106301. | |
| Devimistat | Devimistat is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CPI-613. CAS No. 95809-78-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15453. | |
| Dexamethasone | Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research[1][2][3][4]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Hexadecadrol; Prednisolone F. CAS No. 50-02-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-14648. | |
| Dexamethasone-4,6α,21,21-d4 | Dexamethasone-4,6α,21,21-d4 is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Uses: Scientific research. Category: Signaling pathways. CAS No. 2483831-63-4. Pack Sizes: 1 mg. Product ID: HY-14648S3. | |
| Dexamethasone acetate | Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dexamethasone 21-acetate; Hexadecadrol acetate. CAS No. 1177-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-14648A. | |
| Dexamethasone-d5 | Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hexadecadrol-d5; Prednisolone F-d5. CAS No. 358731-91-6. Pack Sizes: 1 mg. Product ID: HY-14648S. | |
| Dexamethasone (GMP) | Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hexadecadrol (GMP); Prednisolone F (GMP). CAS No. 50-02-2. Pack Sizes: 10 mg; 50 mg. Product ID: HY-14648G. | |
| Dexamethasone impurity 3 | Dexamethasone impurity 3 is an impurity of Dexamethasone (HY-14648). Uses: Scientific research. Category: Signaling pathways. CAS No. 37927-01-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-114432. | |
| Dexamethasone palmitate | Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DXP. CAS No. 14899-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128922. | |
| Dexamethasone phosphate | Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease)[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dexamethasone 21-phosphate. CAS No. 312-93-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B1829. | |
| Dexamethasone phosphate disodium | Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease)[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dexamethasone 21-phosphate disodium. CAS No. 2392-39-4. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1829A. | |
| Dexamethasone (Standard) | Dexamethasone (Standard) is the analytical standard of Dexamethasone. This product is intended for research and analytical applications. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hexadecadrol(Standard); Prednisolone F (Standard). CAS No. 50-02-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-14648R. | |
| Dexamethasone (Water Soluble) | Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research[1].(Sale size is the weight of dexamethasone). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dexamethasone cyclodextrin complex. CAS No. 50-02-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14648C. | |
| Dexchlorpheniramine maleate | Dexchlorpheniramine maleate is an orally taken anti-histamine that has anti-inflammatory, anti-irritant, anti-allergic, and skin barrier effects. Dexchlorpheniramine maleate inhibits myocardial contraction in rats. Dexchlorpheniramine maleate can be used in studies of allergic rhinitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-(+)-Chlorpheniramine maleate salt. CAS No. 2438-32-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg. Product ID: HY-B1062. | |
| Dexfadrostat | Dexfadrostat ((R)-Fadrozole) is an orally active and selective aromatase inhibitor, with human aromatase IC50 values of 6.4 nM. Dexfadrostat suppresses estrogen synthesis, reduces circulating estradiol levels and suppresses aldosterone production. Dexfadrostat can be used for the research of breast cancer, primary aldosteronism, and hypertension[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Fadrozole; (R)-CGS 16949A free base; FAD286. CAS No. 102676-87-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113986. | |
| DEX-maleimide | DEX-maleimide is a coupling agent that can be used to synthesize conjugates containing single-domain antibodies (VHH) conjugated with antigens and anti-inflammatory agents. DEX-maleimide can be used for research on autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2754462-35-4. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-46225. | |
| Dexmedetomidine | Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Medetomidine; (S)-Medetomidine. CAS No. 113775-47-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-12719. | |
| Dexmedetomidine hydrochloride | Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride. CAS No. 145108-58-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17034A. | |
| Dexpramipexole | Dexpramipexole ((R)-Pramipexole) is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704. CAS No. 104632-28-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-17355B. | |
| Dexpramipexole dihydrochloride | Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride. CAS No. 104632-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17355A. | |
| Dexrazoxane | Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells[1] [2] [3] [4] [5] [6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICRF-187; ADR-529; NSC-169780. CAS No. 24584-09-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B0581. | |
| Dextranase, Trichoderma reesei | Dextranase, Trichoderma reesei, glucan hydrolase, is often used in biochemical research. Dextranase can catalyze the hydrolysis of α-(1,6)-glucosidic bonds in dextran, and has a wide range of applications, such as food processing, sugar modification, agent preparation, and medicine for enhancing the activity of endocarditis antibiotics wait[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9025-70-1. Pack Sizes: 5 g; 10 g. Product ID: HY-P2840. | |
| Dextran (MW 40000) | Dextran (MW 40000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds. Dextran has excellent solubility in water, making it useful as a viscosity modifier or stabilizer in foods, paints and adhesives. In the biomedical field, dextran is often used as a plasma expander because of its ability to increase blood volume when administered intravenously. It can also be modified to create dextran-based drug delivery systems, such as targeted nanoparticles. Uses: Scientific research. Category: Signaling pathways. CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-112624C. | |
| Dextran sulfate sodium salt (MW 16000-24000) | Dextran sulfate sodium salt (DSS) (MW 16000-24000) is a polymer of dehydrated glucose with a molecular weight of approximately 16000-24000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 16000-24000) induces STING polymerization and TBK1 activation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSS (MW 16000-24000); DXS (MW 16000-24000). CAS No. 9011-18-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-116282B. | |
| Dextran sulfate sodium salt (MW 35000-45000) | Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium[1][2][3][4][5]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: DSS (MW 35000-45000); DXS (MW 35000-45000). CAS No. 9011-18-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-116282C. | |
| Dextran sulfate sodium salt (MW 450000-550000) | Dextran sulfate sodium salt (DSS) (MW 450000-550000) is a polymer of dehydrated glucose with a molecular weight of approximately 450000-550000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 450000-550000) inhibits replication of HIV-1 and influenza A virus. Dextran sulfate sodium salt (MW 450000-550000) can be formulated as nanoparticles and shows antibacterial activity. Dextran sulfate sodium salt (MW 450000-550000) can be used for functional material preparation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSS (MW 450000-550000); DXS (MW 450000-550000). CAS No. 9011-18-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-116282D. | |
| Dextran T10 (MW 10,000) | Dextran T10 (MW 10,000) (Dextran 10) is a dehydrated glucose polymer with an average molecular weight of 10,000. Dextran T10 (MW 10,000) is composed of repeated glucose units, and it has abundant hydroxyl (-OH) groups, which can be used as a natural "magnetic marker" for chemical exchange saturation transfer (CEST) MRI imaging[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 10; Dextran D10; Dextran T10(MW 8000-12000). CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-112624L. | |
| Dextran T1 (MW 1,000) | Dextran T1 (Dextran 1; Dextran D1) (with a molecular weight of 1,000) is a dehydrated glucose polymer with an average molecular weight of 1,000. Dextran T1 (MW 1,000) has excellent biodegradability and biocompatibility, and can be used as a nanobody carrier scaffold and a freeze-drying protectant. Dextran T1 (MW 1,000) promotes the retention of circulating tumor cells in the capillary bed[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 1; Dextran D1; Dextran T1(MW 800-1200). CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-112624A. | |
| Dextran T200 (MW 200,000) | Dextran T200 (Dextran 200; Dextran D200) (MW 200,000) is a dehydrated glucose polymer with an average molecular weight of 200,000. Dextran T200 (MW 200,000) has excellent biodegradability and good biocompatibility, and can be used as a high-molecular-weight tracer and optical clearing agent[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 200; Dextran D200; Dextran T200(MW 180000-220000). CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-112624N. | |
| Dextran T2 (MW 2,000) | Dextran T2 (Dextran 2; Dextran T2(MW 1600-2400)) is a natural high molecular weight polysaccharide, the glycosidic bonds in its structure can be recognized by endo-dextranase and exo-dextranase. Dextran T2 (MW 2,000) breaks the glycosidic bonds in the enzymatic hydrolysis mechanism, releasing products such as D-glucose, Isomaltose (IM2), and Isomaltotriose (IM3). Dextran T2 (MW 2,000) can be used as a model substrate to characterize the catalytic properties of dextranase (such as optimal pH, temperature and product specificity), and to study enzymatic mechanism research and polysaccharide degradation pathways in glycobiology. The Dextran series of compounds are also a natural polysaccharide drug carrier, which can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 2; Dextran D2; Dextran T2(MW 1600-2400). CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g. Product ID: HY-112624H. | |
| Dextran T4 (MW 4,000) | Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 4; Dextran D4; Dextran T4(MW 3200-4800). CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-112624J. | |
| Dextran T500 (MW 500,000) | Dextran T500 MW 500,000 (Dextran 500; Dextran D500; Dextran T500 MW 440000-560000) is a polymer of anhydroglucose with the average molecular weight of 500,000. Dextran T500 MW 500,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 500; Dextran D500; Dextran T500(MW 440000-560000). CAS No. 9004-54-0. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-112624P. | |
| Dextran T70 (MW 70,000) | Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dextran 70; Dextran D70; Dextran T70(MW 64000-76000). CAS No. 9004-54-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-112624B. | |
| Dextrin | Dextrins are a group of low molecular weight carbohydrates produced by the hydrolysis of starch. Dextrin is commonly used as a thickener, stabilizer or binder in a variety of foods including baked goods, beverages and confectionary. In addition, it is used in the production of adhesives, paper and textiles. Its unique chemical properties make it an important ingredient in a variety of industrial processes, especially in construction and packaging. Uses: Scientific research. Category: Signaling pathways. CAS No. 9004-53-9. Pack Sizes: 100 g; 500 g; 1 k g. Product ID: HY-W115731. | |
| Dezamizumab | Dezamizumab (GSK 2398852) is a fully humanized clonal IgG1 antibody against serum amyloid P component (SAP) with complement activation and amyloid clearance-inducing activities. Dezamizumab binds to SAP associated with amyloid deposits to form complexes that activate complement and mediate phagocytic clearance, triggering activation of the classical complement pathway. Dezamizumab can be used for the research of systemic amyloidosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody (dezamizumab). CAS No. 1662664-56-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99358. | |
| Dezecapavir | Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VH-499; VH4011499. CAS No. 2568911-72-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-159828. | |
| DFHBI | DFHBI is a small molecule that resembles the chromophore of green fluorescent protein (GFP). DFHBI can be used for imaging RNA in living cells. Spinach and DFHBI are essentially nonfluorescent when unbound, whereas the Spinach-DFHBI complex is brightly fluorescent both in vitro and in living cells (Ex/Em = 469/501 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 1241390-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110250. | |
| DFHBI-1T | DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1539318-36-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110251. | |
| DFHO | DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a Kd value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1420815-34-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-136277. | |
| dFKBP-1 | dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1799711-22-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103634. | |
| DFP00173 | DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ~0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 672286-03-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-126073. | |
| D-Fructose | D-Fructose (D(-)-Fructose) is a monosaccharide found in honey, fruits, and other plants. Two D-Fructose molecules can combine to form a disaccharide, sucrose[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D(-)?-Fructose. CAS No. 57-48-7. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N7092. | |
| D-Fructose-13C | D-Fructose-13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D(-)?-Fructose-13C. CAS No. 108311-21-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7092S1. | |
| D-Fructose-13C6 | D-Fructose-13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D(-)?-Fructose-13C6. CAS No. 201595-65-5. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 100 mg. Product ID: HY-N7092S. | |
| D-Fructose 1-phosphate disodium | D-Fructose 1-phosphate disodium is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate disodium acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71662-09-4. Pack Sizes: 1 mg. Product ID: HY-112253A. | |
| D-Fructose-6-phosphate disodium | D-Fructose 6-phosphate disodium is an endogenous metabolite. D-Fructose 6-phosphate disodium can be obtained by hydrolysis of Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate disodium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate disodium can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate disodium can be used to study Lewy body dementia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26177-86-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-113407A. | |
| DfTat | DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2035480-78-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3432. | |
| DG-041 | DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 861238-35-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10835. | |
| DG70 | DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK1733953A. CAS No. 930470-97-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg. Product ID: HY-111086. | |
| D-Galactal | D-Galactal is a monosaccharide that belongs to the class of carbohydrates. It is an aldohexose, which means it has six carbon atoms and an aldehyde functional group. D-Galactal occurs naturally in certain foods such as dairy products, meats and fruits. It can also be synthesized by chemical or enzymatic processes. D-Galactal has various applications in the food industry, especially as a flavoring and sweetening agent. Additionally, it has potential research roles in metabolic disorders, cancer, and inflammation. Uses: Scientific research. Category: Signaling pathways. CAS No. 21193-75-9. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g. Product ID: HY-W047710. | |
| D-Galacto-D-mannan, 95% | D-Galacto-D-mannan from Ceratonia siliqua is a plant cell wall polysaccharide. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carob galactomannan, 95%. CAS No. 11078-30-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W145481. | |
| D(+)-Galactosamine hydrochloride | D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: D-Galactosamine HCl. CAS No. 1772-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-42682. | |
| D(+)-Galactosamine hydrochloride (Standard) | D(+)-Galactosamine (hydrochloride) (Standard) is the analytical standard of D(+)-Galactosamine (hydrochloride). This product is intended for research and analytical applications. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Galactosamine HCl (Standard). CAS No. 1772-03-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-42682R. | |
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