MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dibenzo(a,i)pyrene | Dibenzo (a,i) pyrene is a polycyclic aromatic hydrocarbon and also a carcinogenic ligand of the TCDD (Ah) receptor. Dibenzo (a,i) pyrene binds to the TCDD (Ah) receptor in rat liver. Dibenzo (a,i) pyrene induces DNA adduct formation and upregulates the protein levels of p53 and p21WAF1 in diploid lung fibroblasts. Dibenzo (a,i) pyrene alters the cell cycle distribution of diploid lung fibroblasts, increasing the proportion of cells in the S phase, decreasing the proportions of cells in the G0/G1 and G2/M phases, and causing S phase delay/arrest. Dibenzo (a,i) pyrene is applicable for cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189-55-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-124211. |  |
| Dibenzocyclooctyne-Cy5.5 | Dibenzocyclooctyne-Cy5.5 (DBCO-Cy5.5) is a fluorescent dye. Dibenzocyclooctyne-Cy5.5 can be used to syntheses calcium-binding near-infrared fluorescent nanoprobe for bone tissue imaging[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DBCO-Cy5.5; Cyanine5.5 DBCO. CAS No. 2643308-61-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-D1537. | |
| Dibenzylfluorescein | Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its Km value of 0.87-1.9 μM (Ex=485 nm, Em=535 nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DBF. CAS No. 97744-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-116862. | |
| Dibutyl phthalate | Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials, personal care products, and the coating of oral medications[1]. May cause toxicity and adverse neurobehavioral effects[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84-74-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-Y0304. | |
| Dibutyryl-cGMP sodium | Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [3H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K+ channels[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bt2cGMP sodium. CAS No. 51116-00-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130354. | |
| Dicamba | Dicamba is a herbicide. Dicamba is currently used in agriculture and gardening to control the growth of different unwanted vegetable species, mainly in cereal grain crops, but also on sugar cane and soybeans, among others. Dicambais induces significant DNA damage. Dicambais induces genotoxicity and cytotoxicity. Uses: Scientific research. Category: Induced disease models products. CAS No. 1918-00-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-121267. | |
| Dicamba (Standard) | Dicamba (Standard) is the analytical standard of Dicamba. This product is intended for research and analytical applications. Dicamba is a herbicide with high water solubility and low volatility. Dicamba induces tissue damage and cell death in Gallium aparine L. through lipid peroxidation. Dicamba is widely used in agriculture and horticulture[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1918-00-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-121267R. | |
| Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct | Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a common dichloromethane solvate of the palladium catalyst Pd(dppf)Cl2, a phosphine ligand palladium(II) complex, which can be used as a versatile precatalyst for various cross-coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can stabilize reaction intermediates and lower the reaction activation energy in coupling reactions, and can be used in Suzuki-Miyaura coupling reaction studies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 95464-05-4. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-21623. | |
| Dichloro(1,2-diaminocyclohexane)platinum(II) | Dichloro(1,2-diaminocyclohexane)platinum(II) is a platinum (II) analog and the oxaliplatin parent complex. Dichloro(1,2-diaminocyclohexane)platinum(II) is a potent chemotherapeutic with a wide spectrum of anticancer activity, low toxicity, and lack of cross resistance in many cisplatin-resistant cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52691-24-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W414604. | |
| Dichloroiodomethane | Dichloroiodomethane is a natural compound in human beings[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 594-04-7. Pack Sizes: 1 mg (10 mM * 474 μL in Ethanol); 5 mg (10 mM * 2.37 mL in Ethanol); 10 mg (10 mM * 4.74 mL in Ethanol). Product ID: HY-133642. | |
| Dichlorphenamide | Dichlorphenamide (Diclofenamide) is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Diclofenamide. CAS No. 120-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0397. | |
| Diclazuril-d4 | Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-64433-d4. CAS No. 1632495-80-7. Pack Sizes: 1 mg. Product ID: HY-B0357S. | |
| Diclofenac | Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Uses: Scientific research. Category: Induced disease models products. CAS No. 15307-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-15036. | |
| Diclofenac acyl glucuronide | Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC50 = 0.620 μM), and COX-2 inhibitory activity (IC50 = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers. Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-1-O-G. CAS No. 64118-81-6. Pack Sizes: 500 μg. Product ID: HY-126848. | |
| Diclofenac Sodium | Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GP 45840. CAS No. 15307-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g. Product ID: HY-15037. | |
| Diclofenac Sodium (Standard) | Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GP 45840 (Standard). CAS No. 15307-79-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-15037R. | |
| Dicloromezotiaz | Dicloromezotiaz is a potent insecticide acting on nicotinic acetylcholine receptors (nAChRs). Dicloromezotiaz can be used to control a broad range of lepidoptera[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1263629-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145298. | |
| Dicoumarol | Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dicumarol. CAS No. 66-76-2. Pack Sizes: 500 mg. Product ID: HY-N0645. | |
| Didemnin B | Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer[1]. Uses: Scientific research. Category: Natural products. CAS No. 77327-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105055. | |
| Didesmethyl cariprazine | Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine (HY-14763). Didesmethyl cariprazine is a partial agonist at the D2 and D3 receptors, full agonist at the 5-HT1A receptor, and antagonist at the human 5-HT2B receptor (Ki: 1.41 nM (human D2L), 0.056 nM (human D3), 1.7 nM (human 5-HT1A), 0.52 nM (human 5-HT2B)). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 839712-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100658. | |
| Didesmethylrocaglamide | Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 177262-30-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-19356A. | |
| DIDNTB | DIDNTB is a dye. DIDNTB exhibits chemical sensitivity and specificity toward albumin. DIDNTB is much less affected by other proteins. DIDNTB enables the detection of urinary albumin at concentrations ≥10 mg/L[1].\n . Uses: Scientific research. Category: Signaling pathways. CAS No. 145551-16-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D0862. | |
| DiD perchlorate | DiD is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins (Ex/Em = 633/665 nm)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127274-91-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1028. | |
| DIDS sodium salt | DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDL101114ZA. CAS No. 67483-13-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-D0086. | |
| Didymin | Didymin, a flavonoid glycoside, possesses antioxidant and anticancer properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14259-47-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N2068. | |
| Dieckol | Dieckol, is a naturally occurring phlorotannin found in some brown algal species. Dieckol has anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88095-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147059. | |
| Dienestrol | Dienestrol is an orally active nonsteroidal estrogen. Dienestrol prevents the formation of implantation swellings in the uterus by inhibiting ovum discharge[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg. Product ID: HY-B1403. | |
| Dienogest | Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STS 557. CAS No. 65928-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0084. | |
| Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate | Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC)[1][2][3][4][5][6]. Uses: Scientific research. Category: Induced disease models products. CAS No. 632-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-118594. | |
| Diethylamine NONOate diethylammonium salt | Diethylamine NONOate (DEA NONOate, diethylammonium salt) is a nitric oxide donor. Diethylamine NONOate is a potent antimicrobial agent, which can inhibit Escherichia coli growth. Diethylamine NONOate also can enhance preservation of the donor rat heart[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DEA NONOate diethylamine. CAS No. 372965-00-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131925. | |
| Diethyl bipy55'DC | Diethyl bipy55'DC is an inhibitor of collagen proline 4-hydroxylases (CP4Hs) with antifibrotic and anti-metastatic activities. Diethyl bipy55'DC can inhibit CP4H activity in cultured cells at concentrations that do not cause iron deficiency[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1762-46-5. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-116893. | |
| Diethyl pyrocarbonate | Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609-47-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g. Product ID: HY-D0846. | |
| Diethyl-pythiDC | Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs). Uses: Scientific research. Category: Signaling pathways. CAS No. 1821370-70-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103068. | |
| Diethylstilbestrol | Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56-53-1. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 1 g; 5 g. Product ID: HY-14598. | |
| Diethylstilbestrol-d8 | Diethylstilbestrol-d8 is the deuterium labeled Diethylstilbestrol. Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 91318-10-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-14598S. | |
| Diethylstilbestrol (Standard) | Diethylstilbestrol (Standard) is the analytical standard of Diethylstilbestrol. This product is intended for research and analytical applications. Diethylstilbestrol (Stilbestrol) is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56-53-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14598R. | |
| Diethyl succinate | Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Diethyl Butanedioate. CAS No. 123-25-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-Y0836. | |
| Diethyltoluamide | Diethyltoluamide (DEET) is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Diethyltoluamide is toxic to hepatocytes and can lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DEET; N,N-Diethyl-m-toluamide. CAS No. 134-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B0978. | |
| Diethyltoluamide (Standard) | Diethyltoluamide (Standard) is the analytical standard of Diethyltoluamide. This product is intended for research and analytical applications. Diethyltoluamide (DEET) is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Diethyltoluamide is toxic to hepatocytes and can lead to many physiological, pharmacological, and behavioral abnormal ities, particularly motor deficits and learning and memory dysfunction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DEET (Standard); N,N-Diethyl-m-toluamide (Standard). CAS No. 134-62-3. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-B0978R. | |
| Difamilast | Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPA-15406. CAS No. 937782-05-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109085. | |
| Difelikefalin | Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CR-845; FE-202845. CAS No. 1024828-77-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-17609. | |
| Diflunisal | Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-647. CAS No. 22494-42-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-18342. | |
| Difluprednate | Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednate's active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23674-86-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-17569. | |
| DiFMUP | DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6,8-Difluoro-4-methylumbelliferyl phosphate. CAS No. 214491-43-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120166. | |
| Digeranyl bisphosphonate | Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DGBP. CAS No. 878143-03-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-U00145. | |
| Digitalin | Digitalin (Digitalinum verum) is a cardiac glycoside and can be isolated from Digitalis[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Digitalinum verum. CAS No. 752-61-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N12799. | |
| Digitonin | Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth[1]. Digitonin is an natural detergent[2]. Uses: Scientific research. Category: Natural products. CAS No. 11024-24-1. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-N4000. | |
| Digitoxigenin | Digitoxigenin is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cerberigenin; Echujetin. CAS No. 143-62-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B2151. | |
| Digitoxin | Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure [1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71-63-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1357. | |
| Digoxigenin | Digoxigenin (DIG) is a steroid. DIG is used for situ hybridization as a labeling molecule probe due to long shelf life and fast detection and high sensitivity of DIG-labeled riboprobes[1][3]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Lanadigenin. CAS No. 1672-46-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-B1025. | |
| Digoxigenin NHS ester | Digoxigenin NHS ester is an activated ester which readily reacts with amino groups under mild conditions, attaching the Digoxigenin (HY-B1025) moiety to proteins or amino-. Digoxigenin NHS ester can be used to label proteins and oligonucleotides[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 129273-26-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-155500. | |
| Dihexa | Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimers disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2. CAS No. 1401708-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-16969. | |
| Dihomo-γ-Linolenoyl Ethanolamide | Dihomo-γ-Linolenoyl Ethanolamide, an endocannabinoid, is a cannabinoid (CB) receptor agonist with Kis of 857 nM and 598 nM for human recombinant CB1 and CB2 receptors, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150314-34-4. Pack Sizes: 5 mg (71.52 mM * 200 μL in Ethanol); 10 mg (71.52 mM * 400 μL in Ethanol). Product ID: HY-113070. | |
| Dihydrexidine hydrochloride | Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine hydrochloride can stimulate YAP phosphorylation[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DAR-0100 hydrochloride. CAS No. 137417-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101299B. | |
| Dihydroartemisinin | Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol. CAS No. 71939-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0176. | |
| Dihydroberberine | Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 483-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1934. | |
| Dihydro-β-erythroidine hydrobromide | Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHβE hydrobromide. CAS No. 29734-68-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-107670. | |
| Dihydrocaffeic acid | Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4-Dihydroxy-benzenepropanoic acid. CAS No. 1078-61-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N2406. | |
| Dihydrocapsaicin | Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19408-84-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0361. | |
| Dihydroconiferyl alcohol | Dihydroconiferyl alcohol is a cell division factor. Dihydroconiferyl alcohol can be isolated from the American sycamore (Acer pseudoplatanus L.). Dihydroconiferyl alcohol inhibits the degradation of Indole-3-acetic acid (HY-18569). Dihydroconiferyl alcohol can stimulate the growth of soybean and tobacco callus tissue and synergistically enhance Indole-3-acetic acid-induced hypocotyl elongation in cucumber. Dihydroconiferyl alcohol can be used in the research of plant growth regulation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2305-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-W016393. | |
| Dihydrocurcumin | Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 76474-56-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1967. | |
| Dihydrocytochalasin B | Dihydrocytochalasin B is an Actin disruptor. Dihydrocytochalasin B disrupts actin microfilament bundles, inhibits actin polymerization, and alters intracellular actin cytoskeletal structures. Dihydrocytochalasin B blocks the initiation of DNA synthesis. Dihydrocytochalasin B inhibits Calcium transport. Dihydrocytochalasin B inhibits cytokinesis and alters cell morphology. Dihydrocytochalasin B can be used in studies related to rickets[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39156-67-7. Pack Sizes: 500 μg. Product ID: HY-N6701. | |
| Dihydroergotamine mesylate | Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid that can be used for the research of migraines[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6190-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0670A. | |
| Dihydroethidium | Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hydroethidine; PD-MY 003. CAS No. 104821-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0079. | |
| Dihydroferulic acid | Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hydroferulic acid. CAS No. 1135-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-N7080. | |
| Dihydrogalanthamine hydrobromide | Dihydrogalanthamine hydrobromide is an acetylcholinesterase inhibitor. Dihydrogalanthamine hydrobromide can be used in research on neurological diseases such as sequelae of poliomyelitis and myasthenia gravis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 69353-21-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108723. | |
| Dihydrokaempferol | Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 480-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N2897. | |
| Dihydromorin | Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18422-83-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3748. | |
| Dihydromunduletone | Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 674786-20-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101483. | |
| Dihydromyricetin | Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ampelopsin; Ampeloptin. CAS No. 27200-12-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0112. | |
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