MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| DNase I (filtered) | DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9003-98-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108882C. |  |
| DNase I RNase & Protease free | DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune responses. Decreased DNase I activity may be associated with the onset and progression of systemic lupus erythematosus (SLE). DNase I (RNase & Protease free) is a molecular biology-grade DNase I purified by chromatography to remove RNase and protease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9003-98-9. Pack Sizes: 2.5 KU; 10 KU. Product ID: HY-108882B. | |
| DNDI-6148 | DNDI-6148 is a novel preclinical candidate for the research of visceral leishmaniasis. Uses: Scientific research. Category: Signaling pathways. CAS No. 2243909-59-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-139854. | |
| DNDI-6174 | DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2868298-43-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162066. | |
| DNL343 | DNL343 is a potent, selective, orally active and brain-penetrant activator of eukaryotic initiation factor eIF2B. DNL343 inhibits the activity of the integrated stress response (ISR) in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 can be used in the study of neurodegenerative diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2278265-85-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149555. | |
| D-NMAPPD | D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (1R,2R)-B13. CAS No. 35922-06-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124962. | |
| DNMDP | DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 328104-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028690. | |
| DNMT3A-IN-1 | DNMT3A-IN-1 (compound 1) is an effective and selective DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A, with KI values ranging from 9.16 to 18.85 μM (AdoMet) and 11.37 to 23.34 μM (poly dI-dC). DNMT3A-IN-1 can induce apoptosis in acute myeloid leukemia (AML) cell lines (Apoptosis)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1403598-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144433. | |
| DNP-PEG4-NHS ester | DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 858126-78-0. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-140614. | |
| DO-264 | DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2301866-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114157. | |
| DO34 | DO34 is a selective DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB1 receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1848233-58-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117771. | |
| DO3A trisodium | DO3A (trisodium)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO3A (trisodium) can be used for conjugation of peptides and radionuclides. Uses: Scientific research. Category: Signaling pathways. CAS No. 217973-03-0. Pack Sizes: 10 mM * 1 mL in Water; 1 g; 5 g. Product ID: HY-W250844A. | |
| DOBAQ | DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360461-69-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-144025. | |
| Dobutamine | Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34368-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15746A. | |
| Dobutamine hydrochloride | Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 49745-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15746. | |
| Docetaxel | Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP-56976. CAS No. 114977-28-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 1 g. Product ID: HY-B0011. | |
| Docetaxel-d9 | Docetaxel-d9 is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP-56976-d9. CAS No. 940867-25-4. Pack Sizes: 1 mg. Product ID: HY-B0011S. | |
| Docetaxel (Standard) | Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP-56976 (Standard). CAS No. 114977-28-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0011R. | |
| Docetaxel Trihydrate | Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP-56976 Trihydrate. CAS No. 148408-66-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0011A. | |
| DOCK2-IN-1 | DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4590-86-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-153128. | |
| Docosahexaenoic acid | Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHA; Cervonic acid. CAS No. 6217-54-5. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-B2167. | |
| Docosahexaenoic acid-d5 | Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHA-d5; Cervonic acid-d5. CAS No. 1197205-71-2. Pack Sizes: 1 mg (1.50 mM * 2 mL in Ethanol). Product ID: HY-B2167S. | |
| Docosahexaenoic acid methyl ester | Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Methyl docosahexaenoate; all cis-DHA methyl ester. CAS No. 2566-90-7. Pack Sizes: 10 mM * 1 mL in Ethanol; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-101541. | |
| Docosane-1,22-diol | Docosane-1,22-diol is a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 22513-81-1. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W614137. | |
| Docosanoic acid | Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Behenic acid. CAS No. 112-85-6. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W013049. | |
| Docosanoic acid-d3 | Docosanoic acid-d3 (Behenic acid-d3) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Behenic acid-d3. CAS No. 1193721-67-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W013049S3. | |
| Docosanoyl-L-carnitine hydrochloride | Docosanoyl-L-carnitine (hydrochloride) is an ester product. Uses: Scientific research. Category: Signaling pathways. CAS No. 2133456-10-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-166313. | |
| Docosapentaenoic acid (22n-3) | Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase, with IC50s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clupanodonic acid. CAS No. 24880-45-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113159. | |
| Docosatrienoic Acid | Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: cis-13,16,19-docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid. CAS No. 28845-86-5. Pack Sizes: 5 mg (149 mM * 100 μL in Ethanol); 10 mg (149 mM * 200 μL in Ethanol). Product ID: HY-101408. | |
| DODAP | DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127512-29-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130751. | |
| Dodecanedioic acid | Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 693-23-2. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W012241. | |
| Dodecanoylcarnitine | Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Lauroylcarnitine. CAS No. 25518-54-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113166. | |
| Dodecylbenzenesulfonic acid | Dodecylbenzenesulfonic acid (Dodecylbenzenesulphonic acid) is an anionic surfactant. Dodecylbenzenesulfonic acid serves as a raw material for various detergents. Dodecylbenzenesulfonic acid can be used as a cleaning agent in the daily chemical industry or a chemical oil-displacing agent in tertiary oil recovery[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dodecylbenzenesulphonic acid. CAS No. 27176-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 g; 100 g; 250 g; 500 g; 1 k g. Product ID: HY-W250144. | |
| Dodecyl β-D-glucopyranoside | Dodecyl β-D-glucopyranoside is a non-ionic detergent and surfactant commonly used to solubilize and purify membrane proteins in biochemical research. Dodecyl β-D-glucopyranoside also interacts with bovine serum albumin (BSA) to quench its intrinsic fluorescence. The critical micelle concentration (CMC) of Dodecyl β-D-glucopyranoside (DG) and DG/BSA complex is 2.0 mM and 2.34 mM, respectively. Micelles can be formed in aqueous solutions above this concentration[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59122-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W142692. | |
| Dodecylphosphocholine | Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 29557-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-116013. | |
| Dodecyltrimethylammonium bromide | Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1119-94-4. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-D0838. | |
| DODMA | DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104162-47-2. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-112755. | |
| Dofetilide | Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK 68789. CAS No. 115256-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0232. | |
| DOI hydrochloride | DOI hydrochloride is a serotonin 5-HT2A/2C receptor agonist with Ki values of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 42203-78-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103124. | |
| Dolasetron | Dolasetron (MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron acts as an antiemetics agent and can be used for the research of chemotherapy-induced nausea and vomiting in cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDL-73147. CAS No. 115956-12-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0750. | |
| Dolastatin 10 | Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DLS 10; NSC 376128. CAS No. 110417-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15580. | |
| Dolutegravir | Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S/GSK1349572. CAS No. 1051375-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-13238. | |
| Dolutegravir sodium | Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S/GSK1349572 sodium. CAS No. 1051375-19-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13238A. | |
| Dolutegravir (Standard) | Dolutegravir (Standard) is the analytical standard of Dolutegravir. This product is intended for research and analytical applications. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S/GSK1349572 (Standard). CAS No. 1051375-16-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13238R. | |
| Domagrozumab | Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06252616. CAS No. 1629605-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99857. | |
| Domatinostat | Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4SC-202 free base. CAS No. 910462-43-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16012A. | |
| Domiphen bromide | Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 538-71-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g. Product ID: HY-B1467. | |
| Domperidone | Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R33812. CAS No. 57808-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B0411. | |
| Domvanalimab | Domvanalimab (AB154) is an anti-TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used for studies of non-small cell lung cancer and esophageal cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AB154. CAS No. 2368219-35-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99858. | |
| Donanemab | Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3002813. CAS No. 1931944-80-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99859. | |
| Donepezil | Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E2020 free base. CAS No. 120014-06-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14566. | |
| Donepezil Hydrochloride | Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E2020. CAS No. 120011-70-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-B0034. | |
| Donidalorsen sodium | Donidalorsen (ISIS-721744; IONIS-PKK-LRX) sodium is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen sodium inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen sodium can be used in the research of hereditary angioedema[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ISIS-721744; IONIS-PKK-LRX. CAS No. 2304701-45-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-139787A. | |
| Donitriptan | Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: F-11356 free base. CAS No. 170912-52-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106157. | |
| Donzakimig | Donzakimig is a trispecific anti-IL-13/IL-22/HSA antibody. Donzakimig adopts a Fab-scFv-scFv structural format (without an Fc region), in which the Fab domain is linked to the scFv domains via a S (G4S)2 linker. Donzakimig binds to and inhibits the activities of IL-13 and IL-22, thereby blocking the signal transduction of these two cytokines. Donzakimig can extend its serum half-life by binding to human serum albumin, enhancing its in vivo stability and achieving long-acting efficacy. Donzakimig can be used in research on moderate-to-severe atopic dermatitis, moderate-to-severe asthma (especially eosinophilic type), psoriasis, inflammatory bowel disease, and other conditions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765066-99-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990735. | |
| Dooku1 | Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2253744-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126010. | |
| Dopal | Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5707-55-1. Pack Sizes: 5 mg (65.72 mM * 500 μL in Methanol); 10 mg (65.72 mM * 1 mL in Methanol). Product ID: HY-121252. | |
| Dopamine | Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body[1]. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASL279 free base. CAS No. 51-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0451. | |
| Dopamine acrylamide | Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 201610-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-29035. | |
| Dopamine-d3 hydrochloride | Dopamine-d3 (hydrochloride) is the deuterium labeled Dopamine hydrochloride (ASL279)-[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASL279-d3. CAS No. 53587-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0451AS4. | |
| Dopamine-d5 hydrochloride | Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASL279-d5 hydrochloride. CAS No. 2193106-55-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0451AS7. | |
| Dopamine hydrochloride | Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASL279. CAS No. 62-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-B0451A. | |
| Dopamine hydrochloride (Standard) | Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASL279 (Standard). CAS No. 62-31-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0451AR. | |
| DOPE | DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine. CAS No. 4004-5-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112005. | |
| DOPE-NHS | DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1010188-79-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-150241. | |
| DOPG sodium | DOPG sodium is a naturally occurring anionic phospholipid, containing oleic acid (18:1) inserted at the sn-1 and sn-2 positions. DOPG can form a lipid bilayer in an aqueous solution and is used in the generation of micelles, liposomes, and other artificial membranes. DOPG also exhibits anti-inflammatory properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dioleoylphosphatidylglycerol sodium. CAS No. 67254-28-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-141571. | |
| Doramapimod | Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIRB 796. CAS No. 285983-48-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10320. | |
| Doramapimod hydrochloride | Doramapimod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound with biological activity through inhibition of p38 MAPK. Doramapimod hydrochloride can significantly inhibit the activities of TNF-α and IL-1β induced by LPS, LTA and PGN. Doramapimod hydrochloride showed a stronger inhibitory effect on inflammation induced by all three bacterial toxins, which was more significant compared with the effects of other compounds. Doramapimod hydrochloride can be used in the research of autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIRB 796 hydrochloride. CAS No. 1283526-53-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10320A. | |
| Doravirine | Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-1439. CAS No. 1338225-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16767. | |
| Dordaviprone | Dordaviprone (TIC10) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. Dordaviprone can cross the blood-brain barrier[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TIC10; ONC-201. CAS No. 1616632-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15615A. | |
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