MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| D-Sorbitol | D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sorbitol; D-Glucitol. CAS No. 50-70-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0400. |  |
| D-Sorbitol-13C | D-Sorbitol-13C is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary s. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sorbitol-13C; D-Glucitol-13C. CAS No. 287100-73-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0400S1. | |
| D-Sorbitol-d8 | D-Sorbitol-d8 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sorbitol-d8; D-Glucitol-d8. CAS No. 287962-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B0400S. | |
| DSP-2230 | DSP-2230 is the orally active inhibitor for voltage-gated sodium channel that inhibits Nav1.7-, Nav1.8-, and Nav1.9-derived sodium currents with IC50s of 7.1 μM, 11.4 μM and 6.7 μM, respectively. DSP-2230 can be used to improve neuropathic pain[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ANP-230. CAS No. 1233231-30-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125079. | |
| DSP-4 hydrochloride | DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Neurotoxin DSP 4 hydrochloride. CAS No. 40616-75-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103210. | |
| DSPC | DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,2-Distearoyl-sn-glycero-3-PC; 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. CAS No. 816-94-4. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W040193. | |
| DSPC-d70 | DSPC-d70 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,2-Distearoyl-sn-glycero-3-PC-d70; 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70. CAS No. 56952-01-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W040193S. | |
| DSP Crosslinker | DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation. Uses: Scientific research. Category: Signaling pathways. CAS No. 57757-57-0. Pack Sizes: 100 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-118759. | |
| DSPE-Mal | DSPE-MAL is a phospholipid compound with a maleimide reactive group. DSPE-MAL contains two saturated fatty acids and can self-assemble in water to form a lipid bilayer. DSPE-MAL can be used to prepare liposomes as nanocarriers for active molecules[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360858-99-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W441007. | |
| DSPE-N3 | DSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical[1]. DSPE-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2839508-98-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W440999. | |
| DSPE-NHS | DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. The NHS-ester is reactive with N-terminal of protein/peptide or other amine molecule to form a stable amide linkage. DSPE-NHS labels antibodies. DSPE-NHS can be used to prepare liposomes as agent nanocarrier[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1383932-86-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W441011. | |
| DSPE-PEG1000-Amine ammonium | DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG1000-NH2 ammonium. CAS No. 474922-26-4. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W440823A. | |
| DSPE-PEG 2000 | DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. DSPE-PEG 2000 can be used to form micelles as nanoparticles for drug delivery[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (C2H4O)nC42H82NO10P. CAS No. 892144-24-0. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-142979. | |
| DSPE-PEG2000-alkyne | DSPE-PEG2000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-alkyne can be used in drug delivery research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2421228-20-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-167028. | |
| DSPE-PEG2000-Biotin | DSPE-PEG2000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG2000(2000) Biotin. CAS No. 385437-57-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140736. | |
| DSPE-PEG2000-FITC | DSPE-PEG2000-FITC is a PEG lipid conjugated with fluorescein. FITC is a green dye with a peak absorption at 494 nm and a maximum emission at 520 nm, which is used for staining biological samples or nanoparticles. DSPE-PEG2000-FITC spontaneously forms lipid bilayers or micelles in water and can be used to prepare liposomes for delivering substances such as mRNA vaccines[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1000788-53-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W440915. | |
| DSPE-PEG2000-Mal ammonium | DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG2000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium. CAS No. 474922-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144004. | |
| DSPE-PEG2000-Mannose | DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1829524-73-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168374. | |
| DSPE-PEG4-DBCO | DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2112738-14-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140955. | |
| DSPE-PEG5000-Mal ammonium | DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents[1][2]. DSPE-PEG5000-Mal ammonium contains PEG5000. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG5000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] ammonium. CAS No. 474922-22-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144004A. | |
| DSPE-PEG8-Mal | DSPE-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2112737-94-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-140956. | |
| DSPE-PEG-Amine, MW 2000 ammonium | DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium. CAS No. 474922-26-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125924. | |
| DSPE-PEG-Folate, MW 3350 | DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1236288-25-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144009. | |
| DSPE-Thiol | DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144735-82-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W441004. | |
| DSR-141562 | DSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC50 of 43.9 nM, and the IC50 values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. DSR-141562 can be used for the study of positive symptoms, negative symptoms and cognitive impairments associated with schizophrenia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2007975-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136569. | |
| DSR-6434 | DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1059070-10-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110120. | |
| DSRM-3716 | DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Iodoisoquinoline. CAS No. 58142-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-W021879. | |
| DT-061 | DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1809427-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-112929. | |
| DT2216 | DT2216 is a potent and selective BCL-XL (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax-piperazine (HY-44432), a linker, and a VHL E3 ubiquitin ligase (Pink: Navitoclax-piperazine; Blue: VHL ligand; Black: linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2365172-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130604. | |
| dTAG-13-NEG | dTAG-13-NEG is a negative control of dTAG-13 (HY-114421). dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2451573-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-161157. | |
| dTAG-47 | dTAG-47 is a FKBP12F36V PROTAC degrader. dTAG-47 efficiently degrades FKBP12F36V-MELK(sg3R) in MELK?/? MDA-MB-468-FKBP12F36V-MELK(sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC). (Pink: FKBP12F36V ligand (HY-114420), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-42773), E3 ligase ligand-linker conjugate (HY-175952))[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2265886-81-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147098. | |
| dTAGV-1 | dTAGV-1 is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2451573-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145514D. | |
| dTAGV-1 hydrochloride | dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2624313-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145514C. | |
| dTAGV-1-NEG | dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12F36V-selective degrader[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2451573-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-145514A. | |
| dTAGV-1 TFA | dTAGV-1 TFA is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2624313-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145514. | |
| DTE | DTE (Dithioerythritol) is a sulfur-containing sugar derived from the corresponding 4-carbon monosaccharide erythrose. DTE is an epimer of Dithiothreitol (DTT) (HY-15917). DTE is a thiol reducing agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dithioerythritol; Clelands reagent. CAS No. 6892-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-15916. | |
| D-Tetrahydropalmatine | D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis[1]. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors[2]. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3520-14-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N2003. | |
| DTHIB | DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 897326-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138280. | |
| D-Threitol | D-threitol serves as a antifreeze agent in the Alaskan beetle Upis ceramboides. Uses: Scientific research. Category: Signaling pathways. CAS No. 2418-52-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W012846. | |
| DTME | DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917). DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dithio-bis-maleimidoethane. CAS No. 71865-37-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W106411. | |
| DTNB | DTNB (Ellmans Reagent) is a chemical used to quantify the number or concentration of thiol groups[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ellmans Reagent. CAS No. 69-78-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-15915. | |
| DTP3 | DTP3 TFA is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1809784-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100538. | |
| DTP3 TFA | DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2759216-46-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100538A. | |
| D-(+)-Trehalose | D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Trehalose; α,α-Trehalose. CAS No. 99-20-7. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-N1132. | |
| D-(+)-Trehalose-13C12 | D-(+)-Trehalose-13C12 is a 13C isotope labeled version of D-(+)-Trehalose (HY-N1132). D-(+)-Trehalose,which is widespread, can be used as a food ingredient and pharmaceutical excipient[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Trehalose-13C12; α,α-Trehalose-13C12. CAS No. 1313730-07-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W768345. | |
| D-(+)-Trehalose-d14 | D-(+)-Trehalose-d14 is the deuterium labeled D-(+)-Trehalose. D-(+)-Trehalose, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipi[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Trehalose-d14; α,α-Trehalose-d14. CAS No. 2028292-31-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-N1132S. | |
| D-(+)-Trehalose dihydrate | D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Trehalose dihydrate; α,α-Trehalose dihydrate. CAS No. 6138-23-4. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N1132A. | |
| dTRIM24 | dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170695-14-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111519. | |
| (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 118102-98-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2426. | |
| [D-Trp8]-γ-MSH | [D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 321351-81-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1217. | |
| DTSSP Crosslinker | DTSSP Crosslinker is a crosslinker reactive with primary amines. DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81069-02-5. Pack Sizes: 5 mg. Product ID: HY-126349. | |
| D-Tyrosine-d7 | D-Tyrosine-d7 is the deuterium labeled D-Tyrosine (HY-Y0444)[1]. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1426174-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-Y0444S2. | |
| Dubermatinib | Dubermatinib (TP-0903) is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TP-0903. CAS No. 1341200-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12963. | |
| DUB-IN-1 | DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924296-18-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-50736. | |
| DUB-IN-2 | DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924296-19-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50737A. | |
| DUB-IN-3 | DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924296-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50737. | |
| Dulaglutide | Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY2189265. CAS No. 923950-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0120. | |
| Duligotuzumab | Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody targeting EGFR. Duligotuzumab blocks the binding of ligands to these two receptors, inhibits downstream HER/ErbB, AKT and MAPK signaling pathways, induces antibody-dependent cellular cytotoxicity, reduces the proliferation and migration abilities of cancer cells, promotes apoptosis, exerts radiosensitizing effects, and reverses EGFR resistance in cancer cells. Duligotuzumab can be used in tumor-related research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEHD-7945A; RG 7597. CAS No. 1314238-96-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99866. | |
| Duloxetine | Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY248686. CAS No. 116539-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0161. | |
| Duloxetine hydrochloride | Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-Duloxetine hydrochloride; LY-248686 hydrochloride. CAS No. 136434-34-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0161A. | |
| Duocarmycin DM free base | Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1116745-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128915. | |
| Duocarmycin SA | Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130288-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12456. | |
| Duocarmycin TM | Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBI-TMI. CAS No. 157922-77-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107769. | |
| Duostatin 5 | Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2124210-34-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145149. | |
| DuP-697 | DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX-2 inhibitor (IC50 of 10 nM and 800 nM for human COX-2 and COX-1, respectively). DuP-697 exerts antiproliferative (IC50 of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88149-94-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103387. | |
| DUPA | DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in agent conjugate to selectively deliver cytotoxic agents to prostate cancer cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 302941-52-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111606. | |
| Dupilumab | Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN-668; SAR-231893. CAS No. 1190264-60-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9926. | |
| Duramycin | Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Moli1901; Lancovutide. CAS No. 1391-36-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106302. | |
| Durlobactam sodium | Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ETX2514. CAS No. 1467157-21-6. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117974. | |
| Durvalumab | Durvalumab (MEDI 4736) is an human anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI 4736. CAS No. 1428935-60-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9919. | |
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