MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| DLin-K-C3-DMA | DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217306-46-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145225. |  |
| D-Lin-MC3-DMA | D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. Uses: Scientific research. Category: Signaling pathways. CAS No. 1224606-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-112251. | |
| DL-Isocitric acid trisodium salt | DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is an intermediate product in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637-73-6. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-W009362. | |
| DLK-IN-1 | DLK-IN-1 (Compound 14) is an orally active, blood-brain barrier-penetrable and selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki value of 3 nM. DLK-IN-1 inhibits Flt3, PAK4, STK33 and TrkA. DLK-IN-1 reduces p-c-Jun. DLK-IN-1 can be used in Alzheimer's disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620574-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114331. | |
| DL-Mevalonolactone | DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy[3]. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling[2][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Mevalonolactone; Mevalolactone. CAS No. 674-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-107855. | |
| DL-Mevalonolactone-d7 | DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Mevalonolactone-d7; Mevalolactone-d7. CAS No. 347840-19-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107855S. | |
| DL-Norepinephrine-d6 | DL-Norepinephrine-d6 is the deuterium labeled DL-Norepinephrine. DL-Norepinephrine is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine after being labeled with tritium can be used as a tracer for the research on Parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219908-83-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7142S3. | |
| DL-Norepinephrine hydrochloride | DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-N7142. | |
| DL-Phenylalanine-d5 | DL-Phenylalanine-d5 is the deuterium labeled DL-Phenylalanine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Amino-3-phenylpropionic acid-d5. CAS No. 284664-89-7. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-N0215S4. | |
| DL-Propargylglycine | DL-Propargylglycine is a Glycine (HY-Y0966) derivative[1]. DL-Propargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 50428-03-0. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W040124. | |
| DL-Serine hydroxamate | DL-Serine hydroxamate is a serine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55779-32-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-131894. | |
| DL-Tartaric acid-d2 | DL-Tartaric acid-d2 is the deuterium labeled DL-Tartaric acid (HY-Y1315)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 181376-62-5. Pack Sizes: 1 mg; 10 mg. Product ID: HY-Y1315S. | |
| DL-TBOA | DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 205309-81-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-107522. | |
| DL-threo-PDMP hydrochloride | DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80938-69-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-116392B. | |
| D-Luciferin | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We of er the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin. CAS No. 2591-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-12591A. | |
| D-Luciferin 6-methyl ether | D-Luciferin 6-methyl ether (6-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 μM. D-Luciferin 6-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Methoxyluciferin. CAS No. 24404-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115749. | |
| D-Luciferin potassium | D-luciferin potassium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We offer the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-(-)-Luciferin potassium; Firefly luciferin potassium; Beetle Luciferin potassium. CAS No. 115144-35-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-12591B. | |
| D-Luciferin sodium | D-luciferin sodium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We of er the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-(-)-Luciferin sodium; Firefly luciferin sodium; Beetle Luciferin sodium. CAS No. 103404-75-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-12591. | |
| [D-Lys6]-LH-RH | [D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52671-12-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P3668. | |
| D-Lys(Z)-Pro-Arg-pNA diacetate | D-Lys(Z)-Pro-Arg-pNA diacetate is a chromogenic peptide substrate of activated protein C (APC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Spectrozyme PCa; Chromozym Pca diacetate. CAS No. 108963-70-8. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-P0021A. | |
| DM21 | DM21 is a next-generation linker-payload that combines a maytansinoid microtubule-disrupting payload with a stable tripeptide linker. DM21 is conjugated with a humanized antibody against ADAM9 to obtain IMGC936[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2243689-80-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-139441. | |
| DM4 | DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ravtansine. CAS No. 796073-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12454. | |
| DMA-135 hydrochloride | DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2237925-62-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145932. | |
| DMABA NHS ester | DMABA NHS ester can chemically react with the primary amine groups of the major phospholipid component of the cell membrane, Phosphatidylethanolamine (PE). Through precursor ion scanning, all PE subclasses labeled with DMABA can be detected. DMABA NHS ester can be used in combination with isotope-labeled compounds such as DMABA-d6 NHS ester, DMABA-d10 NHS ester, and DMABA-d4 NHS ester to observe changes in the distribution of PE lipids and the formation of novel PE lipid products[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58068-85-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118431. | |
| D-Mannitol | D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7]. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed[8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mannitol; Mannite. CAS No. 69-65-8. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N0378. | |
| D-manno-Heptose | D-manno-Heptose (D-Mannoheptose) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Mannoheptose. CAS No. 7634-39-1. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-W040140. | |
| D-Mannoheptulose | D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3615-44-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-U00462. | |
| D-Mannosamine hydrochloride | D-Mannosamine ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal) hydrochloride is a six-carbon amino sugar and an amino derivative of D-mannose. D-Mannosamine hydrochloride can block mannose receptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride. CAS No. 5505-63-5. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W021425. | |
| D-Mannose | D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3458-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-N0379. | |
| D-Mannose-6-phosphate disodium | D-Mannose-6-phosphate (disodium) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33068-18-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W854355. | |
| D-Mannuronic acid sodium | D-Mannuronic acid sodium is a uronic acid monosaccharide that is frequently utilized in alginate manufacturing. D-Mannuronic acid can be used for the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 921-56-2. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7703. | |
| DMAPP triammonium | DMAPP (Dimethylallyl diphosphate) triammonium is an isoprenoid precursor. DMAPP triammonium, as an isomer of isopentenyl pyrophosphate (IPP), exists in virtually all life forms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dimethylallyl diphosphate triammonium. CAS No. 1186-30-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-130573A. | |
| DMAPT | DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD50 of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dimethylamino Parthenolide. CAS No. 791595-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16172. | |
| DMAT | DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CK2 Inhibitor; Casein kinase II Inhibitor. CAS No. 749234-11-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15535. | |
| DMBA | DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: 7,12-DMBA; 7,12-Dimethylbenzanthracene. CAS No. 57-97-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-W011845. | |
| DMBP | DMBP is a VPS41 inhibitor. DMBP induces methuosis and inhibits autophagy in cancer cells. DMBP inhibits the fusion of late endosomes and autophagosomes with lysosomes. DMBP effectively inhibits metastasis in a mouse metastatic melanoma model. DMBP can be used for the study of melanoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 133156-42-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-177120. | |
| DMG-PEG2000-Mal | DMG-PEG2000-Mal is a pegylated lipid with a molecular weight of 2000. DMG-PEG-Mal serves as a component of lipid nanoparticles for mRNA delivery[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3101670-33-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-167036. | |
| DMH-1 | DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1206711-16-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12273. | |
| DMHCA | DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects?and can be used for the research of cholesterol homeostasis diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79066-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129098. | |
| DMNB-caged-Serine | DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 780009-55-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136276. | |
| DM-Nitrophen | DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds Ca2+ with high affinity and Mg2+ with considerable affinity before photolysis. DM-Nitrophen releases Ca2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117367-86-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-126789. | |
| DM-NOFD | DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 865488-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-112068. | |
| DMN-Tre | DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling. DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2177287-88-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D2919. | |
| DMOG | DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation?in vitro and in vivo[1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG?acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal[2][4]. DMOG induces cell autophagy[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dimethyloxallyl Glycine. CAS No. 89464-63-1. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15893. | |
| DMP 696 | DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression. Uses: Scientific research. Category: Signaling pathways. CAS No. 202578-52-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12131. | |
| DMP 777 | DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-694458. CAS No. 157341-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-75957. | |
| DMPE | DMPE is the dimyristoylphosphatidylcholine. DMPE is a liposome used to deliver agents[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dimyristoylphosphatidylethanolamine; 1,2-Ditetradecyl-rac-glycero-3-phosphoethanolamine. CAS No. 20255-95-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-142983. | |
| DMPE-PEG2000 ammonium | DMPE-PEG2000 ammonium (14:0 PEG2000 PE ammonium) is a PEG-phospholipid conjugate to prepare nanostructured lipid carrier[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 14:0 PEG2000 PE ammonium; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium. CAS No. 474922-82-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-144006. | |
| DMPG-d54 sodium | 1,2-Dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol)-d54 (sodium) is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium). Uses: Scientific research. Category: Signaling pathways. CAS No. 326495-45-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-22274S. | |
| DMPG sodium | DMPG sodium is a biochemical reagent. DMPG sodium is used as a liposome carrier to load 6-shogaol (HY-14616) with anticancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 200880-40-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-22274. | |
| DMPX | DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A2A adenosine receptor (A2A AR) antagonist that crosses the blood-brain barrier, with a Ki of 11 μM for rat A2 adenosine receptor and a Ki of 45 μM for rat A1 adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,7-Dimethyl-1-propargylxanthine. CAS No. 14114-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-W004425. | |
| DMT1 blocker 1 | DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1354790-56-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126301. | |
| DMT-2'-OMe-Bz-C | DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110764-74-4. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-W115186. | |
| DMT-2'-OMe-D-Ribitol phosphoramidite | DMT-2'-OMe-D-Ribitol phosphoramidite (compound 9) is an abasic phosphoramidite monomer that can be used to introduce the abasic group Y34 into oligonucleotides[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1470023-72-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160884. | |
| DMTAP | DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 197974-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112523A. | |
| DMTMM | DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. CAS No. 3945-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 100 g. Product ID: HY-Y1168. | |
| DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite | DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite allows site-specific introduction of a 2'-O-C22 lipophilic modification at adenosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923115-67-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-164583. | |
| DMTr-2'-O-C22-rC(Ac)-3'-CE-Phosphoramidite | DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at cytidine positions during oligonucleotide synthesis, which is used to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. Construction and mechanism study of DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite nucleic acid silencing molecules[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923115-93-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-164582. | |
| DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite | DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923115-75-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164581. | |
| DMTr-2'-O-C22-rU-3'-CE-phosphoramidite | DMTr-2'-O-C22-rU-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923115-86-8. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-200314. | |
| DMX-5804 | DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2306178-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111754. | |
| D-myo-Inositol-1,3,4,5-tetraphosphate sodium | D-myo-Inositol-1,3,4,5-tetraphosphate sodium is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Uses: Scientific research. Category: Signaling pathways. CAS No. 210488-61-2. Pack Sizes: 100 μg; 500 μg. Product ID: HY-133690. | |
| D-myo-Inositol-1,4,5-triphosphate trisodium | D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Inositol 1,4,5-trisphosphate trisodium; Ins(1,4,5)-P3 trisodium. CAS No. 141611-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-103642A. | |
| DN02 | DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8 (1) (Ki=32 nM), which is 30-fold more affinity than BRD8 (2) (Ki>1000 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055009-00-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148116. | |
| DN-1289 | DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3026597-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152142. | |
| DNA2 inhibitor C5 | DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 35973-25-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128729. | |
| D-N-Acetylgalactosamine | D-N-Acetylgalactosamine is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 1811-31-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-33212. | |
| DNA-PK Substrate | DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11-24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.). Uses: Scientific research. Category: Peptides. CAS No. 146064-85-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5429. | |
| DNA relaxation-IN-1 | DNA relaxation-IN-1 (Compound 27) is a DNA ligase 1 DNA Lig1) inhibitor. DNA relaxation-IN-1 inhibits DNA ligation and disrupts the DNA relaxing activity of DNA Lig1. DNA relaxation-IN-1 induces Apoptosis. DNA relaxation-IN-1, in combination with Topotecan (HY-13768), exhibits synergistic antiproliferative effects against colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2190506-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161152. | |
| DNase I, Bovine pancreas | DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer[1]. Uses: Scientific research. Category: Enzymes. Alternative Names: DNase. CAS No. 9003-98-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-108882. | |
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