MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| DPM-1001 | DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1471172-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-121515. |  |
| DPN | DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Diarylpropionitrile. CAS No. 1428-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-12452. | |
| DPO-1 | DPO-1 is a potent Kv1.5 and Kv1.3 (EC50 = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca2+ influx in Ca2+-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU)-induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K+ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 43077-30-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100712. | |
| DPPC | DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 129Y83. CAS No. 63-89-8. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-109506. | |
| DPPD-Q | DPPD-Q is a quinone derivative of p-phenylenediamine antioxidants and an analog of DTPD-Q (HY-163650). DPPD-Q is identified as a major sewage treatment plant effluent[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3421-8-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W176199. | |
| DPPE-PEG2000 ammonium | DPPE-PEG2000 ammonium (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG2000 ammonium enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG2000 ammonium helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG2000 ammonium serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 16:0 PEG2000 PE ammonium; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium. CAS No. 474922-84-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-144012. | |
| DPPG | DPPG (1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol sodium) is a phospholipid that contains long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions, and it serves as an active component to prevent BaP molecules from entering the water subphase. DPPG is used to prepare micelles, liposomes, and other types of artificial membranes that can resist damage from UV radiation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol sodium. CAS No. 200880-41-7. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-125940. | |
| DPPH | DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2,2-Diphenyl-1-picrylhydrazyl. CAS No. 1898-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-112053. | |
| DPQ | DPQ is a selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 129075-73-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114869. | |
| (D-Pro7)-Angiotensin I/II (1-7) | (D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a Ki of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 586962-44-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1656. | |
| D-Pro-Phe-Arg-Chloromethylketone | D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88546-74-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4245. | |
| D-Psicose | D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Allulose. CAS No. 551-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 g. Product ID: HY-N9914. | |
| D-Psicose (Standard) | D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Allulose (Standard). CAS No. 551-68-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N9914R. | |
| DPTIP | DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 351353-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131002. | |
| DPTN dihydrochloride | DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 325767-87-1. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-153152. | |
| DPyPE | DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 201036-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112766. | |
| DQP-1105 | DQP-1105 is a potent noncompetitive NMDA receptor antagonist. DQP-1105 inhibits GluN2C- and GluN2D-containing receptors (IC50=7.0 and 2.7 μM, respectively). The IC50 values are at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, GluA1-, or GluK2-containing receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 380560-89-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-107711. | |
| D-(-)-Quinic acid | D-(-)-Quinic acid scavenges hydrogen peroxide (IC50=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC50 =93.75 μg/mL). D-(-)-Quinic acid is orally active[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 77-95-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-N0464. | |
| Dracorhodin | Dracorhodin, the main component in sanguis draconis, is a flavylium compound belonging to the anthocyanin family. Dracorhodin can induce vasodilatation[1]. Uses: Scientific research. Category: Natural products. CAS No. 643-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-N4081. | |
| Draflazine | Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freunds adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-75231; R88021. CAS No. 120770-34-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106841. | |
| Dragendorff reagent | Dragendorff reagent is used for detecting alkaloids and other nitrogen-containing compounds. Dragendorff reagent is a solution of potassium bismuth iodide composing of Basic bismuth nitrate (Bi(NO3)3), Tartaric acid (HY-N2436), and Potassium iodide (KI). When contact with alkaloids, Dragendorff reagent produces an orange or orange red precipitate[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39775-75-2. Pack Sizes: 10 mL; 25 mL; 50 mL; 100 mL. Product ID: HY-159051. | |
| DREADD agonist 21 | DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56296-18-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100234. | |
| DREADD agonist 21 dihydrochloride | DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250025-92-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100234A. | |
| Dresbuxelimab | Dresbuxelimab (AK-119) is an IgG-κ monoclonal antibody targeting CD73. The expression system is usually CHO (Chinese Hamster Ovary) cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AK-119. CAS No. 2550560-20-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99865. | |
| D-Ribose 5-phosphate disodium | D-Ribose 5-phosphate disodium is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate disodium is used in the synthesis of nucleotides and nucleic acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18265-46-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W009371. | |
| D-Ribose 5-phosphate disodium dihydrate | D-Ribose 5-phosphate disodium dihydrate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 207671-46-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W009371C. | |
| D-Ribose 5-phosphate disodium (Standard) | D-Ribose 5-phosphate disodium (Standard) is the analytical standard of D-Ribose 5-phosphate disodium (HY-W009371). This product is intended for research and analytical applications. D-Ribose 5-phosphate disodium is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate disodium is used in the synthesis of nucleotides and nucleic acids. Uses: Scientific research. Category: Signaling pathways. CAS No. 18265-46-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W009371R. | |
| D-Ribose(mixture of isomers) | D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-69-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W018772. | |
| D-Ribulose (1 M in water) | D-Ribulose is a biochemical assay reagent. Uses: Scientific research. Category: Signaling pathways. CAS No. 488-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-121305. | |
| DRI-C21045 | DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 μM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 μM and 4.5 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2101765-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-120323. | |
| Drisapersen | Drisapersen (Kyndrisa) is a 2'-O-methyl phosphorothioate RNA antisense oligonucleotide that induces exon 51 skipping. Drisapersen induces skipping of exon 51 during Dystrophin pre-mRNA splicing, allowing the synthesis of partially functional Dystrophin. Drisapersen can be used in research related to Duchenne muscular dystrophy[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kyndrisa; GSK2402968A; PRO051. CAS No. 1251830-50-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-145724. | |
| Driselase, Basidiomycetes sp | Driselase, Basidiomycetes sp, a complex mixt. of wall-digesting enzymes, is a specific commercial fungal protoplasting enzyme preparation. Driselase can be used in combination with lyase to promote protoplast formation in fungi. Driselase is by far the most potent of the enzymes tested for polysaccharide digestion and greatly increases both tensile and indentation compliances, yet it does not induce wall creep, even after 6 h of digestion[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 85186-71-6. Pack Sizes: 50 mg; 100 mg. Product ID: HY-126224. | |
| Droloxifene | Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Hydroxytamoxifen. CAS No. 82413-20-5. Pack Sizes: 5 mg. Product ID: HY-121149. | |
| Dronedarone | Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR 33589. CAS No. 141626-36-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0016. | |
| Dronedarone Hydrochloride | Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents. Uses: Scientific research. Category: Signaling pathways. CAS No. 141625-93-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-75839. | |
| Droperidol | Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 μM. Droperidol has anesthetic and sedative properties[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dehydrobenzperidol. CAS No. 548-73-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1240. | |
| Drospirenone | Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. [1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dihydrospirorenone. CAS No. 67392-87-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0111. | |
| Drospirenone (Standard) | Drospirenone (Standard) is the analytical standard of Drospirenone. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dihydrospirorenone (Standard). CAS No. 67392-87-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0111R. | |
| Drotaverine hydrochloride | Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 985-12-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108974. | |
| Droxidopa | Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-DOPS; DOPS; SM5688. CAS No. 23651-95-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 1 g. Product ID: HY-13458. | |
| Droxinostat | Droxinostat (NS 41080) is a histone deacetylase (HDAC) inhibitor. Droxinostat selectively inhibits HDAC3, HDAC6, and HDAC8 with IC50 values of 16.9 μM, 2.47 μM, and 1.46 μM, respectively. Droxinostat can be used for the research of hepatocellular carcinoma (HCC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NS 41080. CAS No. 99873-43-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13267. | |
| Drozitumab | Drozitumab (PRO 95780) is a human agonistic monoclonal antibody which binds the death receptor DR5. Drozitumab has potent antitumor activity against rhabdomyosarcoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PRO 95780; rhuMAb-DR 5; Anti-Human DR5 Recombinant Antibody. CAS No. 912628-39-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99286. | |
| DRP1i27 | DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1453028-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-152086. | |
| Drp1-IN-1 | Drp1-IN-1 is a dynamin-1-like protein (Drp1) inhibitor with an IC50 of 0.91 μM. Drp1 mediates the fission of the outer mitochondrial membrane. Drp1-IN-1 can be used to study diseases associated with mitochondrial dysfunction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247733-08-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125222. | |
| Drp1 peptide inhibitor P110 | Drp1 peptide inhibitor P110 (Compound P110) is a selective Drp1 peptide inhibitor with neuroprotective properties. Drp1 peptide inhibitor P110 can inhibit the activation of Drp1, prevent MPTP-induced Drp1 mitochondrial translocation, and alleviate MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage, and behavioral deficits, and can be used in the study of Alzheimer's disease. Additionally, Drp1 peptide inhibitor P110 can reduce mitochondrial damage and organ injury in animal models of Huntington's disease, cerebral ischemic injury, and myocardial infarction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2770267-63-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P6437. | |
| Drupanin | Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC50 value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53755-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N10361. | |
| DS02312223 | DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D223. CAS No. 2253733-45-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W1126235. | |
| DS08210767 | DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376334-75-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125879. | |
| DS18561882 | DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2227149-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130251. | |
| DS-1971a | DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1450595-86-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131182. | |
| DS21150768 | DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3074816-62-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157149. | |
| DS21360717 | DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC50 of 0.49 nM. Anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2304654-43-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128576. | |
| DS-3801b | DS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1369412-66-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-144401. | |
| DS-437 | DS-437 is a dual PRMT5/7 inhibitor (IC50s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1674364-87-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124131. | |
| DS44960156 | DS44960156 is a selective MTHFD2 inhibitor with moderate to low blood-brain barrier penetration (IC50=1.6 μM, Ki=1.23 μM). DS44960156 specifically binds to the active site of MTHFD2, disrupts redox homeostasis and blocks serine-mediated one-carbon metabolism, thereby increasing the NAD+/NADH ratio and ROS levels. DS44960156 not only effectively inhibits the proliferation of glioma cells, but also enhances the sensitivity of cells to glutamine starvation-induced death. DS44960156 binds to plasma proteins, shows no mutagenicity, carcinogenicity or acute oral toxicity, and serves as a research agent for glioblastoma multiforme and other cancers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361327-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131943. | |
| DS55980254 | DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488609-43-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158145. | |
| DS68591889 | DS68591889 is a selective and orally active phosphatidylserine synthase 1 (PTDSS1) inhibitor. DS68591889 has no inhibitory activity against PTDSS2. DS68591889 induces the phospholipid imbalance in a wide range of cancer cells. DS68591889 negatively regulates B cell receptor (BCR)-induced Ca2+ signaling and subsequent apoptotic cell death. DS68591889 can be used for the cancer research, such as B cell lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488609-21-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157562. | |
| DS69910557 | DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032750-17-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148350. | |
| DS89002333 | DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM. DS89002333 shows good anti-tumor activity in an FL-HCC patient-derived xenograft model (expressing the DNAJB1-PRKACA fusion gene). DS89002333 can be used in study of fibrolamellar hepatocellular carcinoma (FL-HCC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2832159-79-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150072. | |
| DS-9300 | DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2259641-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-152241. | |
| D-Saccharic acid 1,4-lactone hydrate | D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 61278-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134453A. | |
| (D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) | (D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is an adrenocorticotropic hormone (ACTH) analogue[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18067-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3564. | |
| D-Serine | D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Serine. CAS No. 312-84-5. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-100808. | |
| D-Serine-d3 | D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Serine-d3. CAS No. 1414348-52-9. Pack Sizes: 1 mg. Product ID: HY-100808S. | |
| DSG Crosslinker | DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disuccinimidyl glutarate. CAS No. 79642-50-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-114697. | |
| DSG-PEG2000 | DSG-PEG2000 (DSG-PEG2000 2000) is a type of polyethylene glycol grease. DSG-PEG2000 can be used to prepare liposomes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSG-PEG2000 2000. CAS No. 308805-39-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-W591381. | |
| DSM1465 | DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3109381-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-170780. | |
| DSM265 | DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1282041-94-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-100184. | |
| DSM705 hydrochloride | DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC50=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2989908-08-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132171A. | |
| D-SNAP | D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Nitroso-N-acetylpenicillamine. CAS No. 79032-48-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-101013. | |
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