MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Doripenem | Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S 4661. CAS No. 148016-81-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0187. |  |
| Dornase alfa | Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase) that can specifically degrade extracellular DNA. Dornase alfa catalyzes the cleavage of DNA released by neutrophils in respiratory mucus, reduces sputum viscosity, thereby improving mucus clearance efficiency, reducing airway obstruction and alleviating inflammatory responses. Dornase alfa can be used to improve lung function (such as FEV_1) in cystic fibrosis (CF), reduce the risk of acute pulmonary exacerbations, and has good in vivo tolerability. Dornase alfa acts locally on the respiratory tract through aerosol inhalation, specifically improving the high viscosity of mucus caused by DNA accumulation and related respiratory symptoms[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: rhDNase. CAS No. 143831-71-4. Pack Sizes: 500 μg. Product ID: HY-108858. | |
| D-Ornithine hydrochloride | D-Ornithine ((R)-Ornithine) hydrochloride is a constituent of bacterial cell wall. D-Ornithine hydrochloride promotes the production of L-arginine (HY-N0455). D-Ornithine hydrochloride enhances the expression of pyrrolysine-containing proteins[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Ornithine hydrochloride. CAS No. 16682-12-5. Pack Sizes: 10 mM * 1 mL in Water; 1 g; 5 g; 10 g; 25 g. Product ID: HY-34516. | |
| Dorsomorphin | Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Compound C; BML-275. CAS No. 866405-64-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13418A. | |
| Dorsomorphin dihydrochloride | Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Compound C dihydrochloride; BML-275 dihydrochloride. CAS No. 1219168-18-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13418. | |
| Dorsomorphin dihydrochloride (GMP) | Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP). CAS No. 1219168-18-9. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-13418G. | |
| Dorzagliatin | Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMS5552. CAS No. 1191995-00-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109030. | |
| Dorzolamide hydrochloride | Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L671152 hydrochloride; MK507 hydrochloride. CAS No. 130693-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 100 mg; 250 mg. Product ID: HY-B0109A. | |
| Dosimertinib-d5 mesylate | Dosimertinib-d5 (mesylate) is a potent and orally active EGFR inhibitor. Dosimertinib-d5 (mesylate) decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d5 (mesylate) shows antiproliferative and anti-tumor activity. Dosimertinib-d5 (mesylate) has the potential for the research of non-small-cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD-9291-d5 mesylate; Mereletinib-d5 mesylate. CAS No. 2403760-72-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-142283AS. | |
| Dostarlimab | Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TSR-042; ANB-011; WBP-285. CAS No. 2022215-59-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99345. | |
| Dot1L-IN-5 | Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 0.17 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2565705-03-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135128. | |
| DOTA-ECL1i | DOTA-ECL1i is a conjugate of the CCR2 inhibitor ECL1i (HY-P11553) and DOTA. When radiolabeled with 68Ga, DOTA-ECL1i serves as a PET tracer that targets CCR2 expression. DOTA-ECL1i can be used in research related to pulmonary fibrosis, cardiac injury, abdominal aortic aneurysm inflammation, atherosclerosis, head and neck cancer, and pancreatic cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2850189-48-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11553B. | |
| DOTAGA-anhydride | DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375475-53-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W087187. | |
| DOTAGA-FAP-2286-ALB | DOTAGA-FAP-2286-ALB is a derivative of Rofapitide tetraxetan (HY-147057). DOTAGA-FAP-2286-ALB is a selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 67.5 nM. DOTAGA-FAP-2286-ALB enhances tumor retention via albumin interaction, prolonging blood circulation and improving radiometal complex stability (e.g., with 111In and 225Ac). DOTAGA-FAP-2286-ALB is promising for research of radionuclide therapy (TRT) of FAP-positive solid tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3114056-16-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-173374. | |
| DOTA-GA-maleimide | DOTA-GA-maleimide is a bifunctional chelator with protein conjugation and radiometal chelation capabilities. DOTA-GA-maleimide forms stable complexes with 111In and conjugates with proteins via maleimide chemistry. DOTA-GA-maleimide conjugates with LFn, enabling 111In radiolabeling of LFn through direct or pre-labeling strategies. Radiolabeled LFn is applicable to MMP activity imaging studies. DOTA-GA-maleimide is used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1800229-46-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157977. | |
| DOTA-GPC3 targeting peptide 2 | DOTA-GPC3 targeting peptide 2 (Sequence 30) is a RDC peptide targeting GPC3, with Kd of 0.3 nM. DOTA-GPC3 targeting peptide 2 is composed of DOTA and GPC3 targeting peptide 2. DOTA-GPC3 targeting peptide 2 can be labeled with radioactive elements[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3066439-94-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W1124925. | |
| DOTA-JR11 | DOTA-JR11 is a somatostatin receptor 2 (SSTR2) antagonist. DOTA-JR11 can be labeled by 68Ga, used for paired imaging in neuroendocrine tumors (NETs) research[1]. DOTA-JR11 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Satoreotide tetraxetan. CAS No. 1039726-31-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5128. | |
| DOTA-LM3 | DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis[1][2]. DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. CAS No. 1192362-32-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5126. | |
| DOTAM-mono-acid | DOTAM-mono-acid is a chelator with DOTAM as its core. DOTAM-mono-acid contains a carboxylic acid group that can be activated to form an amide bond with the N-terminus of a peptide. DOTAM-mono-acid can form peptide conjugates for radiometal labeling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 913528-04-8. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-W717743. | |
| DOTAMTATE | DOTAMTATE is a somatostatin analogue. DOTAMTATE marked 212Pb is promising for research of somatostatin receptor positive neuroendocrine tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2415661-92-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10920. | |
| DOTA-?NHS-ester | DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 170908-81-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-128890. | |
| DOTA-NOC | DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging[1]. DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: DOTA-Nal3-octreotide. CAS No. 619300-53-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2112. | |
| DOTAP chloride | DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,2-Dioleoyl-3-trimethylammonium-propane chloride. CAS No. 132172-61-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-112754A. | |
| DOTAP chloride (GMP Like) | DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like). CAS No. 132172-61-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112754AGL. | |
| DOTA-PEG5-azide | DOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 3104986-47-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140752. | |
| DOTAP mesylate | DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 252769-92-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W127426. | |
| DOTAP methylsulfate | DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design | |
| DOTATATE | DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Oxodotreotide. CAS No. 177943-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-106244. | |
| DOTATATE acetate | DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Oxodotreotide acetate. CAS No. 177943-89-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106244A. | |
| DOTA-Thiol | DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides. Uses: Scientific research. Category: Signaling pathways. CAS No. 865470-67-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W678394. | |
| DOTA-tris(tBu)ester NHS ester | DOTA-tris(tBu)ester NHS ester is a bifunctional precursor to a DOTA-based chelating agent. DOTA-tris(tBu)ester NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules, and upon deprotection forms stable complexes with metal ions for applications in molecular imaging[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 819869-77-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-131326. | |
| DOTA-tri(t-butyl ester) | DOTA-tri(t-butyl ester) belongs to the DOTA class of chelating agents. DOTA-tri(t-butyl ester) is a key raw material for synthesizing nanospherical magnetic resonance imaging (MRI) contrast agents, which are used in MR angiography and tumor angiogenesis imaging[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137076-54-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W034551. | |
| Dothiepin | Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dosulepin; Dothep. CAS No. 113-53-1. Pack Sizes: 1 mg. Product ID: HY-12394. | |
| DOTMA | DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104872-42-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-139200. | |
| Dovitinib | Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CHIR-258; TKI258. CAS No. 405169-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50905. | |
| Dovitinib-RIBOTAC | Dovitinib RIBOTAC is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade pre-miR-21. Dovitinib RIBOTAC can inhibit the metastasis of breast cancer and has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2759351-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-139682. | |
| Doxapram | Doxapram is a respiratory stimulant. Doxapram increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively. Doxapram inhibits the Ca²?-activated potassium current (IC50 ? 13 μM) and Ca²?-independent potassium current (IC50 ? 20 μM) in type I cells of the carotid body. Doxapram significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 309-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0551. | |
| Doxapram hydrochloride hydrate | Doxapram hydrochloride hydrate is a respiratory stimulant. Doxapram hydrochloride hydrate increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively. Doxapram hydrochloride hydrate inhibits the Ca²?-activated potassium current (IC50 ? 13 μM) and Ca²?-independent potassium current (IC50 ? 20 μM) in type I cells of the carotid body. Doxapram hydrochloride hydrate significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram hydrochloride hydrate can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7081-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0551A. | |
| Doxazosin | Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK 33274. CAS No. 74191-85-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0098. | |
| Doxercalciferol | Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1.alpha.-Hydroxyvitamin D2. CAS No. 54573-75-0. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32348. | |
| Doxifluridine | Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR. CAS No. 3094-9-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0021. | |
| Doxorubicin hydrochloride | Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy[1][2][3]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Hydroxydaunorubicin hydrochloride; ADR. CAS No. 25316-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15142. | |
| Doxorubicin hydrochloride (Standard) | Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard). CAS No. 25316-40-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15142R. | |
| Doxorubicinol hydrochloride | Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 13-Dihydroadriamycin hydrochloride. CAS No. 63950-05-0. Pack Sizes: 1 mg. Product ID: HY-G0022. | |
| Doxorubicin-SMCC | Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 400647-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116063. | |
| Doxycycline | Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. Uses: Scientific research. Category: Induced disease models products. CAS No. 564-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0565. | |
| Doxycycline hyclate | Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models[1][2][3][4][5]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031. CAS No. 24390-14-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-N0565B. | |
| Doxycycline hyclate (Standard) | Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate (HY-N0565B). This product is intended for research and analytical applications. Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Doxycycline (hydrochloride hemiethanolate hemihydrate) (Standard); WC2031 (Standard). CAS No. 24390-14-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0 | |
| Doxycycline hydrochloride | Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models[1][2][3][4][5]. Uses: Scientific research. Category: Induced disease models products. CAS No. 10592-13-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0565A. | |
| Doxycycline (hydrochloride) (Standard) | Doxycycline hydrochloride (Standard) is the analytical standard of Doxycycline hydrochloride (HY-N0565A). This product is intended for research and analytical applications. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10592-13-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0565AR. | |
| Doxycycline monohydrate | Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17086-28-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-W008923. | |
| Doxylamine succinate | Doxylamine succinate is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine succinate is orally active, possessing analgesic and hypnotic activities. Doxylamine succinate enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine succinate decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine succinate induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine succinate can be used for the research of nausea, allergy, insomnia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 562-10-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g. Product ID: HY-A0069. | |
| DP00477 | DP00477 is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with an IC50 value of 7.0 μM. DP00477 has the potential for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 169120-56-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148383. | |
| DP-1 | DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1472616-61-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132995. | |
| DP-15 | DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models[1]. (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095)). Uses: Scientific research. Category: Signaling pathways. CAS No. 3033837-71-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168936. | |
| D-Panthenol | D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dexpanthenol. CAS No. 81-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B1391. | |
| D-Panthenol-d6 | Dexpanthenol-d6 is deuterium labeled D-Panthenol. D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dexpanthenol-d6. CAS No. 2747917-52-6. Pack Sizes: 1 mg. Product ID: HY-B1391S. | |
| D-Pantothenic acid | D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pantothenate; Vitamin B5. CAS No. 79-83-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0430. | |
| D-Pantothenic acid-13C3,15N hemicalcium hemihydrate | Vitamin B5-13C3,15N hemicalcium hemihydrate is the 13C and 15N labeled Vitamin B5 hemicalcium hemihydrate[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pantothenate-13C3,15N; Vitamin B5-13C3,15N hemicalcium hemihydrate. CAS No. 2483830-09-5. Pack Sizes: 1 mg. Product ID: HY-144432S. | |
| D-Pantothenic acid hemicalcium salt | D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt. CAS No. 137-08-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N0681. | |
| D-Pantothenic acid hemicalcium salt (Standard) | D-Pantothenic acid (hemicalcium salt) (Standard) is the analytical standard of D-Pantothenic acid (hemicalcium salt). This product is intended for research and analytical applications. D-Pantothenic acid hemicalcium salt is a vitamin that reduces patulin in apple juice. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calcium pantothenate (Standard); Calcium D-pantothenate (Standard); Vitamin B5 calcium salt (Standard). CAS No. 137-08-6. Pack Sizes: 10 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-N0681R. | |
| D-Pantothenic acid sodium | D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium pantothenate; Vitamin B5 sodium. CAS No. 867-81-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0430A. | |
| DPCPX | DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 116948. CAS No. 102146-07-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-100937. | |
| DPDPE | DPDPE, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88373-73-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1334. | |
| DPH | DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation. . Uses: Scientific research. Category: Signaling pathways. CAS No. 484049-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12070. | |
| D-Phenylalanine-d5 | D-Phenylalanine-d5 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 362049-55-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-Y0079S. | |
| D-?(+)?-?Phenyllactic acid | D-(+)?-Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-3-Phenyllactic acid. CAS No. 7326-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-30219. | |
| DPhPC | DPhPC is a phospholipid compound characterized by high mechanical and chemical stability, broad temperature phase stability, and high electrical resistance. DPhPC readily forms unilamellar vesicles and solid-supported bilayers. DPhPC is commonly used as a component of nanoliposomal drug carriers or as a model membrane material for studies on membrane proteins/ion channels[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 207131-40-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-143202. | |
| DPI-4452 | DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models[1]. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. CAS No. 2941391-49-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10761. | |
| D-Pinitol | D-pinitol (3-O-Methyl-D-chiro-inositol) is a natural compound presented in several plants, like Pinaceae and Leguminosae plants. D-pinitol exerts hypoglycemic activity and protective effects in the cardiovascular system[1][2]. D-pinitol has antiviral and larvicidal activities[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-O-Methyl-D-chiro-inositol. CAS No. 10284-63-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-N0655. | |
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