MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| COH000 | COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1534358-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114304. |  |
| COH29 | COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RNR Inhibitor COH29. CAS No. 1190932-38-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19931. | |
| COH34 | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 906439-72-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-128760. | |
| Co(III) protoporphyrin IX chloride | Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Protoporphyrin IX cobaltic chloride; CoPPIX-Cl. CAS No. 102601-60-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W250116. | |
| Coixol | Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3]. Uses: Scientific research. Category: Natural products. Alternative Names: 6-Methoxy-2-benzoxazolinone; 6-MBOA. CAS No. 532-91-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0936. | |
| Coixol (Standard) | Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Methoxy-2-benzoxazolinone (Standard); 6-MBOA (Standard). CAS No. 532-91-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0936R. | |
| Col003 | Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 328565-16-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124817. | |
| Colchicine | Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research[1][2][3][4][5]. Uses: Scientific research. Category: Induced disease models products. CAS No. 64-86-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-16569. | |
| Colchicine-d6 | Colchicine-d6 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217651-73-4. Pack Sizes: 1 mg. Product ID: HY-16569S. | |
| Colfosceril miristate | Colfosceril miristate (DMPC) is a synthetic phospholipid. Colfosceril miristate has antiproliferative effects on various tumors. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DMPC; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine; Dimyristoyl phosphatidylcholine. CAS No. 18194-24-6. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-109541. | |
| Colistin methanesulfonate sodium salt | Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Colistimethate sodium. CAS No. 8068-28-8. Pack Sizes: 50 mg; 100 mg. Product ID: HY-A0214. | |
| Colistin sulfate | Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polymyxin E sulfate. CAS No. 1264-72-8. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-A0089. | |
| Colivelin | Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro[1]. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease[2]. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 867021-83-8. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1061. | |
| Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro[1]. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease[2]. Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2803948-60-7. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1061A. | |
| Collagenase I, from Clostridium histolyticum | Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-O0004. | |
| Collagenase IV, Clostridium histolytica | Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Collagenase, Type IV. CAS No. 9001-12-1. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-E70005D. | |
| Collagenase (Type D, animal free) | Collagenase (Type D, animal free) does not contain animal-related components, and has collagenase and secondary protease activities similar to type 1 and type 2 collagenase. The activity of Collagenase (Type D, animal free) is higher than that of Collagenase (Type A, animal free). Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-E70005N. | |
| Collagenase, Type I | Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EC 3.4.24.3. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-E70005A. | |
| Collagenase, Type II | Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005B. | |
| Collagenase, Type III | Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 50 mg; 100 mg. Product ID: HY-E70005C. | |
| Collagenase, Type V | Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-E70005E. | |
| Collagenase, Type VI | Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Type VI collagenase. CAS No. 9001-12-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-E70005I. | |
| Collagenase, Type VIII | Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-E70005H. | |
| Collagen proline hydroxylase inhibitor | Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor, which can be used as an anti-fibrotic agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 223666-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15183. | |
| Collagen, Type I, from bovine achilles tendon | Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. This product is enzymatically hydrolyzed collagen peptide[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9007-34-5. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-P2738. | |
| Collagen, Type II, from bovine snout membrane | Collagen, Type II, from bovine snout membrane is a type II collagen that can be used for cell culture[1]. This product is enzymatically hydrolyzed collagen peptides. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Collagen. CAS No. 9007-34-5. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-NP003. | |
| Colominic acid sodium salt | Colominic acid sodium salt (Polysialic acid sodium salt) could be naturally isolated from the cell wall of Escherichia coli and animals, gives a red color which has an absorption maximum at 530 nm. Colominic acid sodium salt (Polysialic acid sodium salt) possesses anti-bacterial activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polysialic acid sodium salt. CAS No. 70431-34-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7476. | |
| Columbamine chloride | Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an organic heterotetracyclic alkaloid extracted from plants. Columbamine chloride is a metabolite of Berberine (HY-N0716). Columbamine chloride inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 μM). Columbamine chloride induces apoptosis in cancer cells. Columbamine chloride can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Columbamin chloride; Dehydroisocorypalmine chloride. CAS No. 1916-10-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0926A. | |
| Columbianadin | Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 5058-13-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0362. | |
| (+)-Columbianetin | (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-Columbianetin. CAS No. 3804-70-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N0363. | |
| Combretastatin A-1 | Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 109971-63-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121993. | |
| Combretastatin A4 | Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CRC 87-09. CAS No. 117048-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N2146. | |
| Comekibart | HY-P990910 is an IL4R-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MG-K10. CAS No. 2833673-47-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990910. | |
| Competence-stimulating peptide | Competence-stimulating peptide is a competence-stimulating peptide. Competence-stimulating peptide activates the Com-dependent quorum sensing system of S. mutans. Competence-stimulating peptide restores bacteriocin production[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 438620-89-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11175. | |
| Competence-Stimulating Peptide-2 (CSP-2) | Competence-Stimulating Peptide-2 (CSP-2) is a 17-amino acid signal peptide produced by Streptococcus pneumoniae, with an EC50 of 50.7 nM for its compatible receptor ComD2. Competence-Stimulating Peptide-2 (CSP-2) can regulate bacterial phenotypes such as competence development, virulence, and biofilm formation through quorum sensing[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1174553-84-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2522. | |
| Complement C1s-IN-1 | Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033831-40-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-149278. | |
| Complement C5-IN-1 | Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2365402-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128342. | |
| Complete Freund's adjuvant (CFA) | Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 9007-81-2. Pack Sizes: 10 mL; 10 mL * 2; 10 mL * 5. Product ID: HY-153808. | |
| Complete Freund's adjuvant (CFA, 1 mg/ml) | Complete Freund's adjuvant (CFA, 1 mg/ml) is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA, 1 mg/ml) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA, 1 mg/ml) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA, 1 mg/ml) stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more[1][2][3]. Uses: Scientific research. Category: Induced disease models products. CAS No. 9007-81-2. Pack Sizes: 10 mL. Product ID: HY-153808B. | |
| Compound 48/80 | Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Poly-p-methoxyphenethylmethylamine. CAS No. 94724-12-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115768. | |
| Compound 48/80 trihydrochloride | Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C48/80 trihydrochloride. CAS No. 848035-21-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130592. | |
| Compound E | Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Secretase-IN-1. CAS No. 209986-17-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14176. | |
| Compstatin | Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 206645-99-0. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1036. | |
| Compstatin control peptide | Compstatin control peptide is a negative control of Compstatin (HY-P1036). Compstatin is a potent complement system C3 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 301544-78-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1398. | |
| Conatumumab | Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody. CAS No. 896731-82-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99260. | |
| Concanamycin A | Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Antibiotic X 4357B; Folimycin; X 4357B. CAS No. 80890-47-7. Pack Sizes: 25 μg; 50 μg. Product ID: HY-N1724. | |
| Concanavalin A | Concanavalin A can be coupled to agarose to form Concanavalin A (agarose) (HY-P2149A). Concanavalin A (ConA) is a selective, competitive binding agent that targets specific carbohydrate structures containing glucose and mannose; it acts as a mitogen and exhibits varying degrees of cytotoxicity, hepatotoxicity, and teratogenicity. Concanavalin A is also utilized for in vivo blood glucose monitoring in the context of diabetes[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 11028-71-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2149. | |
| Concanavalin A (agarose) | Concanavalin A (agarose) is composed of Concanavalin A (HY-P2149) conjugated with agarose. Concanavalin A (ConA) is a selective competitive binder targeting the specific carbohydrate structures of glucose and mannose, inducing mitosis, and exhibiting certain cytotoxicity, hepatotoxicity, and teratogenicity. Concanav in A (agarose) can be used for in vivo blood glucose monitoring in diabetes, and for "fishing out" specific glycoproteins or removing sugar impurities from complex samples[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 11028-71-0. Pack Sizes: 1 mL; 2 mL; 5 mL. Product ID: HY-P2149A. | |
| Concizumab | Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NN 7415; mAb 2021; Anti-TFPI Recombinant Antibody. CAS No. 1312299-39-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99283. | |
| Conduritol B epoxide | Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 6090-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100944. | |
| Conessine | Conessine is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pKi values of Conessine for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine has antimalarial activity. Conessine can also be used in the research of muscle atrophy[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 546-06-5. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107566. | |
| Congo Red | Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections. Uses: Scientific research. Category: Signaling pathways. CAS No. 573-58-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-D0236. | |
| Coniferin | Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Laricin. CAS No. 531-29-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N3617. | |
| Coniferyl alcohol | Coniferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 458-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N4283. | |
| Coniferyl ferulate | Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC50 = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63644-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N1916. | |
| (±)-Coniine hydrochloride | (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Propylpiperidine hydrochloride. CAS No. 15991-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W099757. | |
| Conivaptan hydrochloride | Conivaptan (hydrochloride) is a non-peptide antagonist of vasopressin receptor, with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YM 087. CAS No. 168626-94-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18347A. | |
| Connexin mimetic peptide 40GAP27 | Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.). Uses: Scientific research. Category: Signaling pathways. CAS No. 403858-30-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P5389. | |
| Conoidin A | Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII)[1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18080-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 100 mg. Product ID: HY-116090. | |
| Conophylline | Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 142741-24-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3619. | |
| Continentalic acid | Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19889-23-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6908. | |
| Convallatoxin | Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 508-75-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2453. | |
| Convicine | Convicine is a pyrimidine glycoside. Convicine, as well as Vicine, is the precursor of the aglycones Divicine and Isouramil. Convicine is the main factors of favism, which is a genetic condition leading to severe hemolysis after faba bean ingestion. Convicine can be isolated from the faba bean[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19286-37-4. Pack Sizes: 1 mg. Product ID: HY-135738. | |
| Convolamine | Convolamine is an alkaloid found in Convolvulus pluricaulis and an effective positive modulator of the sigma-1 receptor (IC50 = 289 nM), exhibiting cognitive and neuroprotective properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 500-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N15339. | |
| COP1-ATGL modulator 1 | COP1-ATGL modulator 1 (86) is an orally active modulator for COP1-ATGL axis. COP1-ATGL modulator 1 (86) could increase ATGL protein expression, reduce ATGL ubiquitination and COP1 autoubiquitination, and diminish lipid accumulation in hepatocytes in the nanomolar range[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2946701-09-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157416. | |
| Copanlisib | Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 80-6946. CAS No. 1032568-63-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15346. | |
| Copanlisib dihydrochloride | Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 80-6946 dihydrochloride. CAS No. 1402152-13-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15346A. | |
| Copper Fluor-4 | Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10-13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CF4. CAS No. 2365532-64-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-150086. | |
| Copper hexadecafluorophthalocyanine | Copper hexadecafluorophthalocyanine (F16CuPc (purified by sublimation)) is a metal-organic framework (MOF). Uses: Scientific research. Category: Signaling pathways. Alternative Names: F16CuPc (purified by sublimation). CAS No. 14916-87-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W110066. | |
| Copper ionophore I | Copper ionophore I is an efficient copper ion carrier. Copper ionophore I can regulate various intracellular copper levels to induce cuproptosis, such as 4T1 (IC50 = 0.45 μM) and MDA-MB-231(IC50 = 1.21 μM) cells. Copper ionophore I can induce an increase in ROS and cause mitochondrial dysfunction. Copper ionophore I can reduce the expression of FDX1, DLAT, and LIAS proteins. Copper ionophore I can activate immune related pathways and promote T cell infiltration. Copper ionophore I can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 101264-90-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-178914. | |
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