MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Clotrimazole-d5 | Clotrimazole-d5 is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1185076-41-8. Pack Sizes: 1 mg. Product ID: HY-10882S. |  |
| Clozapine | Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HF 1854; ZINC000019796155. CAS No. 5786-21-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-14539. | |
| Clozapine-d4 | Clozapine-d4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HF 1854-d4. CAS No. 204395-52-8. Pack Sizes: 1 mg. Product ID: HY-14539S2. | |
| Clozapine N-oxide | Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34233-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17366. | |
| Clozapine N-oxide dihydrochloride | Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250025-93-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17366A. | |
| CLP257 | CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1181081-71-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110143. | |
| CLP290 | CLP290 is an orally available activator of the neuron-specific K+-Cl- cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1181083-81-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103023. | |
| CLPP-2068 | CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3104462-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-173048. | |
| CLZ-8 | CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 678158-55-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122627. | |
| CM037 | CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A37. CAS No. 896795-60-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-110294. | |
| CM-1758 | CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 inhibits tumor growth in vivo. CM-1758 induces acetylation of non-histone proteins in acute myeloid leukemia cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2256079-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161149. | |
| CM-24 | CM-24 is a humanized antibody expressed in CHO cells, targeting CEACAM1/CD66a. The predicted molecular weight (MW) of CM-24 is 145 kDa. The isotype control for CM-24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: MK-6018. CAS No. 1783801-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990569. | |
| CM-272 | CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1846570-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101925. | |
| CM398 | CM398 is a highly selective, orally active Sigma-2 receptor ligand with a Ki value of 0.43 nM. CM398 ameliorates age-related macular degeneration. CM398 exerts analgesic effects on visceral pain, inflammatory pain and neuropathic pain. CM398 can be used in research related to age-related macular degeneration, neuropathic pain and inflammatory pain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1121931-70-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145628. | |
| CMB-087229 | CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1227692-67-2. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg. Product ID: HY-148901. | |
| CMF019 | CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents[1]. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1586787-08-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103080. | |
| CM-H2DCFDA | CM-H2DCFDA is a derivative of H2DCFDA (HY-D0940). CM-H2DCFDA can be used to determine cellular oxidant levels (Ex/Em: 495/530 nm). CM-H2DCFDA is light-sensitive[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 850013-49-9. Pack Sizes: 50 μg. Product ID: HY-D1713. | |
| CMIT/MIT (14.5% in water) | CMIT/MIT is a CMIT and MIT mixture. CMIT and MIT are powerful synthetic biocidal substances. CMIT and MIT are used as preservatives in various cosmetics and industrial products. CMIT and MIT are present in many water-soluble consumer products, such as shampoos, toothpastes. CMIT/MIT (3:1 mixture of CMIT and MIT) produces mitochondrial ROS via inhibiting mitochondrial complex I and II. CMIT/MIT (in 3:1 ratio) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. CMIT/MIT can be used in the research of respiratory diseases and neuroblastoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CMI/MI. CAS No. 55965-84-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 g; 500 g; 1 k g. Product ID: HY-W017982. | |
| CMK | CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. Uses: Scientific research. Category: Signaling pathways. CAS No. 821794-90-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-52101. | |
| CMKLR1 antagonist 1 | CMKLR1 antagonist 1 (compound S-26d) is a potent and orally active chemokine-like receptor 1 (CMKLR1) antagonist, with a pIC50 value of 7.44 in hCMKLR1-transfected CHO cells. CMKLR1 antagonist 1 can be used for psoriasis and metabolic diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033101-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156460. | |
| CMLD-2 | CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 958843-91-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-124828. | |
| CMPD1 | CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41179-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108643. | |
| CMPD101 | CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 865608-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103045. | |
| CMPD-39 | CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50=~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2242582-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141659. | |
| CMP-Sialic acid sodium salt | CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CMP-Neu5Ac sodium salt. CAS No. 1007117-62-5. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112942A. | |
| CMP-sialic acid synthetase (NmCSS) | CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9067-82-7. Pack Sizes: 50 U; 200 U. Product ID: HY-E70024. | |
| CMV pp65 (415-429) | CMV pp65 (415-429) is a CEF control peptide that is derived from the Cytomegalovirus (CMV)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 207847-44-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10660. | |
| CMX-2043 | CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 910627-26-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-119152. | |
| c-Myc inhibitor 6 | c-Myc inhibitor 6 (compound A102) is a c-Myc inhibitor. c-Myc inhibitor 6 decreases cancer cell viability and degrades c-Myc protein. c-Myc inhibitor 6 can be used for the research of c-Myc imbalance, such as cancer, cardiovascular diseases, and viral infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768765-58-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148836. | |
| CN009543V | CN009543V is an epidermal growth factor receptor (EGFR) agonist. CN009543V enhances tyrosine phosphorylation of EGFR at Tyr1068 and Tyr1173, thereby activating the MAPK/ERK cascade. CN009543V inhibits the activity of PTP-1B in MDA MB468 cells. CN009543V can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 375826-84-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115605. | |
| CN128 hydrochloride | CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CN328. CAS No. 1335282-05-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-131060. | |
| CNI103 | CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2366279-86-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10889. | |
| Cnicin | Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24394-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137984. | |
| Cnidicin | Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells[1]. Uses: Scientific research. Category: Natural products. CAS No. 14348-21-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4207. | |
| CNP-38 | CNP-38 is a C-type natriuretic peptide[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413551-27-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5127. | |
| CNQX | CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FG9065. CAS No. 115066-14-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15066. | |
| CNQX disodium | CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FG9065 disodium. CAS No. 479347-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15066A. | |
| CNS-11 | CNS-11 is a brain-penetrant tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 445218-34-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156585. | |
| CNX-1351 | CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6.8 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1276105-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16596. | |
| CNX-2006 | CNX-2006 is a mutant-selective and irreversible EGFR inhibitor with an IC50 below 20 nM for EGFRT790M. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375465-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13897. | |
| CNX-774 | CNX-774 is an orally active, irreversible and selective BTK inhibitor, with an IC50 of < 1 nM. CNX-774 specifically targets Cysteine 481 of Btk for covalent modification[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1202759-32-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13943. | |
| Co 101244 hydrochloride | Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 174494 hydrochloride. CAS No. 193356-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107706. | |
| CO23 | CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1370363-74-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130012. | |
| Cobalt(II) ions probe 1 | Cobalt(II) ions probe 1 (Compound L) is a fluorescent sensor for Co2+ detecting in biological environments. Cobalt(II) ions probe 1 can selectively bind with Co2+ in the presence of other metal ions (Ex: 380 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3047612-66-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D2775. | |
| Cobicistat | Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-9350. CAS No. 1004316-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10493. | |
| Cobimetinib | Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0973; XL518. CAS No. 934660-93-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13064. | |
| Cobimetinib hemifumarate | Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0973 hemifumarate; XL-518 hemifumarate. CAS No. 1369665-02-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13064A. | |
| Cobimetinib racemate | Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0973 racemate; XL518 racemate. CAS No. 934662-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13078. | |
| Cobolimab | Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TSR-022; GSK4069889. CAS No. 2022215-65-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99827. | |
| Cochinchinenin A | Cochinchinenin A serves as the fundamental component responsible for the analgesic properties of Dragon's Blood. Uses: Scientific research. Category: Natural products. CAS No. 1057666-04-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2136. | |
| Coclaurine | Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 486-39-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3610. | |
| Cocoa butter | Cocoa butter can be used as an excipient, such as lubricants, suppository bases. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8002-31-1. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N11684. | |
| Codrituzumab | Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (Kd of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GC33; RO5137382. CAS No. 1365267-33-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99013. | |
| Coelenteramine 400a | Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Coelenterazine 400a; Bisdeoxycoelenterazine. CAS No. 70217-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118462. | |
| Coelenterazine | Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55779-48-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18743. | |
| Coelenterazine h | Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca2+, thus providing a valuable tool for measuring small changes in Ca2+ concentrations (Ex/Em = 437/466 nm)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Deoxycoelenterazine; CLZN-h. CAS No. 50909-86-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1024. | |
| Coenzyme A | Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 85-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128851. | |
| Coenzyme A sodium | Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55672-92-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128851B. | |
| Coenzyme A trilithium | Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18439-24-2. Pack Sizes: 10 mg; 25 mg. Product ID: HY-128851A. | |
| Coenzyme FO | Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 37333-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-136497. | |
| Coenzyme Q0 | Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CoQ0. CAS No. 605-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W016412. | |
| Coenzyme Q10 | Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CoQ10; Ubiquinone-10; Ubidecarenone. CAS No. 303-98-0. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0111. | |
| Coenzyme Q10 (Standard) | Coenzyme Q10 (Standard) is the analytical standard of Coenzyme Q10. This product is intended for research and analytical applications. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CoQ10 (Standard); Ubiquinone-10 (Standard); Ubidecarenone (Standard). CAS No. 303-98-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0111R. | |
| Coenzyme Q9 | Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ubiquinone Q9; CoQ9; Ubiquinone 9. CAS No. 303-97-9. Pack Sizes: 10 mM * 1 mL in Ethanol; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101415. | |
| Coenzyme Q9 (Standard) | Coenzyme Q9 (Standard) is the analytical standard of Coenzyme Q9. This product is intended for research and analytical applications. Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ubiquinone Q9 (Standard); CoQ9 (Standard); Ubiquinone 9 (Standard). CAS No. 303-97-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101415R. | |
| Cofetuzumab | Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06523435; hu24. CAS No. 1869928-62-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99828. | |
| Cofetuzumab pelidotin | Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06647020; ABBV-647; h6M24-vc0101. CAS No. 1869937-48-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99829. | |
| COG 133 | COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 514200-66-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1050. | |
| COG 133 TFA | COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC50 of 445 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2828432-37-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1050A. | |
| COG1410 | COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878009-24-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2136. | |
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