BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| TP 064 | TP 064 is a potent and selective PRMT4 inhibitor with >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP 064 inhibits methylation of H3 (1-25) and MED12 in cellular assays (IC50 values are <10 and 43 nM, respectively). Alternative Names: TP-064; TP064; N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide. Grades: ≥98% by HPLC. CAS No. 2080306-20-1. Molecular formula: C28H34N4O2. Mole weight: 458.6. |  |
| TP-0903 | TP-0903 is a potent anti-cancer agent targeting the AXL receptor tyrosine kinase that has demonstrated profound activity in several cell-based and animal models of cancer. Uses: For research use only. Alternative Names: TP-0903; TP 0903; TP0903. Grades: >98%. CAS No. 1341200-45-0. Molecular formula: C24H30ClN7O2S. Mole weight: 516.06. | |
| TP-10 | TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. It has extremely potent PDE10A inhibitory activity and high selectivity against other PDEs. It is active in the mouse behavioral model for positive symptoms. It demonstrats good in vitro and in vivo activity. Alternative Names: TP-10; TP 10; TP10; 2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline;Substituted pyrazole, 13;2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline. Grades: >98%. CAS No. 898563-00-3. Molecular formula: C26H19F3N4O. Mole weight: 460.45. | |
| TPCA-1 | TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM and 0.40 μM for IKK-1 and IKK-2 respectively. It blocks NF-κB pathway and STAT3 activity. Alternative Names: TPCA1; TPCA 1; 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide; IKK-2 Inhibitor IV. Grades: >98%. CAS No. 507475-17-4. Molecular formula: C12H10FN3O2S. Mole weight: 279.29. | |
| TPT-260 2HCl | TPT-260 2HCl is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation. Alternative Names: TPT-260 Dihydrochloride; TPT-260 (Dihydrochloride); Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride; [5-(Carbamimidoylsulfanylmethyl)thiophen-2-yl]methyl carbamimidothioate dihydrochloride. Grades: 98%. CAS No. 2076-91-7. Molecular formula: C8H14Cl2N4S3. Mole weight: 333.32. | |
| TR-14035 | TR14035 blocked the binding of human alpha(4)beta(7) to an (125)I-MAdCAM-Ig fusion protein with IC(50) values of 0.75 nM. TR14035 blocked binding of human alpha(4)beta(7)-expressing RPMI-8866 cells or murine mesenteric lymph node lymphocytes to MAdCAM-Ig with IC(50) values of 0.1 microM. TR14035 blocked adhesion to HEVs [ED(50) of 0.01-0.1 mpk i.v.]. TR-14035 was taken up by rat and human hepatocytes by an apparently single saturable mechanism with K(m) of 6.7 and 2.1 microM, respectively, and taurocholate and digoxin reduced this uptake. Alternative Names: TR 14035; TR14035; MDK-1191; MDK1191; MDK 1191; SB683698; SB 683698; SB-683698; QJ-2620; TR-14035. Grades: >98%. CAS No. 232271-19-1. Molecular formula: C24H21Cl2NO5. Mole weight: 474.33. | |
| Trabectedin | Trabectedin is an antitumor drug. Alternative Names: Ecteinascidin; Yondelis; Ecteinascidin 743; ET-743; ET743; ET 743. Grades: 98%. CAS No. 114899-77-3. Molecular formula: C39H43N3O11S. Mole weight: 761.84. | |
| Trachelosiaside | Trachelosiaside is isolated from the leaves of Trachelospermum lucidum (D. Don) Schum. Trachelosiaside shows moderate activity against lipoxygenase. Alternative Names: Matairesinol 5-C-glucoside. Grades: 98.0%. CAS No. 106647-12-5. Molecular formula: C26H32O11. Mole weight: 520.52. | |
| Tranexamic acid EP Impurity A | Tranexamic acid EP Impurity A. CAS No. 93940-19-3. | |
| Tranexamic Acid Trifluoroacetate Salt-[13C6] | Tranexamic Acid Trifluoroacetate Salt-[13C6] is a labelled TFA salt of tranexamic acid which is often used as a lysine analogue to characterize binding sites in plasminogen. Alternative Names: trans-4-(Aminomethyl)cyclohexanecarboxylic acid Tranexamsaeure, trifluoroacetate salt-13C6. Molecular formula: C4[13C]6H16F3NO4. Mole weight: 277.19. | |
| trans-1-Amino-4-(hydroxymethyl)cyclohexane | Metabolites of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (Me CCNU). Alternative Names: (4-aminocyclohexyl)methanol; (4-aminocyclohexyl)methanol. CAS No. 1467-84-1. Molecular formula: C7H15NO. Mole weight: 129.20. | |
| trans-2-Aminocyclohexanol | trans-2-Aminocyclohexanol (CAS# 6982-39-4) is a useful building block for organic synthesis. Alternative Names: (1R,2R)-2-amino-1-cyclohexanol; (1R,2R)-2-aminocyclohexan-1-ol. CAS No. 6982-39-4. Molecular formula: C6H13NO. Mole weight: 115.17. | |
| trans-2-Butene-1,4-diol | trans-2-Butene-1,4-diol is an impurity of Gadobutrol, which is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). Alternative Names: 2-Butene-1,4-diol, (2E)-; (2E)-2-Butene-1,4-diol; 2-Butene-1,4-diol, (E)-; 2-Butene-1,4-diol, trans-; (2E)-But-2-ene-1,4-diol; (E)-2-Butene-1,4-diol; Penitricin C; trans-2-Buten-1,4-diol. Grades: ≥95%. CAS No. 821-11-4. Molecular formula: C4H8O2. Mole weight: 88.11. | |
| trans-2-Methyl-2-pentenoic acid | Trans-2-Methyl-2-pentenoic acid is an unsaturated analog of the anticonvulsant Valproic Acid and is used for aroma characterization of different beers with different hops. Alternative Names: 2-Methyl-2-pentenoic acid. Grades: 95 %. CAS No. 16957-70-3. Molecular formula: C6H10O2. Mole weight: 114.14. | |
| trans-2-Methyl-3-octene | trans-2-Methyl-3-octene. CAS No. 52937-36-7. | |
| trans-4-Butylcyclohexanol | Trans-4-Butylcyclohexanol, a vital compound in pharmaceutical and agrochemical industries, serves as a key intermediate in the synthesis of a wide range of organic compounds, including amides, esters, and ketones. Notably, its ability to serve as a starting material in the preparation of drug substances and biochemicals highlights its paramount importance. Its versatility and functional properties make Trans-4-Butylcyclohexanol an indispensable component in the chemical research of life-changing drugs and biochemical products. Alternative Names: 4-Butylcyclohexanol. Grades: 95%. CAS No. 67590-13-0. Molecular formula: C10H20O. Mole weight: 156.26. | |
| trans-4-(Trifluoromethyl)cyclohexanecarboxylic acid | A cyclic haloalkyl substituted carboxylic acid used in the preparation of antiviral agents. Alternative Names: 4-(trifluoromethyl)cyclohexane-1-carboxylic acid. Grades: 95 %. CAS No. 133261-33-3. Molecular formula: C8H11F3O2. Mole weight: 196.17. | |
| trans-doxercalciferol | Trans-doxercalciferol is an isomer of doxercalciferol, a drug used for the treatment of secondary hyperparathyroidism and metabolic bone disease. Alternative Names: (5E,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraene-1α,3β-diol. CAS No. 74007-20-8. Molecular formula: C28H44O2. Mole weight: 412.658. | |
| trans-Hydroxy Loxoprofen | trans-Hydroxy Loxoprofen is an exceptional biomedical compound, packed with remarkable anti-inflammatory and analgesic attributes. Its mode of action involves robustly hindering the biosynthesis of prostaglandins. Alternative Names: Loxoprofen srsrac; trans-Loxoprofen Alcohol; 371753-19-4; 2-[4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]phenyl]propanoic acid; 2-(4-{[(1R,2S)-2-Hydroxycyclopentyl]methyl}phenyl)propanoic acid. Grades: >95%. CAS No. 371753-19-4. Molecular formula: C15H20O3. Mole weight: 248.32. | |
| trans-maxacalcitol | Trans-maxacalcitol is an isomer of maxacalcitol, a derivative of vitamin D3. Maxacalcitol is a potential treatment of secondary hyperparathyroidism. Alternative Names: Impurity A of Maxacalcitol. CAS No. 929721-98-2. Molecular formula: C26H42O4. Mole weight: 418.6. | |
| trans R-138727-[d4] (Mixture of Diastereomers) | trans R-138727-[d4] (Mixture of Diastereomers) is the labelled analogue of trans R-138727 (Mixture of Diastereomers), which is an active metabolite of Prasugrel. Alternative Names: trans R-138727-d4; Prasugrel-d4 Metabolite; (2E)-2-[1-[2-(Cycl; opropyl-d4)-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic Acid; Prasugrel-d4 metabolite R-138727; Prasugrel Impurity 27-d4 (Mixture of Diastereomers). Grades: ≥95%. Molecular formula: C18H16D4FNO3S. Mole weight: 353.44. | |
| (±)-trans-Sertraline-[d3] hydrochloride | One of the isotopic labelled form of (±)-trans-Sertraline, which could probably be used as an antidepressant agent. Alternative Names: rac-trans Sertraline-d3 Hydrochloride; (±)-trans-Sertraline-d3 HCl (N-methyl-d3); (±)-trans-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-phthalemine HCl. Grades: 95% by HPLC; 98% atom D. CAS No. 1330180-66-9. Molecular formula: C17H15D3Cl3N. Mole weight: 345.71. | |
| (+) Tranylcypromine-[d5] | (+) Tranylcypromine-[d5], is the labelled analogue of Tranylcypromine. Tranylcypromine is a monoamine oxidase inhibitor. Alternative Names: (+) Tranylcypromine D5; (1S,2R)-2-(phenyl-d5)cyclopropan-1-amine. Molecular formula: C9H7D5ClN. Mole weight: 174.68. | |
| Tranylcypromine hydrochloride | Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and human liver microsomes, respectively. Alternative Names: (1R,2S)-2-phenylcyclopropan-1-amine;hydrochloride. Grades: > 98 %. CAS No. 1986-47-6. Molecular formula: C9H12ClN. Mole weight: 169.65. | |
| Trapidil | Trapidil, also called as Rocornal, is a platelet aggregation inhibitor with specific platelet-derived growth factor. Uses: Vasodilator agents. Alternative Names: N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-aminerapidilRocornalTrapymin15421-84-8AvantrinTrapymineTrapidil; AR 12008; AR-12008; AR12008Trapidilum [INN-Latin]UNII-EYG5Y6355EMLS000567667N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amineEINECS 239-434-2. CAS No. 15421-84-8. Molecular formula: C10H15N5. Mole weight: 205.26. | |
| Traumatic acid | Traumatic acid. Alternative Names: (E)-2-Dodecenedioic Acid; trans-2-Dodecenedioic Acid; trans-Traumatic Acid; 2E-dodecenedioic acid; (2E)-Dodecenedioic acid; NSC 8125; trans-2-dodecenedioate. Grades: 95%. CAS No. 6402-36-4. Molecular formula: C12H20O4. Mole weight: 228.28. | |
| Traxillaside | Traxillaside is purified from the barks of Torreya nucifera Sieb. et Zucc. It has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells. Alternative Names: (3R,4R)-3-[[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one. Grades: 97.5%. CAS No. 149415-62-3. Molecular formula: C28H36O12. Mole weight: 564.59. | |
| Treosulfan | Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities. Alternative Names: NSC 39069; NSC39069; NSC-39069; Treosulfan; (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate. CAS No. 299-75-2. Molecular formula: C6H14O8S2. Mole weight: 278.29. | |
| Treprostinil-[13C2,d1] | Treprostinil-[13C2,d1] is a labelled analogue of Treprostinil. Treprostinil is an analogue of prostacyclin (PGI2) that is used for the treatment of pulmonary arterial hypertension (PAH). Alternative Names: 2-{[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl](2-D)-1H,2H,3H,3aH,4H,9H,9aH-cyclopenta[b]naphthalen-5-yl]oxy}(1,2-13C2)acetate. Grades: >90% by HPLC; >98% atom D, >98% atom 13C. Molecular formula: C21[13C]2H33DO5. Mole weight: 393.51. | |
| Tretazicar | Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA. Ntr delivery has been achieved in vitro using retroviral and adenoviral vectors and confirmed by immunocytochemical demonstration of Ntr expression. The Ntr-expressing cells have been shown to be sensitized to CB1954 by up to 2000-fold. The Ntr-CB1954 system shows effective bystander killing in mixed populations of Ntr-expressing and non-expressing cells treated with CB1954. The efficacy of this enzyme-prodrug approach in model systems compared with other VDEPT approaches demonstrates the feasibility and future promise of this gene therapy strategy. Uses: Antineoplastic agents. Alternative Names: CB1954; CB-1954; CB 1954; Tretazicar. Grades: 0.98. CAS No. 21919-05-1. Molecular formula: C9H8N4O5. Mole weight: 252.186. | |
| Triacetylpseurotin A | Triacetylpseurotin A is an alkaloid produced from endophyte of Polygonum cuspidatum. Alternative Names: [(5S,8S,9R)-8-benzoyl-2-[(Z,1S,2R)-1,2-diacetyloxyhex-3-enyl]-8-methoxy-3-methyl-4,6-dioxo-1-oxa-7-azaspiro[4.4]non-2-en-9-yl] acetate. Grades: 96.0%. CAS No. 77353-57-2. Molecular formula: C28H31NO11. Mole weight: 557.552. | |
| Triazole lactic acid | Triazole lactic acid. Alternative Names: 2-Hydroxy-3-(1H-1,2,4-triazol-1-yl)propanoic acid; 1H-1,2,4-Triazole-1-propanoic acid, alpha-hydroxy-. CAS No. 1450828-63-3. Molecular formula: C5H7N3O3. Mole weight: 157.13. | |
| Tribuloside | Tribuloside is a flavonoid isolated from Tribulus terrestris L with antimycobacterial activity. Alternative Names: Tiliroside. Grades: 98%. CAS No. 22153-44-2. Molecular formula: C30H26O13. Mole weight: 594.52. | |
| Trichilinin D | Trichilinin D is a natural compound employed within the biomedical sector, used in the research of diverse cancer types spanning lung, breast and ovarian. Alternative Names: Trichilinin D; 220698-24-8; [(1R,2R,4S,5S,6S,10R,11S,12R,15R,16R,18S,19R)-4-Acetyloxy-6-(furan-3-yl)-11,16-dihydroxy-1,5,10,15-tetramethyl-13-oxapentacyclo[10.6.1.02,10.05,9.015,19]nonadec-8-en-18-yl] (E)-3-phenylprop-2-enoate. Grades: >98%. CAS No. 220698-24-8. Molecular formula: C37H44O8. Mole weight: 616.7. | |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine / threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Alternative Names: VQD-002; VQD 002; VQD002; API-2; Akt Inhibitor V; Pentaazacentopthylene; Tricyclic nucleoside; 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine. Grades: 98%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.30. | |
| Triclabendazole-[d3] | Triclabendazole-[d3] is the labelled analogue of Triclabendazole, which is an imidazole anthelmintic drug. Alternative Names: Triclabendazole-D3; 5-Chloro-6-(2,3-dichlorophenoxy)-2-(methyl-D3-thio)-1H-benzoimidazole; Triclabendazole-(methyl-d3); Egaten-d3; Fasinex-d3. Grades: 95% by HPLC; 98% atom D. CAS No. 1353867-93-2. Molecular formula: C14H6D3Cl3N2OS. Mole weight: 362.68. | |
| Tricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaen-5-amine | Tricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaen-5-amine. Alternative Names: Tricyclo(8.2.2.24,7)hexadeca-4,6,10,12,13,15-hexaen-5-amine; 5-Amino[2.2]paracyclophane. Grades: 95%. CAS No. 10122-95-9. Molecular formula: C16H17N. Mole weight: 223.31. | |
| Tricyclohexylphosphine Carbon Disulfide | Tricyclohexylphosphine Carbon Disulfide. CAS No. 2636-88-6. | |
| Trifarotene | Trifarotene is a retinoic acid receptor (RAR) agonist used as an agent for the treatment of acne. Uses: Dermatologic agents. Alternative Names: 3''-tert-Butyl-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)[1,1':3',1'']terphenyl-4-carboxylic Acid; 3''-(1,1-Dimethylethyl)-4'-(2-hydroxyethoxy)-4''-(1-pyrrolidinyl)[1,1':3',1''-terphenyl]-4-carboxylic Acid. CAS No. 895542-09-3. Molecular formula: C29H33NO4. Mole weight: 459.58. | |
| Trifolin | Trifolin is a natural flavonoid compound isolated from the aerial part of Calluna vulgaris L. Trifolin shows anti-inflammatory, antioxidant and antinociceptive activities. . Uses: Anti-inflammatory; antinociceptive. Alternative Names: kaempferol-3-O-galactoside; 2-(4-Hydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; 3-(β-D-Galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: >98%. CAS No. 23627-87-4. Molecular formula: C21H20O11. Mole weight: 448.38. | |
| Trigonosin F | Trigonosin F is extracted from the twigs and leaves of Trigonostemon thyrsoideum. Alternative Names: 4,24-methanolo-2,20,23-(epoxymetheno)-7,10-methanolocyclopenta[b]-1,3-dioxino[4,5-h]oxireno[e]oxacycloheneicosin-16(4H)-one, 11-(benzoyloxy)-4a,5,6,7,8,9,10,11,17a,18,19,20,20a,21,21a,22a,23,23a-octadecahydro-4a,5,20a,21-tetrahydroxy-21a-(hydroxymethyl)-5,18,26,27-tetramethyl-2-phenyl-, (2R,4R,4aR,5S,7S. CAS No. 1262842-73-8. Molecular formula: C46H54O13. Mole weight: 814.94. | |
| Trigothysoid N | Trigothysoid N is extracted from the twigs and leaves of Trigonostemon thyrsoideum. Alternative Names: Butanoic acid, 3-methyl-, (2S,4S,4aS,5R,7R,10S,11S,12E,14Z,17aS,18S,20R,20aS,21S,21aR,22aS,23S,23aR,24R,26S,27R)-4,4a,5,6,7,8,9,10,11,16,17a,18,19,20,20a,21,21a,22a,23,23a-eicosahydro-4a,5,20a,21-tetrahydroxy-21a-(hydroxymethyl)-5,18,26,27-tetramethyl-16-oxo-2-phenyl-4,24-methanolo-2,20,23-(epoxymethe. CAS No. 1501943-08-3. Molecular formula: C44H58O13. Mole weight: 794.95. | |
| Triheptanoin | Triheptanoin is a triglyceride that is used for the treatment of inherited metabolic diseases, epilepsy, ventricular hypertrophy and myocardial glucose oxidation. Alternative Names: Glyceroltriheptanoate; Glycerol trienanthate; 1,2,3-Trienanthoylglycerol; Trioenanthin; heptanoic acid, 1,1,1-(1,2,3-propanetriyl) ester; Triheptanoyl Glycerol; 1,2,3-Triheptanoyl-rac-glycerol; Propane-1,2,3-triyl triheptanoate; 1,3-Di(heptanoyloxy)propan-2-yl heptanoate. Grades: ≥95%. CAS No. 620-67-7. Molecular formula: C24H44O6. Mole weight: 428.6. | |
| Tri-O-tolylphosphine oxide | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Alternative Names: 1-bis(2-methylphenyl)phosphoryl-2-methylbenzene; Phosphine oxide, tri-o-tolyl-; Phosphine oxide, tris(2-methylphenyl)-. CAS No. 6163-63-9. Molecular formula: C21H21OP. Mole weight: 320.372. | |
| Tripterifordin | Tripterifordin is isolated from the roots of Tripterygium wilfordii. Uses: Anti-hiv. Alternative Names: Tripterifordin; 139122-81-9; Hypodiolide A; (1R,2R,5R,6R,8S,11S,12R)-6-hydroxy-6,12-dimethyl-14-oxapentacyclo[10.3.3.15,8.01,11.02,8]nonadecan-13-oneKauran-18-oic acid, 16,20-dihydroxy-, delta-lactone, (4alpha)-. Grades: > 95%. CAS No. 139122-81-9. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| Triptinin B | Triptinin B is extracted from the roots of Tripterygium wilfordii Hook.f. It is one of the leukotriene D4 antagonist constituents. Alternative Names: Triptinin B; 189389-05-7; (4aS,10aS)-8-hydroxy-1,4a-dimethyl-7-propan-2-yl-4,9,10,10a-tetrahydro-3H-phenanthrene-2-carboxylic acid. Grades: 97.0%. CAS No. 189389-05-7. Molecular formula: C20H26O3. Mole weight: 314.42. | |
| Triptobenzene H | Triptobenzene H is a natural diterpenoid compound found in several plants. Alternative Names: 11-Hydroxy-14-methoxy-18(4→;3)-abeo-abieta-3,8,11,13-tetraen-18-oic acid;Hypoglic acid;11-Hydroxy-14-methoxy-18(4-3)-abeo-abieta-3,8,11,13-tetraen-18-oic acid. Grades: >95%. CAS No. 146900-55-2. Molecular formula: C21H28O4. Mole weight: 344.44. | |
| Triptonodiol | Triptonodiol is a natural diterpenoid compound found in several plants. . Alternative Names: (1S,4aS,10aR)-5-hydroxy-1-(hydroxymethyl)-7-isopropyl-8-methoxy-1,4a-dimethyl-3,4,4a,9,10,10a-hexahydrophenanthren-2(1H)-one. Grades: >95%. CAS No. 117456-87-8. Molecular formula: C21H30O4. Mole weight: 346.46. | |
| Triptophenolide | Triptophenolide is a natural product derived from the traditional Chinese medicinal plant Tripterygium wilfordii. It is a diterpenoid compound known for its diverse biological activities, including anti-inflammatory, immunosuppressive, and anticancer properties. Uses: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (dth) reaction induced by dncb and bsa in vitro. it also could diminishe the peripheral blood anae+lymphocytes in rats and micc. it can significautly increase the amount of total serum complement and dramatically decrcase the serum antibody products (1gg ) of rats and mice. Alternative Names: Tryptophenolide; Hypolide; Phenanthro(1,2-c)furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR-trans)-; (+)-Triptophenolide; (3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one; (3bR,9bS)-3b,4,5,9b,10,11-Hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)phenanthro[1,2-c]furan-1(3H)-one. Grades: >98%. CAS No. 74285-86-2. Molecular formula: C20H24O3. Mole weight: 312.40. | |
| Triptoquinone A | Triptoquinone A is a natural compound isolated from the roots of Tripterygium wilfordii Hook.f. It is an interleukin 1 inhibitor. Alternative Names: Triptoquinonea. Grades: 98.0%. CAS No. 142950-86-5. Molecular formula: C20H24O4. Mole weight: 328.41. | |
| Triptoquinone B | Triptoquinone B, also called 19-Hydroxy-8,12-abietadiene-3,11,14-trione, is a natural diterpenoid found in the vines of Tripterygium wilfordii. 19-Hydroxy-8,12-abietadiene-3,11,14-trione is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells. Alternative Names: 19-Hydroxy-8,12-abietadiene-3,11,14-trione. Grades: >98%. CAS No. 142937-50-6. Molecular formula: C20H26O4. Mole weight: 330.4. | |
| Triptoquinonide | Triptoquinonide is a natural diterpenoid isolated from the vines of Tripterygium wilfordii. Alternative Names: Triptoquinide. Grades: >96%. CAS No. 163513-81-3. Molecular formula: C20H22O4. Mole weight: 326.4. | |
| Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine | Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alternative Names: Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane; tert-butyl 3,3'-(2-amino-2-((3-tert-butoxy-3-oxopropoxy)methyl)propane-1,3-diyl)bis(oxy)dipropanoate. Grades: >98.0%. CAS No. 175724-30-8. Molecular formula: C25H47NO9. Mole weight: 505.64. | |
| Tris(4-trifluoromethylphenyl)phosphine | Tris(4-trifluoromethylphenyl)phosphine is an intermediate used in organic synthesis. Alternative Names: tris[4-(trifluoromethyl)phenyl]phosphine; Tris(p-trifluoromethylphenyl)phosphine. Grades: 98%. CAS No. 13406-29-6. Molecular formula: C21H12F9P. Mole weight: 466.28. | |
| Trityl Olmesartan Medoxomil | A metabolite of Olmesartan Medoxomil, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. Alternative Names: Olmesartan Medoxomil N-alkyl impurity; Triphenyl methyl olmesartan; Trityl olmesartan; Tritylolmesartan medoxomil; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate. CAS No. 144690-92-6. Molecular formula: C48H44N6O6. Mole weight: 800.92. | |
| Triumbelletin | Triumbelletin is a coumarin isolated from Wikstroemia indica. Alternative Names: 7-hydroxy-8-(7-hydroxy-2-oxochromen-8-yl)-3-(2-oxochromen-7-yl)oxychromen-2-one. Grades: 98.0%. CAS No. 131559-54-1. Molecular formula: C27H14O9. Mole weight: 482.4. | |
| Trivinylsilane | Trivinylsilane. Alternative Names: triethenylsilane. CAS No. 2372-31-8. Molecular formula: C6H10Si. Mole weight: 110.23. | |
| Troglitazone-[d4] | One of the isotopic labelled form of Troglitazone, which could be used for the treatment of diabetes and inflammation. Alternative Names: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione-d4. Molecular formula: C24H23NO5SD4. Mole weight: 445.57. | |
| Trospium Chloride Related Compound B | Trospium Chloride Related Compound B is an impurity of Trospium Chloride, an antispasmodic agent used to treat the symptoms of overactive bladder. Alternative Names: Endo-8-Azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2,2-diphenylacetate hydrochloride. Grades: 95%. CAS No. 63516-30-3. Molecular formula: C21H23NO3.HCl. Mole weight: 373.88. | |
| TRX-0237 mesylate | TRX-0237 mesylate is a second-generation tau protein aggregation inhibitor applicated for the treatment of AD (Alzheimer's disease) and frontotemporal dementia. TRX-0237 is the purified form of Methylene Blue, an old drug that has being widely used in Africa for the treatment of malaria, methemoglobinemia and other conditions for a long time. TRX-0237 is the stabilized, reduced form of methylthioninium chloride to improve the drug's absorption, bioavailability, and tolerability. TRX-0237 is in Phase I for Parkinson's disease, Phase II for Progressive supranuclear palsy and Phase III for Alzheimer's disease and Dementia. Uses: Parkinson's disease; progressive supranuclear palsy; alzheimer's disease; dementia. Alternative Names: TRX-0237 mesylate; TRX 0237 mesylate; TRX0237 mesylate; Leucomethylene blue (Mesylate); AKOS026750731; CS-5553; AK-499443; HY-19948; CS 5553; AK 499443; HY 19948; CS5553; AK499443; HY19948; N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dimethanesulfonate. Grades: 98%. CAS No. 1236208-20-0. Molecular formula: C18H27N3O6S3. Mole weight: 477.6. | |
| Trypsin from porcine pancreas | Trypsin from porcine pancreas. | |
| Tubastatin A | Tubastatin A is selective at all isozymes except HDAC8 and maintains over 1000-fold selectivity against all isoforms excluding HDAC8, where it has approximately 57-fold selectivity. Grades: >98%. CAS No. 1252003-15-8. Molecular formula: C20H21N3O2. Mole weight: 335.4. | |
| Tuberculosis inhibitor 3 | Tuberculosis inhibitor 3 shows potent anti-TB activity (MIC < 0.016 μg/mL) against drug-sensitive / resistant MTB strains. Grades: ≥98%. CAS No. 2219325-28-5. Molecular formula: C21H22F6N4O3S. Mole weight: 524.48. | |
| Tuberostemonine | Tuberstemonine, coming from the roots of Stemona japonica, exhibited relatively higher intestinal permeabilities. It acts in part as an open-channel blocker at the crayfish neuromuscular junction. Uses: Anti-inflammatory / anti-bacterial / anti-allergy. Alternative Names: (7aR,8aβ,11aβ,11bα,11cβ)-2β-[(2S,4S)-Tetrahydro-4-methyl-5-oxofuran-2-yl]-8β-ethyltetradecahydro-11β-methylfuro[2,3-h]pyrrolo[3,2,1-jk][1]benzoazepine-10-one; 2β-[(2S,4S)-Tetrahydro-4-methyl-5-oxofuran-2-yl]stenine; TUBERSTEMONINE(P). Grades: >98%. CAS No. 6879-1-2. Molecular formula: C22H33NO4. Mole weight: 375.51. | |
| Tubulysin M | Tubulysin M is a Tubulysin D analog with potential anti-cancer properties, used as the cytotoxic component in antibody-drug conjugates. Alternative Names: (2S,4R)-4-{[(2-{(1R,3R)-1-Acetoxy-4-methyl-3-[methyl(N-{[(2R)-1-methyl-2-piperidinyl]carbonyl}-L-isoleucyl)amino]pentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoic acid. Grades: ≥95%. CAS No. 936691-46-2. Molecular formula: C38H57N5O7S. Mole weight: 727.39. | |
| Tucidinostat | Tucidinostat is a novel inhibitor of HDAC1, 2, 3, and 10 with IC50 values of 95, 160, 67, 78 nM, respectively. It increases the acetylation levels of histone H3 and decreases histone deacetylase (HDAC) activity, inducing apoptosis of cancer cells. Alternative Names: HBI-8000; CS-055; Chidamide; Epidaza. CAS No. 1616493-44-7. Molecular formula: C22H19FN4O2. Mole weight: 390.41. | |
| TUG-770 | TUG-770 displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liver microsomes (HLM), no inhibition of selected CYP-enzymes implicated in drug-drug interactions, no P-glycoprotein (P-gp) inhibition, and good permeability in the Caco-2 cell assay. Examination of TUG-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of TUG-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of TUG-770 in rats confirmed a significant glucose lowering effect for the high doses already after 10 min and for all doses after 30 min. Alternative Names: TUG-770; TUG 770; TUG770. Grades: >98%. CAS No. 1402601-82-4. Molecular formula: C19H14FNO2. Mole weight: 307.32. | |
| Tupichinol A | Tupichinol A is a natural compound isolated from the underground parts of Tupistra chinensis. Alternative Names: (2R,3R)-2-(4-hydroxyphenyl)-7-methoxy-8-methyl-3,4-dihydro-2H-chromen-3-ol. Grades: 98.5%. CAS No. 497142-88-8. Molecular formula: C17H18O4. Mole weight: 286.32. | |
| Turofexorate Isopropyl | Turofexorate Isopropyl is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist. Alternative Names: WAY-362450; WAY362450; WAY 362450; XL335; XL 335; XL-335; Turofexorate isopropyl. Grades: >98%. CAS No. 629664-81-9. Molecular formula: C25H24F2N2O3. Mole weight: 438.47. | |
| TWS119 | TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway. Alternative Names: NSC 405020; NSC405020; NSC-405020; 3-((6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenol; TWS-119; TWS119; TWS 119. Grades: >98%. CAS No. 601514-19-6. Molecular formula: C18H14N4O2. Mole weight: 318.336. | |
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