BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Sunitinib-[d10] | One of the isotopic labelled form of Sunitinib, which is a receptor tyrosine kinases inhibitor. Alternative Names: N-[2-(Diethyl-d10)aminoethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; Sutent-d10; SU-11248-d10. Grades: >95%. CAS No. 1126721-82-1. Molecular formula: C22H17D10FN4O2. Mole weight: 408.47. |  |
| Sunitinib malate | Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications. Uses: Angiogenesis inhibitors. Alternative Names: Sunitinib malate; SU011248 L-malate salt; N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid. Grades: >98%. CAS No. 341031-54-7. Molecular formula: C22H27FN4O2.C4H6O5. Mole weight: 532.56. | |
| Sutezolid | Sutezolid, also called as PNU-100480, is an oxazolidinone antibacterial compound to reach Phase-II clinical research for Tuberculosis. Alternative Names: N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamidePF-02341272; PF02341272; PF 02341272; PNU-100480; PNU 100480; PNU100480; U-100480; U 100480; U100480; Sutezolid.168828-58-8. Grades: 95%. CAS No. 168828-58-8. Molecular formula: C16H20FN3O3S. Mole weight: 353.41. | |
| (S)-(-)-Valsartan-[d8] | One of the isotopic labelled form of (S)-(-)-Valsartan, which is a nonpeptide angiotensin II AT1-receptor antagonist and could be used as antihypertensive agent. Alternative Names: (S)-(-)-Valsartan-d8(valine-d8); N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl-1,1'-biphenyl)-4-yl]methyl]-L-valine. Grades: 95% by HPLC; 98% atom D. CAS No. 1089736-72-0. Molecular formula: C24H21D8N5O3. Mole weight: 443.57. | |
| (S)-(-)-Verapamil-[d3] Hydrochloride | One of the isotopic labelled form of (S)-(-)-Verapamil- HCl, which has been found to exhibit inhibition activity against the p-glycoprotein efflux pump. Alternative Names: (S)-(-)-Verapamil-d3 HCl (N-methyl-d3); (2S)-2-(3,4-Dimethoxyphenyl)-5-[N-3,4-dimethylphenylethyl)-methylamino]-2-isopropylvaleronitrile-d3 HCl. Grades: 95% by HPLC; 98% atom D. CAS No. 1398112-33-8. Molecular formula: C27H36D3ClN2O4. Mole weight: 494.09. | |
| (S)-Viloxazine-[d5] Hydrochloride | (S)-Viloxazine-[d5] Hydrochloride is the labelled S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) used as an antidepressant. Uses: The labelled (s)-isomer of. Alternative Names: (S)-2-[((2-Ethoxy-d5)phenoxy)methyl]morpholine Hydrochloride; (S)-2-[(2-Ethoxy-d5)phenoxymethyl]tetrahydro-1,4-oxazine Hydrochloride. Grades: 95%. CAS No. 1246816-39-6. Molecular formula: C13H15D5ClNO3. Mole weight: 278.79. | |
| (S)-Viloxazine Hydrochloride | The S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) used as an antidepressant. Uses: The (s)-isomer of. Alternative Names: (2S)-2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride. CAS No. 56287-61-7. Molecular formula: C13H20ClNO3. Mole weight: 273.76. | |
| Swertianin | Swertianin is found in the herbs of Gentiana bavarica, it has potential anti-inflammatory and antinoceceptive which could be used as a drug candidate against inflammation related conditions. Alternative Names: Gentiakochianin; 1,2,8-Trihydroxy-6-methoxy-9H-xanthen-9-one. Grades: > 95%. CAS No. 20882-75-1. Molecular formula: C14H10O6. Mole weight: 274.23. | |
| Swertiaperennin | Swertiaperennin is a xanthone isolated from Swertia bimaculata. Alternative Names: Methylswertianin; 1,8-Dihydroxy-2,6-dimethoxy-9H-xanthen-9-one; 2-O-Methylswertianin. Grades: 98%. CAS No. 22172-17-4. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Swertisin | Swertisin efficiently changed the morphology of NIH3T3 cells from fibroblastic to round aggregate cell cluster in huge numbers. Dithizone (DTZ) stain primarily confirmed differentiation and gene expression studies signified rapid onset of differentiation signaling cascade in Swertisin-induced ILCC. Alternative Names: Flavocommelitin; 6-C-glucopyranosyl-7-O-methylapigenin; Apigenin 6-glucosyl-7-O-methyl ether. Grades: >98%. CAS No. 6991-10-2. Molecular formula: C22H22O10. Mole weight: 446.4. | |
| Swietemahalactone | Swietemahalactone is an abundantly occurring botanical-derived natural compound boasting potent anti-inflammatory and anticancer characteristics. Alternative Names: methyl (S)-2-((1R,2aS,2a1R,3S,3aR,5aR,6R,9bR,11aS,12S)-6-(furan-3-yl)-2a,11a-dihydroxy-1,3,5a-trimethyl-8,11-dioxo-1,2,2a,2a1,3,3a,4,5,5a,8,11,11a-dodecahydro-6H-1,3-methanofuro[4',3',2':6,1]pentaleno[1,2-f]isochromen-12-yl)-2-hydrox. Grades: 95%. CAS No. 1514669-21-6. Molecular formula: C27H30O10. Mole weight: 514.52. | |
| Synephrine | Synephrine is an α-adrenergic receptor agonist used as a vasoconstrictor. Synephrine is a natural stimulant without any side effects or positive reactions. It is widely used in healthcare industries such as medicine, food, and beverages. Uses: Vasoconstrictor. Alternative Names: Oxedrine; P-Synephrine; Parasympatol; Sympaethamine; rac-Synephrine; (+/-)-Synephrine; 4-[1-hydroxy-2-(methylamino)ethyl]phenol. Grades: ≥ 98%. CAS No. 94-07-5. Molecular formula: C9H13NO2. Mole weight: 167.21. | |
| (-)-Syringaresinol | (-)-Syringaresinol is isolated from the rhizomes of Polygonatum kingianum. DL-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis, may be a potential chemotherapeutic agent for the treatment of cancer. Alternative Names: DL-Syringaresinol; (-)-Lirioresinol B; 4,4'-((1R,3aS,4R,6aS)-Tetrahydro-1H,3H-furo(3,4-C)furan-1,4-diyl)bis(2,6-dimethoxyphenol). Grades: 98.0%. CAS No. 6216-81-5. Molecular formula: C22H26O8. Mole weight: 418.44. | |
| Syringetin-3-O-rutinoside | Syringetin-3-O-rutinoside is found in the leaves of Corylus heterophylla Fisch. Alternative Names: Syringetin-3-O-rutinoside; 53430-50-5; HY-N7889; CS-0138753; 3-[(6-O-alpha-L-Rhamnopyranosyl-beta-D-glucopyranosyl)oxy]-4',5,7-trihydroxy-3',5'-dimethoxyflavone. Grades: > 95%. CAS No. 53430-50-5. Molecular formula: C29H34O17. Mole weight: 654.57. | |
| Syringin pentaacetate | Syringin pentaacetate isolated from the herbs of Liriodendron chinense (Hemsl.) Sarg. Alternative Names: (2E)-3-{3,5-Dimethoxy-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranos yl)oxy]phenyl}-2-propen-1-yl acetate. Grades: 0.98. CAS No. 92233-55-1. Molecular formula: C27H34O14. Mole weight: 582.6. | |
| Syzalterin | Syzalterin is isolated from the herbs of Rhododendron dauricum. Alternative Names: 6,8-Dimethylapigenin. Grades: > 95%. CAS No. 94451-48-6. Molecular formula: C17H14O5. Mole weight: 298.3. | |
| T0901317 | T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice. Alternative Names: T 0901317; T-0901317; TO-901317; TO901317; N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide; T-1317. Grades: >98%. CAS No. 293754-55-9. Molecular formula: C17H12F9NO3S. Mole weight: 481.33. | |
| T863 | T-863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. It causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice. Alternative Names: DGAT-1 inhibitor; DGAT 1 inhibitor; T863; T-863; T 863. Grades: >98%. CAS No. 701232-20-4. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| Tabernanthine | Tabernanthine is an alkaloid isolated from Tabernaemontana hilariana. Tabernanthine can reduce the self-administration of cocaine and morphine in rats. Tabernanthine acts as a benzodiazepine receptor inverse agonist in a discriminant in vitro binding assay. Alternative Names: 13-Methoxyibogamine. Grades: 97.0%. CAS No. 83-94-3. Molecular formula: C20H26N2O. Mole weight: 310.441. | |
| Tacalcitol monohydrate | Tacalcitol is a vitamin D analogue that promotes normal bone development by regulating calcium. It modulates immunological and inflammatory processes and induces nerve growth factor production in epidermal keratinocytes. Alternative Names: 1,24(R)-Dihydroxyvitamin D3, monohydrate. Grades: >98%. CAS No. 93129-94-3. Molecular formula: C27H46O4. Mole weight: 434.65. | |
| Taccalonolide A | Taccalonolide A is a steroid with antimalarial activities. It is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells. Grades: 98%. CAS No. 108885-68-3. Molecular formula: C36H46O14. Mole weight: 702.74. | |
| Tadalafil-[d3] | Tadalafil-[d3] is the labelled analogue of Tadalafil, which is an inhibitor of phosphodiesterase 5 and can be used to treat erectile dysfunction. Tadalafil is also a phosphodiesterase 5 (PDE5) inhibitor. Alternative Names: Tadalafil D3. Grades: 95% by HPLC; 95% atom D. CAS No. 960226-55-5. Molecular formula: C22H16D3N3O4. Mole weight: 392.42. | |
| Tadalafil EP Impurity A | Tadalafil EP Impurity A. CAS No. 171596-27-3. | |
| Tadalafil EP Impurity B | Tadalafil EP Impurity B. CAS No. 629652-72-8. | |
| Tadalafil EP Impurity C | Tadalafil EP Impurity C. CAS No. 171596-28-4. | |
| Tadalafil Impurity B | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Alternative Names: (6R,12aS)-6-(1,3-benzodioxal-5yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]-1,4-dione. Grades: > 95%. CAS No. 951661-82-8. Molecular formula: C20H19N3O3. Mole weight: 349.39. | |
| Tadalafil Impurity N98 | Tadalafil Impurity N98. CAS No. 1795790-92-9. | |
| Tafamidis-[d3] | Tafamidis-[d3] is deuterium labelled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, showing comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis. Alternative Names: Tafamidis-d3; d3-Tafamidis. Molecular formula: C14H4D3Cl2NO3. Mole weight: 311.13. | |
| TAK-243 | TAK-243, a pyrazolopyrimidine derivative, has been found to be an Ubiquitin-protein ligase inhibitor and was just finished the Phase-I trial against solid tumors. Alternative Names: TAK-243; TAK 243; TAK243; MLN7243; MLN-7243; MLN 7243; AOB87172; AOB-87172; AOB 87172. Grades: 98%. CAS No. 1450833-55-2. Molecular formula: C19H20F3N5O5S2. Mole weight: 519.51. | |
| Talabostat mesylate | Talabostat mesylate is the orally bioavailable mesylate salt of an amino boronic dipeptide with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines. Uses: For research used only. Alternative Names: (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid (1:1); PT-100; PT100; PT 100; D05989; D-05989; D 05989; Val-boro-pro; Talabostat. Grades: 98%. CAS No. 150080-09-4. Molecular formula: C10H23BN2O6S. Mole weight: 310.17. | |
| Talatisamine | Talatisamine inhibits the enhanced I(K) caused by Aβ40 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. Alternative Names: 20-Ethyl-1α,16β-dimethoxy-4-(methoxymethyl)aconitane-8,14α-diol. Grades: 95 % (HPLC). CAS No. 20501-56-8. Molecular formula: C24H39NO5. Mole weight: 421.57. | |
| Tamibarotene | Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. It is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It may show sustained plasma levels compared to ATRA. It may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium. Alternative Names: Retinobenzoic acid; Amnoid; AMNOLAKE; Am80; Am 80; Am-80; SY-1425; SY 1425; SY1425; Tamibarotene. Grades: 98%. CAS No. 94497-51-5. Molecular formula: C22H25NO3. Mole weight: 351.44. | |
| Tamsulosin-[d4] hydrochloride | One of the labelled form of Tamsulosin, which is an α1-adrenoceptor antagonist and could be used against benign prostatic hypertrophy. Alternative Names: (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide-D4 hydrochloride; YM 617-d4; Yutanal-d4. Grades: ≥90%. Molecular formula: C20H25D4ClN2O5S. Mole weight: 449.00. | |
| Tamsulosin EP Impurity G hydrochloride | Tamsulosin EP Impurity G hydrochloride. CAS No. 106463-19-8. | |
| Tandospirone | Tandospirone is a potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM. It significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. It also decreased the number of premature responses in a dose-dependent manner. It is used as an antidepressant. Uses: Tandospironeis is used as an antidepressant. Alternative Names: (3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione; Metanopirone; Sediel; SM-3997; SM 3997; SM3997; 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)-; (3αα,4β,7β,7αα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione; (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloride. Grades: > 98%. CAS No. 87760-53-0. Molecular formula: C21H29N5O2. Mole weight: 383.49. | |
| Tannase | Tannase is an enzyme (EC 3.1.1.20) that catalyzes the hydrolysis of ester bonds present in gallotannins, complex tannins, and gallic acid esters. Alternative Names: Tannase from Aspergillus niger; Tannase Enzyme; Tanninyl hydrolase. CAS No. 9025-71-2. Molecular formula: C52H52F12N2O5. Mole weight: 1013.00. | |
| Tanshinlactone | Tanshinlactone is a natural diterpenoid found in Salvia miltiorrhiza. Alternative Names: Tanshinlactone;105351-70-0;6,14-dimethyl-12,16-dioxatetracyclo[8.7.0.02,7.011,15]heptadeca-1(10),2,4,6,8,11(15),13-heptaen-17-one;SCHEMBL3584503;VDYMGLBSIBHGCP-UHFFFAOYSA-;HY-N1180;AKOS032962165;DA-58272;FS-10106;CS-0016471;6,14-DIMETHYL-12,16-DIOXATETRACYCLO[8.7.0.0(2),?.0(1)(1),(1)?]HEPTADECA-1(10),2(7),3,5,8,11(15),13-HEPTAEN-17-ONE;InChI=1/C17H12O3/c1-9-4-3-5-12-11(9)6-7-13-14(12)17(18)20-15-10(2)8-19-16(13)15/h3-8H,1-2H3. Grades: 98.5%. CAS No. 105351-70-0. Molecular formula: C17H12O3. Mole weight: 264.28. | |
| Tanshinone IIA | Tanshinone IIA, under the IUPAC name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione, one of the original anthracyclines isolated from Salvia miltiorrhiza, inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Tanshinone IIA is a natural compound which has anti-oxidative properties, can be used in cosmetics material. Uses: Anti-alzheimer agents; amyloid-β inhibitor; anti-infective agents; anti-inflammatory agents; immunosuppressive agents; anticoagulants; antineoplastic agents, phytogenic. Alternative Names: Tanshinone IIA; 568-72-9; Tanshinone II; Dan Shen Ketone; Tanshinone B; Tanshinon II; 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; C19H18O3; MLS001048863; NSC686519; NSC 686518; SMR000387068; Tanshinone B, Tanshinone II, 568-72-9; 1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dion; 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione; 1,6,6-. Grades: 0.985. CAS No. 568-72-9. Molecular formula: C19H18O3. Mole weight: 294.34. | |
| Tanshinone IIB | Tanshinone IIB isolated from the roots of Salvia miltiorrhiza. It inhibits the uptake of digoxin and vinblastine in membrane vesicles containing PgP or MRP1, moderately stimulates PgP ATPase activity. Uses: Neuro-protective; antioxidant. Alternative Names: (S)-6-(HydroxyMethyl)-1,6-diMethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione. Grades: 0.97. CAS No. 17397-93-2. Molecular formula: C19H18O4. Mole weight: 310.4. | |
| Taraxasterol | Taraxasterol is isolated from the herbs of Taraxacum officinale. It inhibits NO, PGE(2), TNF-α, IL-1β and IL-6 production in LPS-induced RAW 264.7 macrophages in a dose-dependent manner. Alternative Names: (18α,19α)-5α-Urs-20(30)-en-3β-ol;Anthesterin;Taraxasta-20(30)-ene-3β-ol; Isolactucerol. Grades: 98%. CAS No. 1059-14-9. Molecular formula: C30H50O. Mole weight: 426.72. | |
| Taraxerol | Taraxerol, isolated from the herb of Taraxacum mongolicum Hand. Mazz., is a cancer chemopreventive agent. Uses: Ache activity; antiulcer. Alternative Names: alnulin; D-Friedoolean-14-en-3beta-ol; skimmiol; (3β,13α)-13-Methyl-27-norolean-14-en-3-ol; (3β)-D-Friedoolean-14-en-3-ol. Grades: 98.5%. CAS No. 127-22-0. Molecular formula: C30H50O. Mole weight: 426.7. | |
| Taraxerone | Taraxerone is isolated from the herb of Taraxacum mongolicum Hand. Mazz. It can prevent catalase and superoxide dismutase, and reduce glutathione concentration. Alternative Names: D-Friedoolean-14-en-3-one;Taraxera-14-ene-3-one;Taraxeron;27-Norolean-14-en-3-one,13-methyl-, (13a)-;Tarxerone;27-Norolean-14-en-3-one, 13-methyl-, (13α)-. Grades: 98.5%. CAS No. 514-07-8. Molecular formula: C30H48O. Mole weight: 424.7. | |
| TAS0728 | TAS0728 is a potent and seletive HER2 inhibitor possibly used for the treatment of various cancers. It covalently binds to HER2 at C805 and selectively inhibits its kinase activity. Alternative Names: (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-N-(4-(2-(dimethylamino)-2-oxoethyl)-2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide. CAS No. 2088323-16-2. Molecular formula: C26H32N8O3. Mole weight: 504.6. | |
| TAS-102 | TAS-102 is a combination drug composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2'-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI). TAS-102 is used as a third- or fourth-line treatment of metastatic colorectal cancer. Alternative Names: Tipiracil / Trifluridine; Viroptic mixture with 5-CIMU; TAS 102; EX-A1755; Tipiracil hydrochloride / Trifluridine. CAS No. 733030-01-8. Molecular formula: C9H11ClN4O2·HCl·C10H11F3N2O5. Mole weight: 575.328. | |
| Tasimelteon | Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleep-wake disorder (often designated as N24HSWD) in totally blind adults. It is a selective agonist for the melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved. Uses: Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. it helps to correct the circadian rhythm disorder often seen in patients who are visually impaired. Alternative Names: BMS-214,778; BMS-214778; BMS214778; BMS 214778. VEC-162; VEC162; VEC 162. Trade name: Hetlioz. Grades: ≥ 99.0%. CAS No. 609799-22-6. Molecular formula: C15H19NO2. Mole weight: 245.32. | |
| Tatsinine | Tatsinine is a potential natural compound in natural compound used for the research of various cancers. With its unique chemical structure, it has shown promising anti-tumor activity by inhibiting specific signaling pathways involved in cancer progression. Alternative Names: 20-ethyl-16-methoxy-4-methylaconitane-1,7,8,9,14-pentol. Grades: 97.0%. CAS No. 90038-21-4. Molecular formula: C22H35NO6. Mole weight: 409.523. | |
| Tauro-obeticholic acid | Tauro-obeticholic acid is an active metabolite of obeticholic acid, a farnesoid X receptor (FXR) agonist. Alternative Names: Obeticholic acid taurine conjugate; Tauro 6-ethylchenodeoxycholic acid. Grades: ≥95%. CAS No. 863239-61-6. Molecular formula: C28H49NO6S. Mole weight: 527.76. | |
| Taxachitriene B | Taxachitriene B is extracted from the needles of the Chinese yew Taxus chinensis. Alternative Names: (2R,3E,5S,7S,8E,10S,11R,13S)-10-hydroxy-8-(hydroxymethyl)-4,14,15,15-tetramethylbicyclo[9.3.1]pentadeca-1(14),3,8-triene-2,3,5,7,13-pentayl pentaacetate; Bicyclo[9.3.1]pentadeca-3,8,14-triene-2,3,5,7,10,13-hexol, 8-(hydroxymethyl)-4,14,15,15-tetramethyl-, 2,3,5,7,13-pentaacetate, (2R,3E,5S,7S,8E,10S,11R,13S)-. Grades: 98.0%. CAS No. 167906-75-4. Molecular formula: C30H42O12. Mole weight: 594.65. | |
| Taxacin | Taxacin is a natural diterpenoid compound found in several plants. Alternative Names: (1S,3aR,4R,5R,5aR,7S,9S,9aR,10R,11S,11aR)-9a-((benzoyloxy)methyl)-7-(cinnamoyloxy)-11a-hydroxy-1,3a-dimethyl-6-methylene-13-oxotetradecahydro-1,4-ethanobenzo[5,6]cycloocta[1,2-c]furan-5,9,10,11-tetrayl tetraacetate. Grades: >97%. CAS No. 117229-54-6. Molecular formula: C44H48O15. Mole weight: 816.84. | |
| Taxayunnansin A | Taxayunnansin A is isolated from the barks of Taxus chinensis. Alternative Names: (2aR,4S,4aS,5R,6R,8S,9aS,10S,10aR,10bS)-6-(benzoyloxy)-8-hydroxy-9a-(2-hydroxypropan-2-yl)-4a,7-dimethyl-3,4,4a,5,6,8,9,9a,10,10a-decahydro-1H-azuleno[5',6':3,4]benzo[1,2-b]oxete-4,5,10,10b(2aH)-tetrayl tetraacetate. Grades: > 95%. CAS No. 153229-31-3. Molecular formula: C35H44O13. Mole weight: 672.7. | |
| Taxcultine | Taxol D is an impurity of Paclitaxel, an antineoplastic. It is used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. Alternative Names: Baccatin III 13-ester with (2R,3S)-3-butanoylamino-2-hydroxy-3-phenylpropanoic acid; Paclitaxel Propyl analog; Benzenepropanoic acid, α-hydroxy-β-[(1-oxobutyl)amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-; B. Grades: 98%. CAS No. 153415-46-4. Molecular formula: C44H53NO14. Mole weight: 819.89. | |
| Taxifolin 3'-O-glucoside | Taxifolin 3'-O-glucoside is isolated from the leaves of Chamaecyparis obtuse. Alternative Names: 4H-1-Benzopyran-4-one, 2-(3-(beta-D-glucopyranosyloxy)-4-hydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-. Grades: 98.0%. CAS No. 31106-05-5. Molecular formula: C21H22O12. Mole weight: 342.29. | |
| Taxinine B | Taxinine B is isolated from the barks of Taxus chinensis, and it has strong inhibitory effects against AA-induced aggregation. Alternative Names: 2-Propenoic acid, 3-phenyl-, (1S,3S,4aR,5R,6R,11R,12R,12aS)-1,5,11,12-tetrakis(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanolobenzocyclodecen-3-yl ester, (2E)-. Grades: > 95%. CAS No. 18457-44-8. Molecular formula: C37H44O11. Mole weight: 664.8. | |
| Taxinine M | Taxinine M is extracted from the seeds of Chinese yew Taxus chinensis. Alternative Names: 1,4-Ethanobenzo[5,6]cycloocta[1,2-c]furan-13-one, 5,9,10,11-tetrakis(acetyloxy)-9a-[(benzoyloxy)methyl]tetradecahydro-7,11a-dihydroxy-1,3a-dimethyl-6-methylene-, (1S,3aR,4R,5R,5aR,7S,9S,9aR,10R,11S,11aR)-; (2α,5α,7β,9α,10β,12α)-2,7,9,10-Tetraacetoxy-5,11-dihydroxy-13-oxo-12,17-epoxytax-4(20)-en-19-yl benzoate. Grades: 98.0%. CAS No. 135730-55-1. Molecular formula: C35H42O14. Mole weight: 686.70. | |
| Taxumairol B | Taxumairol B is extracted from the seeds of Taxus yunnanensis. Alternative Names: 1-Hydroxy-7,9-dideacetylbaccatin I; 2,5,10,13-Tetraacetoxy-1,7,9-trihydroxy-4,20-epoxytax-11-ene. Grades: 98.0%. CAS No. 142203-64-3. Molecular formula: C28H40O12. Mole weight: 568.61. | |
| Tazarotene | Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with RARalpha-selective ligand. Also, it is a derivative of retinoic acid. Tazarotene is a third-generation prescription topical retinoid that is primarily used to treat plaque psoriasis and acne and is also used to treat photoaged and photodamaged skin. Alternative Names: AGN190168; AGN-190168; AGN 190168; Avage; Fabior; Suretin; Zorac; Tazorac; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; 6-(4,4-Dimethyl-thiochroman-6-ylethynyl)-nicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester. Grades: 98%. CAS No. 118292-40-3. Molecular formula: C21H21NO2S. Mole weight: 351.46. | |
| TBA-354 | TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. Alternative Names: TBA-354, TBA 354, TBA354, SN31354, SN-31354, SN 31354. Grades: >98%. CAS No. 1257426-19-9. Molecular formula: C19H15F3N4O5. Mole weight: 436.34. | |
| TCID | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. Alternative Names: 4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor. Grades: >98%. CAS No. 30675-13-9. Molecular formula: C9H2Cl4O2. Mole weight: 283.92. | |
| T.cruzi Inhibitor | T.cruzi Inhibitor is a novel inhibitor of Trypanosoma cruzi. Alternative Names: N-Benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide. CAS No. 1350920-22-7. Molecular formula: C22H25F3N2O. Mole weight: 390.45. | |
| TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor. Its IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively. It exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. It reduces blood pressure in normotensive and hypertensive rats. Alternative Names: TC-S 7001; TC S 7001; TCS 7001; TC-S-7001; TCS7001; Azaindole-1; Azaindole 1; 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidine-2,4-diamine;Rho Kinase Inhibitor;ROCK inhibitor;ROCK. Grades: >98 %. CAS No. 867017-68-3. Molecular formula: C18H13ClF2N6O. Mole weight: 402.79. | |
| TDZD-8 | TDZD-8 is a derivative of thiadiazolidine (TDZD) and acts as a non-ATP competitive inhibitor of GSK3β. It was shown to inhibit proliferation and self-renewal of glioblastoma stem cells. Alternative Names: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-. Grades: >98%. CAS No. 327036-89-5. Molecular formula: C10H10N2O2S. Mole weight: 222.262. | |
| Tectochrysin | Tectochrysin is a flavonoid isolated from the heartwood of Pinus strobus L. It leads to apoptotic cell death in NSCLC cells through activating of DR3 and Fas expression. Uses: Antioxidant. Alternative Names: 5-hydroxy-7-methoxyflavone; 5-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one. Grades: 99%. CAS No. 520-28-5. Molecular formula: C16H12O4. Mole weight: 268.3. | |
| Tectorigenin | Tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes / macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bcl-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia. Uses: Antioxidant. Alternative Names: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 6-Methoxy-5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-; Isoflavone, 4',5,7-trihydroxy-6-methoxy-; 5,7,4'-Trihydroxy-6-methoxyisoflavone; K 251T; Tectrigenin. Grades: >98%. CAS No. 548-77-6. Molecular formula: C16H12O6. Mole weight: 300.26. | |
| Tectoroside | Tectoroside is a natural sesquiterpene compound found in several plants. Alternative Names: (3aR,4R,6aR,8S,9aR,9bR)-3,6,9-trimethylene-2-oxo-8-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dodecahydroazuleno[4,5-b]furan-4-yl 2-hydroxy-3-(4-hydroxyphenyl)propanoate. Grades: >98%. CAS No. 124960-89-0. Molecular formula: C30H36O12. Mole weight: 588.6. | |
| Tedizolid Phosphate | Torezolid phosphate is a novel oxazolidinone for gram-positive infections, with IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectively. It is commonly used for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by several Gram-positive bacteria. Uses: The treatment of acute bacterial skin and skin structure infections (absssi). Alternative Names: TR-701FA; Torezolid phosphate; Sivextro; Tedizolid (phosphate); UNII-O7DRJ6R4DW. Grades: >98%. CAS No. 856867-55-5. Molecular formula: C17H16FN6O6P. Mole weight: 450.32. | |
| Telaprevir-[d4] | Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver. Alternative Names: (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-[(cyclopropyl-d4)amino]-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide; LY 570310-d4; MP 424-d4; VRT 111950-d4; VX 950-d4. Grades: >98%. Molecular formula: C36H49D4N7O6. Mole weight: 683.87. | |
| Telmisartan EP Impurity B | One of the impurities of Telmisartan, which is an angiotensin II receptor antagonist and could be used in the treatment of hypertensive. Alternative Names: Telmisartan Related Compound B; 4'-[(1,7'-Dimethyl-2'-propyl[2,5'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic Acid. Grades: > 95%. CAS No. 1026353-20-7. Molecular formula: C33H30N4O2. Mole weight: 514.6. | |
| Telmisartan EP Impurity E | One of the impurities of Telmisartan, which is an angiotensin II receptor antagonist and could be used in the treatment of hypertensive. Alternative Names: Telmisartan Diacid Impurity; 6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan; 1-[(2'-Carboxy[1,1'-biphenyl]-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid. Grades: > 95%. CAS No. 884330-12-5. Molecular formula: C26H24N2O4. Mole weight: 428.49. | |
| Telmisartan EP Impurity J | Telmisartan EP Impurity J is one of telmisartan impurities. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Alternative Names: Telmisartan Chloro Impurity; Telmisartan impurity J [EP]; 4'-[(5-chloro-1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-Biphenyl]-2-carboxylic acid. Grades: > 98%. CAS No. 885045-90-9. Molecular formula: C33H29ClN4O2. Mole weight: 549.06. | |
| Telocinobufagin | Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis. Alternative Names: Telobufotoxin; Telocinobufogenin. Grades: >98%. CAS No. 472-26-4. Molecular formula: C24H34O5. Mole weight: 402.52. | |
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