BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Sacubitril Impurity 5 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Alternative Names: (αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid. Grades: > 95%. CAS No. 1012341-56-8. Molecular formula: C23H29NO4. Mole weight: 383.49. |  |
| Sacubitril Impurity 6 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Alternative Names: (αS,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid. Grades: > 95%. CAS No. 1012341-54-6. Molecular formula: C23H29NO4. Mole weight: 383.49. | |
| Sacubitril Impurity 7 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Alternative Names: (αS,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid. Grades: > 95%. CAS No. 1012341-52-4. Molecular formula: C23H29NO4. Mole weight: 383.49. | |
| Safinamide Impurity 5 | An impurity of Safinamide, a selective monoamine oxidase B inhibitor, reducing degradation of dopamine. Alternative Names: (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanoic acid; (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanoic acid. Grades: >95%. CAS No. 1160513-60-9. Molecular formula: C17H18FNO3. Mole weight: 303.34. | |
| Safinamide Impurity 8 | An impurity of safinamide,safinamide is a selective monoamine oxidase B inhibitor, reducing degradation of dopamine. Alternative Names: 4-[(3-Fluorophenyl)methoxy]benzenemethanol. Grades: > 95%. CAS No. 690969-16-5. Molecular formula: C14H13FO2. Mole weight: 232.26. | |
| Safinamide mesylate | Safinamide is a highly selective MAO-B inhibitor in rat brain mitochondria, with an IC50 of 98 nM. safinamide inhibits MAO-B in human brain with an IC50 of 9 nM. Alternative Names: PNU-151774E; (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate. Grades: >98%. CAS No. 202825-46-5. Molecular formula: C17H19FN2O2.CH4O3S. Mole weight: 398.45. | |
| Sageone | Sageone is extracted from the roots of Salvia miltiorrhiza. It has antiviral activity. Alternative Names: 2,3,9,10-Tetrahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4(1H)-phenanthrenone;4(1H)-Phenanthrenone, 2,3,9,10-tetrahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-. Grades: 97.0%. CAS No. 142546-15-4. Molecular formula: C19H24O3. Mole weight: 300.398. | |
| Saikosaponin B1 | Saikosaponin B1 is extracted from the herb of Bupleurum chinense DC. It potently stimulated PGE2 release. Alternative Names: (3b,4a,16b)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl-6-deoxy-3-o-beta-d-glucopyranosyl-beta-d-galactopyranoside; [(4R)-16β,23,28-Trihydroxyoleana-11,13(18)-dien-3β-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside. Grades: >98%. CAS No. 58558-08-0. Molecular formula: C42H68O13. | |
| Saikosaponin B3 | Saikosaponin B3, a triterpene glycoside, is a saikosaponin isolated from Bupleurum chinese DC. Bupleurum chinese DC, also called as Bupleuri Radix, is one of the most important crude drugs used inmany traditional Chinesemedicines. And it is believed that saikosaponins are responsible for part of the pharmaceutical properties of Bupleuri Radix. Alternative Names: β-D-Galactopyranoside, (3β,4α,11α,16β)-16,23,28-trihydroxy-11-methoxyolean-12-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-; (3β,4α,11α,16β)-16,23,28-Trihydroxy-11-methoxyolean-12-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside; Oleanane, β-D-galactopyranoside deriv. Grades: > 98%. CAS No. 58316-42-0. Molecular formula: C43H72O14. Mole weight: 813.02. | |
| Saikosaponin B4 | Saikosaponin B4 is a saikosaponins isolated from Bupleurum chinese DC. It is a Saikosaponins standard to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to. Sho-saiko-to, is a herbal medicine which prevents liver fibrosis and the development of preneoplastic lesions by directly inhibiting the activation of stellate cells. Uses: Anti-inflammatory agents, non-steroidal. Alternative Names: β-D-Galactopyranoside, (3β,4α,11α,16α)-16,23,28-trihydroxy-11-methoxyolean-12-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-; (3β,4α,11α,16α)-16,23,28-Trihydroxy-11-methoxyolean-12-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside. Grades: > 98%. CAS No. 58558-09-1. Molecular formula: C43H72O14. Mole weight: 813.02. | |
| Saikosaponin F | Saikosaponin F, a genuine glycoside, is a saikosaponins extracted from the methanolic extract of Bupleurum chinese DC. Saikosaponins is believed to be responsible for part of the pharmaceutical properties of Bupleuri Radix. Several saikogenins and their derivatives have anti-allergic activity, analgesic action, anti-inflammatory action, plasma cholesterol-lowering action, action for hepatic injuries, etc. Alternative Names: β-D-Glucopyranoside, (3β,16β)-16,28-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-; (3β,16β)-16,28-Dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside. Grades: > 98%. CAS No. 62687-63-2. Molecular formula: C48H80O17. Mole weight: 929.1. | |
| Saikosaponin G | Saikosaponin G, a triterpene glycoside, is a saikosaponin which is believed to be responsible for part of the pharmaceutical properties of Bupleuri Radix. Bupleuri Radix, dried roots of Bupleurum spp. (Apiaceae), has been used as medicine in China for over 2000 years, and it is one of the most common components of Chinese traditional medicine prescriptions for the treatment of chronic hepatitis, kidney syndrome, inflammatory diseases, and ulcers of the digestive system. Alternative Names: (3β,4α,16β)-16,23,28-Trihydroxyoleana-9(11),12-dien-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside. Grades: > 98%. CAS No. 99365-19-2. Molecular formula: C42H68O13. Mole weight: 780.98. | |
| Saikosaponin H | Saikosaponin H is a saikosaponins standard extracted from the Bupleuri Radix (Bupleurum spp. root) which is one of the most important crude drugs used inmany traditional Chinesemedicines (TCM). It helps analyse and resolve the activities of herbal medicines. Alternative Names: β-D-Glucopyranoside, (3β,16β)-16,28-dihydroxyoleana-11,13(18)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-; (3β,16β)-16,28-Dihydroxyoleana-11,13(18)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside. Grades: > 98%. CAS No. 91990-63-5. Molecular formula: C48H78O17. Mole weight: 927.12. | |
| Saikosaponin I | Saikosaponin I, extracted from the root of Bupleurum chinense DC, is a Saikosaponins standard to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to. Sho-saiko-to is a herbal medicine which has been orally administered to patients with chronic liver disease in Japan and has been found to inhibit the development of hepatocellular carcinoma. Alternative Names: (3beta,16beta)-16,28-Dihydroxyoleana-9(11),12-dien-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1→4)-O-[beta-D-glucopyranosyl-(1→6)]-beta-D-glucopyranoside. Grades: > 98%. CAS No. 103629-71-6. Molecular formula: C48H78O17. Mole weight: 927.12. | |
| Salannal | Salannal is isolated from the root of M. azedarach L., which structure is elucidated by spectroscopic means. Grades: >98%. CAS No. 86160-86-3. Molecular formula: C34H44O10. | |
| Salbutamol EP Impurity B Hydrochloride | An impurity of salbutamol. Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Alternative Names: Salbutamol EP Impurity B HCl; Salbutamol Impurity B HCl; Salbutamol Impurity B Hydrochloride; (1RS)-2-[(1,1-Dimethylethyl)amino]-1-(4-hydroxyphenyl)ethanol Hydrochloride. CAS No. 112337-52-7. Molecular formula: C12H19NO2.HCl. Mole weight: 245.75. | |
| Salbutamon Hydrochloride | Salbutamon Hydrochloride is the hydrochloride form of Salbutamon, which is an impurity of Salbutamol. Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. Alternative Names: Salbutamol EP Impurity J hydrochloride; 2-[(1,1-Dimethylethyl)amino]-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanone hydrochloride; Albuterol Related Compound B hydrochloride; Ethanone, 2-[(1,1-dimethylethyl)amino]-1-[4-hydroxy-3-(hydroxymethyl)phenyl]-, hydrochloride (1:1). CAS No. 41489-89-8. Molecular formula: C13H20ClNO3. Mole weight: 273.76. | |
| Salicylic Acid-[13C6] | Salicylic Acid-[13C6] is a labelled analogue of Salicylic acid. Salicylic acid is a natural product extracted from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. Salicylic acid is widely used in organic synthesis and functions as a plant hormone and is known for its ability to ease aches and pains and reduce fevers. Uses: Labelled acetylsalicylic acid impurity b. Alternative Names: Salicylic Acid 13C6; 2-Hydroxy(13C6)benzoic acid; [U-ring-13C6]-Hydroxybenzoic acid. Grades: 95% atom 13C. CAS No. 1189678-81-6. Molecular formula: C[13C]6H6O3. Mole weight: 144.08. | |
| Salirasib | Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Alternative Names: Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS. CAS No. 162520-00-5. Molecular formula: C22H30O2S. Mole weight: 358.54. | |
| Salmeterol Xinafoate | Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms. Uses: Adrenergic beta-2 receptor agonists. Alternative Names: GR-33343G; GR 33343G; GR33343G. Grades: >98%. CAS No. 94749-08-3. Molecular formula: C36H45NO7. Mole weight: 603.75. | |
| Salvigenin | Salvigenin isolated from the roots of Salvia japonica. It reduces tumor cell growth in RIN cell line and inhibits the growth of tumor tissue in vivo. Uses: Antimicrobial; antitumor and immunomodulatory effects. Alternative Names: 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one. Grades: 0.99. CAS No. 19103-54-9. Molecular formula: C18H16O6. Mole weight: 328.3. | |
| Sambutoxin | Sambutoxin is natural alkaloid isolated from the rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines. Alternative Names: 3-[(2S,5R,6R)-6-[(E,4R,6S)-4,6-dimethyloct-2-en-2-yl]-5-methyloxan-2-yl]-4-hydroxy-5-(4-hydroxyphenyl)-1-methylpyridin-2-one. Grades: >98%. CAS No. 160047-56-3. Molecular formula: C28H39NO4. Mole weight: 453.6. | |
| Sanggenol P | Sanggenol P is a natural flavonoid found in the root bark of Morus alba L. Alternative Names: Sanggenol P;1351931-30-0;2-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-5,7-dihydroxy-2,3-dihydrochromen-4-one;HY-N1323;AKOS040762295;FS-9426;DA-57654;CS-0016727. Grades: >95%. CAS No. 1351931-30-0. Molecular formula: C30H36O6. Mole weight: 492.60. | |
| Sanguinarine chloride | anguinaria canadensis (bloodroot) is a perennial, herbaceous flowering plant native to eastern North America. It is the only species in the genus Sanguinaria, included in the family Papaveraceae, and most closely related to Eomecon of eastern Asia. Sanguinaria canadensis is also known as bloodwort redroot, red puccoon,and sometimes pauson. It has also been known as tetterwort,although that name is also used to refer to Chelidonium majus. Plants are variable in leaf and flower shape and have in the past been separated out as different subspecies due to these variable shapes. Currently most taxonomic treatments include these different forms in one highly variable species. In bloodroot, the juice is red and poisonous. Uses: Antibiosis. Alternative Names: 13-METHYL-[1,3]BENZODIOXOLO[5,6-C]-1,3-DIOXOLO[4,5-I] PHENANTHRIDINIUM CHLORIDE; SANGUINARINE CHLORIDE; SANGUINARINE HCL; PSEUDOCHELERYTHRINE; PSEUDOCHELERYTHRINE CHLORIDE; 3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(chlo; sanguinarinehydrochloride; sanguinariumchloride. Grades: >98%. CAS No. 5578-73-4. Molecular formula: C20H14ClNO4. Mole weight: 367.78. | |
| Saponarin | Saponarin is a compound of the flavonoid class found in the seeds of Vaccaria segetalis. Saponarin exhibits antioxidant and anti-inflammatory properties. Alternative Names: Saponaretin-7-O-glucoside; Isovitexin-7-O-glucoside; Isovitexin-7-O-beta-D-glucopyranoside; 5-hydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-7-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one. Grades: >98%. CAS No. 20310-89-8. Molecular formula: C27H30O15. Mole weight: 594.522. | |
| Sappanchalcone | Sappanchalcone is a natural flavonoid extracted from Caesalpinia sappan. It exhibits cytoprotective activity and anti-inflammatory effects, which can reduce clinical arthritis. Sappanchalcone is also a xanthine oxidase inhibitor. Uses: Cytoprotective, anti-inflammatory. Alternative Names: (2E)-3-(3,4-Dihydroxyphenyl)-1-(4-hydroxy-2-Methoxyphenyl)-2-propen-1-one; 3-(3,4-Dihydroxyphenyl)-1-(4-hydroxy-2-Methoxyphenyl)prop-2-en-1-one. Grades: >98%. CAS No. 94344-54-4. Molecular formula: C16H14O5. Mole weight: 286.3. | |
| Sapropterin dihydrochloride | Sapropterin is a naturally occurring cofactor for phenylalanine hydroxylase. Under the trade name Kuvan, sapropterin dihydrochloride is approved for the treatment of hyperphenylalaninaemia and tetrahydrobiopterin deficiency. Alternative Names: BioMarin T 1401; Biopten; Kuvan; SUN 0588; Shiratori SN 0588; (6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride; Phenoptin; (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride; (6R)-Tetrahydrobiopterin hydrochloride; (6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride. Grades: >98%. CAS No. 69056-38-8. Molecular formula: C9H17Cl2N5O3. Mole weight: 314.17. | |
| SAR-405 | SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd=1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines. Alternative Names: SAR 405; SAR405; 4H-Pyrimido[1,2-a]pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-, (8S)-; (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.85. | |
| SAR7334 | SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC. Uses: Sar7334 is a trpc6 inhibitor that could be valuable in studying sorts of diseases related to trpc. Alternative Names: SAR7334; CPA1588; SAR 7334; CPA 1588; SAR-7334; CPA-1588; 4-(((1R,2R)-2-((R)-3-aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile; 1333207-63-8; 1333210-07-3; C21H22ClN3O. Grades: 98%. CAS No. 1333210-07-3. Molecular formula: C21H22ClN3O. Mole weight: 367.87. | |
| Sarafloxacin-[d8] Hydrochloride | Sarafloxacin-[d8] Hydrochloride is the labelled hydrochloride form of Sarafloxacin. Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl-d8)-3-quinolinecarboxylic Acid Hydrochloride; A 56620-d8; PD 121960-d8; Sarafin-d8. Grades: >98%. CAS No. 1352879-52-7. Molecular formula: C20H10D8ClF2N3O3. Mole weight: 429.87. | |
| Sarafloxacin-[d8] hydrochloride hydrate | Sarafloxacin-[d8] hydrochloride hydrate is a labelled analogue of Sarafloxacin. Sarafloxacin is a topoisomerase II ligase inhibitor used as a quinolone antibiotic drug. Alternative Names: Sarafloxacin-D8 hydrochloride hydrate; Difloxacino-d8 hydrochloride hydrate; Difloxacinum-d8 hydrochloride hydrate; Sarafloxacino-d8 hydrochloride hydrate; Sarafloxacinum-d8 hydrochloride hydrate; 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazine-D8-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate. Grades: 95% by HPLC; 98% atom D. Molecular formula: C20H9D8F2N3O3.HCl.H2O. Mole weight: 447.87. | |
| Sarolaner | Sarolaner is an antiparasitic agent. It is used as veterinary drug. Uses: Antiparasitic agent (veterinary use). Alternative Names: Simparica; PF-6450567; PF 6450567; PF6450567; (S)-1-(5'-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one. Grades: 98%. CAS No. 1398609-39-6. Molecular formula: C23H18Cl2F4N2O5S. Mole weight: 581.37. | |
| SARPAGINE | Sarpagine is a natural alkaloid found in the roots of Alstonia yunnanensis Diels, it is effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells. Alternative Names: Sarpagan-10,17-diol;Raupine;Sarpagane-10,17-diol. Grades: >97%. CAS No. 482-68-8. Molecular formula: C19H22N2O2. Mole weight: 310.4. | |
| Sarpogrelate-[d3] HCl | Sarpogrelate-[d3] HCl is a deuterated Sarpogrelate HCl. Sarpogrelate is a drug which acts as an antagonist at the 5HT2A and 5-HT2B receptors. Alternative Names: Sarpogrelate-d3 HCl; Sarpogrelate-D3 hydrochloride. Grades: > 95%. Molecular formula: C24H29D3ClNO6. Mole weight: 468.99. | |
| (S)-Atenolol-[d7] | (S)-Atenolol-[d7] is the labelled analogue of (S)-Atenolol, which is a selective β-adrenergic blocker and could be used as an antihypertensive agent. Alternative Names: (S)-Atenolol-d7 (Iso-propyl-d7); 4-[(2S)-2-Hydroxy-3-[(1-methylethyl-d7)amino]propoxy]benzeneacetamide; (-)-Atenolol-d7; Esatenolol-d7; S-(-)-Atenolol-d7. Grades: 95% by HPLC; 98% atom D. CAS No. 1309283-20-2. Molecular formula: C14H15D7N2O3. Mole weight: 273.38. | |
| Satraplatin | Satraplatin, also known as JM216, is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, satraplatin is the first orally active platinum-based chemotherapeutic drug; other available platinum analogues-cisplatin, carboplatin, and oxaliplatin-must be given intravenously. It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (Satraplatin Expanded Rapid Access). The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. Alternative Names: BMS-182751; BMS 182751; BMS182751; JM 216; JM216; JM-216. CAS No. 129580-63-8. Molecular formula: C10H24Cl2N2O4Pt. Mole weight: 500.28. | |
| Sauchinone | Sauchinone, coming from the herbs of Saururus chinensis(Lour.) Baill, is a useful adjunctive treatment for bacterial infection. Sauchinone inhibited oxidative stress, as assessed by stainings of 4-hydroxynonenal and nitrotyrosine: these events may have a role in its inhibitory effects on HSCs activation. Sauchinone attenuated CCl4-induced liver fibrosis and TGF-β1-induced HSCs activation, which might be, at least in part, mediated by suppressing autophagy and oxidative stress in HSCs. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Uses: Anti-inflammatory / antibacterial. Alternative Names: (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one; (5aα,7α,8β,8aβ,14aS*,14bβ)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one. Grades: >98%. CAS No. 177931-17-8. Molecular formula: C20H20O6. Mole weight: 356.36. | |
| Savinin | Savinin isolated from the heartwood of Pterocarpus santalinus. It exhibits potent spermicidal activity and significant insecticidal activity. Uses: Antifungal. Alternative Names: (4R)-4,5-Dihydro-4-(1,3-benzodioxole-5-ylmethyl)-3-[(E)-1,3-benzodioxol-5-ylmethylene]furan-2(3H)-one; (3E,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-(1,3-benzodioxol-5-ylmethylidene)oxolan-2-one. Grades: 97.5%. CAS No. 493-95-8. Molecular formula: C20H16O6. Mole weight: 352.3. | |
| Savolitinib | Savolitinib is a tyrosine kinase inhibitor with potential anticancer activity. Alternative Names: Volitinib; HMPL 504; HMPL0-504; HMPL504; AZD 6094; AZD 6094; AZD-6094; Savolitinib. Grades: >98%. CAS No. 1313725-88-0. Molecular formula: C17H15N9. Mole weight: 345.37. | |
| Saxagliptin Cyclic Amide | An impurity of saxagliptin. Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of type II diabetes. Alternative Names: Saxagliptin EP Impurity C. Grades: > 95%. CAS No. 1350800-77-9. Molecular formula: C18H24N2O3. Mole weight: 316.4. | |
| Saxagliptin Cyclic Amidine Impurity | An impurity of saxagliptin. Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of type II diabetes. Alternative Names: Saxagliptin EP Impurity A; (1aS,4S,6aR,7aS)-6-Amino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one. Grades: > 95%. CAS No. 1350800-76-8. Molecular formula: C18H25N3O2. Mole weight: 315.42. | |
| Saxagliptin monohydrate | Saxagliptin hydrate is a selective and reversible DPP4 inhibitor. It demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes. It reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion. Alternative Names: BMS-477118 hydrate; BMS 477118 hydrate; BMS477118 hydrate; Onglyza hydrate. Grades: >98%. CAS No. 945667-22-1. Molecular formula: C18H27N3O3. Mole weight: 333.43. | |
| SB1317 | SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. It dose-dependently inhibits signaling pathways downstream of CDKs, JAK2 and FLT3 in cancer cells with the main targets being CDKs. SB1317 is anti-proliferative in a broad range of tumor cell lines, inducing G1 cell cycle arrest and apoptosis. In vivo, SB1317 exhibits favorable pharmacokinetics after oral dosing in xenograft models and accumulates in tumor tissues, inducing an effective blockade of both CDK and STAT signaling. SB1317 induces tumor regression after oral dosing on both daily and intermittent schedules in a murine model of mutant-FLT3 leukemia (MV4-11) and prolongs survival in a disseminated AML model with wild-type FLT3 and JAK2 (HL-60). SB1317 is active in various models of leukemia and provide a rationale for the ongoing clinical evaluation of TG02 in patients with advanced leukemias. Alternative Names: TG02; TG 02; TG-02; SB1317 (Double bond E); TG02 (Double bond E). Grades: ≥98%. CAS No. 1204918-72-8. Molecular formula: C23H24N4O. Mole weight: 372.46. | |
| SB-203580 | SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM. Uses: Enzyme inhibitors. Alternative Names: SB203580; SB203580; SB 203580. Grades: >98%. CAS No. 152121-47-6. Molecular formula: C21H16FN3OS. Mole weight: 377.437. | |
| SB239063 | SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production. SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Uses: Protein kinase inhibitors. Alternative Names: SB-239063; SB 239063. Grades: 0.98. CAS No. 193551-21-2. Molecular formula: C20H21FN4O2. Mole weight: 368.412. | |
| SB 277011A dihydrochloride | SB 277011A dihydrochloride is a selective and brain penetrating dopamine D3 receptor antagonist (pKi = 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B, respectively) with 100-fold selectivity over the hD2 receptor and over 66 other receptors. Alternative Names: SB 277011A dihydrochloride; SB277011A dihydrochloride; SB-277011A dihydrochloride; N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1226917-67-4. Molecular formula: C28H30N4O.2HCl. Mole weight: 511.49. | |
| SB-3CT | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. Besides, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. Alternative Names: MMP-2/MMP-9 Inhibitor IV; 2-((4-phenoxyphenylsulfonyl)methyl)thiirane; SB-3CT; SB3CT; SB3-CT; IN1250; IN 1250; IN-1250. Grades: 98%. CAS No. 292605-14-2. Molecular formula: C15H14O3S2. Mole weight: 306.394. | |
| SB525334 | SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. Alternative Names: SB525334; SB-525334; SB 525334. Grades: >98%. CAS No. 356559-20-1. Molecular formula: C21H21N5. Mole weight: 343.42494. | |
| SB705498 | SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Alternative Names: SB-705498; SB 705498; SB705498. Grades: >98%. CAS No. 501951-42-4. Molecular formula: C17H16BrF3N4O. Mole weight: 429.23. | |
| SB742457 | SB742457 is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease. Alternative Names: SB742457; SB 742457; SB-742457; RVT-101; RVT 101; RVT101. intepirdine. GSK 742457; GSK742457; GSK-742457. Grades: >98%. CAS No. 607742-69-8. Molecular formula: C19H19N3O2S. Mole weight: 353.44. | |
| (S)-BoroLeu-(+)-Pinanediol trifluoroacetate | (S)-BoroLeu-(+)-Pinanediol trifluoroacetate. Alternative Names: 4,6-Methano-1,3,2-benzodioxaborole-2-methanamine, hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-, (alphaS,3aS,4S,6S,7aR)-, 2,2,2-trifluoroacetate (1:1); (S)-BoroLeu-(-)-Pinanediol-CF3COOH. CAS No. 477254-69-6. Molecular formula: C17H29BF3NO4. Mole weight: 379.2. | |
| SC 26196 | SC 26196 is a selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro) that displays >100 fold selectivity over Δ5 and Δ9 desaturases (IC50 >200 μM in vitro). SC 26196 completely inhibits the conversion of linoleic acid to arachidonic acid (AA). It exhibits anti-inflammatory properties in a mouse edema model. Alternative Names: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; PF-o6341724; FT 0674530; SC 26196; FT0674530; SC26196; FT-0674530; SC-26196. Grades: ≥98% by HPLC. CAS No. 218136-59-5. Molecular formula: C27H29N5. Mole weight: 423.55. | |
| Scabioside C | Scabioside C is extracted from Pulsatilla chinensis (Bunge) Regel. Uses: Topoisomerase i inhibitors. Alternative Names: Scabioside C; 17233-22-6; (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; Leontoside B; CHEMBL466974; AKOS040760693; HY-107309; CS-0027942. Grades: >98%. CAS No. 17233-22-6. Molecular formula: C41H66O13. Mole weight: 767. | |
| (+)-Scandine | Scandine is a natural alkaloid isolated from the herbs of Melodinus khasianus. Alternative Names: 3-(Methoxycarbonyl)meloscine. Grades: >97%. CAS No. 24314-59-8. Molecular formula: C21H22N2O3. Mole weight: 350.4. | |
| (S)-(-)-Carbidopa-[d3] Monohydrate | (S)-(-)-Carbidopa-[d3] Monohydrate is the labelled hydrate of Carbidopa. Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor. It is commonly used in combination with L-DOPA for the treatment of Parkinsonism. Alternative Names: (S)-(-)-Carbidopa D3 hydrate; (S)-α-Hydrazino-3,4-dihydroxy-α-methyl Benzenepropanoic Acid-d3 Monohydrate; Carbidopa-d3 Monohydrate. Grades: 95% by HPLC; 98% atom D. CAS No. 1276197-58-0. Molecular formula: C10H11D3N2O4.H2O. Mole weight: 247.27. | |
| SCH 58261 | SCH 58261 is a potent and selective antagonist of adenosine A2A receptor, displaying neuroprotective activity. Uses: Adenosine a2 receptor antagonists. Alternative Names: SCH-58261; SCH 58261; SCH58261. 2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine. Grades: 98%. CAS No. 160098-96-4. Molecular formula: C18H15N7O. Mole weight: 345.366. | |
| SCH772984 | SCH772984 is a potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild-type melanoma. Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines and significantly delayed the onset of acquired resistance in long term in vitro assays. Therefore, SCH772984 may be clinically applicable as a treatment for non-BRAF mutant melanoma or in BRAF-mutant melanoma with innate or acquired resistance, alone or in combination with BRAF inhibitors. Alternative Names: SCH-772984; SCH 772984; (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide. Grades: 95%. CAS No. 942183-80-4. Molecular formula: C33H33N9O2. Mole weight: 587.688. | |
| Schisandrin B | Schisandrin B, a dibenzocyclooctadiene derivative isolated from Schisandra propinqua and Schisandra rubriflora, has antioxidant effects on the liver and heart of rodents. It is used in traditional Chinese medicine to treat hepatitis and myocardial disorders. The anti-inflammatory effect of Schisandrin B is mediated by regulating Nrf2 and NF-κB in lymphocytes. Uses: Anti-cancer. Alternative Names: rel-(6R,7S,13aR)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxole; (±)-γ-Schisandrin; γ-Schizandrin; (±)-γ-Schizandrin; Schisandrin B; Wuweizisu B; gamma-Schisandrin; γ-Schisandrin; Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aR)-rel-; Sch B. Grades: >98%. CAS No. 61281-37-6. Molecular formula: C23H28O6. Mole weight: 400.46. | |
| Schisandrone | Schisandrone is extracted from the fruits of Schisandra sphenanthera. Alternative Names: Arisantetralone C. Grades: >98%. CAS No. 98619-25-1. Molecular formula: C21H24O5. Mole weight: 356.4. | |
| Schisanhenol | Schisanhenol has antioxidative effect on human LDL oxidation. The mechanism of Schisanhenol against LDL oxidation may be through scavenging free radicals. Uses: Ugt2b7 udp-glucuronosyltransferases inhibitor. Alternative Names: (6S,7R)-2,3,10,11,12-pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-1-ol; (+)-Gomisin K3. Grades: >98%. CAS No. 69363-14-0. Molecular formula: C23H30O6. Mole weight: 402.487. | |
| Schisanhenol B | antioxidant. Uses: Antioxidant. Alternative Names: Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer; schisanhenol B. Grades: >98%. CAS No. 102681-52-7. Molecular formula: C22H26O6. Mole weight: 386.444. | |
| Schisantherin A | Schisantherin A is a mechanism-based inhibitor that not only competitively inhibits but irreversibly inactivates CYP3A4. Uses: Antihepatotoxic, antioxidant and antitumoura. Alternative Names: SCHISANTHERIN A 98.0% BY HPLC; Gomisin C(Schisantherin A); Schisantherin A; SCHISANTHERINGOMISIN. Grades: >98%. CAS No. 58546-56-8. Molecular formula: C30H32O9. Mole weight: 536.574. | |
| Schisantherin B | Schisantherin B shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Uses: Hepatoprotection. Alternative Names: SCHISANTHERIN B; 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)-; SCHISANTHERIN B 98.0% BY HPLC; GOMISINB; (5S)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7β-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5α,6β-diol 5-[(Z)-2-methyl-2-butenoate]; (5S)-6α,7β-Dimethyl-1,2,3,12-tetramethoxy-10,11-methylenedioxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5α,6β-diol 5-[(Z)-2-methyl-2-butenoate]; 2-Butenoic acid, 2-methyl-, (5S,6S,7S,13as)-5,6,7,13A-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-F][1,3]benzodioxol-5-yl ester, (2Z)-; (2Z)-2-Methyl-2-butenoic acid(5S,6S,7S,13aS)-5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl ester. Grades: >98%. CAS No. 58546-55-7. Molecular formula: C28H34O9. Mole weight: 514.56. | |
| Schisantherin C | Schisantherin C is found in Kadsura longipedunculata, which has effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Alternative Names: Schizantherin C; Tigloygomisin Q. Grades: 95%. CAS No. 64938-51-8. Molecular formula: C28H34O9. Mole weight: 514.56. | |
| Schizandrin | Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects. Uses: Hepatoprotective activity; a potent p-gp inhibitor. Alternative Names: Schizandrol; Schizandrol-A; Wuweizi alcohol-A. Grades: >98%. CAS No. 7432-28-2. Molecular formula: C24H32O7. Mole weight: 432.51. | |
| Scholaricine | Scholaricine comes from the herbs of Bothrocaryum controversum, and Scholaricine reverses multidrug resistance in vincristine-resistant KB cells. Uses: Anti-inflammatory and analgesic effect. Alternative Names: Methyl (19S)-12,19-dihydroxy-2,16-didehydrocuran-17-oate. Grades: > 95%. CAS No. 99694-90-3. Molecular formula: C20H24N2O4. Mole weight: 356.4. | |
| (S)-Cinacalcet-[d3] | (S)-Cinacalcet-[d3] is the labelled S-enantiomer of Cinacalcet. Cinacalcet is a medication used for the treatment of hyperparathyroidism. Alternative Names: (S)-Cinacalcet-D3; (S)-α-(Methyl-d3)-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine; (S)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-(1-napthyl)ethylamine-d3. Grades: 98% by HPLC; 99% atom D. Molecular formula: C22H19D3F3N. Mole weight: 360.44. | |
| (S)-Cinacalcet-[d3] Hydrochloride | (S)-Cinacalcet-[d3] Hydrochloride is the labelled S-enantiomer of Cinacalcet. Cinacalcet is a medication used for the treatment of hyperparathyroidism. Alternative Names: (S)-Cinacalcet-D3 Hydrochloride; (αS)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine-d3 Hydrochloride; Cinacalcet USP Related Compound D-d3 (HCl). Grades: 97.0% by HPLC; 99% atom D. Molecular formula: C22H20D3ClF3N. Mole weight: 396.89. | |
| Scopolin | Scopolin is an agent for angiogenesis related diseases isolated from the herb of Scopolia japonica. It can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis. Alternative Names: Scopoletin 7-O-Glucoside; 7-(β-D-Glucopyranosyloxy)-6-methoxy-2H-1-benzopyran-2-one; 6-Methoxy-7-(β-D-glucopyranosyloxy)coumarin; 6-Methoxycoumarin 7-O-β-D-glucoside; 7-(β-D-Glucopyranosyloxy)-6-methoxycoumarin; 7-O-β-Glucopyranosylscopoletin; NSC 404560; Scopoletin 7-O-β-D-Glucopyranoside; Scopoletin 7-Glucoside; Scopoline; Scopoloside. Grades: 99%. CAS No. 531-44-2. Molecular formula: C16H18O9. Mole weight: 354.3. | |
| SCR7 pyrazine | SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold, and inhibits nonhomologous end-joining (NHEJ). Alternative Names: SCR7 pyrazine; SCR-7 pyrazine; SCR 7 pyrazine; 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 2-mercapto-6,7-diphenylpteridin-4-ol; 6,7-diphenyl-2-sulfanylpteridin-4-ol. Grades: ≥98% by HPLC. CAS No. 14892-97-8. Molecular formula: C18H12N4OS. Mole weight: 332.38. | |
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