BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Preladenant | Preladenant is a potent adenosine A2 receptor antagonist that has been studied as a therapeutic agent for Parkinson's disease. Alternative Names: SCH420814; SCH-420814; SCH 420814; MK-3814; MK 3814; MK3814; Preladenant2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine. Grades: >98%. CAS No. 377727-87-2. Molecular formula: C25H29N9O3. Mole weight: 503.56. |  |
| Prerubialatin | Prerubialatin is a natural compound isolated from the herbs of Rubia cordifolia, being a precursor of rubialatins A and B. Alternative Names: Prerubialatin; 1667718-89-9. CAS No. 1667718-89-9. Molecular formula: C27H20O7. Mole weight: 456.45. | |
| Presatovir | Presatovir is a viral fusion protein inhibitor with EC50 value of 0.43 nM. It can inhibit a broad range of respiratory syncytial virus clinical isolates by blocking the virus-cell fusion process. It can also inhibit pre- to post-fusion conformational changes of the respiratory syncytial virus fusion protein. Phase II clinical trials for the treatment of respiratory syncytial virus infections is ongoing. Alternative Names: N-(2-((S)-2-(5-((S)-3-aminopyrrolidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide; GS-5806; GS5806; GS 5806. Grades: >98%. CAS No. 1353625-73-6. Molecular formula: C24H30ClN7O3S. Mole weight: 532.06. | |
| Pridopidine | Pridopidine, also known as ACR16, is a dopamine stabilizer used in the treatment of neurologic and psychiatric disorders. Uses: Dopamine d2 receptor antagonists; glutamate modulators; sigma-1 receptor agonists. Alternative Names: 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine; ACR 16; ACR16; ACR-16; FR310826; FR-310826; FR 310826; 4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine. Grades: ≥98%. CAS No. 346688-38-8. Molecular formula: C15H23NO2S. Mole weight: 587.71. | |
| Prionidipene A | Prionidipene A, a promising chemical compound, exhibits therapeutic potential in treating neurological disorders including Alzheimer's disease. This inhibitor of the beta-site amyloid precursor protein cleaving enzyme curtails the production of amyloid beta peptides, an established hallmark of Alzheimer's disease. Interestingly, research proposes that Prionidipene A reduces amyloid beta levels in the brain, which in turn has therapeutic implications. Moreover, improved cognitive function was noted, suggesting that this compound could be a pivotal stepping stone in developing novel therapeutics for Alzheimer's disease. Grades: > 95%. CAS No. 2199455-72-4. Molecular formula: C21H26O3. Mole weight: 326.43. | |
| Pritelivir mesylate | Pritelivir mesylate is a potent helicase primase inhibitor that inhibits HSV replication. Pritelivir is active against both types of herpes simplex virus (HSV-1 and HSV-2). Alternative Names: Pritelivir (mesylate); BAY 57-1293 Methanesulfonate Salt; Pritelivir methanesulfonate. Grades: 98% by HPLC. CAS No. 1428333-96-3. Molecular formula: C19H22N4O6S3. Mole weight: 498.6. | |
| PRN1371 | PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor. Alternative Names: 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one. CAS No. 1802929-43-6. Molecular formula: C26H30Cl2N6O4. Mole weight: 561.46. | |
| Proanthocyanidin A4 | Proanthocyanidin A4 is a Procyanidin isolated from the root of E. sinica. It shows anti-inflammatory effects. Alternative Names: 8,14-Methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol, 2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-, (2S,3R,8S,14R,15R)-; (2S,3R,8S,14R,15R)-2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-2H,14H-8,14-methanobenzo[7,8][1,3]dioxocino[4,5-h]chromene-3,5,11,13,15-pentol; (+)-Epicatechin-(4β-8,2β-O-7)-(-)-catechin, Proanthocyanidin A4. Grades: ≥95%. CAS No. 111466-29-6. Molecular formula: C30H24O12. Mole weight: 576.51. | |
| Probucol Disuccinate | Probucol Disuccinate is the succinate ester form of probucol, which is a potent oxidant. Probucol inhibits the oxidantion of cholesterol in LDLs, and also lowers HDL in patients with heart disease. Probucol is used as an anti-hyperlipidemic drug. Alternative Names: 4-[2,6-ditert-butyl-4-[2-[3,5-ditert-butyl-4-(3-carboxypropanoyloxy)phenyl]sulfanylpropan-2-ylsulfanyl]phenoxy]-4-oxobutanoic acid. CAS No. 216168-45-5. Molecular formula: C39H56O8S2. Mole weight: 716.989. | |
| Prochlorperazine-[d8] Dihydrochloride | Prochlorperazine-[d8] Dihydrochloride, is the labelled analogue of Prochlorperazine. Prochlorperazine is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents, which are used for the antiemetic treatment of nausea and vertigo. Alternative Names: Prochlorperazine D8 Dihydrochloride; Prochlorperazine-d8 2HCl (piperazine-d8). Molecular formula: C20H18D8Cl3N3S. Mole weight: 454.91. | |
| Procumbide | Procumbide is an iridoid compound found in herbs of Andrographis paniculata. Procumbide exhibits anti-inflammatory activity. Uses: Anti-inflammatory. Alternative Names: [(1S)-1,4a,5,6,7,7aα-Hexahydro-4aα,5β-dihydroxy-7-methyl-6α,7α-epoxycyclopenta[c]pyran-1α-yl]β-D-glucopyranoside;[[(1S)-1,4a,5,6,7,7aα-Hexahydro-6α,7α-epoxy-7-methyl-4aα,5β-dihydroxycyclopenta[c]pyran]-1-yl]β-D-glucopyranoside. Grades: >96%. CAS No. 20486-27-5. Molecular formula: C15H22O10. Mole weight: 362.3. | |
| Prohexadione calcium | Prohexadione calcium (CAS# 127277-53-6 ) is a useful research chemical. Alternative Names: Prohexadione-Calcium; calcium 3-oxido-5-oxo-4-propionylcyclohex-3-enecarboxylate; ProCa. Grades: 95 %. CAS No. 127277-53-6. Molecular formula: C20H22CaO10. Mole weight: 462.46. | |
| Prontosil | Prontosil is one of the earliest antimicrobial drugs that was widely used in mid-20th century. It has an effect against gram-positive cocci but not against enterobacteria. Alternative Names: Sulfamidochrysoidine; Rubiazol; Prontosil rubrum; 4-[(2,4-diaminophenyl)diazenyl]benzenesulfonamide. CAS No. 103-12-8. Molecular formula: C12H13N5O2S. Mole weight: 291.329. | |
| Propanoic acid, 2-methyl-, 1-(1,1-dimethylethyl)-2-methyl-1,3-propanediyl ester | Propanoic acid, 2-methyl-, 1-(1,1-dimethylethyl)-2-methyl-1,3-propanediyl ester. Alternative Names: Bisisobutyric acid 2,4,4-trimethylpentane-1,3-diyl ester; Diisobutyric acid 1-tert-butyl-2-methyl-1,3-propanediyl ester; 1,1-dimethyl-3-(3-nitrophenyl)urea. Grades: 95%. CAS No. 74381-40-1. Molecular formula: C16H30O4. Mole weight: 286.41. | |
| Propargyl-NHS Ester | Propargyl-NHS ester is an indispensable small molecule tool in the biomedical field and is a key coupling agent that promotes bioconjugation reactions. This compound labels a range of biomolecules including proteins and peptides, facilitating their unambiguous identification and meticulous monitoring. With its sheer versatility, Propargyl-NHS Ester coordinates a range of tasks, including drug delivery systems, diagnostics and targeted therapies. Alternative Names: Propargyl-PEG1-NHS ester; 2,5-dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate; N-Succinimidyl 3-(propargyloxy)propionate; Propargyl-N-hydroxysuccinimidyl ester. Grades: 95% by NMR. CAS No. 1174157-65-3. Molecular formula: C10H11NO5. Mole weight: 225.20. | |
| Propargyl-PEG2-Tos | Propargyl-PEG2-Tos is a PROTAC linker containing a tosyl group and a propargyl group. Alternative Names: 2-(prop-2-yn-1-yloxy)ethyl 4-methylbenzene-1-sulfonate. Grades: 95%. CAS No. 145916-41-2. Molecular formula: C12H14O4S. Mole weight: 254.30. | |
| Propericiazine | Pericyazine, with antipsychotic effect, is a psychotherapeutic phenothiazine. Uses: Psychotherapeutic phenothiazine. antipsychotic. Alternative Names: periciazine; propericyazine; Neuleptil; Aolept; Bayer 1409; 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine. Grades: 98%. CAS No. 2622-26-6. Molecular formula: C21H23N3OS. Mole weight: 365.49. | |
| Propionyl-L-Carnitine HCl | The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases. Uses: The hydrochloride salt form of l-propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases. Alternative Names: PROPIONYL-L-CARNITINE CHLORIDE;PROPIONYL L-CARNITINE HCL;PROPIONYL-L-CARNITINE HYDROCHLORIDE;PROPIONYL-LEVO-CARNITINE HYDROCHLORIDE;(r)-2-propionyl-3-(trimethylaminium)butanoic acid chloride;Propionyl L-Carnitine. Grades: 95%. CAS No. 119793-66-7. Molecular formula: C10H20ClNO4. Mole weight: 253.73. | |
| Propoxur-[d3] | Propoxur-[d3], is the labelled analogue of Propoxur, which is a carbamate non-systemic insecticide. Alternative Names: Propoxur D3; Propoxur D3 (N-methyl D3). Grades: 95% by CP; 98% atom D. CAS No. 1219798-56-7. Molecular formula: C11H12D3NO3. Mole weight: 212.26. | |
| Propyl thiocyanate | Propyl thiocyanate. Alternative Names: Popyl Thiocyanate; propyl rhodanate; propyl rhodanide; propyl sulfocyanide; propyl thiocyanide. Grades: 95%. CAS No. 4251-16-5. Molecular formula: C4H7NS. Mole weight: 101.17. | |
| Protein Kinase Inhibitors 1 | Protein Kinase Inhibitors 1 is a HIPK2 inhibitor with IC50 of 74 nM and Kd of 9.5 nM. Alternative Names: 2,4-Thiazolidinedione, 5-[[1,2-dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-; 5-((2-oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione; 5-[[1,2-Dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-2,4-thiazolidinedione. Grades: ≥95%. CAS No. 1365986-44-2. Molecular formula: C18H17N5O3S. Mole weight: 383.43. | |
| Prothioconazole | Prothioconazole is an antifungal agent that can be used as agricultural fungicide and herbicide. Alternative Names: 3H-1,2,4-Triazole-3-thione, 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-; 2-[2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione; Acceleron DX 342; JAU 6476; Joao; Proline (fungicide); Proline 275; Proline 480SC; Redigo; Rudis. Grades: >95%. CAS No. 178928-70-6. Molecular formula: C14H15Cl2N3OS. Mole weight: 344.26. | |
| Protopanaxatriol | 20S-Protopanaxatriol (g-PPT), a dammarane-type tetracyclic terpene sapogenin, may be used to study its binding to and modulation of cell function via glucocortoid (GR) and oestrogen (ER) receptors. Protopanaxatriol can be used in health products. Alternative Names: 20(S)-APPT; g-PPT. Grades: >98%. CAS No. 34080-08-5. Molecular formula: C30H52O4. Mole weight: 476.73. | |
| Protopine | Protopine is an alkaloid isolated from the tubers of Corydalis yanhusuo W.T.Wang. It shows weak spasmolytic, smooth muscle stimulant activities. Uses: Bactericidal; sedative; antihypertensive. Alternative Names: 7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one; Biflorine. Grades: 98%. CAS No. 130-86-9. Molecular formula: C20H19NO5. Mole weight: 353.4. | |
| Protosappanin B | Protosappanin B is a natural compound found in the heart wood of Caesalpinia sappan L. Protosappanin B exhibits antitumor and anti-oxidant activity that can inhibit the oxidation of linoleic acid. Uses: Antitumor, anti-oxidant. Alternative Names: (-)-Protosappanin B; 6H-Dibenz[b,d]oxocin-3,7,10,11-tetrol, 7,8-dihydro-7-(hydroxymethyl)-, (7S,12aS)-. Grades: >95%. CAS No. 102036-29-3. Molecular formula: C16H16O6. Mole weight: 304.30. | |
| PRT062607 | PRT062607 is a highly specific and potent inhibitor of spleen tyrosine kinase (Syk) (IC50 = 1-2 nM). Alternative Names: PRT-062607; PRT 062607; P505-15; PRT-2607; PRT 2607; PRT2607; BIIB 057; 4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide; 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-; 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide. Grades: >98%. CAS No. 1370261-96-3. Molecular formula: C19H23N9O. Mole weight: 393.45. | |
| PRT062607 monohydrochloride | PRT062607, also known as PRT2607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. PRT062607 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL. Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with PRT062607 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations. PRT062607 may be a therapeutic agent for B-cell malignancies. A dose finding study in healthy volunteers has been completed. Alternative Names: 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, hydrochloride (1:1); PRT2607 HCl; PRT-2607 HCl; PRT 2607 HCl; RPRT062607 HCl; PRT-062607 HCl; PRT 062607 HCl; P505-15 HCl; BIIB057 HCl; BIIB 057 HCl; 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride. Grades: 98%. CAS No. 1370261-97-4. Molecular formula: C19H23N9O.HCl. Mole weight: 429.91. | |
| Przewalskin | Przewalskin is isolated from the roots of Salvia miltiorrhiza. Uses: Antitumor activity. Alternative Names: (5ξ,7β)-13-Methyl-7,17-epoxypodocarpa-8,11,13-trien-12-ol. Grades: 98%. CAS No. 119400-87-2. Molecular formula: C18H24O2. Mole weight: 272.4. | |
| PS-1145 | PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. Alternative Names: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide; PS-1145; PS 1145; PS1145. Grades: 98%. CAS No. 431898-65-6. Molecular formula: C17H11ClN4O. Mole weight: 322.75. | |
| PS 48 | PS 48 is an allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1; PDK1) binding to the PIF-binding pocket of PDK1. Alternative Names: PS-48; PS48; (2z)-5-(4-Chlorophenyl)-3-Phenylpent-2-Enoic Acid. Grades: 98%. CAS No. 1180676-32-7. Molecular formula: C17H15ClO2. Mole weight: 286.75. | |
| Pseudolaric Acid A | Pseudolaric acid A can inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels. Alternative Names: (2E,4E)-5-[(4aS)-4a-(acetyloxy)-3,7-dimethyl-1-oxo-3,4,4a,5,6,9-hexahydro-4,9a-ethanocyclohepta[c]pyran-3(1H)-yl]-2-methylpenta-2,4-dienoic acid. Grades: >98%. CAS No. 82508-32-5. Molecular formula: C22H28O6. Mole weight: 388.5. | |
| Pseudolaric acid A-O-beta-D-glucopyranoside | Pseudolaric acid A-O-beta-D-glucopyranoside can be found in the root bark of Pseudolarix amabilis. Alternative Names: Pseudolaricid A-O-β-D-glucopyranoside; Pseudolaric acid A beta-D-glucoside. Grades: >98%. CAS No. 98891-44-2. Molecular formula: C28H38O11. Mole weight: 550.6. | |
| Pseudolaric acid B | Pseudolaric acid B (PAB), which comes from the bark of Pseudolarix kaempferi Gordon, has diverse effects that are relevant to cancer therapy, including apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease. The future development of PAB as a cancer therapeutic is ongoing. Besides, PAB significantly suppressed proliferation of DU145 cells in a dose-dependent manner without obvious cytotoxicity. PAB may inhibit growth of HRPC DU145 cells and induce apoptosis through ROS generation and Bcl-2 degradation via the activation of the ubiquitin-proteasome pathway. Uses: Antifungal / antifertility. Alternative Names: PLAB; 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-; Pseudolarix acid B; Pseudolaric acid. Grades: >98%. CAS No. 82508-31-4. Molecular formula: C23H28O8. Mole weight: 432.46. | |
| Pseudolaric acid B-O-beta-D-glucopyranoside | Pseudolaric acid B-O-beta-D-glucopyranoside can be found in the root bark of Pseudolarix amabilis. Alternative Names: Pseudolaric acid B-glucopyranoside; Pseudolaric acid B beta-D-glucoside. Grades: >98%. CAS No. 98891-41-9. Molecular formula: C29H38O13. Mole weight: 594.6. | |
| Pseudolaric Acid C | Pseudolaric Acid C usually can be isolated from the root bark of Pseudolarix amabilis. Alternative Names: (3R,4R,4aS,9aR)-rel-3-[(1E,3E)-4-Carboxy-1,3-pentadienyl]-3,4,4a,5,6,9-hexahydro-4a-hydroxy-3-methyl-1-oxo-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylic acid 7-methyl ester; Deacetylpseudolaric acid B. Grades: >98%. CAS No. 82601-41-0. Molecular formula: C21H26O7. Mole weight: 390.4. | |
| Pseudolaric acid D | Pseudolaric acid D is isolated from the root bark of Pseudolarix amabilis. Alternative Names: ent-18-hydroxy-15-kauren-17-oic acid; (5β,8α,9β,10α,13α)-19-Hydroxykaur-15-en-17-oic acid. Grades: > 95%. CAS No. 115028-67-6. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| Pseudopalmatine | Pseudopalmatine isolated from the herbs of Tinospora sinensis. Uses: Antiplasmodial activity; anti-ache ic50 values. Alternative Names: 5,6-Dihydro-2,3,10,11-tetramethoxydibenzo[a,g]quinolizinium;5,6-Dihydro-8-desmethylcoralyne; 2,3,10,11-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium. Grades: > 95%. CAS No. 19716-66-6. Molecular formula: C21H22NO4. Mole weight: 352.4. | |
| PSI 7411 | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Alternative Names: 5'-Uridylic acid, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-; (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic acid; PSI-7411; PSI7411; 2'-Fluoro-2'-methyl(up)-uridine-5'-monophosphate; 2'-F-2'-Me(up)-UMP; Sofosbuvir Impurity 34 (GS-606965). Grades: ≥95%. CAS No. 1015073-43-4. Molecular formula: C10H14FN2O8P. Mole weight: 340.20. | |
| Psidial A | Psidial A, a natural triterpenoid isolated from the leaves of Psidium guajava L, exhibits the activity to enzyme PTP1B and also reduces tumor growth and stimulates uterus proliferation. Uses: Anti-tumour. Alternative Names: (1S,4S,7R,11R,12R)-14,16-dihydroxy-1,5,5-trimethyl-8-methylidene-12-phenyl-19-oxatetracyclo[9.8.0.04,7.013,18]nonadeca-13,15,17-triene-15,17-dicarbaldehyde; 7,9-dihydroxy-2,2,4a- trimethyl-13-methylene-10-phenyl-1,2,2a,3,4,4a,10, 10a,11,12,13,13a-dodecahydrocyclobuta[6,7] cyclonona[b]chromene-6,8-dicarbaldehyde. Grades: >98%. CAS No. 1207181-35-8. Molecular formula: C30H34O5. Mole weight: 474.6. | |
| Psoralidin | Psoralidin is a furanocoumarin natural product used in Chinese medicine. Psoralidin, a PTP1B inhibitor, has been shown to have anticancer activity with a variety of mechanisms proposed. Psoralidin induces ROS generation in androgen-independent prostate cancer cells, leading to inhibition of cell proliferation. Psoralidin has been found to downregulate NOTCH1 signaling, causing growth arrest in both breast cancer stem cells and breast cancer cells. Uses: Anticancer and chemopreventive properties. Alternative Names: 3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one; 3,9-Dihydroxy-2-prenylcoumestan. Grades: >98%. CAS No. 18642-23-4. Molecular formula: C20H16O5. Mole weight: 336.34. | |
| PTC-209 | PTC-209 is a potent BMI-1 inhibitor with potential anticancer activity. PTC-209 inhibits endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. Alternative Names: PTC-209; PTC 209; PTC209. CAS No. 315704-66-6. Molecular formula: C17H13Br2N5OS. Mole weight: 495.19. | |
| Pterisolic acid A | Pterisolic acid A is a natural diterpenoid found in the herbs of Pteris semipinnata. Alternative Names: (4alpha,6alpha)-6,13-Dihydroxy-15-oxokaura-9(11),16-dien-18-oic acid. Grades: >98%. CAS No. 1401419-85-9. Molecular formula: C20H26O5. Mole weight: 346.4. | |
| Pterisolic acid C | Pterisolic acid C is a natural diterpenoid found in the herbs of Pteris semipinnata. Alternative Names: (4alpha)-13-Hydroxy-15-oxokaura-9(11),16-dien-18-oic acid. Grades: >98%. CAS No. 1401419-87-1. Molecular formula: C20H26O4. Mole weight: 330.4. | |
| Pterisolic acid D | Pterisolic acid D is a natural diterpenoid found in the herbs of Pteris semipinnata. Alternative Names: (4alpha,6beta)-6,9-Dihydroxy-15-oxokauran-18-oic acid. Grades: >97%. CAS No. 1401419-88-2. Molecular formula: C20H30O5. Mole weight: 350.5. | |
| Pterisolic acid E | Pterisolic acid E is extracted from the herbs of Pteris semipinnata. Alternative Names: (4alpha,12beta)-9,12-Dihydroxy-15-oxokauran-18-oic acid. Grades: 95.0%. CAS No. 1401419-89-3. Molecular formula: C20H30O5. Mole weight: 350.50. | |
| Pterisolic acid F | Pterisolic acid F is a natural diterpenoid found in the herbs of Pteris semipinnata. Alternative Names: (4alpha,16alpha)-9,16,17-Trihydroxy-15-oxokauran-18-oic acid. Grades: >95%. CAS No. 1401419-90-6. Molecular formula: C20H30O6. Mole weight: 366.5. | |
| Pterokaurene L3 | Pterokaurene L3 is a natural diterpenoid found in the herbs of Wedelia trilobata. Alternative Names: 9beta-Hydroxy-ent-kaur-16-en-oic acid. Grades: >95%. CAS No. 77658-38-9. Molecular formula: C20H30O3. Mole weight: 318.46. | |
| Pteroside D | Pteroside D is a natural sesquiterpenoid isolated from the herbs of Pteris multifida. Alternative Names: (S)-6-[2-(β-D-Glucopyranosyloxy)ethyl]-2,3-dihydro-3-hydroxy-2,2,5,7-tetramethyl-1H-inden-1-one. Grades: >98%. CAS No. 35943-38-5. Molecular formula: C21H30O8. Mole weight: 410.5. | |
| Pteryxin | Pteryxin, a natural coumarin compound found in the herbs of Peucedanum harry-smithii var. subglabrum, shows muscle-relaxant property. Pteryxin exhibits hepatoprotective and nitric oxide production inhibitory activity. Uses: Muscle-relaxant. Alternative Names: (Z)-2-Methyl-2-butenoic acid[(9R)-9-acetoxy-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10α-yl] ester. Grades: >98%. CAS No. 13161-75-6. Molecular formula: C21H22O7. Mole weight: 386.4. | |
| Pulchinenoside B | Pulchinenoside B is an extract derived from a distinct plant, acting as a remarkable natural compound widely recognized in the field of diverse ailments research. Alternative Names: Anemoside B. Grades: >98%. CAS No. 135247-95-9. Molecular formula: C53H86O22. Mole weight: 1221.4. | |
| Pulsatilla saponin D | Pulsatilla saponin D, isolated from the root of Pulsatilla koreana, has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer. It effectively inhibited the growth of gastric cancer cells. It also strongly suppressed the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) and colon cancer cells and induced their apoptosis. Besides, it showed anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF. Alternative Names: Hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside; Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-; (3β,4α)-3-[[O-6-Deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid; 3β-[(O-β-D-Glucopyranosyl-(1→4). Grades: >98%. CAS No. 68027-15-6. Molecular formula: C47H76O17. Mole weight: 913.10. | |
| Pungiolide A | Pungiolide A is a sesquiterpene lactone isolated from the aerial parts of Xanthium sibiricum. Alternative Names: Spiro[2H-cyclohepta[b]furan-3(3aH),6'(2'H)-furo[2',3':5,6]cyclohepta[1,2-b]pyran]-2,2'-dione, 7'-acetyl-3',3'a,4,4',4'a,7,8,8a,8'a,9',10',10'a-dodecahydro-8'a-hydroxy-7,9'-dimethyl-3'-methylene-6-[(1E)-3-oxo-1-butenyl]-, (3R,3aR,3'aR,4'aR,7R,8aS,8'aR,9'S,10'aR)-; Spiro[2H-cyclohepta[b]furan-3(3aH),6'(2'H)-furo[2',3':5,6]cyclohepta[1,2-b]pyran]-2,2'-dione, 7'-acetyl-3',3'a,4,4',4'a,7,8,8a,8'a,9',10',10'a-dodecahydro-8'a-hydroxy-7,9'-dimethyl-3'-methylene-6-(3-oxo-1-butenyl)-, [3'aR-[3'aα,4'aα,6'β[3aR*,6(E),7R*,8aS*],8'aβ,9'β,10'aα]]-; (3R,3aR,3a'R,4a'R,7R,8aS,8a'R,9'S,10a'R)-7'-acetyl-8a'-hydroxy-7,9'-dimethyl-3'-methylene-6-((E)-3-oxobut-1-en-1-yl)-3a,3',3a',4',4a',7,8,8a,8a',9',10',10a'-dodecahydro-2H,2'H,4H-spiro[cyclohepta[b]furan-3,6'-furo[2',3':5,6]cyclohepta[1,2-b]pyran]-2,2'-dione. Grades: ≥95%. CAS No. 130395-54-9. Molecular formula: C29H34O8. Mole weight: 510.58. | |
| Punicalin | Punicalin is an ellagitannin. It is a highly active carbonic anhydrase inhibitor with strong antioxidative activity. Punicalin have anti-hepatotoxic activity but the larger dose of punicalin induced liver damage. Alternative Names: D-Glucose, cyclic 4,6-[(2S,2'S)-2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]]; 2,20,1,23-(Epoxy[2]propene[1,2]diyl[3]ylidene)-11H,15H-tribenzo[g,i,q][1,5,12]trioxacyclononadecin, D-glucose deriv.; [1]Benzopyrano[5,4,3-cde][1]benzopyran, D-glucose deriv. Grades: 98% (mixture of anomers). CAS No. 65995-64-4. Molecular formula: C34H22O22. Mole weight: 782.53. | |
| Purine nucleoside phosphorylase (EaPNP) | Purine nucleoside phosphorylase (EaPNP). | |
| Purvalanol A | Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated. These findings demonstrate that the coordinated inhibition of cell cycle progression and tyrosine kinase signaling by the multi-selective purvalanol A is effective in suppressing cancer progression associated with c-Src up-regulation. Alternative Names: Purv; NG60; NG-60; NG 60; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine. Grades: 98%. CAS No. 212844-53-6. Molecular formula: C19H25ClN6O. Mole weight: 388.89. | |
| Purvalanol B | Purvalanol B is a potent, selective, reversible and ATP-competitive inhibitor of CDK with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2 / cyclin B, CDK2 / cyclin A, CDK2 / cyclin E, CDK4 / cyclin D1 and CDK5-p35, respectively. Alternative Names: NG 95; NG95; NG-95. Grades: >98%. CAS No. 212844-54-7. Molecular formula: C20H25ClN6O3. Mole weight: 432.91. | |
| PXS 4728A | PXS 4728A is a VAP-1 (aka SSAO/AOC3) inhibitor with IC50 values 5 nM in the clinical trial for the treatment of non-alcoholic steatohepatitis (NASH). Studies show that it inhibits neutrophil rolling and tethering in mouse cremaster model, and alleviates respiratory inflammation in multiple models. Uses: Treatment of non-alcoholic steatohepatitis (nash). Alternative Names: BI-1467335 HCl; (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride. Grades: 98%. CAS No. 1478364-68-9. Molecular formula: C15H21FN2O2.HCl. Mole weight: 316.8. | |
| Pyridine-2,6-dicarboximidamide dihydrochloride | Pyridine-2,6-dicarboximidamide dihydrochloride. CAS No. 1394382-56-9. | |
| Pyrimidifen | Pyrimidifen is a pyrimidinamine insecticide. Alternative Names: Miteclean; 5-chloro-N-(2-(4-(2-ethoxyethyl)-2,3-dimethylphenoxy)ethyl)-6-ethyl-4-pyrimidinamine. Grades: ≥95%. CAS No. 105779-78-0. Molecular formula: C20H28ClN3O2. Mole weight: 377.91. | |
| Pyromellitic diimide | Pyromellitic diimide is a high-temperature, thermally stable, and photostable intramolecular hydrogen acceptor that has been used in the synthesis of a variety of organic compounds. Alternative Names: Pyromellitimide; Pyromellitic acid diimide; Benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2H,6H)-tetrone. Grades: 95%. CAS No. 2550-73-4. Molecular formula: C10H4N2O4. Mole weight: 216.15. | |
| Pyrotinib | Pyrotinib, also known as SHR-1258, is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. Alternative Names: (R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide; Pyrotinib; SHR-1258; SHR1258; SHR 1258; Pyrotinib maleate. CAS No. 1269662-73-8. Molecular formula: C32H31ClN6O3. Mole weight: 582.21. | |
| Pyrrole-2,3,5-Tricarboxylic Acid | Pyrrole-2,3,5-tricarboxylic Acid is the most characteristic degrdadation product of melanins. It is an important biomarker for Melatonin metabolism. Alternative Names: 1H-Pyrrole-2,3,5-tricarboxylic Acid. Grades: > 95%. CAS No. 945-32-4. Molecular formula: C7H5NO6. Mole weight: 199.12. | |
| Pyrvinium pamoate | Pyrvinium pamoate, a nonabsorbed anthelmintic drug, is a potent androgen receptor inhibitor and a selective WNT pathway inhibitor. Pyrvinium pamoate is a potential drug candidate for the treatment of cryptosporidiosis in both immunocompetent and immunocompromised individuals. Uses: Anthelmintics. Alternative Names: VPC-14337; VPC 14337; VPC14337; 6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)-quinolinium; Alnoxin; Altolat; NSC 223622; PP; Pamovin; Vermitibier; Vipyrvinium embonate. CAS No. 3546-41-6. Molecular formula: C26H28N3.1/2C23H14O6. Mole weight: 575.7. | |
| Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1?4)-β-D-oleandropyranosyl-(1?4)-β-D-cymaropyranosyl-(1?4)-β-D-cymaropyranoside | Derived from the root of Cynanchum otophyllum Schneid, Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-oleandropyranosyl- (1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside stands as an intriguing natural compound with potential anti-tumor activity. This promising molecule is traditionally used in Chinese medicine and may be particularly effective in the treatment of hepatocellular carcinoma, a lethal form of cancer that is notoriously resistant to conventional therapies. Its active constituents exhibit a remarkably complex structure that is worthy of further study, as the implications for cancer treatment may be significant. Alternative Names: AKOS040762539; 1808159-02-5; Qingyangshengenin 3-O-??-L-cymaropyranosyl-(1??4)-??-D-oleandropyranosyl-(1??4)-??-D-cymaropyranosyl-(1??4)-??-D-cymaropyranoside. Grades: 92.0%. CAS No. 1808159-02-5. Molecular formula: C56H84O20. Mole weight: 1077.27. | |
| Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1?4)-β-D-digitoxopyranoside | Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside is an intriguing natural compound derived from traditional Chinese medicine, notable for its exceptional antiviral and anti-inflammatory capabilities. Its efficacy in studying viral infections, inflammation-related disorders and sundry ailments has captivated the attention of scientific minds. Grades: 97.5%. CAS No. 1186628-87-4. Molecular formula: C41H58O14. Mole weight: 774.903. | |
| Qingyangshengenin 3-O-β-D-oleandropyranosyl-(1?4)-β-D-cymaropyranosyl-(1?4)-β-D-digitoxopyranoside | Qingyangshengenin 3-O-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside, a naturally occurring compound, is a promising medicinal agent that demonstrates profound therapeutic potential in treating cancer and cardiovascular diseases. Its potent anti-tumor activity and the ability to promote apoptosis in cancerous tissues make it an effective treatment for cancer. Furthermore, it possesses anti-inflammatory properties and can be employed as a therapeutic agent for heart failure by restoring cardiac function and reducing mortality rates. The multifaceted properties of this compound underscore its potential as a valuable asset for healthcare innovation. Grades: 98.0%. CAS No. 1186628-88-5. Molecular formula: C48H70O17. Mole weight: 919.074. | |
| QS 7 | QS 7. CAS No. 208933-54-4. | |
| Quarfloxin | Quarfloxin, also known as Quarfloxacin and CX-3543, is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells. Disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis. Alternative Names: 3H-Benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-; 3H-Benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-; 5-Fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide; CX 3543; Itarnafloxin; Quarfloxacin. Grades: >98%. CAS No. 865311-47-3. Molecular formula: C35H33FN6O3. Mole weight: 604.69. | |
| Quercetagitrin | Quercetagitrin is a flavonoid isolated from Tagetes erecta L with anti-inflammatory activity. Alternative Names: Quercetagetin-7-O-glucoside. Grades: 98%. CAS No. 548-75-4. Molecular formula: C21H20O13. Mole weight: 480.4. | |
| Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1-2)-L-rhamnoside | Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1-2)-L-rhamnoside is a flavonoid compound isolated from Ginkgo biloba L. Grades: > 98%. Molecular formula: C36H36O18. Mole weight: 756.66. | |
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