BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Rediocide C | Rediocide C is extracted from the herbs of Trigonostemon reidioides (Kurz) Craib. It has antimycobacterial activity with the MIC value of 3.84 uM. It also shows potent activity against D. pteronyssinus with LC50 value of 5.59 microg/cm2. Alternative Names: 4,24-methanolo-2,20,23-(epoxymetheno)-7,10-methanolocyclopenta[b]-1,3-dioxino[4,5-h]oxireno[e]oxacycloheneicosin-16(4H)-one, 11-(benzoyloxy)-4a,5,6,7,8,9,10,11,17a,18,19,20,20a,21,21a,22a,23,23a-octadecahydro-4a,5,20a,21-tetrahydroxy-21a-(hydroxymethyl)-5,18,26,27-tetramethyl-2-phenyl-, (2S,4S,4aS,5R,7R. Grades: >98%. CAS No. 677277-98-4. Molecular formula: C46H54O13. Mole weight: 814.92. |  |
| Regadenoson | Regadenoson, as a coronary vasodilator it is a selective A2A adenosine receptor agonist in myocardial imaging. Uses: A selective a2a adenosine receptor agonist in myocardial imaging. Alternative Names: 1-[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]-N-methylpyrazole-4-carboxamide CVT 3146 CVT-3146 CVT3146 Lexiscan regadenoson. Grades: >99%. CAS No. 313348-27-5. Molecular formula: C15H18N8O5. Mole weight: 390.35. | |
| Regorafenib Hydrochloride | Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1. Alternative Names: BAY73-4506 hydrochloride. Grades: >98%. CAS No. 835621-07-3. Molecular formula: C21H16Cl2F4N4O3. Mole weight: 519.28. | |
| Regorafenib Impurity 6 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Alternative Names: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)-3-fluorophenoxy)-; 4-(4-((4-Chloro-3-(trifluoromethyl)phenyl)carbamoylamino)-3-fluoro-phenoxy)pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. Grades: > 95%. CAS No. 1187945-05-6. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. | |
| Regorafenib monohydrate | Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2. Alternative Names: BAY 73-4506. Grades: >98%. CAS No. 1019206-88-2. Molecular formula: C21H17ClF4N4O4. Mole weight: 500.83. | |
| Regorafenib N-Oxide (M2 Metabolite) | A metabolite of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Alternative Names: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-Oxide. Grades: > 95%. CAS No. 835621-11-9. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. | |
| Rehmannic acid | Rehmannic acid is a natural triterpenoid found in the herbs of Lantana camara. Rehmannic acid has inhibit succinoxidase activity. Alternative Names: 22β-[[(Z)-2-Methyl-1-oxo-2-butenyl]oxy]-3-oxoolean-12-en-28-oic acid. Grades: >95%. CAS No. 467-81-2. Molecular formula: C35H52O5. Mole weight: 552.8. | |
| Reichardt's dye | Reichardt's dye. CAS No. 10081-39-7. | |
| Relacorilant | Relacorilant is an antagonist of glucocorticoid receptor which is under development for the treatment of Cushing's syndrome. CAS No. 1496510-51-0. Molecular formula: C27H22F4N6O3S. Mole weight: 586.6. | |
| Remodelin hydrobromide | Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Alternative Names: Remodelin HBr; Remodelin Hydrobromide. Grades: >98%. CAS No. 1622921-15-6. Molecular formula: C15H15BrN4S. Mole weight: 363.28. | |
| Renzapride | Renzapride is a full 5-HT4 agonist and partial 5-HT3 antagonist. Renzapride has been used for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Uses: Serotonin antagonists. Alternative Names: Renzapridum; Benzamide, 4-amino-N-(1R,4S,5R)-1-azabicyclo[3.3.1]non-4-yl-5-chloro-2-methoxy-, rel-. Grades: 95%. CAS No. 112727-80-7. Molecular formula: C16H22ClN3O2. Mole weight: 323.82. | |
| Renzapride hydrochloride | Renzapride is a gastroprokinetic agent and antiemetic which acts as a 5-HT4 full agonist and 5-HT3 antagonist. Alternative Names: ATL-1251; Renzapride HCl; 4-Amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide hydrochloride. CAS No. 109872-41-5. Molecular formula: C16H23Cl2N3O2. Mole weight: 360.279. | |
| Repaglinide | Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used for the treatment of type II diabetes. Alternative Names: AG-EE 388 ZW; AG-EE388 ZW; AG-EE-388 ZW; AG-EE 623 ZW; AG-EE623 ZW, AG-EE-623 ZW; Prandin; GlucoNorm; Surepost; NovoNorm. Grades: >98%. CAS No. 135062-02-1. Molecular formula: C27H36N2O4. Mole weight: 452.59. | |
| Repaglinide Impurity E | An impurity of Repaglinide, an antidiabetic drug. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus. Uses: Hypoglycemic agents. Alternative Names: 2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic Acid; (-)-Repaglinide; AG-EE 624ZW; Repaglinide EP Impurity E; R-Repaglinide; (R)-(-)-Repaglinide. Grades: > 95%. CAS No. 147852-26-4. Molecular formula: C27H36N2O4. Mole weight: 452.6. | |
| (R)-Equol | Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. Alternative Names: (+)-Equol; Isoequol; (3R)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol. Grades: ≥98%. CAS No. 221054-79-1. Molecular formula: C15H14O3. Mole weight: 242.27. | |
| Resorufin | Resazurin is a blue dye, itself weakly fluorescent until it is irreversibly reduced to the pink colored and highly red fluorescent resorufin. It can be used as an oxidation-reduction indicator in cell viability assays for both aerobic and anaerobic respiration. Alternative Names: 7-Hydroxy-3H-phenoxazin-3-one; Resorufine. Grades: > 95%. CAS No. 635-78-9. Molecular formula: C12H7NO3. Mole weight: 213.19. | |
| Retatrutide | Retatrutide is a triple glucagon, GIP, and GLP-1 receptor agonist. Retatrutide showed glucose control and weight loss in patients with type 2 diabetes mellitus (T2DM). Uses: retatrutide is a new peptide medication that has showed great promise in drug discovery because of its distinct mode of action and its medicinal uses. the high specificity and affinity of retitrutide for its target receptors is one of the main characteristics that make it an attractive option for drug discovery. this peptide is engineered to bind specifically to specific cell surface receptors. Alternative Names: LY3437943; LY 3437943; LY-3437943. Grades: 98% by HPLC. CAS No. 2381089-83-2. Molecular formula: C221H342N46O68. Mole weight: 4731.33.… | |
| (R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. CAS No. 149709-59-1. Molecular formula: C25H31NO4. Mole weight: 409.526. | |
| (R)-Etodolac | (R)-Etodolac. CAS No. 87226-41-3. | |
| (R)-(-)-Etodolac-[d3] | (R)-(-)-Etodolac-[d3] is the labelled R-enantiomer of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Alternative Names: (R)-(-)-Etodolac D3; (1R)-1,8-(Diethyl-d3)-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic Acid; (-)-(R)-Etodolac-d3; (-)-Etodolac-d3; (-)-Etodolic Acid-d3; R-Etodolac-d3. Grades: >95%. CAS No. 1246815-33-7. Molecular formula: C17H18D3NO3. Mole weight: 290.38. | |
| (R)-Ezetimibe | A stereoisomer of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L9) protein, a cholesterol transporter located in the apical membrane of enterocytes. Alternative Names: R,R,S-Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3'R)-Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; (3'R)-SCH 58235; 3'R,3R,4S-Isomer of Ezetimibe; Ezetimibe (3R,4S,3'R)-Isomer; Ezetimibe (3R)-Isomer; (3R,4S,3'R)-Ezetimibe. Grades: >95%. CAS No. 163380-16-3. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| RG108 | RG108 is a DNA methyltransferase inhibitor with IC50 value of 115 nM. RG108 can enhance reprogramming of somatic cells to induced pluripotent stem (iPS) cells. Alternative Names: N-Phthalyl-L-tryptophan; RG-108; (2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid. Grades: >98%. CAS No. 48208-26-0. Molecular formula: C19H14N2O4. Mole weight: 334.33. | |
| RG7800 | RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 shows excellent pharmacokinetic and in vivo efficacy and has a favorable safety profile. RG7800 can correct alternative splicing of the human. Phase I/II clinical trials for the treatment of Spinal muscular atrophyis on-going. Uses: Spinal muscular atrophy. Alternative Names: RG7800; RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247. 2-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methylpiperidin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one. Grades: 98%. CAS No. 1449598-06-4. Molecular formula: C24H28N6O. Mole weight: 416.52. | |
| RGB-286638 Free base | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine / threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Alternative Names: 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea; RGB 286638; RGB286638. Grades: >98%. CAS No. 784210-88-4. Molecular formula: C29H35N7O4. Mole weight: 545.63. | |
| RGW 611 | RGW 611 is an impurity of Nimorazole, which is an anti-infective agent against anaerobic bacteria and protozoa. Nimorazole is being researched for the treatment of head and neck cancer. Alternative Names: 4-(2-(4-nitro-1H-imidazol-1-yl)ethyl)morpholine. CAS No. 6497-78-5. Molecular formula: C9H14N4O3. Mole weight: 226.236. | |
| Rhamnocitrin | Rhamnocitrin is a natural flavonoid found in the rhizoma of Alpinia officinarum Hance. Rhamnocitrin shows anti-inflammatory activity and can prevent atherogenesis through suppressing macrophage uptake of oxLDL. Uses: Anti-inflammatory. Alternative Names: 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-;7-Methylkaempferol;Kaempferol 7-methyl ether. Grades: >97%. CAS No. 569-92-6. Molecular formula: C16H12O6. Mole weight: 300.27. | |
| Rhein | Rhein is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is the best raw material for formulating health products. It can reduce fat and lose weight, lax detoxification, clean the internal environment, prevent gastric cancer, and delay aging. Uses: Antitumor agent. Alternative Names: Monorhein; Rhubarb Yellow; Cassic acid; 4,5-Dihydroxyanthraquinone-2-carboxylic acid; 1,8-Dihydroxy-3-carboxyanthraquinone; Chrysazin-3-carboxylic acid. Grades: > 98 %. CAS No. 478-43-3. Molecular formula: C15H8O6. Mole weight: 284.22. | |
| Rhodamine 110 chloride | Rhodamine 110 is a green fluorescent cationic dye that can be used in ezyme assays when incorporated with a hydrolytic substrate. Rhodamine 110 has also been used in a fluorescence quenching method for determining trace nitrite and as a probe for cytochrome P450 activity. Alternative Names: Rhodamine 110; Rhodamine 560; Rhodamine N; 3,6-diamino-9-(2-carboxyphenyl)-xanthylium, monochloride; 2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid hydrochloride. Grades: 95%. CAS No. 13558-31-1. Molecular formula: C20H15ClN2O3. Mole weight: 366.80. | |
| Rhodamine-123 | Rhodamine-123 is a cell-permeant green-fluorescent probe that is taken up by active mitochondria. Alternative Names: Rh 123. CAS No. 62669-70-9. Molecular formula: C21H17ClN2O3. Mole weight: 380.82. | |
| Ribavirin Impurity A | An impurity of Ribavirin. Ribavirin is an anti-viral medication used to treat RSV infection, hepatitis C, and viral hemorrhagic fever. Alternative Names: Ribavirin carboxylic acid; 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid; USP Ribavirin Impurity A; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxylic acid. Grades: ≥95%. CAS No. 39925-19-4. Molecular formula: C8H11N3O6. Mole weight: 245.19. | |
| Riboflavin, 2',3',4',5'-tetraacetate | An impurity of Riboflavin. Riboflavin is a vitamin found in food and used as a dietary supplement. As a supplement it is used to prevent and treat riboflavin deficiency and prevent migraines. Alternative Names: Riboflavin tetraacetate. CAS No. 752-13-6. Molecular formula: C25H28N4O10. Mole weight: 544.5. | |
| (R)-Ibuprofen-[d3] | (R)-Ibuprofen-[d3] is the labelled analogue of (R)-Ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID). Alternative Names: (R)-Ibuprofen D3; (R)-(-)-Ibuprofen-d3; (αR)-α-(Methyl-d3)-4-(2-methylpropyl)benzeneacetic Acid; (-)-Ibuprofen-d3; (R)-2-(4-Isobutylphenyl)propanoic Acid-d3; (R)-Ibuprofen-d3; R-(-)-p-Isobutylhydratropic Acid-d3. Grades: ≥98% by HPLC; ≥99% atom D. CAS No. 121702-86-1. Molecular formula: C13H15D3O2. Mole weight: 209.31. | |
| Rifampicin EP Impurity B | Rifampicin EP Impurity B. CAS No. 125833-03-6. | |
| Rigosertib sodium | Rigosertib (ON-01910 sodium salt), a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine / threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Alternative Names: Glycine, N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, monosodium salt (9CI); (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone sodium salt; Novonex; ON 01910 sodium; ON01910 sodium; ON-01910 sodium; ON 01910 sodium salt; Rigosertib sodium. CAS No. 1225497-78-8. Molecular formula: C21H24NNaO8S. Mole weight: 473.47. | |
| Rimonabant Hydrochloride | Rimonabant Hydrochloride, used as a tool to investigate CB receptor properties, it is a selective antagonist of cannabinoid CB1 receptor (Ki = 1.98 nM) and inverses adenylyl cyclase inhibition (IC50 = 48 nM). Uses: A brain cannabinoid receptor (cb1) antagonist. antiobesity agent. Alternative Names: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide; Rimonabant free base, SR141716; SR 141716; SR-141716; A 281; A-281; A281; Rimonabant, Acomplia, Zimulti. Grades: 98%. CAS No. 158681-13-1. Molecular formula: C22H21Cl3N4O.HCl. Mole weight: 500.25. | |
| Rimsulfuron-[d6] | A deuterated labelled Rimsulfuron. Rimsulfuron is used as a pesticide. Alternative Names: N-((4,6-bis(methoxy-d3)pyrimidin-2-yl)carbamoyl)-3-(ethylsulfonyl)pyridine-2-sulfonamide. Grades: > 95%. Molecular formula: C14H11D6N5O7S2. Mole weight: 437.49. | |
| Rineterkib | Rineterkib is a RAF and ERK1/2 inhibitor developed for the treatment of proliferative diseases characterized by activating mutations in the MAPK pathway. Alternative Names: ERK-IN-1; LTT-462. CAS No. 1715025-32-3. Molecular formula: C26H27BrF3N5O2. Mole weight: 578.4. | |
| Ripretinib | Ripretinib is an orally bioavailable KIT / PDGFR inhibitor with antitumor effect. It binds to both wild-type and mutant forms of KIT and PDGFRa at their switch pocket binding site. Alternative Names: DCC-2618; 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea. CAS No. 1442472-39-0. Molecular formula: C24H21BrFN5O2. Mole weight: 510.36. | |
| Risedronate acid | Risedronate acid is a bisphosphonate medication primarily used to treat and prevent osteoporosis in postmenopausal women and men, as well as to manage Paget's disease of bone and glucocorticoid-induced osteoporosis. It works by inhibiting bone resorption, thereby increasing bone density and reducing the risk of fractures. Alternative Names: P,P'-[1-Hydroxy-2-(3-pyridinyl)ethylidene]bis[phosphonic acid]; 1-Hydroxy-2-(3-pyridinyl)ethane-1,1-diphosphonic acid; 1-Hydroxy-2-(3-pyridinyl)ethylidene bisphosphonic acid; 1-Hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonic acid; 1-Hydroxy-2-pyrid-3-ylethylidene-1,1-bisphosphonic acid; [1-Hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid; Benet; BPH 2; NE 58019; Risedronate. Grades: >98%. CAS No. 105462-24-6. Molecular formula: C7H11NO7P2. Mole weight: 283.11. | |
| Rivaroxaban | Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. Alternative Names: BAY59-7939; BAY 59-7939; BAY-59-7939; Rivaroxaban; trade name: Xarelto. Grades: >99%. CAS No. 366789-02-8. Molecular formula: C19H18ClN3O5S. Mole weight: 435.879. | |
| Rivastigmine-[d6] oxalate | Rivastigmine-[d6] oxalate is a labelled impurity of Rivastigmine. Rivastigmine is a parasympathomimetic or cholinergic drug for the treatment of dementia. Alternative Names: Rivastigmine-d6 oxalate; Rivastigmine oxalate-d6; N-Ethyl-N-methylcarbamic Acid 3-[1-(Dimethylamino-d6) ethyl]phenyl Ester; Ethylmethylcarbamic Acid 3-[1-(Dimethylamino-d6)ethyl]phenyl Ester. Molecular formula: C16H18D6N2O6. Mole weight: 346.41. | |
| Rivastigmine Hydrogen Tartrate EP Impurity F | Rivastigmine Hydrogen Tartrate EP Impurity F. CAS No. 889443-69-0. | |
| Rivastigmine USP Related Compound B | Rivastigmine USP Related Compound B. CAS No. 25081-93-0. | |
| Rivastigmine USP Related Compound F | An impurity of Rivastigmine, a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Alternative Names: 3-Vinylphenyl ethyl(methyl)carbamate; 3-Ethenylphenyl ethyl(methyl)carbamate; N-Ethyl-N-methyl-3-vinylphenyl Carbamate. Grades: > 95%. CAS No. 1346602-84-3. Molecular formula: C12H15NO2. Mole weight: 205.26. | |
| Rivulobirin E | Rivulobirin E is a natural coumarin isolated from the roots of Heracleum candicans. Alternative Names: 9-{[(2R)-2-Hydroxy-3-({(2R)-3-hydroxy-3-methyl-1-[(7-oxo-7H-furo[ 3,2-g]chromen-9-yl)oxy]-2-butanyl}oxy)-3-methylbutyl]oxy}-7H-furo [3,2-g]chromen-7-one. Grades: >95%. CAS No. 237407-59-9. Molecular formula: C32H30O11. Mole weight: 590.6. | |
| Rizatriptan Impurity C | An impruity of Rizatriptan. Rizatriptan is a serotonin 5-HT1 receptor agonist. It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. CAS No. 208941-96-2. Molecular formula: C15H19N5. Mole weight: 269.35. | |
| (R)-(-)-JQ1 | (R)-(-)-JQ1 is the R-isomer and an inactive control of JQ1, a BET bromodomain inhibitor. Alternative Names: (-)-JQ1; (-)-JQ 1; (-)-JQ-1; (R)-JQ1; (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate. Grades: >95%. CAS No. 1268524-71-5. Molecular formula: C23H25ClN4O2S. Mole weight: 456.989. | |
| RKI-1313 | RKI-1313 is a negative control of RKI-1447, which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activity. Alternative Names: RKI-1313; RKI 1313; RKI1313. 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. CAS No. 1342276-76-9. Molecular formula: C17H16N4O2S. Mole weight: 340.401. | |
| RKI-1447 | RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition. Alternative Names: RKI 1447; 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. Grades: >98%. CAS No. 1342278-01-6. Molecular formula: C16H14N4O2S. Mole weight: 326.374. | |
| (R)-Linezolid | (R)-Linezolid is an enatiomeric impurity of Linezolid, an antibiotic used for the treatment of infections caused by Gram-positive bacteria. Alternative Names: N-{[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl}acetamide; Linezolid R-Isomer; N-[[(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide; Acetamide, N-[[(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-; Linezolid R-isomer [USP-RS]; Linezolid Impurity R-isomer. Grades: ≥95%. CAS No. 872992-20-6. Molecular formula: C16H20FN3O4. Mole weight: 337.35. | |
| (R)-Linezolid-[d3] | (R)-Linezolid-[d3] is the labelled analogue of (R)-Linezolid, which is an enatiomeric impurity of Linezolid. Alternative Names: (R)-Linezolid-d3; N-[[(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide-d3. Grades: >95%. CAS No. 1795786-02-5. Molecular formula: C16H17D3FN3O4. Mole weight: 340.36. | |
| RMC-4550 | RMC-4550 is a potent and selective SHP-2 inhibitor with IC50 value of 1.55 nM. It inhibits RAS / MAPK signaling in cancer cell lines with Class 3 BRAF mutations. Alternative Names: RMC 4550; RMC4550. CAS No. 2172651-73-7. Molecular formula: C21H26Cl2N4O2. Mole weight: 437.36. | |
| (R)-Metoprolol hydrochloride | (R)-Metoprolol is the (R)-Enantiomer of Metoprolol, a β1 receptor blocker medication. Alternative Names: (2R)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hydrochloride; (+)-Metoprolol hydrochloride; (R)-(+)-Metoprolol hydrochloride. Grades: > 95%. Molecular formula: C15H25NO3.HCl. Mole weight: 303.83. | |
| (R)-N-(2-acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)-acetamide-[13C] | Intermediate in the preparation of labelled Amrubicin. Alternative Names: (R)-N-(2-acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)-acetamide-13C; N-[(2R)-2-Acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl]-acetamide-13C. CAS No. 1391067-98-3. Molecular formula: C15[13C]H21NO4. Mole weight: 292.33. | |
| (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine | (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine, a vital compound, serves as an essential precursor in the pharmaceutical synthesis used to treat different maladies. This compound has demonstrated the property of improving the functioning of GABAergic neurotransmission, which makes it a promising therapeutic agent for combating anxiety and depression. Its potential in treating various mood disorders is a subject of ongoing scientific inquiry. Alternative Names: N-(3,5-Dinitrobenzoyl)phenylglycine; DNBPG. Grades: >98.0%(LC)(T). CAS No. 74927-72-3. Molecular formula: C15H11N3O7. Mole weight: 345.26. | |
| (R)-N-Desacryloyl N-3-Propionyl Ibrutinib | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Alternative Names: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one. Grades: ≥95%. CAS No. 1288338-96-4. Molecular formula: C25H25ClN6O2. Mole weight: 476.96. | |
| (R)-(-)-Nirvanol | (R)-(-)-Nirvanol is a Mephentoin metabolite with anticonvulsant and hypnotic properties. Alternative Names: (R)-5-Ethyl-5-phenylimidazolidine-2,4-dione; R-(-)-N-Desmethyl Mephenytoin; (-)-5-Ethyl-5-phenylhydantoin. Grades: 95%. CAS No. 65567-32-0. Molecular formula: C11H12N2O2. Mole weight: 204.23. | |
| RO1138452 | RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Alternative Names: RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine. CAS No. 221529-58-4. Molecular formula: C19H23N3O. Mole weight: 309.413. | |
| RO27-3225 TFA | RO27-3225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Alternative Names: RO273225 TFA; RO 273225 TFA; Butir-His-D-Phe-Arg-Trp-Sar-NH2. Molecular formula: C41H53F3N12O8. Mole weight: 898.93. | |
| RO-5028442 | RO-5028442 is a potent and brain-penetrant hV1a antagonist. RO-5028442 is undergoing clinical trials for autistic disorder therapy. Alternative Names: RO-5028442; RO 5028442; RO5028442. [6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone. CAS No. 920022-47-5. Molecular formula: C25H28ClN3O2. Mole weight: 437.968. | |
| Ro 61-8048 | Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Blood-brain barrier permeable. Orally active. Alternative Names: Ro61-8048; Ro 61-8048; Ro-61-8048; Ro618048; Ro 618048; Ro-618048. Grades: >98%. CAS No. 199666-03-0. Molecular formula: C17H15N3O6S2. Mole weight: 421.45. | |
| Robinin | Robinin is a flavonoid glycoside isolated from the barks of Rauvolfia yunnanensis Tsiang. Robinin exhibits protective effect against the ox-LDL induced inflammation stress in hPBMCs by inhibiting TLR4-NF-κB signaling pathway. Alternative Names: Kaempferol-3-O-gal-rham-7-O-rham; Kaempferol-3-O-robinoside-7-O-rhamnoside; 4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-7-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-; 3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-7-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranosyl 7-O-α-L-rhamnopyranoside; Kaempferol 3-robinoside-7-rhamnoside. Grades: >98%. CAS No. 301-19-9. Molecular formula: C33H40O19. Mole weight: 740.66. | |
| ROC-325 | ROC-325 is a lysosomal-mediated autophagy inhibitor. It exhibits superior preclinical anticancer activity compared with hydroxychloroquine (HCQ). Uses: Antineoplastic agents. Alternative Names: ROC 325; ROC325; 1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one. Grades: 98%. CAS No. 1859141-26-6. Molecular formula: C28H27ClN4OS. Mole weight: 503.06. | |
| ROCAGLAMIDE | Rocaglamide is the first cyclopenta[b]benzofuran derivative extracted from Aglaia elliptifolia in 1982 by King and colleagues. Its IC50 value is ~50 nM for the heat shock reporter. It has antileukemic activity and displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities. It is an immunosuppressant that inhibits activation of NF-kB and NF-AT. It markedly inhibited tumor growth from Huh-7 cells propagated in severe combined immunodeficient mice. It induces apoptosis in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells. It inhibit protein synthesis without affecting DNA or RNA synthesis. Uses: Rocaglamide has antileukemic activity and displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities. it is an immunosuppressant that inhibits activation of nf-kb and nf-at. it inhibit protein synthesis without affecting dna or rna synthesis. Alternative Names: Rocaglamide; Rocaglamide A; RocA; NSC 326408. (1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide;NSC 326408;Roc-A;Rocaglamide A;1H-Cyclopenta(b)benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-;[1R-(1α,2α,3β. Grades: 95%. CAS No. 84573-16-0. Mo | |
| Rociletinib | Rociletinib is a third-generation irreversible kinase inhibitor of epidermal growth factor receptor (EGFR). Rociletinib was shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR. It also exhibits anti-tumor activity in NSCLC EGFR mutant xenograft models. Alternative Names: CO-1686; CO1686; CO 1686; AVL-301; AVL 301; AVL301; CNX-419; CNX 419; CNX419; N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide. CAS No. 1374640-70-6. Molecular formula: C27H28F3N7O3. Mole weight: 555.562. | |
| Rocilinostat | Rocilinostat is an orally bioavailable histone deacetylase 6 (HDAC6) inhibitor with potential antineoplastic activity. It selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Compared to non-selective HDAC inhibitor, Rocilinostat is able to reduce the toxic effects on normal, healthy cells. Uses: Antineoplastic agents. Alternative Names: ACY-1215; ACY1215; ACY 1215; Rocilinostat; 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide. Grades: 98%. CAS No. 1316214-52-4. Molecular formula: C24H27N5O3. Mole weight: 433.512. | |
| Rocuronium bromide EP impurity F | An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Alternative Names: 2-Pyrrolidinyl-3-acetyl Desmorpholinylrocuronium Bromide; 1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-pyrrolidinyl)androstan-16-yl]-1-(2-propen-1-yl)-pyrrolidinium. Grades: > 95%. CAS No. 1190105-66-8. Molecular formula: C34H55N2O4.Br. Mole weight: 635.72. | |
| Rocuronium EP Impurity E | An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Alternative Names: 2-Pyrrolidinyl Desmorpholinylrocuronium Bromide; 1-[(2β,3α,5α,16β,17β)-17-(Acetyloxy)-3-hydroxy-2-(1-pyrrolidinyl)androstan-16-yl]-1-(2-propen-1-yl)-pyrrolidinium Bromide. Grades: > 95%. CAS No. 1190105-65-7. Molecular formula: C32H53N2O3. Br. Mole weight: 593.69. | |
| Rocuronium EP Impurity G | An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Alternative Names: 2β-(4-Morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstane-3α,17β-diol; (2β,3α,5α,16β,17β)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstan-3,17-diol; Desacetyl Desallyl Rocuronium. Grades: 99 %. CAS No. 119302-20-4. Molecular formula: C27H46N2O3. Mole weight: 446.68. | |
| (R)-O-Demethylmetoprolol | (R)-O-Demethylmetoprolol is an impurity of Betaxolol, which is a selective beta1 adrenergic receptor blocker for the treatment of hypertension and glaucoma. Alternative Names: O-Demethylmetoprolol, (+)-; (R)-(+)-O-Demethylmetoprolol. CAS No. 131564-70-0. Molecular formula: C14H23NO3. Mole weight: 253.342. | |
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