BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Thiabendazole-[d4] | Labelled Thiabendazole. Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. Alternative Names: 2-(4-Thiazolyl)-1H-benzimidazole-d4; 4-(2-Benzymidazolyl)thiazole-d4; MK 360-d4; Equizole-d4; Mertect-d4; Mintezol-d4; Tecto-d4. CAS No. 1190007-20-5. Molecular formula: C10H3D4N3S. Mole weight: 205.27. |  |
| Thiabendazole NH-[d6] | Labelled Thiabendazole. Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. Alternative Names: Thiabendazole NH D6,1H-Benzimidazole-4,5,6,7-d4. Grades: >98%. CAS No. 1262551-89-2. Molecular formula: C10HD6N3S. Mole weight: 207.28. | |
| Thiamine Disulfide | Thiamine, also called as vitamin B1, is used in combination with other B vitamins to regulate important functions of the cardiovascular system, endocrine system, and digestive system. Alternative Names: thiamine disulfide|67-16-3|NCGC00181294-01|DSSTox_CID_26890|DSSTox_RID_81993|DSSTox_GSID_46890|SCHEMBL397373|CHEMBL3188440|DTXSID6046890|Tox21_112773|CAS-67-16-3|DB-054994. Grades: > 95%. CAS No. 67-16-3. Molecular formula: C24H34N8O4S2. Mole weight: 562.72. | |
| Thiamine EP Impurity B | An impurity of Thiamine which is an important vitamin in carbohydrate (sugar and starch) metabolism, maintenance of normal growth, and transmission of nerve impulses. Alternative Names: Desmethylthiamine; 2-Northiamin; Desmethyl Thiamine; 3-((4-Amino-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium. Grades: 98%. CAS No. 7771-57-5. Molecular formula: C11H15N4OS. Mole weight: 251.33. | |
| Thiamine Impurity E | An impurity of Thiamine which is an important vitamin in carbohydrate (sugar and starch) metabolism, maintenance of normal growth, and transmission of nerve impulses. Alternative Names: Thiothiamine; Thioxothiamine. Grades: > 95%. CAS No. 299-35-4. Molecular formula: C12H16N4OS2. Mole weight: 296.42. | |
| Thiamphenicol-methyl-[d3] | Thiamphenicol-methyl-[d3] is the labelled analogue of Thiamphenicol, which is an antimicrobial antibiotic. Alternative Names: Thiamphenicol-methyl-d3; 2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl-d3)phenyl]ethyl]acetamide. Molecular formula: C12H12D3Cl2NO5S. Mole weight: 359.24. | |
| Thieno[3,4-d]pyrimidin-4-amine CEP | Thieno[3,4-d]pyrimidin-4-amine CEP. Alternative Names: Methanimidamide, N'-[7-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-methyl-β-D-ribofuranosyl]-3,4-dihydro-4-oxothieno[3,4-d]pyrimidin-2-yl]-N,N-dimethyl-. Grades: ≥95%. CAS No. 1883778-97-9. Molecular formula: C45H55N6O8PS. Mole weight: 871.00. | |
| thiethylperazine | Thiethylperazine is a dopamine receptor antagonist It is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects. It is useful in the treatment of nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. Uses: Antiemetic. Alternative Names: Torecan; Tietilperazina; Thiethylperazinum; Norzine; 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine. Grades: 98%. CAS No. 1420-55-9. Molecular formula: C22H29N3S2. Mole weight: 399.62. | |
| Thiocolchicoside | Thiocolchicoside is a semi-synthetic derivative of colchicine, an anti-inflammatory glycoside extracted from the flower seeds of superba gloriosa. Thiocolchicoside acts as a GABAA receptor antagonist exhibiting anti-inflammatory and analgesic activity. It is used as a muscle relaxant. Alternative Names: N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; (S)-N-[3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; Coltramyl; Coltrax; Miorel; Miotens; Muscoril; Colchicoside, 10-thio-; 2-Demethoxy-2-glucosidoxythiocolchicine; Etoshine MR; NSC 147755; R 271; Thiocholshikoside. Grades: >98%. CAS No. 602-41-5. Molecular formula: C27H33NO10S. Mole weight: 563.62. | |
| Thioctate trometamol | Thioctate trometamol, a derivative of alpha-lipoic acid, displays potent antioxidant effects that aid in the management of diabetic neuropathy, alcoholic liver disease, and associated ailments. By boosting glucose metabolism and mitigating oxidative stress, this pharmaceutical compound facilitates the restoration of metabolic homeostasis. Conventionally available in tablet form for oral administration, Thioctate trometamol boasts excellent patient tolerance. Its striking antioxidant attributes are infinitely promising for disease mitigation in diverse clinical settings. Alternative Names: Dexlipotam; Thioctic acid tromethamine; 5-(1,2-Dithiolaln-3-yl)-pentanoic acid tromethamine; Lipoic Acid Tromethamine Salt; 1,2-Dithiolane-3-pentanoic acid, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1). Grades: ≥95%. CAS No. 14358-90-8. Molecular formula: C8H14O2S2.C4H11NO3. Mole weight: 327.46. | |
| Thioctic acid EP Impurity A | An impurity of thioctic acid, an antioxidant that helps turn glucose into energy in human body. Alternative Names: 6,8-Epitrithiooctanoic acid; 1,2,3-Trithiane-4-pentanoic acid. CAS No. 1204245-29-3. Molecular formula: C8H14O2S3. Mole weight: 238.39. | |
| Thioxanthen-9-one | Thioxanthen-9-one is a photoinitiator. Alternative Names: 9-thioxanthenone. Grades: 97 %. CAS No. 492-22-8. Molecular formula: C13H8OS. Mole weight: 212.27. | |
| threo-1-C-Syringylglycerol | threo-1-C-Syringylglycerol is a chemical with possible inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells which is constituent from Kandelia candel, the product is from the roots of Coix lachryma-jobi. Uses: Effects on pro-inflammatory cytokines production in lps-stimulated bone marrow-derived dendritic cells. Alternative Names: (1R,2R)-rel-1-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2,3-propanetriol; (R*,R*)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2,3-propanetriol. Grades: >95%. CAS No. 121748-11-6. Molecular formula: C11H16O6. Mole weight: 244.2. | |
| Thymine-[methyl-d3,6-d1] | Thymine-[methyl-d3,6-d1], a ubiquitous component in nucleic acids research, merits consideration in assessments of thymine metabolism. Its incorporation expedites the study of metabolic activities and kinetics of DNA synthesis in cancerous tissues, which necessitate considerably augmented synthesis rates. Alternative Names: thymine-d4 (methyl-d3,6-d1); Thymine-methyl-d3,6-d1; Thymine-methyl-d3,6-d; Thymine-alpha,alpha,alpha,6-d4. CAS No. 156054-85-2. Molecular formula: C5H2D4N2O2. Mole weight: 130.14. | |
| THZ1 | THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Alternative Names: HY-80013; THZ-1; HY 80013; THZ 1; HY80013; THZ1; N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide. Grades: >98%. CAS No. 1604810-83-4. Molecular formula: C31H28ClN7O2. Mole weight: 566.062. | |
| Tiadinil | Tiadinil is a plant activator of systemic acquired resistance, boosts the production of herbivore-induced plant volatiles; insecticide agent. Alternative Names: 5-(3-Chloro-4-methylanilinocarbonyl)-4-methyl-1,2,3-thiadiazole, N-(3-Chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide. Grades: >98%. CAS No. 223580-51-6. Molecular formula: C11H10ClN3OS. Mole weight: 267.73. | |
| Tiagabine hydrochloride | Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1. Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders. Alternative Names: Gabitril hydrochloride; NO050328 hydrochloride; NO328 hydrochloride; NO-050328 hydrochloride; NO 328 hydrochloride; NO O050328 hydrochloride; NO 328 hydrochloride; TGB hydrochloride. Grades: >98%. CAS No. 145821-59-6. Molecular formula: C20H26ClNO2S2. Mole weight: 412.01. | |
| Ticagrelor EP Impurity B | Ticagrelor EP Impurity B is an impurity of Ticagrelor, which is a reversible P2Y12 receptor antagonist used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. Alternative Names: Ticagrelor sulphone; Ticagrelor related compound B; Ticagrelorsulphone; (1S,2S,3R,5S)-3-[[3-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]-pyrimidin-7-yl]amino]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; (1S,2S,3R,5S)-3-((3-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Ticagrelor Impurity B; Ticagrelor Related Compound 41; 1,2-Cyclopentanediol, 3-[[3-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-; (1S,2S,3R,5S)-3-[[3-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol; Ticagrelor USP Related Compound B; USP Ticagrelor Related Compound B. Grades: >95%. CAS No. 1788033-05-5. Molecular formula: C23H28F2N6O4S. Mole weight: 522.57. | |
| Ticagrelor impurity 40 | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Alternative Names: Ticagrelor Related Compound 40; Ticagrelor Impurity O; 2,2-(((3aR,3aR,4S,4S,6R,6aS,6R,6aS)-((5-amino-2-(propylthio)pyrimidine-4,6-diyl)bis(azanediyl))bis(2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxole-6,4-diyl))bis(oxy))bis(ethan-1-ol). Grades: >95%. CAS No. 1882095-51-3. Molecular formula: C27H45N5O8S. Mole weight: 599.74. | |
| Ticagrelor impurity G | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Alternative Names: (1S,2R,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopentane-1,2,3-triol. Grades: >95%. CAS No. 220347-05-7. Molecular formula: C21H24F2N6O3S. Mole weight: 478.51. | |
| Ticagrelor Related Compound 16 | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Alternative Names: Ticagrelor Impurity; 1,2-Cyclopentanediol, 3-[7-[[(1S,2R)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-; (1S,2S,3R,5S)-3-[7-[[(1S,2R)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol; (1S,2S,3R,5S)-3-(7-(((1S,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol. Grades: >98%. CAS No. 2096989-56-7. Molecular formula: C23H28F2N6O4S. Mole weight: 522.57. | |
| Ticagrelor Related Compound 29 | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Alternative Names: ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate. Grades: >95%. CAS No. 1265919-24-1. Molecular formula: C12H21NO5. Mole weight: 259.30. | |
| Ticagrelor Related Compound 75 | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Alternative Names: 4,6-dichloro-2-(propylthio)pyrimidine. CAS No. 1401318-10-2. Molecular formula: C7H8Cl2N2S. Mole weight: 223.12. | |
| Tigecycline Related Compound B | An impurity of Tigecycline, which is a glycylcycline antibiotic used to treat infection by drug resistant bacteria such as Staphylococcus aureus (Staph aureus) and Acinetobacter baumannii. Alternative Names: 9-Aminominocycline hydrochloride; (4s,4as,5ar,12as)-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride (1:1). Grades: 95%. CAS No. 149934-21-4. Molecular formula: C23H29ClN4O7. Mole weight: 508.95. | |
| Tilifodiolide | Tilifodiolide can be extracted from the herbs of Salvia tiliaefolia. Alternative Names: Naphtho[1,2-c]furan-3(1H)-one,8-(2,5-dihydro-2-oxo-3-furanyl)-1-(3-furanyl)-6,7,8,9-tetrahydro-, (1R,8S)-; (1R,8S)-1α-(3-Furanyl)-6,7,8,9-tetrahydro-8α-[(2,5-dihydro-2-oxofuran)-3-yl]naphtho[1,2-c]furan-3(1H)-one. Grades: >98%. CAS No. 126724-95-6. Molecular formula: C20H16O5. Mole weight: 336.3. | |
| Tiliroside | Tiliroside, also called 6''-O-trans-p-Coumaroylastragalin, is a natural flavonoid found in the herbs of Agrimonia pilosa Ledeb. Tiliroside shows a hepatoprotective effect against D-galactosamine (D-GalN) / lipopolysaccharide (LPS)-induced liver injury in mice. Tiliroside also exhibits anticarcinogenic, antioxidant, anti-inflammatory and anti-diabetic activities. Uses: Anticarcinogenic; antioxidant; anti-inflammatory; anti-diabetic. Alternative Names: 6''-O-trans-p-Coumaroylastragalin. Grades: >98%. CAS No. 20316-62-5. Molecular formula: C30H26O13. Mole weight: 594.5. | |
| Tilorone dihydrochloride | Tilorone dihydrochloride, as a broad-spectrum, orally active antiviral agent, is an orally active interferon inducer. Alternative Names: 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride. Grades: ≥ 98 %. CAS No. 27591-69-1. Molecular formula: C25H34N2O3 ยท 2HCl. Mole weight: 483.47. | |
| Timapiprant | Timapiprant is a potent and selective D prostanoid receptor 2 (DP2; CRTH2) antagonist. It effectively improves lung function and symptoms in patients with atopic eosinophilic asthma. It was shown to reduce both nasal and eye symptoms in allergic subjects exposed to grass pollen. Alternative Names: OC-000459; OC 000459; OC000459; 2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid. CAS No. 851723-84-7. Molecular formula: C21H17FN2O2. Mole weight: 348.37. | |
| Timapiprant sodium | Timapiprant is a potent and selective D prostanoid receptor 2 (DP2; CRTH2) antagonist. It effectively improves lung function and symptoms in patients with atopic eosinophilic asthma. It was shown to reduce both nasal and eye symptoms in allergic subjects exposed to grass pollen. Alternative Names: OC-000459 sodium; OC 000459 sodium; OC000459 sodium; sodium 2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetate. CAS No. 950688-14-9. Molecular formula: C21H16FN2NaO2. Mole weight: 370.35. | |
| Timolol EP Impurity E | An impurity of Ticlopidine which has been shown to lower the IOP in normal human volunteers without affecting the pupil size, visual acuity, blood pressure, or pulse rate. Alternative Names: Timolol maleate ester; (2Z)-4-[(1S)-1-[[(1,1-Dimethylethyl)amino]methyl]-2-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]-4-oxobut-2-enoic acid. Grades: > 95%. CAS No. 1026075-53-5. Molecular formula: C17H26N4O6S. Mole weight: 414.48. | |
| Timolol Impurity G | An impurity of Ticlopidine which is a potent, highly specific β-adrenergic antagonist, significantly inhibiting both β-l- and β-2-adrenergic agonist activity. Alternative Names: 4-(Morpholin-4-yl)-1,2,5-thiadiazol-3(2H)-one-1-oxide. Grades: > 95%. CAS No. 75202-36-7. Molecular formula: C6H9N3O3S. Mole weight: 203.22. | |
| Timosaponin A1 | Timosaponin A1 a coprostane type steroidal saponin isolated from Rhizoma Anemarrhenae which is the dry rootstock of Anemarrhenae asphodeloides Bunge (Liliaceae) dug in spring and fall. The rhizome of Anemarrhena asphodeloides Bunge (Liliaceae), has been used for a long time in traditional Chinese medicine with anti-diabetic activity anti-platelet aggregation activity and diuretic activity. Alternative Names: (3β,5β,25S)-Spirostan-3-yl β-D-galactopyranoside; β-D-Galactopyranoside, (3β,5β,25S)-spirostan-3-yl; Sarsasapogenin, β-D-galactopyranoside (7CI). Grades: > 98%. CAS No. 68422-00-4. Molecular formula: C33H54O8. Mole weight: 578.78. | |
| Timosaponin B II | Timosaponin BII is extracted from the rhizomes of Anemarrhena asphodeloides Bunge. It has antioxidant, potential anti-dementia activity. It remarkably inhibited the up-regulation of BACE1 and reduced the over-production of β-CTF and Aβ in rat retina. Alternative Names: (25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol; (25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol. Grades: >98%. CAS No. 136656-07-0. Molecular formula: C45H76O19. Mole weight: 921.1. | |
| Timsaponin C | The rhizomes of Anemarrhena asphodeloides Bunge. Alternative Names: Timsaponin C. Grades: >98%. CAS No. 185432-00-2. Molecular formula: C45H74O18. Mole weight: 903.1. | |
| Tinosporol A | Tinosporol A, a constituent of Tinospora cordifolia, boasts anti-inflammatory and anticancer properties. Its effectiveness at thwarting the growth of cancer cells - leukemic and colon alike - is scientifically documented. Moreover, Tinosporol A has shown inhibitory capacities in the production of inflammatory cytokines, contributing to its potential as an anti-inflammatory agent. Grades: > 95%. CAS No. 2244777-12-4. Molecular formula: C21H26O8. Mole weight: 406.43. | |
| Tinuvin | Tinuvin. CAS No. 3896-11-5. | |
| Tioconazole Related Compound A | One impurity of Tioconazole, which could be used as an antifungal agent and exhibit activities against Candida glabrata mutant strains. Alternative Names: 2-Deschlorothien-3-yl Tioconazole Hydrochloride; 1-[2-(2,4-Dichlorophenyl)-2-(3-thienylmethoxy)ethyl]-1H-imidazole Monohydrochloride. CAS No. 61709-33-9. Molecular formula: C16H14Cl2N2OS. HCl. Mole weight: 389.73. | |
| Tiotropium bromide hydrate | Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Alternative Names: BA 679BR. Grades: >98%. CAS No. 139404-48-1. Molecular formula: C19H22NO4S2.Br.xH2O. Mole weight: 490.43. | |
| Tipiracil HCl | Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally. Alternative Names: Tipiracil, TPI. Grades: 0.99. CAS No. 183204-72-0. Molecular formula: C9H12Cl2N4O2. Mole weight: 279.121. | |
| Tirapazamine | Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. Alternative Names: US brand name: Tirazone. Code names: SR 4233. WIN 59075. SR-259075, NSC-130181, Win-59075, SR-4233. Grades: 0.98. CAS No. 27314-97-2. Molecular formula: C7H6N4O2. Mole weight: 178.15. | |
| Tirofiban Hydrochloride Monohydrate | Tirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb / IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina. Uses: The treatment of unstable angina. Alternative Names: N-(Butylsulfonyl)-4-(4-(4-piperidyl)butoxy)-L-phenylalanine monohydrochloride monohydrate; Aggrastat; L 700462; L700462; L-700,462; MK-383; MK 383; MK383; Tirofiban; Tirofiban hydrochloride monohydrate. Grades: >98%. CAS No. 150915-40-5. Molecular formula: C22H39ClN2O6S. Mole weight: 495.07. | |
| Tirofiban Impurity C | One of the impurities of Tirofiban, which has been found to be a glycoprotein IIb / IIIa inhibitor and could be used as an antiplatelet agent. Alternative Names: N-(n-Butanesulfonyl)-O-[4-(4-pyridinyl)-butyl]-(S)-tyrosine; 2-(Butane-1-sulfonylamino)-3-[4-(4-pyridin-4-yl-butoxy)-phenyl]-popionic Acid. CAS No. 149490-61-9. Molecular formula: C22H30N2O5S. Mole weight: 434.56. | |
| Titanium diboride | Titanium diboride. Alternative Names: TiB2; Titanium diboride. Grades: 98%. CAS No. 12045-63-5. Molecular formula: B2Ti. Mole weight: 69.49. | |
| Tivozanib | Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. Check for active clinical trials or closed clinical trials using this agent. Alternative Names: AV-951; AV951; AV 951; KRN951; KRN 951; KRN-951; Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-; N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea; Fotivda; Kil 8951; Tivozanib. Grades: ≥95%. CAS No. 475108-18-0. Molecular formula: C22H19ClN4O5. Mole weight: 454.86. | |
| Tixocortol Pivalate | Tixocortol Pivalate is a corticosteroid showing topical anti-inflammatory properties. It is marketed under the brand name Pivalone. Alternative Names: Pivalone; Tixocortol 21-pivalate. Grades: >95%. CAS No. 55560-96-8. Molecular formula: C26H38O5S. Mole weight: 462.645. | |
| Tizoxanide-[d4] | Tizoxanide-[d4] is the labelled analogue of Tizoxanide. Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. Alternative Names: Tizoxanide D4; 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide-d4. Grades: 95% by HPLC; 98% atom D. CAS No. 1246817-56-0. Molecular formula: C10H3D4N3O4S. Mole weight: 269.27. | |
| TJ-M2010-5 | TJ-M2010-5 is an inhibitor of MyD88 which binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. Grades: 99%. CAS No. 1357471-57-8. Molecular formula: C23H26N4OS. Mole weight: 406.55. | |
| TM-5275 sodium salt | TM-5275 sodium salt is an orally bioavailable, potent and selective plasminogen activator inhibitor-1 (PAI-1). It delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Uses: Tm-5275 sodium salt delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Alternative Names: TM5275 sodium salt; TM 5275 sodium salt; TM-5275 sodium salt; 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt; Sodium 2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate. Grades: >98%. CAS No. 1103926-82-4. Molecular formula: C28H27ClN3NaO5. Mole weight: 543.98. | |
| TMC-58B | Aurantiamide, a natural alkaloid found in the herbs of Walsura yunnanensis, is used as significant anti-inflammatory and antinociceptive. it can serve as the natural compound for inhibiting cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. It may suppress the growth of malignant gliomas by blocking autophagic flux. Uses: Anti-neuroinflammatory; anti-inflammatory; antinociceptive. Alternative Names: (S)-α-(Benzoylamino)-N-[(S)-1-(hydroxymethyl)-2-phenylethyl]benzenepropanamide. Grades: >95%. CAS No. 58115-31-4. Molecular formula: C25H26N2O3. Mole weight: 402.5. | |
| Toceranib phosphate | Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect. Alternative Names: SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639. Grades: >98%. CAS No. 874819-74-6. Molecular formula: C22H28FN4O6P. Mole weight: 494.45. | |
| Tocopherol Impurity 1 | One of the impurities of Vitamin E, which has been found to exhibit antioxidant activity. Alternative Names: 2H-1-Benzopyran-6-ol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-. CAS No. 3808-26-2. Molecular formula: C29H48O2. Mole weight: 428.69. | |
| Toddalolactone | Toddalolactone usually can be isolated from the roots of Toddalia asiatica Lam. Uses: Anti-inflammatory / analgesic / anti-cancer. Alternative Names: 6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-1-benzopyran-2-one; Toddaline; (+)-Toddalolactone; 6-[(2R)-2,3-dihydroxy-3-methyl-butyl]-5,7-dimethoxy-chromen-2-one; 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one; 6-[(2R)-2,3-dihydroxy-3-methyl-butyl]-5,7-dimethoxy-coumarin. Grades: >98%. CAS No. 483-90-9. Molecular formula: C16H20O6. Mole weight: 308.33. | |
| Toddalosin | Toddalosin is a bicoumarin isolated from Toddalia asiatica. Alternative Names: 8-[(1S,6R)-6-[(R)-(5,7-dimethoxy-2-oxochromen-8-yl)-hydroxymethyl]-3,5,5-trimethylcyclohex-2-en-1-yl]-5,7-dimethoxychromen-2-one. Grades: 98.0%. CAS No. 137182-37-7. Molecular formula: C32H34O9. Mole weight: 562.615. | |
| TOFA | TOFA is a cell-permeable, potent, reversible, and competitive allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). It inhibits the fatty acid biosynthesis by blocking the synthesis of malonyl-CoA. Uses: Hypolipidemic agents. Alternative Names: 5-tetradecoxyfuran-2-carboxylic acid; 5-(tetradecyloxy)-2-furancarboxylic acid; 5-(tetradecyloxy)-2-furoic acid; RMI 14514; RMI-14514. CAS No. 54857-86-2. Molecular formula: C19H32O4. Mole weight: 324.45. | |
| Tofacitinib | Tofacitinib is an orally available JAK3 inhibitor (IC50 = 1 nM), exhibiting 20- and 100-fold less potency against JAK2 and JAK1. Tofacitinib induces G1 cell cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. It is approved for the treatment of rheumatoid arthritis (RA). Alternative Names: Tasocitinib; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550. Grades: >98%. CAS No. 477600-75-2. Molecular formula: C16H20N6O. Mole weight: 312.37. | |
| Tofogliflozin hydrate | Tofogliflozin(CSG-452) hydrate is a potent and highly specific sodium / glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. Alternative Names: CSG452 hydrate; CSG-452 hydrate; CSG 452 hydrate. Grades: >98%. CAS No. 1201913-82-7. Molecular formula: C22H28O7. Mole weight: 404.45. | |
| Tolcapone | Tolcapone functions as a selective peripheral and central COMT inhibitor, exerting no effect on adrenergic, serotonergic, or cholinergic receptors or other enzymes involved in synthesis or catabolism of catecholamines. Alternative Names: Ro 40-7592; Ro40-7592; Ro-40-7592. Grades: >98%. CAS No. 134308-13-7. Molecular formula: C14H11NO5. Mole weight: 273.24. | |
| Tolfenpyrad | Tolfenpyrad is used as foliar insecticide for the control of green peach aphids in broccoli. Alternative Names: 4-Chloro-3-ethyl-1-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl]-1H-pyrazole-5-carboxamide; Tolfenpyrad; Hachihachi EC; NAI 2302; NAI-2302; NAI2302; NAI 2303; OMI 88; OMI-88; OMI88. Grades: >98%. CAS No. 129558-76-5. Molecular formula: C21H22ClN3O2. Mole weight: 383.87. | |
| Tolterodine Tartrate | Tolterodine has a high affinity and specificity for muscarinic receptors in vitro and it exhibits selectivity for the urinary bladder over salivary glands in vivo. Uses: Urological agents. Alternative Names: PNU-200583E. Grades: >98%. CAS No. 124937-52-6. Molecular formula: C22H31NO.C4H6O6. Mole weight: 475.57. | |
| Toltrazuril | Toltrazuril can be used to treat poultry coccidiosis. Alternative Names: Baycox; Toltrazurilo; Toltrazurilum. Grades: >98%. CAS No. 69004-03-1. Molecular formula: C18H14F3N3O4S. Mole weight: 425.38. | |
| tolycaine | Tolycaine is an amide local anaesthetic used for dental injection. Alternative Names: Baycain; Benzoic acid, 2-[[(diethylamino)acetyl]amino]-3-methyl-, methyl ester. Grades: 95%. CAS No. 3686-58-6. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| Tomentin | Tomentin, a natural plant coumarin which is isolated from the barks of Jatropha curcas, exhibits anti-inflammatory activity. Tomentin also can inhibit papain-like protease. Uses: Anti-inflammatory. Alternative Names: 5-Hydroxy-6,7-dimethoxycoumarin. Grades: >98%. CAS No. 28449-62-9. Molecular formula: C11H10O5. Mole weight: 222.2. | |
| Topiroxostat | Topiroxostat is a novel and potent xanthine oxidoreductase (XOR) inhibitor. Uses: Enzyme inhibitors. Alternative Names: FYX051; FYX051; FYX 051; Topiroxostat. trade names Topiloric Uriadec. Grades: >98%. CAS No. 577778-58-6. Molecular formula: C13H8N6. Mole weight: 248.24. | |
| Topotecan | Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. It has also been used for in vitro apoptosis assays in PA317 cells. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-; (S)-Topotecan; 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin; 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin; Evotopin; Hycamptamine; Hycamptin; Nogitecan; NSC 609699; Potactasol; SKF 104864; SKF-S 104864; TopoCED; Topophore C; Topotecan lactone; ZINC 1611274. Grades: ≥95%. CAS No. 123948-87-8. Molecular formula: C23H23N3O5. Mole weight: 421.45. | |
| Topotecan hydrochloride | Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Uses: Topoisomerase i inhibitors. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Hycamtin; Nogitecan hydrochloride; NSC 609669; SKF 104864A; SKFS 104864A; Topotecan chlorohydrate; Xinze. Grades: >98%. CAS No. 119413-54-6. Molecular formula: C23H24ClN3O5. Mole weight: 457.91. | |
| Torachrysone | Torachrysone is a natural phenol isolated from the seeds of Cassia obtusifolia. Alternative Names: 2-Acetyl-3-methyl-6-methoxynaphthalene-1,8-diol. Grades: >97%. CAS No. 22649-04-3. Molecular formula: C14H14O4. Mole weight: 246.3. | |
| Tormentic acid | Tormentic acid is a terpenoid isolated from the herb of Potentilla tormentilla. It inhibits LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. Alternative Names: Jacarandic acid; (1R,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; 2α,19α-Dihydroxyursolic acid. Grades: >98%. CAS No. 13850-16-3. Molecular formula: C30H48O5. Mole weight: 488.709. | |
| Tosedostat | Tosedostat is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively, and does not effectively inhibit either PILSAP, MetAP-2, LTA4 hydrolase, or MetAP-2 with IC50 values are > 1000, > 5000, > 10000 and > 30000 nM for aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2 respectively. Phase 2. Tosedostat potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo. Alternative Names: CHR2797; CHR-2797; CHR 2797; Tosedostat. cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate. Grades: 98%. CAS No. 238750-77-1. Molecular formula: C21H30N2O6. Mole weight: 406.479. | |
| Tosylglycolic Acid | Tosylglycolic Acid is an intermediate of Cefmetazole. Alternative Names: 2-[[(4-Methylphenyl)sulfonyl]oxy]acetic Acid. CAS No. 39794-77-9. Molecular formula: C9H10O5S. Mole weight: 230.24. | |
| Tozasertib | The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 μM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase. Alternative Names: VX680; VX 680; VX-680; MK0457; MK 0457; MK-0457; VE465; VE-465; VE 465; Tozasertib. CAS No. 639089-54-6. Molecular formula: C23H28N8OS. Mole weight: 464.59. | |
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