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| Product | Description | |
|---|---|---|
| A-674563 hydrochloride | A-674563 hydrochloride is a potent, orally available Akt1 inhibitor with Ki of 11 nM. Alternative Names: (S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine hydrochloride. Grades: 98%. CAS No. 2070009-66-2. Molecular formula: C22H23ClN4O. Mole weight: 394.90. |  |
| A6770 | A6770, a potentially key metabolite of THI, induces [3H]dhS1P increase and is a potent and orally active inhibitor of sphingosine 1-phosphate lyase (S1PL). A6770 is phosphorylated, and the phosphorylated form directly inhibits S1P lyased. Alternative Names: Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-; 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]ethan-1-one. Grades: ≥95%. CAS No. 1331754-16-5. Molecular formula: C6H8N2O2. Mole weight: 140.14. | |
| A68930 | A68930 is a dopamine D1 receptor agonist that can be used in the study of bronchiectasis. Uses: Dopamine agonists. Alternative Names: 5,6-Dihydroxy-3-phenyl-1-aminomethylisochroman; 1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-phenyl-, (1R-cis)-; (1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-2-benzopyran-5,6-diol. Grades: 95%. CAS No. 130465-45-1. Molecular formula: C16H17NO3. Mole weight: 271.31. | |
| A 68930 hydrochloride | A 68930 hydrochloride is a potent and selective dopamine D1-like receptor agonist (EC50 = 2.1 and 3910 nM for D1-like and D2-like receptors, respectively). Alternative Names: A-68930 hydrochloride; A 68930 hydrochloride; A68930 hydrochloride; cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol hydrochloride. Grades: ≥98% by HPLC. CAS No. 130465-39-3. Molecular formula: C16H17NO3.HCl. Mole weight: 307.78. | |
| A7132 | A7132 is an antibacterial agent and possesses broad and potent antibacterial activity. Alternative Names: 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. CAS No. 100490-21-9. Molecular formula: C19H16F2N4O3. Mole weight: 386.35. | |
| A 71378 | A 71378 is a high potency, selectivity CCK-A receptors agonist with the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. Alternative Names: A-71378; Desamino-tyr(SO3H)-nle-gly-trp-nle-(N-methyl)asp-phe-NH2. CAS No. 127902-33-4. Molecular formula: C48H62N8O13S. Mole weight: 991.12. | |
| A-71623 | A-71623 is a tetrapeptide and acts as a potent CCK1 agonist (IC50 = 3.7 nM) displaying 1200-fold selectivity over the CCK2 receptor. A-71623 is used to suppress appetite and reduce food intake following central or peripheral administration. Alternative Names: A 71623; A-71623; A71623; N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide. CAS No. 130408-77-4. Molecular formula: C44H56N8O9. Mole weight: 840.97. | |
| A 71915 | A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Alternative Names: (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat); H-Arg-Cys-β-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13); L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic(2→13)-disulfide. Grades: ≥95%. CAS No. 132956-87-7. Molecular formula: C69H116N26O15S2. Mole weight: 1613.95. | |
| A-72363 A1 | A-72363 A1 is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Alternative Names: A-72363 A-1; 4alpha,5beta-Dihydroxy-6beta-(acetylamino)piperidine-3alpha-carboxylic acid. Molecular formula: C8H14N2O5. Mole weight: 218.21. | |
| A-72363 A2 | A-72363 A2 is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Alternative Names: A-72363 A-2; 4beta,5beta-Dihydroxy-6beta-(acetylamino)piperidine-3alpha-carboxylic acid. Molecular formula: C8H14N2O5. Mole weight: 218.21. | |
| A-72363 C | A-72363 C is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Alternative Names: A-72363; 4alpha,5alpha-Dihydroxy-6alpha-(acetylamino)piperidine-3alpha-carboxylic acid. Molecular formula: C8H14N2O5. Mole weight: 218.21. | |
| A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Alternative Names: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
| A-75943 | A-75943 is is a bone resorption inhibitor produced by Streptomyces sp. SANK61296. In vitro tests, it has the effect of inhibiting bone resorption with IC50 of 0.35 μmol/L. It also inhibits the bone resorption in rats with thyroid and parathyroidectomy. Alternative Names: 2H-Pyran-4-acetamide, 2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)tetrahydro-6-oxo-, (2R,4S)-. Grades: >98%. CAS No. 201215-10-3. Molecular formula: C15H23NO4. Mole weight: 281.35. | |
| A-769662 | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase / FBPase activity. Alternative Names: 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile. Grades: ≥95%. CAS No. 844499-71-4. Molecular formula: C20H12N2O3S. Mole weight: 360.4. | |
| A-770041 | A-770041 is an selective and orally bioavailable pyrazolo[3,4-d]pyrimidine exhibiting selectivity for Lck compared with previously reported compounds. It is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. It is currently in the preclinical developlent stage and no clinical data are available. Alternative Names: A-770041; A 770041; A770041. Grades: >98%. CAS No. 869748-10-7. Molecular formula: C34H39N9O3. Mole weight: 621.73. | |
| A-77-01 | A-77-01 is an inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5( IC50 =25nM). Uses: Potent alk5 inhibitor. Alternative Names: A77-01; A 77-01; A-77-01. 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinoline;4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline. Grades: ≥98%. CAS No. 607737-87-1. Molecular formula: C18H14N4. Mole weight: 286.34. | |
| A 77636 hydrochloride | A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 = 8.97 and < 5 for D1-like and D2-like receptors, respectively). A 77636 exhibits anti-Parkinsonian activity following oral administration in vivo. Uses: Potential treatment of neurological disorders. Alternative Names: A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride; (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride. Grades: ≥98% by HPLC. CAS No. 145307-34-2. Molecular formula: C20H27NO3.HCl. Mole weight: 365.9. | |
| A 779 | A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor) (IC50 = 0.3 nM) with no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Alternative Names: A-779; A779; (D-Ala7)-Angiotensin I/II (1-7); Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH; 5-L-isoleucine-7-D-alanine-1-7-angiotensin II; 7-Ala-angiotensin (1-7); A 778; A 779; A-778; A779 peptide; angiotensin (1-7), Ala(7)-; angiotensin (1-7), alanyl(7)-; Asp-Arg-Val-Tyr-Ile-His-Ala; aspartyl-arginyl-valyl-tyrosyl-isoleucyl-histidyl-alanine. Grades: 98%. CAS No. 159432-28-7. Molecular formula: C39H60N12O11. Mole weight: 872.97. | |
| A 779 TFA | A 779 TFA is a potent angiotensin (1-7) receptor antagonist. Alternative Names: H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH.TFA; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine trifluoroacetic acid; A-779 trifluoroacetate salt; (D-Ala7)-Angiotensin I/II (1-7) Trifluoroacetate; 5-L-Isoleucine-7-D-alanine-1-7-angiotensin II trifluoroacetate; A 779 TFA. Grades: ≥95%. Molecular formula: C41H61F3N12O13. Mole weight: 987.01. | |
| A 784168 | A 784168 is a potent and selective TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin) exhibiting no activity against a range of receptors such as TRPA1, GABA, opioid, and purinergic receptors. Alternative Names: A 784168; A784168; A-784168; 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide; 1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide. Grades: ≥99% by HPLC. CAS No. 824982-41-4. Molecular formula: C19H15F6N3O3S. Mole weight: 479.4. | |
| A 790742 | A 790742. CAS No. 854755-48-9. Molecular formula: C49H65N7O7. Mole weight: 864.1. | |
| A 792611 | A 792611. CAS No. 854758-17-1. Molecular formula: C47H60N6O6. Mole weight: 805. | |
| A-7 hydrochloride | A-7 hydrochloride is a cell-permeable antagonist of calmodulin that inhibits calmodulin-activated PDE activity with an IC50 of 3 μM. Calmodulin is a calcium-dependent protein expressed in all eukaryotic cells, modulating the interaction of calcium with target proteins. Alternative Names: A-7 monohydrochloride; A 7 hydrochloride; A7 hydrochloride; N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride; N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide monoydrochloride. Grades: ≥95%. CAS No. 79127-24-5. Molecular formula: C20H29ClN2O2S.HCl. Mole weight: 433.44. | |
| A-802715 | A802715, a methylxanthine derivative, is an anti-tumor agent with a TD50 (toxic dose of 50%) of 0.9-1.1 mM. Alternative Names: 1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propylpurine-2,6-dione; 1-(5-hydroxy-5-methyl)hexyl-3-methyl-7-propylxanthine; A 80 2715; A 802715; A-802715. CAS No. 107767-58-8. Molecular formula: C16H26N4O3. Mole weight: 322.4. | |
| A-803467 | A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM). Alternative Names: A-803467; A 803467; A803467. Grades: >98%. CAS No. 944261-79-4. Molecular formula: C19H16ClNO4. Mole weight: 357.79. | |
| A 80426 | A 80426 is a potent α2-adrenoceptor antagonist and a selective 5-HT uptake inhibitor (Ki = 2.01 and 3.77 nM, respectively). It displays low affinity for a panel of structurally homologous GPCRs. Alternative Names: A-80426; A80426; (R)-2-(Benzofuran-6-yl)-N-((5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)-N-methylethanamine. Grades: >98 %. CAS No. 152148-63-5. Molecular formula: C23H27NO2. Mole weight: 349.5. | |
| A 80426 mesylate | A 80426 mesylate is a potent α2-adrenoceptor antagonist and a selective 5-HT uptake inhibitor (Ki = 2.01 and 3.77 nM, respectively). It displays low affinity for a panel of structurally homologous GPCRs. Alternative Names: A-80426 mesylate; A 80426 mesylate; A80426 mesylate; N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate. Grades: ≥98% by HPLC. CAS No. 152148-64-6. Molecular formula: C23H27NO2.CH3SO3H. Mole weight: 445.57. | |
| A 804598 | A 804598 is a potent and competitive P2X7 receptor antagonist (IC50 = 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors, respectively). Alternative Names: A-804598; A 804598; A804598. N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine; 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine. Grades: ≥99% by HPLC. CAS No. 1125758-85-1. Molecular formula: C19H17N5. Mole weight: 315.37. | |
| A-80915 A | A-80915 A is a naphthoquinone antibiotic produced by Streptomyces aculeolatus A80915. Activity against gram-positive bacteria. Alternative Names: 2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4a-dichloro-10a-((3-chloro-2,2-dimethyl-6-methylenecyclohexyl)methyl)-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2,7-trimethyl-. Grades: >98%. CAS No. 127875-60-9. Molecular formula: C26H31Cl3O5. Mole weight: 529.88. | |
| A-80915 B | A-80915 B is a naphthoquinone antibiotic produced by Streptomyces aculeolatus A80915. Activity against gram-positive bacteria. Alternative Names: Antibiotic A 80915B; Napyradiomycin A80915B. CAS No. 127875-61-0. Molecular formula: C26H29Cl3N2O5. Mole weight: 555.88. | |
| A-80915 C | A-80915 C is a naphthoquinone antibiotic produced by Streptomyces aculeolatus A80915. Activity against gram-positive bacteria. Alternative Names: 3,4a-dichloro-10a-(3-chloro-6-hydroxy-2,2,6-trimethyl-cyclohexylmethyl)-6,8-dihydroxy-2,2,7-trimethyl-3,4,4a,10a-tetrahydro-2H-benzo[g]chromene-5,10-dione. CAS No. 127875-62-1. Molecular formula: C26H33Cl3O6. Mole weight: 547.89. | |
| A-80915 D | A-80915 D is a naphthoquinone antibiotic produced by Streptomyces aculeolatus A80915. Activity against gram-positive bacteria. Alternative Names: Antibiotic A 80915D. CAS No. 127875-63-2. Molecular formula: C26H31Cl3N2O6. Mole weight: 573.89. | |
| A-80987 | A-80987. Alternative Names: 144141-97-9;A-80987;A 80987;2-Oxa-4,7,12-triazatridecan-13-oic acid, 9-hydroxy-5-(1-methylethyl)-3,6-dioxo-8,11-bis(phenylmethyl)-1-(2-pyridinyl)-, 3-pyridinylmethyl ester, (5S,8S,9S,11S)-;UNII-145DTK1W1Y;145DTK1W1Y;Ro-32-2175;pyridin-2-ylmethyl N-[(2S)-1-[[(2S,3S,5S)-3-hydroxy-1,6-diphenyl-5-(pyridin-3-ylmethoxycarbonylamino)hexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate;12-OXA-2,7,10-TRIAZATRIDECANOIC ACID, 5-HYDROXY-9-(1-METHYLETHYL)-8,11-DIOXO-3,6-BIS(PHENYLMETHYL)-13-(2-PYRIDINYL)-, 3-PYRIDINYLMETHYL ESTER, (3S,5S,6S,9S)-;SCHEMBL2771252;CHEBI:80009;DTXSID10162623;AKOS040747680;HY-19194;CS-0014936;Q27149156;2-OXA-4,7,12-TRIAZATRIDECAN-13-OIC ACID, 9-HYDROXY-5-(1-METHYLETHYL)-3,6-DIOXO-8,11-BIS(PHENYLMETHYL)-1-(2-PYRIDINYL)-, 3-PYRIDINYLMETHYL ESTER, (5S-(5R*,8R*,9R*,11R*))-;3-pyridylmethyl N-[(1S,3S,4S)-1-benzyl-3-hydroxy-4-[[(2S)-3-methyl-2-(2-pyridylmethoxycarbonylamino)butanoyl]amino]-5-phenyl-pentyl]carbamate;9-HYDROXY-5-(1-METHYLETHYL)-3,6-DIOXO-8,11-BIS(PHENYLMETHYL)-1-(2-PYRIDINYL)-2-OXA-4,7,12-TRIAZATRIDECAN-13-OIC ACID, 3-PYRIDINYLMETHYL ESTER(5S-(5R*,8R*,9R*,11R*));pyridin-3-ylmethyl N-[(2S,4S,5S)-4-hydroxy-5-[[(2S)-3-methyl-2-(pyridi n-2-ylmethoxycarbonylamino)butanoyl]amino]-1,6-diphenyl-hexan-2-yl]car bamate. CAS No. 144141-97-9. Molecular formula: C37H43N5O6. Mole weight: 653.77. | |
| A81988 | A81988 is a potent, orally active angiotensin I1 antagonist with a long duration of action whose pharmacological profile has established it as an important tool for the investigation of a variety of A11 mediated pathological conditions. Uses: Angiotensin ii type 1 receptor blockers. Alternative Names: 2-[propyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyridine-3-carboxylic acid; 2-(N-propyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyridine-3-carboxylic acid; A 81988; A-81988; A81988; Abbott 81988; Abbott-81988. CAS No. 141887-34-5. Molecular formula: C23H22N6O2. Mole weight: 414.46. | |
| A-82548A | A82548A is a macrolide antibiotic containing spiroacetal produced by Streptomyces diastatochromogenes. Alternative Names: A82548A. CAS No. 171423-45-3. Molecular formula: C47H81NO14. Mole weight: 884.14. | |
| A-82846C | A-82846C. Alternative Names: OrienticinC; UNII-604D60A94G; 112848-47-2; Dechloroeremomycin; AntibioticA-82846C; 604D60A94G. Grades: 95%. CAS No. 112848-47-2. Molecular formula: C73H90N10O26. Mole weight: 1523.5471. | |
| A-83-01 | A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Alternative Names: A8301; A 8301; A-8301. Grades: 98%. CAS No. 909910-43-6. Molecular formula: C25H19N5S. Mole weight: 421.52. | |
| A83016A | A83016A is a kinamycin antibiotic produced by an unidentified actinomycete 83016. It has activity against gram-positive bacteria such as Staphylococcus, Streptococcus, Streptococcus pneumoniae and Enterococcus. The MIC is between 0.06-4.0 μg/mL, similar to other members of the Kinamycin group. Alternative Names: 1-(Acetyloxy)-5-cyano-3,7-dihydroxy-3-methyl-6,11-dioxo-2,3,4,5,6,11-hexahydro-1H-benzo[b]carbazole-2,4-diyl bis(2-methylpropanoate). Grades: >98%. CAS No. 142383-42-4. Molecular formula: C28H28N2O10. Mole weight: 552.53. | |
| A83016F | A83016F is an Aurodox antibiotic produced by an unidentified actinomycete 83016F. It has weak antibacterial activity. Alternative Names: A-83016F; A 83016F. Grades: >98%. CAS No. 142435-72-1. Molecular formula: C37H55NO10. Mole weight: 673.83. | |
| A 83-01 sodium | A-83-01 is a small molecule inhibitor, which was found to be more potent in the inhibition of ALK5. Alternative Names: A 83-01 (sodium salt). Grades: 95%. Molecular formula: C25H19N5NaS+. Mole weight: 444.51. | |
| A83586C | A83586C is an ester peptide antibiotic produced by Streptomyces karnatakensis. It has strong anti-Gram-positive bacteria activity, and the MIC of Staphylococcus aureus and Streptococcus is 0.008-0.06 μg/mL. The IC50 for human T-cell leukemia CCRF-CEM cells is 0.0135 μg/mL. Alternative Names: Antibiotic A 83586C. Grades: >98%. CAS No. 116364-81-9. Molecular formula: C47H76N8O14. Mole weight: 977.15. | |
| A-837093 | A-837093. CAS No. 847442-84-6. Molecular formula: C24H27N3O6S2. Mole weight: 517.6. | |
| A 839977 | A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg. Alternative Names: 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine. Grades: >98 %. CAS No. 870061-27-1. Molecular formula: C19H14Cl2N6O. Mole weight: 413.26. | |
| A 841720 | A 841720 is a potent non-competitive mGlu1 receptor antagonist (IC50 = 10 nM) exhibiting 34-fold selectivity over mGluR5 and inactive to other mGluR receptors, neurotransmitter receptors, ion channels, and transporters. It inhibits complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 μmol/kg) and decreases mechanical allodynia (ED50 = 28 μmol/kg) in mouse models. Alternative Names: A-841720; A 841720; A841720; 3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one. Grades: 99%. CAS No. 869802-58-4. Molecular formula: C17H21N5OS. Mole weight: 343.45. | |
| A 844606 | A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 = 1.4 and 2.2 μM at human and rat receptors, respectively). It has no measurable effect on α4β2 nAChRs. Alternative Names: A 844606; A844606; A-844606; 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one. Grades: ≥99% by HPLC. CAS No. 861119-08-6. Molecular formula: C20H20N2O2. Mole weight: 320.38. | |
| A 848837 | A 848837. CAS No. 847442-91-5. Molecular formula: C25H29N3O6S2. Mole weight: 531.6. | |
| A 85380 dihydrochloride | A 85380 dihydrochloride is a selective α4β2 nACh receptor agonist (Ki = 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors, respectively). Alternative Names: A 85380 dihydrochloride; A85380 dihydrochloride; A-85380 dihydrochloride; 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 174740-86-4. Molecular formula: C9H12N2O.2HCl. Mole weight: 237.13. | |
| A-85783 | A-85783. CAS No. 161395-33-1. Molecular formula: C29H23FN4O2S. Mole weight: 510.58. | |
| A-859261 | A-859261. CAS No. 851523-11-0. Molecular formula: C19H20N4. Mole weight: 304.4. | |
| A-867744 | A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Alternative Names: A-867744; A 867744; A867744. Grades: >98%. CAS No. 1000279-69-5. Molecular formula: C20H19ClN2O3S. Mole weight: 402.89. | |
| A 876828 | A 876828. CAS No. 909106-60-1. Molecular formula: C30H32N4O6S2. Mole weight: 608.7. | |
| A-88696-C | A-88696-C. CAS No. 155520-96-0. | |
| A 887826 | A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). A 887826 is effective on reducing tactile allodynia in neuropathic rat models. Alternative Names: A 887826; A887826; A-887826; 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide. Grades: ≥97% by HPLC. CAS No. 1266212-81-0. Molecular formula: C26H29ClN4O3. Mole weight: 480.99. | |
| A-887826-[d8] | The labelled analogue of A 887826. A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). A 887826 is effective on reducing tactile allodynia in neuropathic rat models. Alternative Names: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl-d8)-3-pyridinyl]methyl]-3-pyridinecarboxamide; A 887826-d8. CAS No. 1794753-88-0. Molecular formula: C26H21D8ClN4O3. Mole weight: 489.04. | |
| A-893 | A-893 is an inhibitor of SMYD2, which is a lysine methyltransferase. The co-crystal structure reveals the origin of enhanced potency, and effective inhibition of p53K370 methylation in a lung carcinoma (A549) cell line. Alternative Names: A893; A 893; (R)-N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide; Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[(2R)-2-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-8-yl)-2-hydroxyethyl]amino]ethyl]-; N-Cyclohexyl-N3-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-β-alaninamide. Grades: ≥98%. CAS No. 1868232-32-9. Molecular formula: C29H38Cl2N4O4. Mole weight: 577.54. | |
| A8SGLP-1 | A8SGLP-1. CAS No. 753024-08-7. | |
| A-92 | A-92 inhibits the stress response of general control nonderepressible 2 kinase (GCN2 or EIF2AK4) (IC50 value of <0.3 μM). It is potentially used as a chemotherapeutic drug for the treatment of cancer. Uses: Potential chemotherapeutic drug. Alternative Names: A-92; A 92; A92. Grades: 99%. CAS No. 1448693-69-3. Molecular formula: C19H18N10O. Mole weight: 402.41. | |
| A922500 | A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. Alternative Names: A922500; A 922500; A-922500. Grades: >98%. CAS No. 959122-11-3. Molecular formula: C26H24N2O4. Mole weight: 428.48. | |
| A 924825 | A 924825. CAS No. 909106-97-4. Molecular formula: C33H38N4O6S2. Mole weight: 650.8. | |
| A939572 | A939572 is a effective and highly selective cell-permeable inhibitor of SCD1(stearoyl-CoA desaturase 1) which could be mediated by hormonal and dietary actions. It is under early phase clinical trials for its potential effect in obesity and diabetes. IC50. Uses: A939572 is a effective and highly selective cell-permeable inhibitor of scd1(stearoyl-coa desaturase 1) which could be mediated by hormonal and dietary actions. Alternative Names: A939572; A-939572; A 939572. SCD inhibitor; 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide; 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide; CHEMBL469169; 4-(2-CHLOROPHENOXY)-N-[3-[(METHYLAMINO)CARBONYL]PHENYL]-1-PIPERIDINECARBOXAM. Grades: 95%. CAS No. 1032229-33-6. Molecular formula: C20H22ClN3O3. Mole weight: 387.86. | |
| A 943931 | A 943931 is a potent and selective histamine H4 receptor antagonist. Alternative Names: A-943931; A 943931; A943931; D0P8DW; 4-[(3R)-3-aminopyrrolidin-1-yl]-6,7-dihydro-5H-benzo[1,2]cyclohepta[3,4-b]pyrimidin-2-amine. Grades: 99%. CAS No. 1027330-97-7. Molecular formula: C17H21N5. Mole weight: 295.38. | |
| A 943931 dihydrochloride | A 943931 dihydrochloride is a potent and selective histamine H4 receptor antagonist (pKi = 7.15 and 8.12 at human and rat receptors, respectively). A 943931 blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models. Alternative Names: A 943931 dihydrochloride; A943931 dihydrochloride; A-943931 dihydrochloride; 4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine. Grades: ≥98% by HPLC. CAS No. 1227675-50-4. Molecular formula: C17H21N5.2HCl. Mole weight: 368.31. | |
| A-966492 | A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. Alternative Names: A966492; A 966492. Grades: >98%. CAS No. 934162-61-5. Molecular formula: C18H17FN4O. Mole weight: 324.35. | |
| A 967079 | A 967079 is a selective TRPA1 channel blocker (IC50 = 67 and 289 nM at human and rat TRPA1 receptors, respectively) with 1000-fold selectivity for TRPA1 over other TRP channels. A 967079 was shown to have analgesic effects in a rat osteoarthritic pain model. Alternative Names: A-967079; A 967079; A967079; (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime; 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime. Grades: ≥98% by HPLC. CAS No. 1170613-55-4. Molecular formula: C12H14FNO. Mole weight: 207.24. | |
| A-971432 | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Alternative Names: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grades: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. | |
| A-9758 | A-9758 is an RORγ ligand and a potent and selective RORγt inverse agonist (IC50 = 5 nM), and shows strong potency against IL-17A release. A-9758 can effectively inhibit Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and effectively blocks skin and joint inflammation. Alternative Names: 4-Piperidinecarboxylic acid, 1-[2,4-dichloro-3-[[1,4-dimethyl-6-(trifluoromethyl)-1H-indol-2-yl]methyl]benzoyl]-; 1-(2,4-Dichloro-3-{[1,4-dimethyl-6-(trifluoromethyl)-1H-indol-2-yl]methyl}benzoyl)-4-piperidinecarboxylic acid. Grades: ≥95%. CAS No. 2055271-22-0. Molecular formula: C25H23Cl2F3N2O3. Mole weight: 527.36. | |
| A 987306 | A 987306 is a potent histamine H4 receptor antagonist (pKi = 8.24 and 8.47 in human and rat H4 receptors, respectively) with 162-, 620-, and > 1600-fold selectivity over human H3, H1 and H2 receptors. It suppresses zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip). Alternative Names: A 987306; A987306; A-987306; (±)-(7aR,11aR)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine. Grades: ≥98% by HPLC. CAS No. 1082954-71-9. Molecular formula: C18H25N5O. Mole weight: 327.42. | |
| A-988056 | A-988056. Alternative Names: (NZ,3R)-3-fluoro-N-[5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-1,4-benzodioxin-6-yl)-1,3-thiazol-2-ylidene]pyrrolidine-1-carboxamide; UNII-P4P3H8I844; A-988056; SCHEMBL3001634; P4P3H8I844; 1-Pyrrolidinecarboxamide,3-fluoro-N-(5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-2(3H)-thiazolylidene)-,(N(Z),3S)-. Grades: 95%. CAS No. 1000859-51-7. Molecular formula: C17H14F5N3O4S. Mole weight: 451.367776. | |
| AA 147 | AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM). Alternative Names: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide; N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide. Grades: ≥98%. CAS No. 393121-74-9. Molecular formula: C16H17NO2. Mole weight: 255.31. | |
| AA26-9 | AA26-9, synthesized based on a piperazine scaffold, is a potent and broad spectrum serine hydrolase inhibitor. Alternative Names: AA 26-9; AA-26-9; AA26-9; AA 269; AA-269; AA269; pyrrolidin-1-yl(triazol-1-yl)methanone; Pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone. CAS No. 1312782-34-5. Molecular formula: C7H10N4O. Mole weight: 166.18. | |
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