MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Tamoxifen | Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757)[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen. CAS No. 10540-29-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 100 mg * 2; 100 mg * 5; 100 mg * 10; 5 g; 10 g. Product ID: HY-13757A. |  |
| Tamoxifen Citrate | Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice[1][2][3][4][5][6]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate. CAS No. 54965-24-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-13757. | |
| Tamoxifen (Standard) | Tamoxifen (Standard) is the analytical standard of Tamoxifen (HY-13757A). This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[5]. Tamoxifen activates autophagy and induces apoptosis[4]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI 47699(Standard); (Z)-Tamoxifen(Standard); trans-Tamoxifen (Standard). CAS No. 10540-29-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-13757AR. | |
| TAMRA alkyne,5-isomer | TAMRA alkyne, 5-isomer (Compound 3) is an alkyne derivative of TAMRA and can be used for the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. TAMRA alkyne, 5-isomer contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Azide groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 945928-17-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W423080. | |
| TAMRA amine, 5-isomer hydrochloride | TAMRA amine, 5-isomer hydrochloride is a rhodamine dye with excitation/emission maximum 553/575 nm. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Uses: Scientific research. Category: Signaling pathways. CAS No. 2158336-48-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W998707. | |
| Tamra azide | Tamra azide is an azide-terminated fluorescent dye and click reaction partner. Tamra azide undergoes CuI-catalyzed cycloaddition click reaction with alkyne-functionalized nanodiamonds. After conjugation with nanodiamonds, Tamra azide serves as a fluorescent label that can be excited at a specific wavelength to exhibit characteristic luminescence (Ex/Em=555/580 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1006592-61-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W800705. | |
| TAMRA azide, 5-isomer | TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for TAMRA. The azide group of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups (Ex/Em = 555/580 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 825651-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151857. | |
| TAMRA azide, 6-isomer | TAMRA azide, 6-isomer is an isomer of TAMRA. TAMRA azide, 6-isomer is the linker of TAMRA. Uses: Scientific research. Category: Signaling pathways. CAS No. 1192590-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1306. | |
| TAMRA-Azide-PEG-biotin | TAMRA-Azide-PEG-biotin is a dye derivative of TAMRA (HY-135640). TAMRA-Azide-PEG-biotin contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1797415-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-140947. | |
| TAMRA-PEG2-Maleimide | TAMRA-PEG2-Maleimide is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond. Uses: Scientific research. Category: Signaling pathways. CAS No. 2304558-24-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W190932. | |
| TAMRA-PEG3-Azide | TAMRA-PEG3-Azide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1228100-59-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123629. | |
| TAN-452 | TAN-452 is an orally active, selective peripherally acting δ-opioid receptor (DOR) antagonist with a Ki of 0.47?nM and a Kb of 0.21?nM. TAN-452 is an antagonist for μ-opioid receptor (MOR; Ki=36.56?nM and Kb=9.43?nM) and κ-opioid receptor (KOR; Ki=5.31?nM and Kb=7.18?nM). TAN-452, a derivative of Naltrindole, demonstrates low brain penetrability and attenuates morphine-induced side effects without affecting pain control[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 892039-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136208. | |
| Tanerasertib | Tanerasertib (Compound 456) is an AKT1 inhibitor, targerting to AKT1E17K with the EC50 of 15-60 nM. Tanerasertib can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034255-93-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176299. | |
| Tanespimycin | Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90[1][5]. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-AAG; NSC 330507; CP 127374. CAS No. 75747-14-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10211. | |
| Tanezumab | Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RN-624; PF 4383119. CAS No. 880266-57-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99221. | |
| Taniborbactam | Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VNRX-5133. CAS No. 1613267-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-109124. | |
| Taniborbactam hydrochloride | Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VNRX-5133 hydrochloride. CAS No. 2244235-49-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-109124A. | |
| Tanimilast | Tanimilast (CHF-6001) is an orally active and selective phosphodiesterase 4 inhibitor (IC50=0.026 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration. Tanimilast increases cellular cAMP levels, and inhibits NF-κB signaling pathway. Tanimilast is used for the research of obstructive lung diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CHF-6001. CAS No. 1239278-59-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19929. | |
| Tannic acid | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1401-55-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-B2136. | |
| Tanruprubart | Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG1 kappa, Isotype Control (HY-P99001). The IC50 of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC50 is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ANX005. CAS No. 2065212-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990545. | |
| Tanshinone I | Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tanshinone A. CAS No. 568-73-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0134. | |
| Tanshinone IIA | Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dan Shen ketone. CAS No. 568-72-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0135. | |
| Tanuxiciclib trihydrochloride | Tanuxiciclib trihydrochloride is a cyclin dependent kinase (CDK) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1983984-11-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-145599A. | |
| Tanzisertib | Tanzisertib (CC-930) is a potent JNK1/2/3 inhibitor with IC50s of 61/7/6 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-930. CAS No. 899805-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15495. | |
| TAO Kinase inhibitor 1 | TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP 43. CAS No. 850467-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112136. | |
| Tapencarium | Tapencarium (RZL-012) is a serine/threonine kinase inhibitor. Tapencarium can reduce subcutaneous fat volume. Tapencarium is promising for research of fat-related disorders such as Dercums disease and aesthetic applications[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RZL-012; Utenpanium chloride. CAS No. 1436920-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172241. | |
| TAPI-0 | TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 163958-73-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-118694. | |
| TAPI-1 | TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 163847-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-16657. | |
| TAPI-2 | TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP[1]. TAPI-2 blocks the entry of infectious SARS-CoV[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TNF Protease Inhibitor 2. CAS No. 187034-31-7. Pack Sizes: 10 mM * 1 mL in Ethanol; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100211. | |
| Tapinarof | Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WBI-1001; Benvitimod; GSK2894512. CAS No. 79338-84-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-109044. | |
| Taplucainium chloride | Taplucainium chloride is a sodium channel blocker. Taplucainium chloride selectively inhibits nociceptors in an activated or inflammatory state. Taplucainium chloride may be used in research on chronic cough[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2489565-37-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148802. | |
| Tapotoclax | Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-176. CAS No. 1883727-34-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101565. | |
| Taq DNA polymerase | Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2304873-37-6. Pack Sizes: 500 U. Product ID: HY-E70086. | |
| Tarafenacin D-tartrate | Tarafenacin (SVT-40776) D-tartrate is an orally active, selective M3 muscarinic receptor (M3 muscarinic receptor) antagonist with 203-fold selectivity over the M2 muscarinic receptor. Tarafenacin D-tartrate does not affect atrial contraction, arterial blood pressure or arterial pressure at high doses. Tarafenacin D-tartrate can be used in the research of overactive bladder[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SVT-40776 D-tartrate. CAS No. 1159101-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14825A. | |
| Taragarestrant meglumine | Taragarestrant (D-0502) meglumine is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant meglumine shows potent activity in various ER+ breast cancer cell lines and xenograft models[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-0502 meglumine. CAS No. 2446618-18-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147402A. | |
| Taranabant | Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0364. CAS No. 701977-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-10013. | |
| Taranabant racemate | Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0364 racemate. CAS No. 701977-00-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10013A. | |
| Taraxasterol | Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1059-14-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N1178. | |
| Taraxerol | Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127-22-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2477. | |
| Tarcocimab | Tarcocimab (OG1953) is a humanized anti-VEGFA monoclonal antibody (IgG1 type). Tarcocimab is available for research in retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD). Uses: Scientific research. Category: Signaling pathways. Alternative Names: OG1953. CAS No. 2408661-40-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99576. | |
| Tarenflurbil | Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Flurbiprofen; MPC7869. CAS No. 51543-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-10291. | |
| Tarextumab | Tarextumab (OMP-59R5) is a cross-reactive, fully human IgG2 antibody that selectively inhibits Notch2 and Notch3 signaling. Tarextumab demonstrates broad-spectrum antitumor efficacy in xenograft models of epithelial tumors. Tarextumab can be used for the study of pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody. CAS No. 1359940-55-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99320. | |
| Targapremir-210 | Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM)[1]. Targapremir-210 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TGP-210. CAS No. 1049722-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15861. | |
| Targefrin | Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031514-44-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3717. | |
| Taribavirin hydrochloride | Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 40372-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10545A. | |
| Tariquidar | Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XR9576. CAS No. 206873-63-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10550. | |
| Tariquidar methanesulfonate, hydrate | Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XR9576 methanesulfonate, hydrate. CAS No. 625375-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-10550A. | |
| Tariquidar (Standard) | Tariquidar (Standard) is the analytical standard of Tariquidar. This product is intended for research and analytical applications. Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XR9576 (Standard). CAS No. 206873-63-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10550R. | |
| Tarlatamab | Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the KDs of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the KDs of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-757. CAS No. 2307488-83-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99575. | |
| Tarloxotinib bromide | Tarloxotinib bromide (TH-4000) is an irreversible EGFR/HER2 inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TH-4000. CAS No. 1636180-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17632. | |
| Tarlox-TKI | Tarlox-TKI, the active metabolite of Tarloxotinib, is an irreversible pan-ErbB TKI (Tarlox-TKI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2135696-72-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-43533. | |
| Tartrazine | Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acid Yellow 23; FD&C Yellow No. 5. CAS No. 1934-21-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-D0257. | |
| TAS0612 | TAS0612 is the orally active inhibitor of RSK, AKT and S6K. TAS0612 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2148902-58-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-157133. | |
| TAS-103 | TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-247615. CAS No. 174634-08-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13758. | |
| TAS-103 dihydrochloride | TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-247615 dihydrochloride. CAS No. 174634-09-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13758A. | |
| TAS-114 | TAS-114 is an orally active dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1198221-21-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124062. | |
| TAS-119 | TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1453099-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137377. | |
| TAS1553 | TAS1553 is a potent, orally active protein-protein interaction (PPI) inhibitor with an IC50 values of 0.0396 μM. TAS1553 inhibits DNA replication and reduces intracellular dATP pool. TAS1553 induces apoptosis. TAS1553 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2166023-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150785. | |
| TAS2R14 agonist-2 | TAS2R14 agonist-2 (compound 28.1) is a potent and selective TAS2R14 agonist with an EC50 value of 72 nM. TAS2R14 agonist-2 reveals marked selectivity over a panel of 24 non-bitter taste human G protein-coupled receptors. TAS2R14 agonist-2 can be used for the studies of asthma or chronic obstructive pulmonary disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883007-69-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153265. | |
| TAS4464 | TAS4464 is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) (IC50=0.955 nM), and also inhibits CAII with an IC50 of 0.73 μM, which is less potent than MLN4924 (HY-70062). The IC50 values of TAS4464 against other E1 enzymes UAE and SAE are 449 nM and 1280 nM, respectively. TAS4464 targets NEDD8 in an ATP-dependent manner to inhibit NAE, blocks the neddylation pathway, causes accumulation of CRL ubiquitin ligase substrates (such as CDT1, p27, phosphorylated IκBα), and further induces tumor cell apoptosis. TAS4464 exhibits antiproliferative and cytotoxic effects, and has broad-spectrum antitumor activity against various hematologic and solid tumor cell lines as well as patient-derived tumor cells. TAS4464 has a wide selcetive window, without obvious toxicity. TAS4464 can be used in the research of hematologic malignancies (leukemia, lymphoma, multiple myeloma, etc.) and solid tumors (small cell lung cancer, colorectal cancer, sarcoma, endometrial cancer, ovarian cancer, etc.)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1848959-10-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-128586. | |
| Taselisib | Taselisib (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with Kis of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0032; RG-7604. CAS No. 1282512-48-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13898. | |
| Tasimelteon | Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-214778; VEC-162. CAS No. 609799-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14803. | |
| TASIN-1 | TASIN-1 is a selective inhibitor of truncated APCTR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC mutant colorectal cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 792927-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116572A. | |
| TASIN-30 | TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1678515-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164561. | |
| Tasisulam | Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 573636. CAS No. 519055-62-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14804. | |
| Tasosartan | Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WAY-ANA 756. CAS No. 145733-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-A0250. | |
| Taspoglutide | Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC50 value of 0.06 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITM077; R1583; BIM51077. CAS No. 275371-94-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0165. | |
| Tasquinimod | Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABR-215050. CAS No. 254964-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10528. | |
| TAT | TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAT(47-57); HIV-1 TAT protein (47-57). CAS No. 191936-91-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0281. | |
| TAT-amide | TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 697226-52-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2193. | |
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