MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Tat-beclin 1 | Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1423821-88-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P2260. |  |
| TAT-cyclo-CLLFVY | TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1446322-66-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1420. | |
| TAT-EE3 | TAT-EE3 is a neuroprotective peptide which can uncouple TRPM2-NMDARs interaction. TAT-EE3 inhibits TRPM2-induced enhancement of NMDAR surface expression and current amplitude.TAT-EE3 protects neurons against ischemic injury in vitro and in vivo. TAT-EE3can be used for the study of ischemic stroke[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2899218-49-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11117. | |
| TAT-Gap19 | TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1507930-54-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1136B. | |
| TAT-GluA2 3Y | TAT-GluA2 3Y is a blood-brain barrier-permeable AMPA receptor inhibitory peptide that crosses cell membranes via the HIV-1 TAT protein domain. TAT-GluA2 3Y blocks the endocytosis of AMPA receptors, including the internalization of GluA1/GluA2 subunits, by disrupting interactions with the AP2, Brag2 and Syt3-GluA2 complexes, while also inhibiting long-term depression. TAT-GluA2 3Y blocks hypoxia-mediated AMPAR internalization, alleviates A1R-induced persistent synaptic inhibition, and reduces cerebral ischemic volume, neurological deficits and spatial memory deficits. TAT-GluA2 3Y blocks the effect of NLRP3 deficiency on fear generalization, inhibits amphetamine-induced behavioral/neurochemical sensitization, weakens the unconditioned stimulus-conditioned stimulus association of morphine, and promotes the extinction of morphine CPP. TAT-GluA2 3Y can be used in studies related to fear generalization, ischemic stroke, hypoxia, drug addiction and opioid addiction[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1404188-93-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2259. | |
| TAT-HA2 Fusion Peptide | TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide is a transactivator of transcription and hemaglutanin for endosomal release. TAT-HA2 Fusion Peptide enhances cellular uptake of macromolecules[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 923954-79-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P4108. | |
| TAT-M2NX | TAT-M2NX (tatM2NX) is a selective inhibitor targeting human TRPM2 channels and exerts inhibitory effects on ischemic stroke. TAT-M2NX reduces H2O2-induced calcium influx via TRPM2 channels. After traumatic brain injury in mice, TAT-M2NX preserves hippocampal long-term potentiation, improves memory function, and reduces infarct volume after middle cerebral artery occlusion, but it shows no effect on female mice. TAT-M2NX can be used in studies related to traumatic brain injury and ischemic stroke[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: tatM2NX. CAS No. 2126166-03-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P5883. | |
| Tat-NR2B9c | Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1][2][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tat-NR2Bct; NA-1. CAS No. 500992-11-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0117. | |
| Tat-NR2B9c TFA | Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tat-NR2Bct TFA; NA-1 TFA. CAS No. 1834571-04-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0117A. | |
| TAT-P110 | TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P110. CAS No. 2247617-97-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2280. | |
| TAT-PiET-PROTAC | TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445), which is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can reduce BRD4 and JMJD6 levels and inhibit cell proliferation. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells. TAT-PiET-PROTAC can be used for the research of cancer, such as breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036046-04-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P10446. | |
| TAU-IN-1 | TAU-IN-1 (compound 051) is a TAU protein inhibitor with an EC50 value of 325 nM. TAU-IN-1 can be used in the study of neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1383373-65-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13486. | |
| TAU-IN-4 | TAU-IN-4 (compound I1.21) is a potent Tau aggregation inhibitor with a KD of 1.58 μM. TAU-IN-4 can be used in the study of Alzheimers disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2109305-45-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172973. | |
| TAU-IN-5 | TAU-IN-5 (compound 13) is a TAU protein inhibitor with an EC50 of 0.81 μM. TAU-IN-5 inhibits the formation of tau (2N4R isoform) oligomers and reduces the formation of tau dimers. TAU-IN-5 can be used in the study of Alzheimer's disease (AD) and Parkinson's disease (PD)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3118812-61-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-175840. | |
| Tau ligand-1 | Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier[1]. In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM[1]. Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3063166-64-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-173291. | |
| Tau Peptide (255-314) (Repeat 2 Domain) (human) | Tau Peptide (255-314) (Repeat 2 Domain) (human) (Tau-F protein (255-314)) is a polypeptide. Tau Peptide (255-314) (human) is the 255-314 fragment of Tau-F (also known as Tau-4, the 2N4 isoform), a major isoform of the Tau protein. Tau Peptide (255-314) (human) contains two core driving sequences for Tau aggregation, namely PHF6* (275-280, VQIINK) and PHF6 (306-311, VQIVYK), and spans the C-terminal half of repeat domain R1, the entire repeat domain R2, and the N-terminal half of repeat domain R3 within the microtubule-binding region (MTBR). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tau-F protein (255-314). CAS No. 2022995-68-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P4933. | |
| Tau Peptide (306-336) (Repeat 3 Domain) | Tau Peptide (306-336) (Repeat 3 Domain) is aTau fragment. Uses: Scientific research. Category: Signaling pathways. CAS No. 330456-26-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4966. | |
| Tau Peptide (337-368) (Repeat 4 Domain) | Tau Peptide (337-368) (Repeat 4 Domain) is a 32-amino acid peptide derived from the fourth microtubule-binding repeat sequence (R4) of the tau protein. Tau Peptide (337-368) (Repeat 4 Domain) can be used in research on neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 330456-27-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4968. | |
| Tau protein aggregation-IN-1 | Tau protein aggregation-IN-1 (Compound 0c) is a Tau protein aggregation inhibitor. Tau protein aggregation-IN-1 can be used in the study of protein folding disorders such as Alzheimer's disease, dementia, Parkinson's disease, Huntington's disease and prion-based spongiform encephalopathies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 916179-45-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153427. | |
| Taurine | Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Aminoethanesulfonic acid. CAS No. 107-35-7. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g. Product ID: HY-B0351. | |
| Taurine-13C2 | Taurine-13C2 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Aminoethanesulfonic acid-13C2. CAS No. 70155-54-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0351S1. | |
| Taurine-d4 | Taurine-d4 is the deuterium labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Aminoethanesulfonic acid-d4. CAS No. 342611-14-7. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-B0351S. | |
| Tauro-α-muricholic acid | Tauro-α-muricholic acid (T-α-MCA) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid is a FXR antagonist with an IC50?of ?28 μM. Tauro-α-muricholic acid attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T-α-MCA. CAS No. 25613-05-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-133890. | |
| Tauro-α-muricholic acid sodium | Tauro-α-muricholic acid sodium (T-α-MCA sodium) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid sodium is a FXR antagonist with an IC50?of ?28 μM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T-α-MCA sodium. CAS No. 2260905-08-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-133890A. | |
| Tauro-β-muricholic acid | Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TβMCA. CAS No. 25696-60-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; | |
| Tauro-β-muricholic acid sodium | Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T-βMCA sodium. CAS No. 145022-92-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135103. | |
| Taurochenodeoxycholic acid | Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 12-Deoxycholyltaurine. CAS No. 516-35-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N2027. | |
| Taurochenodeoxycholic acid-d4 sodium | Taurochenodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 12-Deoxycholyltaurine-d4 sodium. CAS No. 2410279-85-3. Pack Sizes: 1 mg. Product ID: HY-N2027S. | |
| Taurochenodeoxycholic acid sodium | Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 12-Deoxycholyltaurine sodium. CAS No. 6009-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-N1429. | |
| Taurocholic acid | Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: N-Choloyltaurine. CAS No. 81-24-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1788. | |
| Taurocholic acid-d4 sodium | Taurocholic acid-d4 (sodium) is the deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Choloyltaurine-d4 sodium. CAS No. 2410279-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1788S. | |
| Taurocholic acid sodium | Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Sodium taurocholate; N-Choloyltaurine sodium. CAS No. 145-42-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-N0545. | |
| Taurocholic acid sodium salt hydrate | Taurocholic acid (N-Choloyltaurine) sodium salt hydrate has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium salt hydrate has immunoregulation effect[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Sodium taurocholate hydrate; N-Choloyltaurine sodium salt hydrate. CAS No. 345909-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B1131. | |
| Taurodehydrocholic acid sodium | Taurodehydrocholic acid sodium is a biliary cholesterol secretion activator. Taurodehydrocholic acid sodium significantly increases the expression of Abcg5 and decreases the expression of abc8. Taurodehydrocholic acid sodium can be used in the study of cholesterol metabolism[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57011-24-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N9516A. | |
| Taurodeoxycholate sodium | Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1180-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg. Product ID: HY-128853. | |
| Taurodeoxycholic acid | Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Taurodeoxycholate. CAS No. 516-50-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B1899. | |
| Taurohyocholic acid | Taurohyocholic acid is a taurine-conjugated hyocholic acid. Taurohyocholic acid is predictor of the efficacy of tyrosine kinase inhibitors combined withPD-1 inhibitors in hepatocellular carcinoma (HCC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: THCA. CAS No. 32747-07-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121799. | |
| Taurolidine | Taurolidine is a potent antimicrobial and anticancer agent. Taurolidine inhibits cell proliferation. Taurolidine induces apoptosis and autophagy. Taurolidine rescues mice from sepsis-associated lethality[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19388-87-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-W011522. | |
| Taurolithocholic acid | Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 516-90-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-113308. | |
| Taurolithocholic acid 3-sulfate disodium | Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6 ?and 69.4 (absence of Zn2+) and 9 and 9.6 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Sulfotaurolithocholic acid disodium. CAS No. 64936-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-137255. | |
| Taurolithocholic acid sodium salt | Taurolithocholic acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6042-32-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113308A. | |
| Tauro-ω-muricholic acid sodium | Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TωMCA sodium. CAS No. 2456348-84-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136066. | |
| Tauroursodeoxycholate | Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tauroursodeoxycholic acid; TUDCA; UR 906. CAS No. 14605-22-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-19696. | |
| Tauroursodeoxycholate-d4 | Tauroursodeoxycholate-d4 is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tauroursodeoxycholic acid-d4; TUDCA-d4; UR 906-d4. CAS No. 2410279-94-4. Pack Sizes: 100 μg (198.52 μM * 1 mL in Methanol); 1 mg; 5 mg. Product ID: HY-19696S1. | |
| Tauroursodeoxycholate dihydrate | Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease[1][2][3][4][5][6][7][8][9][10]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate. CAS No. 117609-50-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-19696B. | |
| Tauroursodeoxycholate sodium | Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium. CAS No. 35807-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-19696A. | |
| Tauroursodeoxycholate sodium (Standard) | Tauroursodeoxycholate (sodium) (Standard) is the analytical standard of Tauroursodeoxycholate (sodium). This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tauroursodeoxycholic acid sodium (Standard); TUDCA sodium (Standard); UR 906 sodium (Standard). CAS No. 35807-85-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19696AR. | |
| Tau tracer 2 | Tau tracer 2 (PI-2620) is a Tau tracer used for imaging Tau protein aggregates. Tau tracer 2 can be used to diagnose neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PI-2620. CAS No. 2173361-80-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134880. | |
| Tavaborole | Tavaborole (AN-2690) is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AN-2690. CAS No. 174671-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10980. | |
| Tavapadon | Tavapadon (PF-06649751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06649751; CVL-751. CAS No. 1643489-24-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119486. | |
| Tavilermide | Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MIM-D3. CAS No. 263251-78-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17622. | |
| Taxifolin | Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Dihydroquercetin; (+)-Taxifolin. CAS No. 480-18-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-N0136. | |
| Taxifolin (Standard) | Taxifolin (Standard) is the analytical standard of Taxifolin. This product is intended for research and analytical applications. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Dihydroquercetin (Standard); (+)-Taxifolin (Standard). CAS No. 480-18-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0136R. | |
| Tazarotene | Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGN 190168. CAS No. 118292-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15388. | |
| Tazemetostat | Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EPZ-6438; E-7438. CAS No. 1403254-99-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13803. | |
| Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH | Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2750350-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147090. | |
| Tazemetostat de(methyl morpholine)-COOH | Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2, which can be used to synthesis of EZH2 degraders (PROTACs). EZH2 degraders have potent cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2685873-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147091. | |
| Tazemetostat (Standard) | Tazemetostat (Standard) is the analytical standard of Tazemetostat. This product is intended for research and analytical applications. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EPZ-6438 (Standard); E-7438 (Standard). CAS No. 1403254-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13803R. | |
| Tazobactam | Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CL-298741; YTR-830H. CAS No. 89786-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-B1418. | |
| Tazobactam sodium | Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp. Uses: Scientific research. Category: Signaling pathways. CAS No. 89785-84-2. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-W009168. | |
| Tazobactam sodium (Standard) | Flutianil (Standard) is the analytical standard of Flutianil. This product is intended for research and analytical applications. Flutianil is a fungicide, which specifically inhibits the powdery mildew species. Flutianil inhibits the haustorium formation and subsequent mycelia growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89785-84-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W009168R. | |
| TB500 | TB500 is a synthetic version of an active region of thymosin β4. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885340-08-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0170. | |
| TBAJ-587 | TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2252316-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111747. | |
| TBB | TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC50 of 0.15 μM for rat liver CK2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 231634; Casein Kinase II Inhibitor I. CAS No. 17374-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14394. | |
| TBHQ | TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2[1]. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: tert-Butylhydroquinone. CAS No. 1948-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-100489. | |
| TBI-166 | TBI-166, a riminophenazine analogue, is an orally active anti-tuberculosis agent with fewer adverse reactions than the lead riminophenazine compound, Clofazimine (HY-B1046) [1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1353734-12-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-148564. | |
| TBI-223 | TBI-223 is an orally active oxazolidinone antibiotic and an antimicrobial. TBI-223 shows activity against Mycobacterium tuberculosis (Mtb). TBI-223 exhibits an IC50 of 68 μg/mL for inhibiting mitochondrial protein synthesis (MPS) in HepG2 cells. TBI-223 is effective in three mouse models (bloodstream infection, skin infection, and bone infection) of methicillin-resistant staphylococcus aureus infection. TBI-223 can be used for the study of tuberculosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2071265-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139398. | |
| tBID | tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of 0.33 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639895-85-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100464. | |
| TBK1/IKKε-IN-2 | TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1292310-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12453. | |
| TBK1/IKKε-IN-4 | TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1381930-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124652. | |
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