MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| TDSRCVIGLYHPPLQVY | TDSRCVIGLYHPPLQVY is a disordered control peptide. TDSRCVIGLYHPPLQVY is a peptide containing the same amino acids as LP17 (HY-P3400) but in a different sequence order[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 887973-01-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3460. |  |
| TDZD-8 | TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK-3β Inhibitor I; NP 01139. CAS No. 327036-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11012. | |
| TEAD1/3/4-IN-1 | TEAD1/3/4-IN-1 is an orally active inhibitor of TEAD1/3/4. TEAD1/3/4-IN-1 inhibits the YAP/TAZ-TEAD interaction, with its EC50 being 2 nM. TEAD1/3/4-IN-1 has anti-proliferative activity against NCI-H226 cells. TEAD1/3/4-IN-1 can be used in the research of lung squamous cell carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2762619-63-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174275. | |
| TEAD-IN-1 | TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2412761-57-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137479. | |
| TEAD-IN-11 | TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032196-88-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161569. | |
| Tebanicline dihydrochloride | Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ebanicline dihydrochloride; ABT-594 dihydrochloride. CAS No. 209326-19-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14316A. | |
| Tebapivat | Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG-946; PKR activator 2. CAS No. 2283422-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-135884. | |
| Tebentafusp | Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMCgp100. CAS No. 1874157-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99339. | |
| Tebideutorexant | Tebideutorexant is an OX1R-selective inhibitor with oral bioavailability and blood-brain barrier permeability, with human OX1R pKi 8.17 and rat OX1R pKi 8.13.Tebideutorexant selectively modulates OX1R, with no significant functional effect on OX2R. Tebideutorexant can be used for the research of panic and anxiety disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-61393215. CAS No. 1637681-55-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147403S. | |
| Tebipenem | Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LJC 11036. CAS No. 161715-21-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0076. | |
| Tebipenem pivoxil | Tebipenem pivoxil (L084) is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L084. CAS No. 161715-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0396. | |
| Tebotelimab | Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGD-013. CAS No. 2245725-04-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99573. | |
| Tebuconazole (Standard) | Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 107534-96-3. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0852R. | |
| Tebufenozide | Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112410-23-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B2054. | |
| Tecaginlimab | Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BNT-312; DuoBody-CD40x-4-1BB; GEN1042. CAS No. 2253891-70-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99572. | |
| Tecalcet Hydrochloride | Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-568 hydrochloride; NPS R-568. CAS No. 177172-49-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10167A. | |
| Tecarfarin | Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ATI-5923. CAS No. 867257-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14854. | |
| Tecastemizole | Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Norastemizole. CAS No. 75970-99-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105014. | |
| Teclistamab | Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-7957; JNJ-64007957; Tecvayli. CAS No. 2119595-80-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99392. | |
| Tecotabart | HY-P990946 is an CLDN18-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: LM-102. CAS No. 2823329-10-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990946. | |
| Tecovirimat | Tecovirimat (ST-246) is an orally bioavailable and selective compound against orthopoxviruses including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ST-246. CAS No. 869572-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14805. | |
| Tecovirimat monohydrate | Tecovirimat (ST-246) monohydrate is the monohydrate form of Tecovirimat (HY-14805). Tecovirimat monohydrate is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat monohydrate is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat monohydrate targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat monohydrate exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat monohydrate could be used in the study for orthopoxvirus-induced diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ST-246 monohydrate. CAS No. 1162664-19-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14805A. | |
| Tectol | Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24449-39-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7634. | |
| Tectoridin | Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 611-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0791. | |
| Tectorigenin | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria lobate Benth. Uses: Scientific research. Category: Natural products. CAS No. 548-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0792. | |
| TED-347 | TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4?Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2378626-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125269. | |
| Tedizolid | Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TR 700; Torezolid; DA-7157. CAS No. 856866-72-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14855. | |
| Tedizolid phosphate | Tedizolid phosphate (TR-701FA) is a MAO-A and MAO-B inhibitor with activity against Gram-positive bacteria[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TR-701FA. CAS No. 856867-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14855B. | |
| Teduglutide | Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALX-0600. CAS No. 197922-42-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1624. | |
| Tegafur | Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FT 207; NSC 148958. CAS No. 17902-23-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-17400. | |
| Tegaserod | Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 145158-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14153. | |
| Tegaserod maleate | Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod maleate has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SDZ-HTF-919; HTF-919. CAS No. 189188-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-14153A. | |
| Tegatrabetan | Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tegavivint; BC2059. CAS No. 1227637-23-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109103. | |
| Tegeprotafib | Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PTPN2/1-IN-1. CAS No. 2407610-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153446. | |
| Teglicar | Teglicar is a selective and reversible orally active liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor with an IC50 value of 0.68 μM and a Ki value of 0.36 μM. Teglicar has a potential antihyperglycemic propert. Teglicar can be used for the research of diabetes and neurodegenerative disease including Huntington's disease (HD)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 250694-07-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-16482. | |
| Tegobuvir | Tegobuvir is a specific, covalent inhibitor of the HCV NS5B polymerase. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS 333126; GS-9190. CAS No. 1000787-75-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10544. | |
| Tegoprazan | Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a reversible, orally active and highly selective inhibitor of gastric H+/K+-ATPase. Tegoprazan inhibits gastric acid secretion and motility against porcine, canine and human H+/K+-ATPase with IC50 values ranging from 0.29-0.52 μM in vitro. Tegoprazan significantly improves colitis and enhances the intestinal epithelial barrier function in mice. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CJ-12420; RQ-00000004. CAS No. 942195-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17623. | |
| Tegoprubart | Tegoprubart (AT-1501) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT-1501. CAS No. 2628092-47-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990083. | |
| TEI-9647 | TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 173388-20-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12398. | |
| Teicoplanin | Teicoplanin is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Antibiotic MDL-507; MDL-507. CAS No. 61036-62-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0097. | |
| Telacebec | Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Q203; IAP6. CAS No. 1334719-95-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101040. | |
| Telaglenastat | Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CB-839. CAS No. 1439399-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-12248. | |
| Telaprevir | Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide[1][2][3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-950. CAS No. 402957-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10235. | |
| Telatinib | Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR2, VEGFR3, PDGFα, and c-Kit with IC50s of 6, 4, 15 and 1 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bay 57-9352. CAS No. 332012-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10527. | |
| Telavancin hydrochloride | Telavancin hydrochloride is the hydrochloride form of Telavancin (HY-112959). Telavancin hydrochloride is a semisynthetic derivative of vancomycin, and exhibits antibacterial efficacy through inhibition of cell wall synthesis and disruption of cell membrane barrier function. Telavancin hydrochloride is efficient against antibiotic resistant S. aureus strains MRSA, VISA, and hVISA. Telavancin hydrochloride attenuates gram positive bacteria induced complicated skin and skin structure infections (cSSSI)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TD-6424 hydrochloride. CAS No. 560130-42-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-16485. | |
| Telazorlimab | Telazorlimab (GBR-830) is a humanized monoclonal antibody against OX40 costimulatory receptor on activated T cells. Telazorlimab can be used for the research of autoimmune diseases[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: GBR-830. CAS No. 2126777-87-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99570. | |
| Telcagepant | Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0974. CAS No. 781649-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-32709. | |
| Telisotuzumab | Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-700; ABBV-400 Antibody. CAS No. 1781223-80-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99391. | |
| Telisotuzumab vedotin | Telisotuzumab vedotin (ABBV-399) (Teliso-V) is an anti-c-Met antibody-drug conjugate. Telisotuzumab vedotin consists of an anti-c-Met monoclonal antibody Telisotuzumab (ABT-700) (HY-P99391) and Monomethyl Auristatin E (HY-15162). Telisotuzumab vedotin exerts antitumor activity with acceptable toxicity in vivo. Telisotuzumab vedotin can be used for non-small cell lung cancer (NSCLC) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABBV-399. CAS No. 1714088-51-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141601. | |
| Telitacicept | Telitacicept (RC18) is a fully human TACI-Fc fusion protein. Telitacicept is a dual B lymphocyte stimulator (BLyS)/APRIL (a proliferation-inducing ligand) inhibitor that effectively blocks proliferation of B lymphocytes. Telitacicept can be used in research of B-cell autoimmune disease[1]. The component ratio of this product is Active ingredient : Excipients = 1: 0.5-1: 0.8. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RC18. CAS No. 2136630-26-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99568. | |
| Telithromycin | Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMR3647; RU66647. CAS No. 191114-48-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0062. | |
| Telmisartan | Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBR 277. CAS No. 144701-48-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-13955. | |
| Telmisartan impurity 8 | Telmisartan impurity 8 is an impurity of Telmisartan. Uses: Scientific research. Category: Signaling pathways. CAS No. 1026353-20-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-Z8776. | |
| Telocinobufagin | Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na+/K+-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Telobufotoxin; Telocinobufogenin. CAS No. 472-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0885. | |
| Telomerase-IN-2 | Telomerase-IN-2 is a telomerase inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC50 of 0.89?μM. Anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1610878-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126482. | |
| Telotristat | Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LP-778902. CAS No. 1033805-28-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13055B. | |
| Telotristat ethyl | Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LX1032; LX1606. CAS No. 1033805-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13055A. | |
| Telotristat etiprate | Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LX1606 Hippurate. CAS No. 1137608-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13055. | |
| Telratolimod | Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI9197; 3M-052. CAS No. 1359993-59-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109104. | |
| Temafloxacin | Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMFX; TA-167 free acid; A-62254 free acid. CAS No. 108319-06-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-16487. | |
| Tembotrione | Tembotrione is a herbicide belonging to the HPPD (dioxygenase) inhibitor class with crop selectivity. Tembotrione effectively controls a variety of weeds including broadleaf and gramineous species by disrupting carotenoid synthesis, which leads to chlorophyll degradation and leaf whitening. Mixing Tembotrione with isoxaflutole or adding surfactants optimizes its efficacy and reduces phytotoxicity, with no residual impact on subsequent cruciferous crops, thus helping to increase maize grain yield. The activity of Tembotrione decreases under drought conditions, and under specific conditions (such as double-dose treatment), it may cause reversible yellowing and even yield reduction in crops such as poppy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 335104-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-137910. | |
| Temoporfin | Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: m-THPC; KW2345. CAS No. 122341-38-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16488. | |
| Temozolomide | Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 362856; CCRG 81045; TMZ. CAS No. 85622-93-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-17364. | |
| Temozolomide acid | Temozolomide acid is a carboxylic acid derivative of Temozolomide (HY-17364) with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113942-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-W018326. | |
| Tempo | Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2564-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-W001187. | |
| Tempol | Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Hydroxy-TEMPO. CAS No. 2226-96-2. Pack Sizes: 10 mM * 1 mL in Water; 200 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-100561. | |
| Tempone-15N,d16 | Tempone-15N,d16 is the deuterium and 15N labeled Tempone[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Oxo-Tempo-15N,d16. CAS No. 80404-14-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129242S. | |
| Temporin A | Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 188713-69-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1629. | |
| Temsavir | Temsavir (BMS-626529) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-626529. CAS No. 701213-36-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15440. | |
| Temsirolimus | Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model[8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCI-779. CAS No. 162635-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50910. | |
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