MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Theophylline | Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,3-Dimethylxanthine; Theo-24. CAS No. 58-55-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 50 g; 100 g. Product ID: HY-B0809. |  |
| Theophylline monohydrate | Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate. CAS No. 5967-84-0. Pack Sizes: 100 mg; 500 mg; 5 g. Product ID: HY-B0809A. | |
| Theralizumab | Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti-CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TGN1412; TAB08. CAS No. 906068-56-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P9975. | |
| Thermolysin, Bacillus thermoproteolyticus rokko | Thermolysin, Bacillus thermoproteolyticus rokko (EC 3.4.24.27) (TML) is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1].Optimal pH: 8.0. Considerably stable from pH 5 to 9.5.Optimal temperature : 70 °C. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EC 3.4.24.27; TML. CAS No. 9073-78-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1748. | |
| Thermopsine | Thermopsine is a quinolone-type alkaloid. Thermopsine exhibits low to moderate anti-E. faecalis activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 486-90-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N5009. | |
| Thermospermine | Thermospermine, a structural isomer of Spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 70862-11-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151224. | |
| Thiabendazole | Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tiabendazole; 2-(4-Thiazolyl)benzimidazole. CAS No. 148-79-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0263. | |
| Thiabendazole-13C6 | Thiabendazole-13C6 is the 13C6 labeled Thiabendazole. Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-(4-Thiazolyl)benzimidazole-13C6. CAS No. 2140327-29-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0263S1. | |
| Thiabendazole-d4 | Thiabendazole-d4 is a deuterated form of Thiabendazole, which is an antiseptic, antifungal and antiparasitic agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-(4-Thiazolyl)benzimidazole-d4. CAS No. 1190007-20-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0263S. | |
| Thiacetazone | Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thioacetazone; Amithiozone. CAS No. 104-06-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B1526. | |
| Thialysine hydrochloride | Thialysine (hydrochloride) is a cysteine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4099-35-8. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-122526. | |
| Thiamet G | Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA. Uses: Scientific research. Category: Signaling pathways. CAS No. 1009816-48-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12588. | |
| Thiamine hydrochloride | Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thiamine chloride hydrochloride; Vitamin B1 hydrochloride. CAS No. 67-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g. Product ID: HY-N0680. | |
| Thiamine monochloride | Thiamine monochloride (Vitamin B1) is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vitamin B1. CAS No. 59-43-8. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-A0100. | |
| Thiamine pyrophosphate | Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cocarboxylase. CAS No. 154-87-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-113076. | |
| Thiamine pyrophosphate-d3 | Thiamine pyrophosphate-d3 is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Uses: Scientific research. Category: Signaling pathways. CAS No. 2483831-79-2. Pack Sizes: 1 mg. Product ID: HY-113076S. | |
| Thiazole Orange | Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λex = 510 nm (488 nm and 470 nm also show strong excitation) and λem = 527 nm, respectively[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 107091-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-D0150. | |
| Thiazole orange dimer YOYO 1 | Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA). Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm). Uses: Scientific research. Category: Signaling pathways. Alternative Names: YOYO 1; YOYO1. CAS No. 143413-85-8. Pack Sizes: 635 μg (5 mM * 100 μL in DMSO). Product ID: HY-D0916. | |
| Thiazolyl Blue | Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide. CAS No. 298-93-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-15924. | |
| Thiazovivin | Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226056-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13257. | |
| Thiazovivin (GMP) | Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226056-71-8. Pack Sizes: 10 mg; 50 mg. Product ID: HY-13257G. | |
| Thidiazuron | Thidiazuron is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 51707-55-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-B0872. | |
| Thiethylperazine dimaleate | Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1179-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1794A. | |
| Thioacetamide | Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model[1][2][3][4]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Acetothioamide; TAA; Thiacetamide. CAS No. 62-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-Y0698. | |
| Thiocarbonyldiimidazole | Thiocarbonyldiimidazole is a synthetic chemical reagent that serves as a nitrogen-containing MOF ligand for synthetic applications. Thiocarbonyldiimidazole enables the preparation of thiocarbonyl imidazolides from alcohols, and is used in the Barton-McCombie deoxygenation reaction and natural product synthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6160-65-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y0689. | |
| Thiocarlide | Thiocarlide is a potent antibacterial agent. Thiocarlide inhibits Mycobacterium tuberculosis H37Rv, Mycobacterium bovisBCG, Mycobacterium avium, and Mycobacterium aurum A+ with MICs of 2.5, 0.5, 2.0 and 2.0 μg/mL, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isoxyl. CAS No. 910-86-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113784. | |
| Thiodigalactoside | Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TDG. CAS No. 51555-87-4. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 25 mg. Product ID: HY-130208. | |
| Thioflavine S | Thioflavine S is a fluorescent histochemical marker of dense core senile plaques. Thioflavine S can be used for Alzheimer's research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thioflavin S; Direct Yellow 7. CAS No. 1326-12-1. Pack Sizes: 100 mg. Product ID: HY-D0972. | |
| Thioflavin T | Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free); ~450 nm (bound); Emission max.: ~445 nm (free); ~485 nm (bound)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Basic Yellow 1. CAS No. 2390-54-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-D0218. | |
| Thiolactomycin | Thiolactomycin is an orally active bacterial type II fatty acid synthase (FAS-II) inhibitor with antibacterial and antimalarial activities. Thiolactomycin specifically targets KasA/KasB in mycobacteria and FabB/FabF in bacteria, thereby inhibiting the biosynthesis of fatty acids and mycolic acids. Thiolactomycin can be used in studies related to tuberculosis, systemic bacterial infections, and experimental pyelonephritis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 82079-32-1. Pack Sizes: 1 mg. Product ID: HY-122394. | |
| ThioLox | ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1202193-89-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139196. | |
| Thiol-PEG2-thiol | Thiol-PEG2-thiol is a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 14970-87-7. Pack Sizes: 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-W022204. | |
| Thiol-PEG4-alcohol | Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-PEG4-OH. CAS No. 90952-27-5. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-133292. | |
| Thiol-PEG4-NH2 hydrochloride | Thiol-PEG4-NH2 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SH-PEG4-NH2 hydrochloride. CAS No. 2762393-21-3. Pack Sizes: 25 mg; 50 mg. Product ID: HY-138446. | |
| Thiol-PEG8-acid | Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 866889-02-3. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-130542. | |
| Thiolutin | Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetopyrrothin. CAS No. 87-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N6712. | |
| Thiomuscimol | Thiomuscimol is a GABAA receptor agonist (IC50=19 nM). It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex. Uses: Scientific research. Category: Signaling pathways. CAS No. 62020-54-6. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-129927. | |
| Thionicotinamide adenine dinucleotide | Thionicotinamide adenine dinucleotide (Thio-NAD) is a thione-modified analog of the coenzyme nicotinamide adenine dinucleotide (NAD+). Thionicotinamide adenine dinucleotide can replace NAD+ in enzymatic reactions and shift the absorption peak to 405 nM, enabling sensitive, real-time kinetic detection of enzyme activity, which is particularly suitable for high-sensitivity diagnostic cyclic detection systems[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thio-NAD. CAS No. 4090-29-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-131924. | |
| Thioperamide | Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release. Thioperamide inhibits [3H]histamine synthesis with a Ki of 31 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MR-12842. CAS No. 106243-16-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-12206. | |
| Thioperamide maleate | Thioperamide maleate (MR-12842 maleate) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release. Thioperamide maleate inhibits [3H]histamine synthesis with a Ki of 31 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MR-12842 maleate. CAS No. 148440-81-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-12206A. | |
| Thiophanate-Methyl | Thiophanate-Methyl is a pesticide residue and fungicide. Thiophanate-Methyl induces hepatotoxicity via caspase-3-mediated apoptosis and oxidative stress, thereby causing metabolic imbalance in the liver of zebrafish. Thiophanate-Methyl impairs the rhizobacteria-mediated defense response of cucumber against fusarium wilt[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23564-05-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B0842. | |
| Thiophene-2 | Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 420089-51-6. Pack Sizes: 5 mg. Product ID: HY-117145. | |
| Thiophene-2-amidoxime | Thiophene-2-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis. Uses: Scientific research. Category: Signaling pathways. CAS No. 108443-93-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-117052. | |
| Thioproperazine | Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP 7843; SKF 5883; Thioperazine. CAS No. 316-81-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0151. | |
| Thioredoxin reductase | Thioredoxin reductase (TrxR) is a selenoprotein that plays a central role in cellular redox homeostasis by utilizing highly reactive selenocysteine ??(Sec) residues exposed to solvents at its active site. Thioredoxin reductase can be used for the study of diverse diseases, from rheumatoid arthritis and ischemia to cancer and parasitic infections[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TrxR. CAS No. 9074-14-0. Pack Sizes: 10 μg; 50 μg. Product ID: HY-P2759. | |
| Thioridazine | Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-52-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0965A. | |
| Thioridazine hydrochloride | Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0965. | |
| Thiorphan | Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 76721-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W013375. | |
| Thiostrepton | Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1393-48-2. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0990. | |
| Thio-TEPA | Thio-TEPA is a DNA alkylating agent, with antitumor activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 52-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-17574. | |
| Thioxanthone | Thioxanthone is a powerful photocatalyst for organic reactions. Thioxanthone is a heterocyclic compound with the ability to participate successfully in merger reactions with metal complexes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 492-22-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g. Product ID: HY-W039724. | |
| THIP | THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gaboxadol. CAS No. 64603-91-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10232. | |
| THIQ | THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 312637-48-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10624. | |
| THK5351 (R enantiomer) | THK5351 R enantiomer is an R enantiomer of THK5351. Uses: Scientific research. Category: Signaling pathways. CAS No. 2101218-44-2. Pack Sizes: 1 mg. Product ID: HY-101183A. | |
| Thonzonium bromide | Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 553-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1246. | |
| Thr101 | Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P).Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 727664-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124890. | |
| (Thr4,Gly7)-Oxytocin | (Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60786-59-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3467. | |
| THR-β agonist 2 | THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2440027-77-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143613. | |
| Threo-dihydrobupropion hydrochloride | Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 357637-18-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131479. | |
| Thrombin (MW 37kDa) | Thrombin (MW 37kDa) is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-4-4. Pack Sizes: 1000 U; 2000 U. Product ID: HY-114164. | |
| Thrombospondin (TSP-1)-derived CD36 binding motif | Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 138849-26-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5322. | |
| Thromboxane B3 | Thromboxane B3 is a prostaglandin analog derived from arachidonic acid (AA) in the cyclooxygenase (COX) metabolic pathway. Thromboxane B3 is generated from arachidonic acid (AA) in platelets and vascular endothelial cells through the catalysis of cyclooxygenase (COX) and thromboxane synthase (TXS). Thromboxane B3 has been reported to be formed by human platelets upon ingestion of eicosapentaenoic acid (C20: 5ω3)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71953-80-5. Pack Sizes: 25 μg (271.40 μM * 250 μL in Methyl acetate); 50 μg (271.40 μM * 500 μL in Methyl acetate); 100 μg (271.40 μM * 1 mL in Methyl acetate). Product ID: HY-113445. | |
| THRX-144644 | THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2442519-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-150169. | |
| THS-044 | THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 can be used for the study of diseases related to hypoxia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62054-67-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19621. | |
| THX6 | THX6 is an hClpP activator with an EC50 of 1.18 μM. THX6 improves off-target profile with no affinity for hD2R and only weak affinity for hD3R (Ki = 51.1 μM) in HEK293 cells. THX6 shows good cytotoxicity in ONC201-resistant cells with an IC50 of 0.13 μM. THX6 changes the levels of fatty acids (PUFAs, MUFAs, and SFAs) in DIPG cells. THX6 decreases the level of proteins involved in oxidative phosphorylation, biogenesis, and mitophagy proteins, thereby resulting in a global collapse of mitochondrial integrity and function. THX6 can be used for diffuse intrinsic pontine glioma research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076954-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172199. | |
| THX-B | THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1372206-64-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137322. | |
| Thymalfasin | Thymalfasin is an immunomodulating agent able to enhance the Thl immune response. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thymosin α1. CAS No. 62304-98-7. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0091. | |
| Thymidine | Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DThyd; NSC 21548. CAS No. 50-89-5. Pack Sizes: 500 mg; 1 g. Product ID: HY-N1150. | |
| Thymidine-13C | Thymidine-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1] | |
| Thymidine-13C10,15N2 | Thymidine-13C10,15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DThyd-13C10,15N2; NSC-13C10,15N2. CAS No. 1821188-00-4. Pack Sizes: 1 mg. Product ID: HY-N1150S8. | |
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