MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Thymidine-13C5 | Thymidine-13C5 (DThyd-13C5; NSC 21548-13C5) is 13C-labeled Thymidine (HY-N1150)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DThyd-13C5; NSC 21548-13C5. CAS No. 156968-81-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W779017. |  |
| Thymidine 3',5'-diphosphate tetrasodium | Thymidine 3',5'-diphosphate (Deoxythymidine 3,5-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deoxythymidine 3,5-diphosphate tetrasodium; pdTp tetrasodium. CAS No. 118675-87-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-115581A. | |
| Thymidine 5'-monophosphate-13C10,15N2 dilithium | Thymidine 5'-monophosphate-13C10,15N2 (Thymidine-5'-phosphate-13C10,15N2) dilithium is 13C and 15N-labeled Thymidine 5'-monophosphate (HY-W392933). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thymidine-5'-phosphate-13C10,15N2 dilithium. CAS No. 2483830-49-3. Pack Sizes: 1 mg (100 mM in 28.90 μL Tris HCl * H2O buffer pH=7.5); 5 mg (100 mM in 145 μL Tris HCl * H2O buffer pH=7.5); 10 mg (100 mM in 289 μL Tris HCl * H2O buffer pH=7.5). Product ID: HY-W392933S4. | |
| Thymidine-5'-monophosphate disodium salt | Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMP disodium salt. CAS No. 33430-62-5. Pack Sizes: 10 mM * 1 mL in Water; 100 mg. Product ID: HY-128738. | |
| Thymidine 5-monophosphate p-nitrophenyl ester sodium | Thymidine 5-monophosphate p-nitrophenyl ester sodium (Compound 2a) is the derivative of thymidine 5'-phosphate (TMP). Thymidine 5-monophosphate p-nitrophenyl ester sodium is potential as an antitumor prodrug[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 98179-10-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-137807. | |
| Thymidine (Standard) | Thymidine (Standard) is the analytical standard of Thymidine. This product is intended for research and analytical applications. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DThyd (Standard); NSC 21548 (Standard). CAS No. 50-89-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1150R. | |
| Thymol | Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89-83-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-N6810. | |
| Thymol (Standard) | Thymol (Standard) is the analytical standard of Thymol. This product is intended for research and analytical applications. Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89-83-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6810R. | |
| Thymoquinone | Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation [1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 490-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-D0803. | |
| Thyroglobulin | Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thyroglobulin from bovine. CAS No. 9010-34-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107903. | |
| Thyroid hormone receptor antagonist (1-850) | Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 251310-57-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-127024. | |
| Thyrotropin | Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4][13]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TSH; Pretiron. CAS No. 9002-71-5. Pack Sizes: 5 μg; 10 μg; 25 μg; 50 μg; 100 μg. Product ID: HY-107916. | |
| Thyroxine sulfate | Thyroxine sulfate is a thyroid hormone metabolite. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T4 Sulfate. CAS No. 77074-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101406. | |
| THZ1 | THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1604810-83-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-80013. | |
| TH-Z145 | TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2260887-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150168. | |
| THZ531 | THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1702809-17-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103618. | |
| TH-Z835 | TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766209-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-146243. | |
| THZ-P1-2 | THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2058075-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136351. | |
| TI17 | TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1005178-02-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-Q04764. | |
| Tiagabine | Tiagabine (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NO050328; NO328; TGB. CAS No. 115103-54-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0696. | |
| Tiagabine hydrochloride | Tiagabine hydrochloride (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine hydrochloride exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine hydrochloride is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride. CAS No. 145821-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0696A. | |
| Tiamulin | Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thiamutilin. CAS No. 55297-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g. Product ID: HY-B2060. | |
| Tiamulin fumarate | Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thiamutilin fumarate. CAS No. 55297-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g. Product ID: HY-B2060A. | |
| Tianeptine | Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 72797-41-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-90003. | |
| Tiapride hydrochloride | Tiapride hydrochloride is a selective and orally active D2 and D3 dopamine receptors antagonist with IC50 values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51012-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1196. | |
| Tibulizumab | Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 3090106. CAS No. 1849636-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99563. | |
| TIC10 isomer | TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONC201 isomer. CAS No. 41276-02-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15615. | |
| Ticagrelor | Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD6140; AR-C 126532XX. CAS No. 274693-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10064. | |
| Ticagrelor-d7 | Ticagrelor-d7 is the deuterium labeled Ticagrelor. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1265911-55-4. Pack Sizes: 500 μg; 1 mg. Product ID: HY-10064S. | |
| Ticlatone | Ticlatone is an antifungal that can be used for the research of mycoses[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Chlorobenzo[d]isothiazol-3(2H)-one. CAS No. 70-10-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-138136. | |
| Ticlopidine | Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PCR 5332. CAS No. 55142-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100386. | |
| Tideglusib | Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NP031112. CAS No. 865854-05-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14872. | |
| Tie2 kinase inhibitor 1 | Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 948557-43-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100556. | |
| TIE-2/VEGFR-2 kinase-IN-2 | TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 501693-48-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12572. | |
| Tienilic acid | Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ticrynafen; ANP 3624. CAS No. 40180-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-21065. | |
| Tifcemalimab | Tifcemalimab (JS004; Icatolimab) is a humanized IgG4 monoclonal antibody against BTLA (B and T lymphocyte attenuator). By binding to BTLA, tifcemalimab blocks the interaction of HVEM-BTLA, thereby inhibiting the BTLA-mediated inhibitory signaling pathway. Tifcemalimab can be used in research related to squamous cell non-small cell lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JS004; Icatolimab. CAS No. 2236068-83-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99961. | |
| Tifenazoxide | Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NN414. CAS No. 279215-43-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-119322. | |
| Tigatuzumab | Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody. CAS No. 918127-53-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99270. | |
| Tigecycline | Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannII), respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GAR-936. CAS No. 220620-09-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0117. | |
| Tigecycline hydrate | Tigecycline (GAR-936) hydrate is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline hydrate for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannII), respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GAR-936 hydrate. CAS No. 1229002-07-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0117D. | |
| Tigilanol tiglate | Tigilanol tiglate (EBC-46) is a protein kinase C (PKC)/C1 domain activator. Tigilanol tiglate is associated with mitochondrial/endoplasmic reticulum (ER) dysfunction, leading to activation of the unfolded protein response (UPRmt/ER) and subsequent induction of ATP depletion, organelles expansion, Caspase activation, gasdermin E cleavage, and terminal necrosis. Tigilanol tiglate, as a small anti-tumor molecule with immunomodulatory effects, can be used in the study of head and neck squamous cell carcinoma and soft tissue sarcoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EBC-46. CAS No. 943001-56-7. Pack Sizes: 250 μg; 500 μg; 1 mg. Product ID: HY-109076. | |
| Tiglyl carnitine | Tiglyl carnitine is found to be associated with celiac disease and mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Uses: Scientific research. Category: Signaling pathways. CAS No. 64681-36-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113408. | |
| Tilatamig | Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the Top1 inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD9592 Antibody. CAS No. 2868265-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P990947. | |
| Tilavonemab | Tilavonemab (ABBV-8E12) is a humanized anti-tau monoclonal antibody that binds to amino acids 25-30 near the N-terminus of the tau protein. Tilavonemab can block the ability of human and mouse neurons to uptake tau aggregates. Tilavonemab can be used for research on Alzheimers disease and other tauopathies[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABBV-8E12; C2N-8E12. CAS No. 2096513-89-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99163. | |
| Tildrakizumab | Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (Kd: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 900222; MK 3222; Anti-Human IL23 Recombinant Antibody. CAS No. 1326244-10-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99256. | |
| Tilfrinib | Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1600515-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-110244. | |
| Tilianin | Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects[1][2][3]. Uses: Scientific research. Category: Natural products. CAS No. 4291-60-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2555. | |
| Tilivapram | Tilivapram (AVE8112) is an orally active PDE4 inhibitor with procognitive effects. Tilivapram exhibits in vivo efficacy and improves processing speed and psychomotor speed. Oral administration of tilivapram may induce dose-related adverse reactions such as nausea and dizziness, but transdermal delivery enables slow, controlled elevation of plasma concentrations, thereby significantly reducing gastrointestinal discomfort and dizziness. Tilivapram is applicable to research related to neuropsychiatric disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AVE8112. CAS No. 166741-91-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14826. | |
| Tilogotamab | Tilogotamab is an agonistic hexamer formation-enhanced mixture of two antibodies that target two separate epitopes on death receptor type 5 (DR5). Tilogotamab specifically binds to and activates DR5. Tilogotamab can be used for the research of multiple myeloma (MM)[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: HexaBody-DR5/DR5; Hx-DR5-01/05. CAS No. 2109731-10-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99559. | |
| Tilpisertib | Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-4875. CAS No. 2065153-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137456. | |
| Tilrekimig | Tilrekimig (PF-07275315) is a monoclonal antibody targeting human interleukin-4 (IL-4), interleukin-13 (IL-13) and thymic stromal lymphopoietin (TSLP). Tilrekimig can be used in the research of allergic and inflammatory diseases, such as asthma and atopic dermatitis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-07275315. CAS No. 2981469-90-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991162. | |
| Tilsotolimod | Tilsotolimod (IMO-2125) is a TLR9 agonist. Tilsotolimod activates the TLR9 signaling pathway, triggers downstream pro-inflammatory and immunostimulatory pathways, enhances the uptake and killing of cancer cells, and induces adaptive immune responses. Tilsotolimod is applicable to research related to melanoma and colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMO-2125. CAS No. 1948266-37-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150212. | |
| Tiludronate disodium | Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tiludronic acid disodium. CAS No. 149845-07-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-A0213A. | |
| Tilvestamab | Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGB149. CAS No. 2226775-26-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99161. | |
| TIM-063 | TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2493978-38-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148757. | |
| TIM-3-IN-1 | TIM-3-IN-1 (Compound 38) is a TIM-3 inhibitor that can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883237-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139738. | |
| TIM-3-IN-2 | TIM-3-IN-2 is a TIM-3 inhibitor. TIM-3-IN-2 blocks the interactions of TIM-3 with PtdSer, CEACAM1 and Gal-9, and inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 restores IFNγ release from peripheral blood mononuclear cells. TIM-3-IN-2 inhibits the proliferation of acute myeloid leukemia cells. TIM-3-IN-2 can be used for the research of acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1113126-49-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155175. | |
| Timapiprant | Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant (OC000459) potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OC000459. CAS No. 851723-84-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15342. | |
| Timcodar | Timcodar is a macrolide agent, and studies have shown that during adipogenesis, timcodar can significantly inhibit fat accumulation, with an effect similar to that of rapamycin. However, unlike rapamycin, timcodar does not cause immunosuppression and glucose resistance. In addition, timcodar can effectively inhibit the adipogenic transcriptional regulators PPAR?? and C/EBP??, thereby inhibiting genes involved in fat accumulation. These studies lay the foundation for timcodar as a potential anti-obesity therapy, as obesity is becoming a global epidemic. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-853. CAS No. 179033-51-3. Pack Sizes: 1 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13766. | |
| Timosaponin AIII | Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 41059-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0810. | |
| Timosaponin AIII (Standard) | Timosaponin AIII (Standard) is the analytical standard of Timosaponin AIII. This product is intended for research and analytical applications. Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 41059-79-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0810R. | |
| Timosaponin BII | Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Prototimosaponin A III. CAS No. 136656-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0812. | |
| Tinengotinib | Tinengotinib (TT00420) is an orally active, spectrally selective small molecule kinase inhibitor targeting Aurora A/B (IC50=1.2-3.3 nM), FGFR1/2/3 (IC50=1.5-3.5 nM), VEGFRs, JAK1/2 and CSF1R. Tinengotinib blocks Aurora kinase-mediated cell cycle progression (inducing G2/M arrest), inhibits FGFR/JNK-JUN signaling pathway and activates MEK/ERK-dependent apoptotic pathway. Tinengotinib has the activity of anti-tumor proliferation, inducing apoptosis, inhibiting angiogenesis and regulating tumor microenvironment. Tinengotinib can be used in the study of triple-negative breast cancer (TNBC), gallbladder cancer and tumor immune microenvironment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TT 00420. CAS No. 2230490-29-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145601. | |
| Tin(II) chloride dihydrate | Tin (II) chloride dihydrate (Tinchloridedihydrate) is a hydrated salt of tin (II)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stannous chloride dihydrate; Tin dichloride dihydrate. CAS No. 10025-69-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 100 g. Product ID: HY-Y0481A. | |
| Tinlarebant | Tinlarebant (LBS-008) is an orally active non-retinoid RBP4 (retinol-binding protein 4) antagonist. Tinlarebant can be used for the research of the Stargardt disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LBS-008; BPN-14967. CAS No. 1821327-95-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123623. | |
| Tinlorafenib | Tinlorafenib (PF-07284890) is the orally active inhibitor for BRAF and CRAF with IC50s of 5.8 nM and 4.1 nM. Tinlorafenib (Compound 10) inhibits V600E mutated BRAF and V600K mutanted BRAF with IC50s of 4.25 nM and 2.7 nM. Tinlorafenib can cross the blood brain barrier. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-07284890; ARRY-461. CAS No. 2573781-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147405. | |
| Tinodasertib | Tinodasertib (ETC-206) is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ETC-206. CAS No. 1464151-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112424. | |
| Tinostamustine | Tinostamustine (EDO-S101) is a pan HDAC inhibitor; inhibits HDAC6, HDAC1, HDAC2 and HDAC3 with IC50 values of 6 nM, 9 nM, 9 nM and 25 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EDO-S101; NL-101. CAS No. 1236199-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101780. | |
| Tin protoporphyrin IX dichloride | Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX. CAS No. 14325-05-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101194. | |
| Tinurilimab | Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 1834942. CAS No. 2226224-30-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99051. | |
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