MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| TMI-1 | TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α, IL-1β, IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WAY-171318. CAS No. 287403-39-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101448. |  |
| TML-6 | TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimers disease (AD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1462868-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137315. | |
| TM-N1324 | TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39. Uses: Scientific research. Category: Signaling pathways. CAS No. 1144477-35-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108699. | |
| TMP195 | TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with Kis of 59, 60, 26, 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314891-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18361. | |
| TMP269 | TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314890-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-18360. | |
| TMP778 | TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. Uses: Scientific research. Category: Signaling pathways. CAS No. 1422053-04-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102075A. | |
| TMPD dihydrochloride | TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases[1][2]. TMPD dihydrochloride is also a complex IV substrate[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 637-01-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W012145. | |
| TMPyP4 tosylate | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2[1][2][3][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMP 1363. CAS No. 36951-72-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108477. | |
| TMPyP tetrachloride | TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K+ -free single-molecule G4-DNA nanowires via intercalation, and binds to K+ -type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92739-63-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W112938. | |
| TMRE | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tetramethylrhodamine ethyl ester perchlorate. CAS No. 115532-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0985A. | |
| TMRM Perchlorate | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T668. CAS No. 115532-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0984A. | |
| TMRM Perchlorate (solution) | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1].Solvent and concentration: DMSO: 10 mM. Uses: Scientific research. Category: Signaling pathways. CAS No. 115532-50-8. Pack Sizes: 500 μL; 1 mL. Product ID: HY-DY1042. | |
| TMS | TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC50=300 nM) and CYP1A2 (IC50=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E)-2,3',4,5'-tetramethoxystilbene. CAS No. 24144-92-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19340. | |
| TMX1 | TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the BRD4-TMX1-DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3079093-92-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153385. | |
| TMX-2039 | TMX-2039 is a pan-CDK inhibitor for both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5 and CDK6) and transcriptional CDKs (CDK7 and CDK9), with IC50s of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5 and 25 nM, respectively. TMX-2039 acts as a Ligands for Target Protein for PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488892-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151069. | |
| TMX-2172 | TMX-2172 is a selective bivalent cereblon-recruiting PROTAC-based dual CDK2 and CDK5 degrader with IC50 values of 6.5 nM and 6.8 nM, respectively. TMX-2172 shows selectivity for CDK2 and CDK5 over other cell cycle CDKs (CDK1, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). TMX-2172 inhibits CDK2/CDK5 enzymatic activity, induces their proteasomal degradation, reduces ASCL1 protein levels and half-life, induces cancer cell death, and exerts antiproliferative effects. TMX-2172 can be used for the research of ovarian cancer and small cell lung cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488892-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155218. | |
| TMX-3013 | TMX-3013 is a CDK inhibitor capable of inhibiting the activity of CDK1, CDK2, CDK4, CDK5, and CDK6, with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. TMX-3013 can be used as a target protein ligand, conjugated with the PROTAC linker and the CRBN ligand Thalidomide (HY-14658) for the synthesis of PROTAC TMX-2138 (HY-164906). TMX-3013 can also act as an effector ligand, binding to target proteins HaloTag or FKBP, and can be used in the synthesis of regulated induced proximity targeting chimeras (RIPTACs)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488761-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151071. | |
| TMX-4100 | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2367619-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145321. | |
| TMX-4113 | TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766385-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145320. | |
| TMX-4116 | TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766385-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145322. | |
| TMX-4153 | TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2867519-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153119. | |
| TNAP-IN-1 | TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC50 of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 496014-13-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14210. | |
| TNF-α (31-45), human | TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144796-71-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1860. | |
| TNF-α-IN-1 | TNF-α-IN-1 (Compound I-7) is a TNF-α inhibitor. TNF-α-IN-1 can be studied in research for cancers, heart disease, autoimmune disease and infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 444287-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112275. | |
| TNF-α-IN-2 | TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2074702-04-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134471. | |
| TNF-α-IN-6 | TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (KD = 6.8 nM). TNF-α-IN-6 has anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2699704-20-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142618. | |
| TNG260 | TNG260 is a selective, orally effective inhibitor of HDAC1 and CoREST complex, with a 10-fold selectivity for HDAC1 over HDAC3 and a 500-fold selectivity for CoREST complex over NuRD and Sin3 complex. TNG260 reshapes the tumor immune microenvironment, reduces immunosuppressive neutrophil infiltration, promotes effector T cell recruitment, and reverses anti-PD-1 resistance caused by STK11 deficiency by inhibiting the activity of the CoREST-HDAC1 complex. TNG260 induces durable tumor regression in combination with α-PD1 in MC38 tumor-bearing mice with STK11 mutations, and has lower toxicity to bone marrow cells than non-selective HDAC inhibitors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2935964-98-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153358. | |
| TNG348 | TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2839740-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160700. | |
| TNIK-IN-5 | TNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2754265-66-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143437. | |
| TNIK-IN-6 | TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC50 of 0.93 μM, that plays important roles in neurological and psychiatric disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375196-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-156817. | |
| TNIK-IN-7 | TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1417795-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156818. | |
| TNIK-IN-8 | TNIK-IN-8 (Compound 35b) is a potent, orally active TNKI inhibitor with a IC50 value of 6 nM. TNIK-IN-8 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3068941-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162314. | |
| TNP | TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 519178-28-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110079. | |
| TNP-470 | TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGM-1470. CAS No. 129298-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-101932. | |
| TNS sodium | TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-(p-Tolylamino)naphthalene-2-sulfonate sodium. CAS No. 53313-85-2. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W250727. | |
| Tobevibart | Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VIR-3434. CAS No. 2645440-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990015. | |
| Tobramycin | Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nebramycin Factor 6; Deoxykanamycin B. CAS No. 32986-56-4. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B0441. | |
| Tobramycin sulfate | Tobramycin (Nebramycin Factor 6) sulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin sulfate can be used to pneumonia research caused by Pseudomonas aeruginosa[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate. CAS No. 49842-07-1. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B0441A. | |
| Toceranib | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU11654; PHA 291639E. CAS No. 356068-94-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10330. | |
| Toceranib phosphate | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1] [2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU11654 phosphate; PHA 291639E phosphate. CAS No. 874819-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10330A. | |
| Tocilizumab | Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis[1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease)[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1. CAS No. 375823-41-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9917. | |
| Tocofersolan | Tocofersolan is synthetic polyethylene glycol derivative of α-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TPGS; D-α-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS. CAS No. 9002-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0717. | |
| Tocopherols | Tocopherols are an important class of fat-soluble vitamins, the most common form of which is gamma-tocopherol, followed by beta-tocopherol and alpha-tocopherol[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1406-66-2. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-126400. | |
| TOFA | TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ). Uses: Scientific research. Category: Signaling pathways. Alternative Names: RMI14514; MDL14514. CAS No. 54857-86-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-101068. | |
| Tofacitinib | Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tasocitinib; CP-690550. CAS No. 477600-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g. Product ID: HY-40354. | |
| Tofacitinib citrate | Tofacitinib citrate is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tasocitinib citrate; CP-690550 citrate. CAS No. 540737-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg. Product ID: HY-40354A. | |
| Tofacitinib metabolite-1 | Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1640971-51-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136336. | |
| Tofacitinib (Standard) | Tofacitinib (Standard) is the analytical standard of Tofacitinib. This product is intended for research and analytical applications. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tasocitinib (Standard); CP-690550 (Standard). CAS No. 477600-75-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-40354R. | |
| Tofersen | Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIIB067; ISIS-SOD1Rx; ISIS 333611. CAS No. 2088232-70-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132580. | |
| Tofersen sodium | Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium. CAS No. 1898254-60-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132580A. | |
| Tofisopam | Tofisopam, a 2,3-benzodiazepine compound, is an orally active anxiolytic agent. Tofisopam can inhibit phosphodiesterase PDE isoenzyme activity, withIC50 values of 2.11 μM, 1.98 μM, 0.42 μM, and 0.92 μM for PDE-2A3, PDE-3A, PDE-4A1, and PDE-10A1, respectively. Tofisopam can be used for the study of anxiety[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 22345-47-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0165. | |
| Tofogliflozin | Tofogliflozin(CSG-452) is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CSG452. CAS No. 903565-83-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14902. | |
| Tofogliflozin hydrate | Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2[1]. Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CSG-452 hydrate. CAS No. 1201913-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13413. | |
| Tolbutamide | Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 64-77-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0401. | |
| Tolcapone | Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 40-7592. CAS No. 134308-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17406. | |
| Tolebrutinib | Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR442168; PRN2246. CAS No. 1971920-73-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109192. | |
| Tolfenamic Acid | Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GEA 6414. CAS No. 13710-19-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-B0335. | |
| Tolimidone | Tolimidone is a potent and selective allosteric activator of Lyn kinase with an EC50 of 63 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MLR-1023. CAS No. 41964-07-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-59047. | |
| Tolinapant | Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP). Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASTX660. CAS No. 1799328-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109565. | |
| Tolnaftate (Standard) | Tolnaftate (Standard) is the analytical standard of Tolnaftate. This product is intended for research and analytical applications. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NP-27 (Standard). CAS No. 2398-96-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0370R. | |
| Tolprocarb | Tolprocarb is an oomyces fungicide, which has a strong inhibitory effect on rice blast fungus Magnaporthe grisea by inhibiting polyketide synthase in melanin synthesis pathway [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 911499-62-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W775186. | |
| Tolrestat | Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AY-27773. CAS No. 82964-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16500. | |
| Tolrestat (Standard) | Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AY-27773 (Standard). CAS No. 82964-04-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16500R. | |
| Tolterodine | Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583. CAS No. 124937-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0024. | |
| Tolterodine tartrate | Tolterodine tartrate (Kabi-2234) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine tartrate competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine tartrate restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine tartrate ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine tartrate can be used for the research of urinary tract infections and overactive bladder[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kabi-2234; PNU-200583E. CAS No. 124937-52-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-90010. | |
| Toltrazuril | Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-i 9142. CAS No. 69004-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0175. | |
| Toluidine Blue | Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Toluidine Blue O. CAS No. 92-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-D0220. | |
| Tolvaptan | Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-41061. CAS No. 150683-30-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17000. | |
| Tomaralimab | Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPN-305. CAS No. 1449294-76-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99555. | |
| Tomatidine | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine activates autophagy either in mammal cells or C elegans[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 77-59-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2149. | |
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