MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| TREM-1 inhibitory peptide GF9 | TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer[1][2]. Uses: Scientific research. Category: Peptides. Alternative Names: Human TREM-1(213-221). CAS No. 1289375-12-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10086. |  |
| TREM2 agonist-5 | TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimers disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3114105-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175510. | |
| TREM2-IN-1 | TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206+ and CX3CR1+ immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2000236-36-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160421. | |
| Tremelimumab | Tremelimumab (Ticilimumab) is a fully human monoclonal antibody specific for cytotoxic T-lymphocyte antigen-4 (CTLA-4) and can be used for metastatic melanoma research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ticilimumab; CP-675206. CAS No. 745013-59-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9918. | |
| Treosulfan | Treosulfan (NSC 39069) is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 39069; Treosulphan. CAS No. 299-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16503. | |
| Trepibutone | Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AA 149; Supacal. CAS No. 41826-92-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108283. | |
| Treprostinil | Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UT-15. CAS No. 81846-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100441. | |
| Treprostinil palmitil | Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INS-1009. CAS No. 1706528-83-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109163. | |
| Treprostinil sodium | Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UT-15 sodium. CAS No. 289480-64-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16504. | |
| Trequinsin hydrochloride | Trequinsin hydrochloride (HL 725) is a PDE inhibitor, CatSper channel activator, and sperm potassium channel modulator. Trequinsin hydrochloride targets PDE3 with an IC50 of <1 nM. Trequinsin hydrochloride enhances currents and elevates intracellular calcium and cGMP levels via direct activation of the CatSper channel, while inhibiting the outward current conductance of sperm potassium channels. Without inducing premature acrosome reaction, Trequinsin hydrochloride significantly enhances sperm hyperactivated motility, forward motility, and the ability to penetrate viscous media. Trequinsin hydrochloride exerts age-specific positive inotropic and positive lusitropic effects on rabbit ventricular papillary muscles. Trequinsin hydrochloride has been used in studies on the mechanisms underlying male infertility (e.g., asthenozoospermia)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HL 725. CAS No. 78416-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18740A. | |
| Trestolone | Trestolone is a synthetic anabolic-androgenic steroid (AAS) of the nandrolone (19-nortestosterone) group. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7α-Methylnandrolone. CAS No. 3764-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-101734. | |
| Tretazicar | Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CB 1954. CAS No. 21919-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13543. | |
| Trevogrumab | Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN-1033; SAR391786. CAS No. 1429201-24-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99388. | |
| Trevotamig | HY-P991034 is an EPCAM/CD3E-targeting H-γ1_L-κ-scFvhl dimer type bispecific antibody[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2920215-79-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991034. | |
| TREX1-IN-1 | TREX1-IN-1 is a TREX1 inhibitor with an IC50 value for hTREX1 less than 0.1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2756594-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160785. | |
| TRFS-green | TRFS-green is a highly selective off-on fluorescent probe for imaging selenoprotein thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. After it is activated by TrxR, the maximum absorbance shifts to around 440 nm[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1513848-14-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-115640. | |
| TRi-1 | TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 246020-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125006. | |
| TRI-611 | TRI-611 is a brain-penetrant, orally active molecular glue degrader targeting ALK. TRI-611 engages ALK via a distal degron, forms a ternary complex with CRBN, triggers ALK polyubiquitination and degradation, including TKI-resistant ALK fusion proteins. TRI-611 inhibits ALK downstream signaling pathways, induces anti-proliferative effects in ALK-positive cancer cells. TRI-611 induces regression of ALK-positive non-small cell lung cancer tumors in preclinical xenograft models. TRI-611 can be used for the research of ALK-positive non-small cell lung cancer, including TKI-refractory tumors and central nervous system metastases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3117940-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-183116. | |
| TRIA-662 | TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Methylnicotinamide chloride. CAS No. 1005-24-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-113527. | |
| TRIA-662-d3 | TRIA-662-d3 is the deuterium labeled TRIA-662[1]. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Methylnicotinamide-d3chloride. CAS No. 1218993-18-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113527S. | |
| Triacetoxyborate sodium-d | Triacetoxyborate sodium-d is the deuterium labeled Triacetoxyborate sodium. Uses: Scientific research. Category: Signaling pathways. CAS No. 347165-29-1. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-W1128514S. | |
| Triacsin C | Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C exhibits highly inhibitory effect against rotavirus replication[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WS 1228A; FR 900190. CAS No. 76896-80-5. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-N6707. | |
| Triamcinolone | Triamcinolone is a long-acting corticosteroid with anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory and neuroprotective effects through binding to glucocorticoid receptors. Triamcinolone can relieve several dermatitis, immune diseases and ocular diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0328. | |
| Triamcinolone acetonide | Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 76-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0636. | |
| Triamcinolone acetonide-d6 | Triamcinolone acetonide-d6 is deuterium labeled Triamcinolone acetonide. Uses: Scientific research. Category: Signaling pathways. CAS No. 352431-33-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0636S3. | |
| Tri(Amino-PEG3-amide)-amine | Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2523025-40-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140249. | |
| Triamterene | Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 396-01-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0575. | |
| Triapine | Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-AP; PAN-811; OCX191. CAS No. 143621-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10082. | |
| Triazabicyclodecene | Triazabicyclodecene is a bicyclic guanidine compound that can serve as a pharmaceutical intermediate for the formation of amides or esters[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5807-14-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 100 g; 500 g. Product ID: HY-59156. | |
| Triazinetriethanol | Triazinetriethanol is a volatile compound that can be found in internal can coating of food and beverages[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4719-4-4. Pack Sizes: 10 mM * 1 mL in DMSO; 250 g; 500 g; 1 k g. Product ID: HY-W018156. | |
| Tributyl phosphate-D27 | Tributyl phosphate-d27 is the deuterium labeled Tributyl phosphate[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 61196-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117600S. | |
| Tributyrin | Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glyceryl tributyrate. CAS No. 60-01-5. Pack Sizes: 5 mL; 10 mM * 1 mL in DMSO. Product ID: HY-W011404. | |
| Tricaine methanesulfonate | Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MS-222. CAS No. 886-86-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg. Product ID: HY-W011777. | |
| Tricaprilin | Tricaprilin (Trioctanoin) is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimers disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trioctanoin; Glyceryl trioctanoate. CAS No. 538-23-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B1804. | |
| Tricetin | Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 520-31-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-131592. | |
| Trichostatin A | Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TSA. CAS No. 58880-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15144. | |
| Tricin | Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 [1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 520-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1127. | |
| Tricine | Tricine is widely used as a buffer in protein electrophoresis, nucleic acid analysis, and immunology, which can help adjust pH and stabilize chemical reactions. In addition, the compound can also be used in research in certain medical fields, such as in antibody detection and drug screening. Uses: Scientific research. Category: Signaling pathways. CAS No. 5704-4-1. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g; 250 g. Product ID: HY-D0860. | |
| Triciribine | Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: API-2; NSC 154020; TCN. CAS No. 35943-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15457. | |
| Triclabendazole | Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGA89317. CAS No. 68786-66-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0621. | |
| Tricyclazole | Tricyclazole is a pentaketone melanin biosynthesis inhibitor and a unique fungicide for controlling rice blast. Tricyclazole alters the structure and function of fungal cell walls, reduces fungal pathogenicity and penetration, and causes dose-dependent liver damage in animals[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41814-78-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0848. | |
| Triethylammonium bicarbonate buffer (1.0M pH 8.5) | Triethylammonium bicarbonate is a biochemical reagent that can be used to prepare buffer solutions that maintains the stable pH environment required for processes such as enzyme-catalyzed reactions [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 15715-58-9. Pack Sizes: 1 mL; 10 mM * 1 mL in Water; 5 mL; 10 mL. Product ID: HY-W694629. | |
| Triethylene glycol | Triethylene glycol (PROTAC Linker 25) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC Linker 25. CAS No. 112-27-6. Pack Sizes: 10 mM * 1 mL in Water; 500 g; 1 k g. Product ID: HY-W017440. | |
| Trifarotene | Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ~65-fold and ~16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM), respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CD5789. CAS No. 895542-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100256. | |
| Trifloxystrobin | Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGA 279202. CAS No. 141517-21-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-123230. | |
| Triflumezopyrim | Triflumezopyrim, a mesoionic insecticide, has high efficiency at a low dosage, and is mainly used to control hopper species. Triflumezopyrim mainly acts on the nicotinic acetylcholine receptor (nAChR) inhibition, which is very highly efficient, rapidly effective, and nearly nontoxic to nontarget arthropods[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1263133-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145296. | |
| Trifluoperazine | Trifluoperazine, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine is a potent α1-adrenergic receptor antagonist. Trifluoperazine is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine can be used for the research of schizophrenia. Trifluoperazine acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-B0532. | |
| Trifluoperazine dihydrochloride | Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 440-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-B0532A. | |
| Trifluoperazine N-Glucuronide | Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UGT1A4. CAS No. 165602-90-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137083. | |
| Trifluoromethanesulfonate lithium | Trifluoromethanesulfonate (Triflate;Trifluoromethylsulfonate) lithium is a stable lithium salt and dopant with four resonance states, which is commonly used as an electrolyte component in polymer light-emitting electrochemical cells and primary lithium batteries. Trifluoromethanesulfonate lithiumalso acts as a catalyst for the preparation of the herbicide Imazapyr. In MEH-PPV-based light-emitting electrochemical cells, Trifluoromethanesulfonate lithium promotes electrochemical p-type doping at the anode interface under applied bias, thereby facilitating the formation of p-i-n junctions, exciton generation, and light emission. Trifluoromethanesulfonate lithiumexhibits strong ion pairing in non-aqueous electrolytes, but its electrochemical stability window is narrower than that of lithium bistrifluoromethylsulfonyl imidee[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Triflate lithium; Trifluoromethylsulfonate lithium; Trifluoromethanesulphonic acid lithium. CAS No. 33454-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g. Product ID: HY-21170B. | |
| Trifluralin | Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1582-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B2050. | |
| Trifluridine | Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trifluorothymidine; 5-Trifluorothymidine; TFT. CAS No. 70-00-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg. Product ID: HY-A0061. | |
| Trifluridine/tipiracil hydrochloride mixture | Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS-102; FTD/TPI. CAS No. 733030-01-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16478. | |
| Triflusal | Triflusal is an orally bioavailable, blood-brain barrier-permeable dual Cyclooxygenase-1 (COX-1)/cAMP phosphodiesterase inhibitor. Triflusal inhibits platelet aggregation, NF-κB activation, iNOS activity, and prostaglandin synthesis in ischaemic tissue. Triflusal stimulates neutrophil nitric oxide production, eNOS protein expression, and cNOS activity. Triflusal alleviates cerebral ischemic injury in rats and ameliorates pathological lesions and related gene expression in transgenic Alzheimers disease models. Triflusal can be used for the research of thromboembolic/ischemic cardiovascular and cerebrovascular diseases, and Alzheimers disease[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 322-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0531. | |
| Trifolirhizin | Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC50 value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6807-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N0616. | |
| tri-GalNAc biotin | tri-GalNAc biotin is a biotinylated ASGPR (Asialoglycoprotein receptor) ligand. tri-GalNAc biotin promotes cellular uptake of neutravidin (NA) via ASGPR. tri-GalNAc biotin delivers neutravidin to lysosomes for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3062597-46-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147102. | |
| tri-GalNAc-COOH | tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1953146-81-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139482. | |
| Tri-GalNAc-DBCO | Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2999748-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148476. | |
| Tri-GalNAc(OAc)3 | Tri-GalNAc(OAc)3 is a trivalent N-acetylgalactosamine (tri-GalNAc) derivative, which can be used as a linker to synthesize LYTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1159408-64-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148118. | |
| Trigonelline | Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trigenolline. CAS No. 535-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0414. | |
| Triheptanoin | Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UX007. CAS No. 620-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W013136. | |
| Trihydro(tetrahydrofuran)boron-d3 | Trihydro(tetrahydrofuran)boron-d3 is the deuterium labeled Trihydro(tetrahydrofuran)boron[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (T-4)-Trihydro-d3-(tetrahydrofuran)boron; Hydride-d, boron complex; Trideuterio(tetrahydrofuran)boron; Trideuteroborane-tetrahydrofuran complex. CAS No. 96220-57-4. Pack Sizes: 444.8 mg (1 M * 5 mL in THF); 889.6 mg (1 M * 10 mL in THF); 2.224 g (1 M * 25 mL in THF); 4.448 g (1 M * 50 mL in THF). Product ID: HY-Y1239S. | |
| Triiodothyronine sulfate | Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 31135-55-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126996. | |
| Triisopropylsilane, 98% | Triisopropylsilane, 98% is a strong reducing agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TIS, 98%. CAS No. 6485-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y1410. | |
| Trilaciclib | Trilaciclib (G1T28) is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: G1T28. CAS No. 1374743-00-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101467. | |
| Trilaciclib hydrochloride | Trilaciclib (G1T28) hydrochloride is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib hydrochloride can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib hydrochloride attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: G1T28 hydrochloride. CAS No. 1977495-97-8. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-101467A. | |
| Trilobatin | Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4192-90-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N4100. | |
| Trilysine | Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lys-Lys-Lys; H-Lys-Lys-Lys-OH. CAS No. 13184-14-0. Pack Sizes: 25 mg; 50 mg. Product ID: HY-W009004. | |
| Trilysine TFA | Trilysine TFA is a tripeptide and also a substrate for specific peptidases. Trilysine TFA serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lys-Lys-Lys TFA; H-Lys-Lys-Lys-OH TFA. CAS No. 3018057-84-3. Pack Sizes: 50 mg; 100 mg. Product ID: HY-W009004B. | |
| Trimebutine 3-TCBS | Trimebutine 3-TCBS (GIC-1001) is an innovative formulation designed to release hydrogen sulfide (H2S) in vivo. This compound combines trimebutine with an H2S-releasing antagonist (phenyl 3-thiocarbamate) and exhibits enhanced anti-nociceptive effects in a mouse colonic distension model, superior to conventional trimebutine. GIC-1001 can reduce visceral pain and discomfort associated with lumen distension in a dose-dependent manner, showing potential superiority[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GIC-1001. CAS No. 1456509-46-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-B0380B. | |
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