MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| TXNIP-IN-1 | TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1268955-50-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115688. |  |
| TY-52156 | TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 934369-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19736. | |
| TYA-018 | TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2653254-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153392. | |
| TYD-68 | TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways.TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359); Black: Linker (HY-W007732B); Blue: E3 ligase ligand (HY-14658); E3 ligase ligand + Linker (HY-173358))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3110703-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173357. | |
| Tyk2-IN-19 | Tyk2-IN-19 (Compound 1) is an orally active and blood-brain barrier (BBB) permeable Tyk2 inhibitor. Tyk2-IN-19 can be used for study of neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2866415-98-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161683. | |
| Tylosin | Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1401-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0519A. | |
| Tylosin tartrate | Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 74610-55-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0519. | |
| Tyloxapol | Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol is used to induce hyperlipidemia in animals[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 25301-02-4. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B1068. | |
| Tylvalosin | Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetylisovaleryltylo?sin. CAS No. 63409-12-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-128423A. | |
| Tylvalosin tartrate | Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetylisovaleryltylo?sin tartrate. CAS No. 63428-13-7. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-128423. | |
| Type I Collagen, from rat tail | Collagen, rat tail is a kind of collagen extracted from rat tail tendon tissue. Collagen, rat tail stimulates cell growth. Collagen, rat tail is often used as an attachment substrate for cell culture[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9007-34-5. Pack Sizes: 2 mL; 5 mL. Product ID: HY-NP010. | |
| Typhaneoside | Typhaneoside is an orally bioavailable signal modulator and cellular regulator. Typhaneoside regulates the PI3K/Akt/mTOR autophagy transduction pathway. Typhaneoside promotes the activation of AMP-activated protein kinase and Caspase-3, induces apoptosis, ferroptosis, autophagy, ROS accumulation, and cell cycle arrest at the G2/M phase, and reduces cancer cell viability. Typhaneoside activates the farnesoid X receptor signaling pathway, improves glucose and lipid metabolism, alleviates inflammatory responses, oxidative stress and hepatic lipid accumulation, and exerts hepatoprotective effects. Typhaneoside is applicable to research related to post-myocardial infarction heart failure, acute myeloid leukemia, non-alcoholic fatty liver disease, and neurological disorders[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104472-68-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N0712. | |
| [Tyr11]-Somatostatin | [Tyr11]-Somatostatin is a neuroavtive peptide for proteomics research. Somatostatin is one of many neuroactive substances that influence retinal physiology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59481-27-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3062. | |
| [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat | [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 198277-54-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3689. | |
| TYRA-200 | TYRA-200 is a potent and orally active FGFR2 inhibitor. TYRA-200 inhibits the kinase activity of wild-type FGFR2 and its mutants. TYRA-200 induces significant tumor regression in FGFR2-driven cancer models. TYRA-200 can be used for the research of FGFR2-altered advanced solid tumors, intrahepatic cholangiocarcinoma, and endometrial cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2823289-77-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175743. | |
| Tyramide alkyne | Tyramide alkyne is an alternative labeling substrate that can be coupled to detection or enrichment moieties via a Copper-catalyzed Azide/Alkyne Cycloaddition (CuAAC) click reaction. Tyramide alkyne can be used for ascorbate peroxidase 2 (APEX2) labeling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230051-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155639. | |
| Tyramine hydrochloride | Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60-19-5. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g. Product ID: HY-W016823. | |
| Tyramine O-sulfate sodium | Tyramine O-sulfate (Tyramine sulfate) sodium is a metabolite of Tyramine (HY-W007606) formed via sulfation, which serves as a biomarker for depression. Tyramine O-sulfate sodium can be used in the research of depression[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tyramine sulfate sodium. CAS No. 2083619-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-156836A. | |
| Tyramine oxidase, Microorganism | Tyramine oxidase, Microorganism (EC 1.4.3.4) is a copper enzyme found in the cytoplasm of animal cells that catalyzes the oxidation of phenolic amine substrates. Tyramine oxidase, Microorganism involves in the metabolism and clearance of phenolamine compounds and has an important role in maintaining homeostasis in vivo. Tyramine oxidase, Microorganism is promising for research of hypertension, asthma, and depression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37255-42-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-E70519. | |
| Tyr-Gly-Gly-Phe-Met-OH | Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Met-Enkephalin; Methionine enkephalin; Metenkefalin. CAS No. 58569-55-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0073. | |
| Tyroserleutide hydrochloride | Tyroserleutide hydrochloride is a tripeptide isolated from the degradation products of porcine spleen with antitumor activity. Tyroserleutide hydrochloride can upregulate the expression of the tumor suppressor gene PTEN and inhibit the activity of AKT and PDK1. Tyroserleutide hydrochloride inhibits tumor cell proliferation and MDM2 phosphorylation by inhibiting the PI3K/AKT pathway, and also upregulates P21, P27, P53, and induces mitochondrial damage and cell apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852982-42-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106263B. | |
| Tyrosinase, Mushroom | Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes. Tyrosinase can be used in research on Parkinson's disease, melanoma and pigmentation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyphenol oxidase. CAS No. 9002-10-2. Pack Sizes: 1 KU; 5 KU. Product ID: HY-125860. | |
| Tyrosine decarboxylase, Microorganism | Tyrosine decarboxylase, Microorganism (TDC) is a tyrosine decarboxylase produced by microorganisms. Tyrosine decarboxylase is a PLP-dependent enzyme that catalyzes the decarboxylation of L-tyrosine, L-phenylalanine, and L-dopa to produce tyramine, 2-phenethylamine, and dopamine, respectively. Tyrosine decarboxylase mediates acid stress resistance, maintains intracellular pH homeostasis, and generates proton motive force[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TDC; TyrDC. CAS No. 9002-9-9. Pack Sizes: 25 U. Product ID: HY-P2825. | |
| Tyrosol (Standard) | Tyrosol (Standard) is the analytical standard of Tyrosol. This product is intended for research and analytical applications. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 501-94-0. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-N0474R. | |
| Tyrothricin | Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1404-88-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120435. | |
| Tyrphostin AG1296 | Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG1296. CAS No. 146535-11-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13894. | |
| Tyrphostin AG 879 | Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG 879. CAS No. 148741-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-20878. | |
| TZ9 | TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1002789-86-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18643. | |
| Tz-Thalidomide | Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2087490-42-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101460. | |
| U0124 | U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 108923-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107621. | |
| U0126 | U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 109511-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12031A. | |
| U0126-EtOH | U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173097-76-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg. Product ID: HY-12031. | |
| U-104 | U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SLC-0111. CAS No. 178606-66-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13513. | |
| U18666A | U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3039-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107433. | |
| U-46619 | U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 9,11-Methanoepoxy PGH2. CAS No. 56985-40-1. Pack Sizes: 1 mg (28.5 mM * 100 μL in Methyl acetate); 5 mg (28.5 mM * 500 μL in Methyl acetate); 10 mg (28.5 mM * 1 mL in Methyl acetate). Product ID: HY-108566. | |
| (-)-U-50488 hydrochloride | (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+)?trans-(1R,2R) U-50488 (HY-15997A)?or the (±)?trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Trans-(1S,2S)-U-50488 hydrochloride. CAS No. 114528-79-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15997. | |
| (±)-U-50488 hydrochloride | (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Trans-(1R,2R)-U-50488 hydrochloride. CAS No. 67197-96-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-15997B. | |
| U-69593 | U-69593 is a potent and selective κ1-opioid receptor agonist[1]. U-69593 attenuates addictive agent-induced behavioral sensitization in the rat[2]. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice[3]. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 96744-75-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-12363. | |
| U-73122 | U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 μM for PLC. Uses: Scientific research. Category: Signaling pathways. CAS No. 112648-68-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13419. | |
| U-73343 | U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 142878-12-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-108630. | |
| U7D-1 | U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC50 of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3094177-94-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148369. | |
| UAMC-1110 | UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448440-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100684. | |
| UAMC-3203 | UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FXT-001. CAS No. 2271358-64-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112909. | |
| UAMC-3203 hydrochloride | UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FXT-001 hydrochloride. CAS No. 2271358-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112909A. | |
| UBA5-IN-1 | UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1831169-11-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148266. | |
| Ubamatamab | Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN4018. CAS No. 2305629-50-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99539. | |
| UBCS039 | UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 358721-70-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115453. | |
| UBE2T/FANCL-IN-1 | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1359415-02-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126539. | |
| Ubiquinone-1 | Ubiquinone-1 is an intermediate in the synthesis of Coenzyme Q. Ubiquinone-1 can be reduced by NADPH oxidase, hepatoma cells, Ascorbic acid (HY-B0166)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 727-81-1. Pack Sizes: 1 mg (40 mM * 100 μL in Ethanol); 5 mg (40 mM * 500 μL in Ethanol); 10 mg (40 mM * 1 mL in Ethanol); 25 mg (40 mM * 2.5 mL in Ethanol); 50 mg (40 mM * 5 mL in Ethanol); 100 mg (40 mM * 10 mL in Ethanol). Product ID: HY-113449. | |
| Ubiquitination-IN-1 | Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1819330-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135199. | |
| Ubiquitin Isopeptidase Inhibitor I, G5 | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC144303. CAS No. 108477-18-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100738. | |
| Ublituximab | Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LFB-R603; TG-1101; TGTX-1101. CAS No. 1174014-05-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99538. | |
| UBP310 | UBP310 is a selective GluR5 antagonist, with a Kd of 130 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 902464-46-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107602. | |
| UBP316 | UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a Kb value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACET. CAS No. 936095-50-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107601. | |
| Ubretid | Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Distigmine dibromide. CAS No. 15876-67-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-119577. | |
| Ubrogepant | Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-1602. CAS No. 1374248-77-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12366. | |
| UBX1325 | UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2271269-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150069. | |
| UC-1728 | UC-1728 is a potent rabbit soluble epoxide hydrolase (sEH) inhibitor, with an IC50 of 2 nM on rabbit liver. Uses: Scientific research. Category: Signaling pathways. Alternative Names: t-TUCB. CAS No. 948304-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114266. | |
| UC2288 | UC2288 is a potent and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1394011-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112780. | |
| UC-514321 | UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 299420-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120395. | |
| UC-764864 | UC-764864 is a selective UBE2N inhibitor. UC-764864 covalently binds UBE2N catalytic Cys87, blocks ubiquitin-UBE2N thioester formation and polyubiquitin chain synthesis. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates, and induces cell apoptosis. UC-764864 can be used for the research of acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 278806-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153775. | |
| UCB-5307 | UCB-5307 is a potent TNF signaling inhibitor with a KD of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1515887-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147045. | |
| UCB-6876 | UCB-6876 is a TNFα inhibitor. UCB-6876 specifically binds to the asymmetric crystalline form of TNF-α trimer with a KD of 22 μM. UCB-6876 is applicable to research related to autoimmune diseases (rheumatoid arthritis and Crohn's disease)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 637324-45-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156454. | |
| UCB-9260 | UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13?nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1515888-53-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133122. | |
| UCB9386 | UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3096082-93-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170360. | |
| Ucenprubart | Ucenprubart is an anti-CD200R1 human IgG4κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003). Uses: Scientific research. Category: Inhibitory antibodies. CAS No. 2414559-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990770. | |
| Ucf-101 | Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 313649-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125959. | |
| UCK2 Inhibitor-1 | UCK2 Inhibitor-1 (Compound 20874830-2) is a non-competitive UCK2 inhibitor with an IC50 of 4.7 μM. UCK2 Inhibitor-1 acts as a non-competitive inhibitor against uridine and ATP, and functionally inhibits the enzymatic activity of UCK2. UCK2 Inhibitor-1 suppresses the uridine salvage pathway. UCK2 Inhibitor-1 can be used in chronic myeloid leukemia research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 902289-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148394. | |
| UCK2 Inhibitor-3 | UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 μM and 16 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376687-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148396. | |
| UCL 1684 dibromide | UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 199934-16-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108579. | |
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