MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Uridine diphosphate glucuronic acid | Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a glucuronic acid donor. Uridine diphosphate glucuronic acid transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UDP-α-D-glucuronic acid. CAS No. 2616-64-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125954. |  |
| Uridine diphosphate glucuronic acid ammonium | Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UDP-α-D-glucuronic acid ammonium. CAS No. 43195-60-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-125954A. | |
| Uridine triacetate | Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine (HY-B1449). Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tri-O-acetyl uridine. CAS No. 4105-38-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-14905. | |
| Uridine triphosphate trisodium dihydrate | Uridine triphosphate (trisodium dihydrate) (UTP (trisodium dihydrate); Uridine 5'-triphosphate (trisodium dihydrate)) is a biochemical reagent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UTP trisodium dihydrate; Uridine 5'-triphosphate trisodium dihydrate. CAS No. 116295-90-0. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-107372A. | |
| Uridine triphosphate trisodium salt | Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UTP trisodium salt; Uridine 5'-triphosphate trisodium salt. CAS No. 19817-92-6. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W013093. | |
| URMC-099 | URMC-099 is an orally bioavailable and potent mixed lineage kinase type 3 (MLK3) (IC50=14 nM) inhibitor with with excellent blood-brain barrier penetration properties. Uses: Scientific research. Category: Signaling pathways. CAS No. 1229582-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12599. | |
| Urocortin, human | Urocortin, human, a 40-aa neuropeptide, acts as an agonist of endogenous CRF receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I. CAS No. 176591-49-4. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1295. | |
| Urocortin II, human | Urocortin II, human is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human has an effect of promoting satiet and neuroprotective effect. Urocortin II, human also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 351999-18-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1752. | |
| Urocortin II, mouse | Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ?100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 330648-32-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2847. | |
| Uroguanylin (human) | Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 154525-25-4. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P3099. | |
| Urolithin A | Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1143-70-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100599. | |
| Urolithin B | Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1139-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-126307. | |
| Urolithin C | Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 165393-06-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135897. | |
| Urolithin D | Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC50 of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4,8,9-Tetrahydroxy urolithin. CAS No. 131086-98-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133178. | |
| Urolithin E | Urolithin E is a biological molecule. Uses: Scientific research. Category: Signaling pathways. CAS No. 1453297-45-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W746164. | |
| Urolithin M5 | Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC50 values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Decarboxyellagic acid. CAS No. 91485-02-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N7922. | |
| Ursocholic acid | Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2955-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113212. | |
| Ursodeoxycholic acid | Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ursodeoxycholate; Ursodiol; UDCA. CAS No. 128-13-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-13771. | |
| Ursodeoxycholic acid sodium | Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium. CAS No. 2898-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-13771A. | |
| Ursodeoxycholic acid (Standard) | Ursodeoxycholic acid (Standard) is the analytical standard of Ursodeoxycholic acid. This product is intended for research and analytical applications. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ursodeoxycholate (Standard); Ursodiol (Standard); UDCA (Standard). CAS No. 128-13-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-13771R. | |
| Ursolic acid | Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Prunol; Urson; Malol. CAS No. 77-52-1. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg. Product ID: HY-N0140. | |
| Ursolic acid acetate | Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetylursolic acid; 3-Acetylursolic acid. CAS No. 7372-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N2815. | |
| Ursonic acid | Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Ketoursolic acid. CAS No. 6246-46-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1486. | |
| Usmarapride | Usmarapride (SUVN-D4010) (Example 3)is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=27.5 nM). Usmarapride (SUVN-D4010) can be used for the research of cognitive deficits associated with Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SUVN-D4010. CAS No. 1428862-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116565. | |
| Usnoflast | Usnoflast is the selective, orally active inhibitor for NLRP3 that blocks the release of IL-1β, and exhibits anti-inflammatory activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2455519-86-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-156647. | |
| USP10-IN-3 | USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 μM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3059565-11-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163622. | |
| USP15-IN-1 | USP15-IN-1 is a potent USP15 inhibitor with an IC50 value of 3.76 μM. USP15-IN-1 can be used for researching anticancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2260826-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148046. | |
| USP1-IN-2 | USP1-IN-2 (Compound I-193) is a potent ubiquitin-specific protease 1 (USP1) inhibitor with an IC50 of less than about 50 nM. USP1-IN-2 can be used for the study of cancers such as osteosarcoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098212-05-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148099. | |
| USP25/28 inhibitor AZ1 | USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZ1. CAS No. 2165322-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117370. | |
| USP28-IN-4 | USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2931509-15-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149230. | |
| USP30 inhibitor 11 | USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 μΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2067332-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111623. | |
| USP5-IN-1 | USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851040-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139979. | |
| USP7-797 | USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor (IC50=0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2, thereby increasing the stability and activity of p53, leading to cell cycle arrest and apoptosis. USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: USP7-IN-7. CAS No. 2413944-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136910. | |
| USP7 activator 1 | USP7 activator 1 (compound MS-8) is an activator of USP7 by engaging the allosteric C-terminal binding pocket of USP7[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 868940-26-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-173352. | |
| USP7-IN-11 | USP7-IN-11 is a potent ubiquitin-specific protease 7 (USP7) (Deubiquitinase) inhibitor with an IC50 of 0.37 nM. USP7-IN-11 has anticancer effects (WO2022048498A1; Example 187)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2763872-32-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-148482. | |
| USP7-IN-9 | USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2444374-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146887. | |
| USP8-IN-1 | USP8-IN-1 is a USP8 inhibitor with an IC50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI50 of 82.04 μM (CN111138358A; U10)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2477650-96-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147032. | |
| Ustekinumab | Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNTO-1275; L04AC05; TT-20. CAS No. 815610-63-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P9909. | |
| UT-155 | UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD. Uses: Scientific research. Category: Signaling pathways. CAS No. 2031161-35-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112895. | |
| UT-34 | UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC50 values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 2168525-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136242. | |
| Utidelone | Utidelone (Epothilone D) is a potent microtubule stabilizer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Epothilone D; UTD1; KOS 862. CAS No. 189453-10-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15278. | |
| Utomilumab | Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to 4-1BB/CD137. Utomilumab can be used in the research of tumors such as follicular and other CD20+ non-Hodgkin lymphomas[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF 05082566. CAS No. 1417318-27-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99056. | |
| Utreloxastat | Utreloxastat (PTC857) is an orally active and blood-brain barrier-permeable 15-lipooxygenase inhibitor. Utreloxastat is a weak inhibitor of CYP1A2 and 2B6 with an IC50 of >5.3 μM. Utreloxastat reduces oxidative stress and inhibits the consumption of reduced glutathione and ferroptosis. Utreloxastat can be used in the study of neurodegenerative diseases characterized by high levels of oxidative stress and mitochondrial pathology, such as amyotrophic lateral sclerosisc[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PTC857. CAS No. 1213269-96-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132845. | |
| UU-T02 | UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1500080-17-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117233. | |
| UV Cleavable Biotin-PEG2-Azide | UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. UV Cleavable Biotin-PEG2-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1192802-98-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140920. | |
| UVI 3003 | UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 847239-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107500. | |
| Uzansertib phosphate | Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INCB053914 phosphate. CAS No. 2088852-47-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101870B. | |
| UZH1 | UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 μM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2925713-02-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134673. | |
| UZH1a | UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. UZH1a also can be used as a chemical probe for studying METTL3[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2813577-78-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134673A. | |
| UZH2 | UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2756566-45-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115717. | |
| V-0219 | V-0219 is an orally active glucagon-like peptide-1 receptor (GLP-1R) positive allosteric modulator. V-0219 potentiates GLP-1R stimulation, and enhances GLP-1-induced cAMP production and insulin secretion. V-0219 potentiates glucose-dependent insulin secretion. V-0219 improves glucose handling in normal and diabetic rodents. V-0219 can be used for the research of obesity-associated diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878453-71-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-143312. | |
| V-0219 hydrochloride | V-0219 hydrochloride is an orally active glucagon-like peptide-1 receptor (GLP-1R) positive allosteric modulator. V-0219 hydrochloride potentiates GLP-1R stimulation, and enhances GLP-1-induced cAMP production and insulin secretion. V-0219 hydrochloride potentiates glucose-dependent insulin secretion. V-0219 hydrochloride improves glucose handling in normal and diabetic rodents. V-0219 hydrochloride can be used for the research of obesity-associated diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922283-73-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143312A. | |
| V-9302 | V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 μM) in HEK-293 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1855871-76-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112683. | |
| V-9302 hydrochloride | V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 μM) in HEK-293 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2416138-42-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112683A. | |
| Vabicaserin hydrochloride | Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCA 136. CAS No. 887258-94-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111200. | |
| Vaborbactam | Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RPX7009. CAS No. 1360457-46-0. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19930. | |
| Vactosertib | Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EW-7197; TEW-7197. CAS No. 1352608-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-19928. | |
| Vactosertib Hydrochloride | Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EW-7197 Hydrochloride; TEW-7197 Hydrochloride. CAS No. 1352610-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19928A. | |
| Vacuolin-1 | Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin?1 is a potent and selective PIKfyve inhibitor and inhibits late?stage autophagy by impairing lysosomal maturation. Vacuolin-1 can induce vacuole formation and increase the percentage of enucleated cells[1][2][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 351986-85-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-118630. | |
| Vadadustat | Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor[1]. Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PG-1016548; AKB-6548. CAS No. 1000025-07-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101277. | |
| Vadadustat (Standard) | Vadadustat (Standard) is the analytical standard of Vadadustat (HY-101277). This product is intended for research and analytical applications. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor[1]. Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PG-1016548 (Standard); AKB-6548 (Standard). CAS No. 1000025-07-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101277R. | |
| Vadastuximab | Vadastuximab (Anti-Human CD33 Recombinant Antibody) is a humanized monoclonal antibody targeting CD33. Vadastuximab can be used to synthesize an ADC compound, Vadastuximab talirine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human CD33 Recombinant Antibody. CAS No. 1436390-63-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99329. | |
| Vadimezan | Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DMXAA; ASA-404. CAS No. 117570-53-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10964. | |
| VAF347 | VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 574759-62-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135750. | |
| Vafidemstat | Vafidemstat (ORY-2001) is an oral, brain penetrant, dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ORY-2001. CAS No. 1357362-02-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-112623. | |
| VA-K-14 hydrochloride | VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1171341-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122974. | |
| VAL-083 | VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dianhydrodulcitol; Dianhydrogalactitol. CAS No. 23261-20-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16513. | |
| Valacyclovir hydrochloride | Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Valaciclovir hydrochloride. CAS No. 124832-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-17425A. | |
| Val-Ala-PAB | Val-Ala-PAB is a cleavable ADC linker that can be used for ADCs synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1343476-44-7. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 10 g. Product ID: HY-125933. | |
| Val-Ala-PABC-Exatecan | Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Val-Ala-PABC-Exatecan can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2845164-91-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147095. | |
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