MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| UNC1999 | UNC1999, a chemical probe, is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC50s of <10 nM and 45 nM, repectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1431612-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15646. |  |
| UNC2025 | UNC2025 is a potent, ATP-competitive, highly orally active and BBB-permeable Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429881-91-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12344. | |
| UNC2025 hydrochloride | UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active and BBB-permeable Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070015-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12344A. | |
| UNC2383 | UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2123481-48-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157261. | |
| UNC2400 | UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1433200-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12845. | |
| UNC2541 | UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM). UNC2541 abolishes the analgesic and anti-inflammatory effects of ozone in vivo and in vitro[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1612782-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-125510. | |
| UNC3230 | UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1031602-63-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110150. | |
| UNC3866 | UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel. Uses: Scientific research. Category: Signaling pathways. CAS No. 1872382-47-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100832. | |
| UNC5293 | UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226789-82-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132200. | |
| UNC569 | UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC569 also inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC569 can be used for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1350547-65-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117596. | |
| UNC 669 | UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314241-44-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15839. | |
| UNC6852 | UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2688842-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-130708. | |
| UNC6934 | UNC6934 is a selective NSD2-PWWP1 antagonist with a Kd of 91 nM against human targets. UNC6934 binds to the canonical methyl-lysine binding pocket of NSD2-PWWP1 and directly competes with H3K36me2 for binding. UNC6934 induces the aggregation of NSD2 within the nucleolus, without altering ribosomal RNA transcription, global H3K36me2 levels or the proliferation of KMS-11 cells. UNC6934 can be used in studies related to multiple myeloma and diffuse intrinsic pontine glioma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2561494-77-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145103. | |
| UNC7437 | UNC7437 is a inositol phosphate multikinase (IPMK) inhibitor, with an IC50 value of 26.2 nM. UNC7437 exhibits anti-proliferative activity against glioblastoma cells. UNC7437 decreases the accumulation of InsP4, InsP5, and InsP6 in cells. UNC7437 can be used for the study of TEN-negative glioblastoma models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2967647-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-175476. | |
| UNC7467 | UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922283-43-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150607. | |
| UNC8153 TFA | UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2929304-61-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157251. | |
| UNC926 | UNC926 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1184136-10-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16510. | |
| UNC9426 | UNC9426 is a potent and selective TYRO3 inhibitor (IC50 = 2.1 nM), demonstrating 276-fold and 90-fold selectivity over MERTK and AXL, respectively. UNC9426 reduces platelet aggregation without increasing bleeding time and blocks TYRO3-dependent functions in tumor cells and macrophages. UNC9426 demonstrates a favorable safety profile with no significant increase in bleeding risk in vivo. UNC9426 can be used for functional studies of TYRO3-dependent phenotypes such as non-small cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3051784-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173268. | |
| UNC9512 | UNC9512 is a selective 53BP1 inhibitor with an IC50 of 0.46 μM, and a Kd values of 0.17 μM. UNC9512 binds 53BP1 and its tandem Tudor domain, disrupts histone H4 interaction, and inhibits 53BP1 activity. UNC9512 can be used as a probe for DNA damage repair and Gene editing[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032393-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-156257. | |
| UNC9994 hydrochloride | UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108826-33-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111385. | |
| Unesbulin | Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PTC596. CAS No. 1610964-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112041. | |
| UniPR129 | UniPR129 is a potent and orally active Eph/ephrin antagonist. UniPR129 can inhibit EphA2-ephrin-A1 interaction with an IC50 of 945 nM and a Ki of 370 nM. UniPR129 can inhibit angiogenesis and show antitumor and neuroprotective effect. UniPR129 can be used for the researches of cancer and neurological disease, such as colorectal cancer and optic neuropathy[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639159-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123607. | |
| UniPR1331 | UniPR1331 is an orally active 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and inhibits subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells. UniPR1331 exhibits anti-angiogenesis, anti-cancer and anti-inflammation effects. UniPR1331 can be used for the researches of cancer and inflammation, such as glioma and colitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1809170-59-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123927. | |
| Unlabeled FXX489 | Unlabeled FXX489 (NNS309) is a fibroblast activation protein (FAP)-targeting ligand. Unlabeled FXX489 can be labeled with 68Ga and 177Lu and shows anticancer effects. Unlabeled FXX489 can be used for the study of pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), breast cancer (BC), and colorectal cancer (CRC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NNS309. CAS No. 3076330-05-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10944. | |
| UP12 | UP12 is an ATPase activity activator that activates the ATPase activity of valosin-containing protein (VCP), with an EC50 of 1.24 μM. UP12 is applicable to research related to multisystem proteinopathies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 443353-87-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168325. | |
| UP158 | UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 2.57 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 489402-33-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-168324. | |
| UP163 | UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 591242-60-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-168323. | |
| Upacicalcet sodium | Upacicalcet sodium is a non-peptide calcimimetic that acts as a CaSR agonist (EC50 = 10.8 nM). Upacicalcet sodium reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet sodium sodium improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet sodium sodium inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet sodium is useful for studying SHPT[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SK-1403; AJT240; PLS240. CAS No. 2052969-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109106A. | |
| Upadacitinib | Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-494. CAS No. 1310726-60-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-19569. | |
| Upadacitinib (Standard) | Upadacitinib (Standard) is the analytical standard of Upadacitinib. This product is intended for research and analytical applications. Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-494 (Standard). CAS No. 1310726-60-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19569R. | |
| Upamostat | Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WX-671. CAS No. 590368-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16511. | |
| UPCDC-30245 | UPCDC-30245 is an allosteric p97 inhibitor with an IC50 of approximately 27 nM[1]. UPCDC-30245 inhibits the p97 mutant N660K similar to wild type (WT; IC50=300 nM) and shows 3-fold resistance for p97 mutant T688A[2]. UPCDC-30245 can be used in the research of cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883351-01-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123636. | |
| UPF 1069 | UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1048371-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14478. | |
| UPF-523 | UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AIDA. CAS No. 168560-79-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-101311. | |
| UPF-648 | UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 213400-34-1. Pack Sizes: 10 mM * 1 mL in Ethanol; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15600. | |
| Upifitamab | Upifitamab is a humanized monoclonal antibody targeting NaPi2b. Upifitamab can be used to synthesize ADC such as Upfitamab rilsodotin. Upfitamab rilsodotin can be used in research for solid tumors including high-grade serious epithelial ovarian, fallopian tube and primary peritoneal cancer (OC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XMT-1535; Upinitatug. CAS No. 2254118-43-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99229. | |
| Uprosertib | Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK2141795. CAS No. 1047634-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15965. | |
| UR-1505 | UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor. UR-1505 can suppress CD3/CD28 induced T cell proliferation, increase p27KIP levels, and induce G1/S cell cycle arrest. UR-1505 can also inhibit the production of IL-5 and IFN-γ in activated T cells. UR-1505 has immunomodulatory properties and can be used in the study of atopic dermatitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 651331-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19486. | |
| UR778Br | UR778Br targets the GTPase-activating protein-related domain (GRD domain) of IQGAP1 proteins. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML), arrests the cell cycle at the G2/M phase, and induces apoptosis. UR778Br inhibits colony formation of primary and AML cells, without significant impacts on normal bone marrow cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 866127-80-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163707. | |
| Urabrelimab | Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SRF-231; SRF231. CAS No. 2249722-58-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99533. | |
| Uracil | Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 66-22-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-I0960. | |
| Uracil-d4 | Uracil-d4 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24897-55-0. Pack Sizes: 25 mg. Product ID: HY-I0960S9. | |
| Uralenol | Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor in many cellular and biochemical studies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 139163-15-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9326. | |
| Urapidil hydrochloride | Urapidil hydrochloride is an orally active and blood-brain barrier permeability α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 64887-14-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B0354A. | |
| URB-597 | URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KDS-4103. CAS No. 546141-08-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10864. | |
| Urcosimod | Urcosimod (OK 101) is a lipid-coupled chemokine peptide, a ChemR23 G protein-coupled receptor agonist, which has been shown to have anti-inflammatory and analgesic activities. Urcosimod can be used for dry eye research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OK 101. CAS No. 1610366-43-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P11273. | |
| Urea | Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carbonyl diamide. CAS No. 57-13-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 5 g. Product ID: HY-Y0271. | |
| Urea-15N2 | Urea-15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carbonyl diamide-15N2. CAS No. 2067-80-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-Y0271S. | |
| Urease, Jack bean | Urease, Jack bean is derived from jack bean and Catalyzes hydrolysis of urea to carbon dioxide and ammonia. Urease, Jack bean is useful in the determination of urea in body fluids. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-13-5. Pack Sizes: 10 KU; 20 KU. Product ID: HY-P2767. | |
| Ureidopropionic acid | Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Ureidopropionic acid. CAS No. 462-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-113285. | |
| Ureidopropionic acid (Standard) | Ureidopropionic acid (Standard) is the analytical standard of Ureidopropionic acid. This product is intended for research and analytical applications. Ureidopropionic acid (3-Ureidopropionic acid) is an intermediate in the metabolism of uracil. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Ureidopropionic acid (Standard). CAS No. 462-88-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113285R. | |
| Urelumab | Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 934823-49-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99055. | |
| Uric acid | Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 69-93-2. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B2130. | |
| Uric acid-15N2 | Uric acid-15N2 is the 15N labeled Uric acid[1]. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62948-75-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B2130S1. | |
| Uric acid sodium | Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Monosodium urate. CAS No. 1198-77-2. Pack Sizes: 200 mg. Product ID: HY-B2130A. | |
| Uricase, Microorganism | Uricase, Microorganism (Uox, Microorganism) is a uricase (urate oxidase) derived from Microorganism. Uricase, Microorganism converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Microorganism can be used for research on chronic refractory gout and hyperuricemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Uox, Microorganism. CAS No. 9002-12-4. Pack Sizes: 1 KU; 5 KU. Product ID: HY-P2921. | |
| Uridine | Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-Uridine. CAS No. 58-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B1449. | |
| Uridine 13C-4 | Uridine 13C-4 is the 13C labeled Uridine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-Uridine 13C-4. CAS No. 35803-42-0. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-B1449S7. | |
| Uridine-13C5 | Uridine-13C5 (β-Uridine-13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-Uridine-13C5. CAS No. 159496-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B1449S10. | |
| Uridine-13C9,15N2 | Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is 13C and 15N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-Uridine-13C9,15N2. CAS No. 202406-84-6. Pack Sizes: 1 mg (100 mM * 0.039 mL in Water). Product ID: HY-W751165. | |
| Uridine 3,5-diphosphate | Uridine 3,5-diphosphate (3,5-UDP; Compound pUp) is a competitive RNase inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,5-UDP. CAS No. 2922-95-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154828. | |
| Uridine-5'-diphosphate disodium salt | Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27821-45-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W010832. | |
| Uridine 5'-diphosphate sodium salt | Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21931-53-3. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W010820. | |
| Uridine 5-diphosphoglucose-13C disodium | Uridine 5-diphosphoglucose-13C (UDP-D-Glucose-13C) disodium is the 13C labeled Uridine 5-diphosphoglucose disodium (HY-N7032)[1]. Uridine 5-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue[2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UDP-D-Glucose-13C disodium. CAS No. 478529-38-3. Pack Sizes: 1 mg. Product ID: HY-N7032S. | |
| Uridine 5-diphosphoglucose disodium | Uridine 5-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UDP-D-Glucose disodium. CAS No. 28053-08-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N7032. | |
| Uridine-5'-diphosphoglucose pyrophosphorylase | Uridine-5'-diphosphoglucose pyrophosphorylase is involved in the catalysis of UDP-glucose synthesis. Uridine-5'-diphosphoglucose pyrophosphorylase can be used to determine the concentration of pyrophosphate in urine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9026-22-6. Pack Sizes: 25 U; 200 U; 500 U; 1 KU. Product ID: HY-P3018. | |
| Uridine 5-diphosphoglucose (Standard) | Uridine 5-diphosphoglucose (Standard) (UDP-D-Glucose (Standard)) is the analytical standard of Uridine 5-diphosphoglucose (HY-113044). This product is intended for research and analytical applications. Uridine 5-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UDP-D-Glucose (Standard). CAS No. 133-89-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113044R. | |
| Uridine 5'-monophosphate | Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-Uridylic acid. CAS No. 58-97-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-101981. | |
| Uridine 5'-monophosphate disodium salt | Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-Uridylic acid disodium salt. CAS No. 3387-36-8. Pack Sizes: 100 mg; 1 g; 5 g. Product ID: HY-W013175. | |
| Uridine 5'-monophosphate (Standard) | Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-Uridylic acid (Standard). CAS No. 58-97-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101981R. | |
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