MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Trimetazidine | Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5011-34-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-B0968A. |  |
| Trimetazidine dihydrochloride | Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13171-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0968. | |
| Trimethadione | Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,5,5,-Trimethyloxazolidine-2,4-dione. CAS No. 127-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-A0092. | |
| Trimethoprim | Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4]. Uses: Scientific research. Category: Induced disease models products. CAS No. 738-70-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-B0510. | |
| Trimethoprim-d9 | Trimethoprim-d9 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1189460-62-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B0510S. | |
| Trimethoprim lactate | Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23256-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g. Product ID: HY-B0510C. | |
| Trimethoprim (Standard) | Trimethoprim (Standard) is the analytical standard of Trimethoprim. This product is intended for research and analytical applications. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 738-70-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0510R. | |
| Trimethylamine N-oxide | Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3]. Uses: Scientific research. Category: Induced disease models products. CAS No. 1184-78-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-116084. | |
| Trimethylamine N-oxide-d9 | Trimethylamine N-oxide-d9 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1161070-49-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-116084S. | |
| Trimethylammonium chloride-d9 | Trimethylammonium chloride-d9 is the deuterium labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 18856-86-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-Y0504S3. | |
| Trimethyl chitosan | Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N,N,N-Trimethylchitosan. CAS No. 52349-26-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-148033. | |
| Trimethyllysine-d9 | Trimethyllysine-d9 is the deuterium labeled Trimethyllysine (HY-143711)[1]. Trimethyllysine is an important post-translationally modified amino acid, involving in carnitine biosynthesis and epigenetic processes[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1182037-78-0. Pack Sizes: 2.5 mg. Product ID: HY-143711S. | |
| Trimetrexate | Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CI-898. CAS No. 52128-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-10373. | |
| Trimipramine maleate | Trimipramine maleate is a 5-HT receptor antagonist, with blood-brain barrier permeability. Trimipramine maleate has pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine maleate has vascular activity and anxiolytic efficacy[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 521-78-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1213. | |
| Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate | Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid prepared by the conjugate addition of alkylamines to acrylates. Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate can be used in various drug delivery systems to deliver polynucleotides, siRNA for example[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 304O13. CAS No. 1566559-80-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153137. | |
| Triolein | Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122-32-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-N1981. | |
| Triolein-d5 | Triolein-d5 is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60892-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N1981S1. | |
| Tripentadecanoin-d29 | Tripentadecanoin-d29 is the deuterium labeled Tripentadecanoin. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TG(15:0/15:0/15:0)-d29; 1,2,3-Tripentadecanoyl glycerol-d29. CAS No. 352431-43-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-146726S. | |
| Tripeptide-10 citrulline | Tripeptide-10 citrulline (T10-C) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient[1]. Uses: Scientific research. Category: Peptides. Alternative Names: T10-C. CAS No. 960531-53-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P5242. | |
| Tripeptide-41 | Tripeptide-41 (CG-Lipoxyn) is a signal peptide. Tripeptide-41 activates the NF-kB signaling pathway, inhibits the expression of C/EBP and increases cAMP. Tripeptide-41 is an important intracellular signaling factor that causes lipolysis by promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 can be used in cosmetics that targets fat accumulation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CG-Lipoxyn. CAS No. 1093241-16-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-P5275. | |
| Tripeptide YYY | (S)-2-((S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoic acid is a tyrosine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7390-78-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-W010777. | |
| Triphenyltin chloride-d15 | Triphenyltin chloride-d15 is the deuterium labeled Triphenyltin chloride[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 358731-94-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W134259S. | |
| Triprolidine hydrochloride monohydrate | Triprolidine hydrochloride monohydrate, a first-generation antihistamine, is an oral active histamine H1 antagonist. Triprolidine hydrochloride monohydrate can be used for the research of allergic rhinitis. Triprolidine hydrochloride monohydrate exhibits spinal motor and sensory block in rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6138-79-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1301. | |
| Triptohypol C | Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 193957-88-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117469. | |
| Triptolide | Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: PG490. CAS No. 38748-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32735. | |
| Triptolide (Standard) | Triptolide (Standard) is the analytical standard of Triptolide. This product is intended for research and analytical applications. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PG490 (Standard). CAS No. 38748-32-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32735R. | |
| Triptonide | Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 165677; PG 492. CAS No. 38647-11-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32736. | |
| Tris(2,4-di-tert-butylphenyl)phosphate | Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 95906-11-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-136177. | |
| Tris(2,4-di-tert-butylphenyl) phosphite (Standard) | Tris(2,4-di-tert-butylphenyl) phosphite (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl) phosphite. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. CAS No. 31570-04-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-W020986R. | |
| Tris(2-chloroethyl) phosphate | Tris(2-chloroethyl) phosphate (TCEP) is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca²?) influx, a decrease in mitochondrial membrane potential (?Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TCEP. CAS No. 115-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107859. | |
| Tris(2-phenylpyridinato-C2,N)iridium(III) | Tris(2-phenylpyridinato-C2,N)iridium(III) (Ir(ppy)3) is an iridium(III) containing organometallic complex, which is used as a phosphorescent light-emitting material. Tris(2-phenylpyridinato-C2,N)iridium(III) exhibits high luminous efficiency and good thermal stability, that can be used in organic optoelectronics, especially in improving the luminescence efficiency and stability of organic light-emitting diodes (OLEDs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ir(ppy)3; Tris[2-(pyridin-2-yl)phenyl]iridium. CAS No. 94928-86-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W007596. | |
| Tris(3-hydroxypropyltriazolylmethyl)amine | Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and protects cells from oxidants generated by copper-catalyzed reduction of oxygen by ascorbate. In addition, Tris(3-hydroxypropyltriazolylmethyl)amine can also protect the histidine moiety of biomolecules in a manner proportional to the ligand concentration[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: THPTA. CAS No. 760952-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W021042. | |
| Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride | Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3]2+) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S2O82-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36309-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g; 5 g. Product ID: HY-W074143. | |
| Tris(benzyltriazolylmethyl)amine | Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand that acts as a biochemical tool for the tagging of proteins and enzymes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TBTA. CAS No. 510758-28-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-116677. | |
| Tris(dibenzylideneacetonyl)bis-palladium | Tris(dibenzylideneacetonyl)bis-palladium is a catalyst that catalyzes the coupling reaction of N-methyl-2-pyrrolidinone (NMP)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51364-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W018864. | |
| tris-NTA | tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 862778-60-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1288A. | |
| tris-NTA Biotin | Tris-NTA Biotin is a biotin-labeled version of tris-NTA. Tris-NTA Biotin, as a bridge connecting His-tagged proteins with streptavidin, can reversibly label proteins and cell surfaces. Tris-NTA Biotin can be used in experiments such as protein immobilization, kinetic determination, live cell labeling, and Western blot detection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1070867-85-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D2355. | |
| Trisodium phosphate | Trisodium phosphate is a food additive. Trisodium phosphate affects the growth parameters (lag phase, maximum growth rate) of Listeria monocytogenes and increases the sensitivity of Gram-negative bacteria to Lysozyme (HY-P1068) and Nisin (HY-P1607)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7601-54-9. Pack Sizes: 10 mM * 1 mL in Water; 100 g; 500 g; 1 k g. Product ID: HY-Y1329. | |
| Trisodium phosphate (dodecahydrate) | Trisodium phosphate dodecahydrate is an Antibacterial agent. Trisodium phosphate dodecahydrate reduces the counts of Escherichia coli O157:H7 and Salmonella typhimurium attached to the surfaces of beef fat and fascia. Trisodium phosphate dodecahydrate modulates the growth parameters of Listeria monocytogenes in vitro: low concentrations shorten the lag phase and increase the maximum growth rate, while high concentrations prolong the lag phase and decrease the maximum growth rate. Trisodium phosphate dodecahydrate is used in poultry processing[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10101-89-0. Pack Sizes: 10 mM * 1 mL in Water; 250 g; 500 g; 1 k g; 2.5 k g. Product ID: HY-W088066. | |
| Tris(perfluorophenyl)borane | Tris (perfluorophenyl) borane is a biochemical reagent that can be used as a biomaterial or organic compound for life science-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1109-15-5. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g; 5 g. Product ID: HY-W008525. | |
| Tristearin | Tristearin (Glycerol tristearate) is a triglyceride derived from three units of stearic acid[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glycerol tristearate. CAS No. 555-43-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-127035. | |
| Tritriacontane | Tritriacontane is an ester product. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-tritriacontane. CAS No. 630-05-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W540836. | |
| TrkA-IN-1 | TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1680179-43-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-129634. | |
| TrkA/NGF-IN-1 | TrkA/NGF-IN-1 (Peptide 19) is an inhibitor of protein-protein interactions between TrkA and NGF (IC50: 21 nM for human TrkA in PathHunter assay). TrkA/NGF-IN-1 shows an analgesic effect in a rat incisional pain model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3105660-96-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11480. | |
| Trofinetide | Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NNZ-2566. CAS No. 853400-76-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-16757. | |
| Troglitazone | Troglitazone is an orally active PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CS-045. CAS No. 97322-87-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50935. | |
| Troleandomycin | Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Triacetyloleandomycin. CAS No. 2751-9-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108881. | |
| Trolox | Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53188-07-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-101445. | |
| Trontinemab | Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG6102; RO-7126209. CAS No. 2568868-35-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P9999. | |
| Tropifexor | Tropifexor (LJN452) is a highly potent agonist of FXR with an EC50 of 0.2 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LJN452. CAS No. 1383816-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-107418. | |
| Tropolone | Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 533-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N7135. | |
| Troriluzole | Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BHV-4157. CAS No. 1926203-09-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122487. | |
| Trospium chloride | Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10405-02-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0461. | |
| Trospium chloride (Standard) | Trospium (chloride) (Standard) is the analytical standard of Trospium (chloride). This product is intended for research and analytical applications. Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10405-02-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0461R. | |
| Trotabresib | CC-90010 (compound 1) is a reversible and orally active BET inhibitor. CC-90010 is applied in the study for advanced solid tumors[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-90010. CAS No. 1706738-98-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137573. | |
| Trovafloxacin | Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 147059-72-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0170. | |
| Trovafloxacin mesylate | Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 147059-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103399. | |
| TROX-1 | TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC50 value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1309601-26-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120751. | |
| TRPC6-PAM-C20 | TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 667427-75-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136190. | |
| TRPM4-IN-1 | TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBA. CAS No. 351424-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122605. | |
| TRPM4-IN-2 | TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBA. CAS No. 667411-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128172. | |
| TRPM8-IN-1 | TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC50<5 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1159996-20-9. Pack Sizes: 2 mg. Product ID: HY-108461. | |
| TRPV2-selective blocker 1 | TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC50 of 6.3 μM against rat TRPV2, and shows no activity against TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2 during immune processes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2242724-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157131. | |
| TRPV3 antagonist 74a | TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1432051-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131868. | |
| True Blue | True Blue (NCI 240899) is a fluorescent dye, as neuronal retrograde tracer (excitation wavelength 395-425 nm, barrier filter 450 nm). True Blue can label neuron and has no effects on neuronal survival[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NCI 240899. CAS No. 71431-30-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D1161. | |
| TRULI | TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lats-IN-1. CAS No. 1424635-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138489. | |
| TRV055 | TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1] | |
| TRV-120027 | TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling[1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TRV027. CAS No. 1234510-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2141. | |
| Trypan red | Trypan red is a vital stain. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C.I. 22850. CAS No. 574-64-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-D0983. | |
| Trypsin | Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation[1][2][3][4][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-7-7. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-129047. | |
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