MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Tomatidine hydrochloride | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6192-62-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2149A. |  |
| Tomatine | Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-Tomatine; Lycopersicin; Tomatin. CAS No. 17406-45-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N2166. | |
| Tominersen | Tominersen (RG6042) is a second-generation 2-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntingtons disease (HD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG6042; IONIS-HTTRx. CAS No. 1709886-74-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132579. | |
| Tomivosertib | Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: eFT508. CAS No. 1849590-01-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100022. | |
| Tomuzotuximab | Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human EGFR Recombinant Antibody; CetuxiMab-GEX, GEXMab52201. CAS No. 1646321-00-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99324. | |
| Tonabersat | Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB-220453. CAS No. 175013-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15204. | |
| Toosendanin | Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities[1]. Uses: Scientific research. Category: Natural products. CAS No. 58812-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0263. | |
| TopBP1-IN-1 | TopBP1-IN-1 is a TopBP1 inhibitor. TopBP1-IN-1 has a synergistic effect with PARP inhibitors. TopBP1-IN-1 has antitumor activity [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1212595-23-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-160409. | |
| Topilutamide | Topilutamide is a topical nonsteroidal antiandrogen (NSAA). Uses: Scientific research. Category: Signaling pathways. Alternative Names: BP766; Fluridil. CAS No. 260980-89-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19470. | |
| Topi MF-6 | Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 can be used as an ADC payload[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2944016-96-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175203. | |
| Topiramate | Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: McN 4853; RWJ 17021. CAS No. 97240-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0122. | |
| Topobexin | Topobexin is a TOP2B-selective inhibitor with IC50 values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076446-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174374. | |
| Topoisomerase I inhibitor 8 | Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 210346-40-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-148058. | |
| Topotecan | Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKF 104864A; NSC 609669. CAS No. 123948-87-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13768. | |
| Topotecan hydrochloride | Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKF 104864A hydrochloride; NSC 609669 hydrochloride. CAS No. 119413-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13768A. | |
| TOPS | TOPS is a chromogenic substrate. TOPS undergoes an oxidative coupling reaction with 4-aminoantipyrine in the presence of H2O2 and nanocrystalline cobalt selenide. TOPS is used in studies related to uric acid detection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 40567-80-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-15933. | |
| Toralizumab | Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohns disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IDEC-131; Anti-Human CD40 ligand Recombinant Antibody. CAS No. 252662-47-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99325. | |
| Torcetrapib | Torcetrapib (CP-529414) is a selective, potent cholesteryl ester transfer protein (CETP) inhibitor. A typical inhibition curve for whole human plasma, having a CETP concentration of 37 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-529414. CAS No. 262352-17-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12089. | |
| Toreforant | Toreforant is a potent and selective histamine H4 receptor (H4R) antagonist, with a Ki at the human receptor of 8.4 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-38518168. CAS No. 952494-46-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16756. | |
| Toremifene | Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 μM and 2.6 μM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-Toremifene; NK 622 free base; FC-1157a free base. CAS No. 89778-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg. Product ID: HY-B0005A. | |
| Toremifene citrate | Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 μM and 2.6 μM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-Toremifene citrate; NK 622; FC-1157a. CAS No. 89778-27-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0005. | |
| Torin 1 | Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222998-36-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13003. | |
| Torin 2 | Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM). Torin 2 also inhibits DNA-PK with an IC50 of 0.5 nM in the cell free assay. Torin 2 can suppress both mTORC1 and mTORC2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223001-51-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13002. | |
| Toripalimab | Toripalimab is a selective, recombinant, humanized monoclonal antibody against PD-1. Toripalimab is able to bind to PD-1 and block the interaction with its ligands. Toripalimab has exhibited primary anti-tumor effects in tumors such as melanoma, lung cancer, digestive tract tumors, hepatobiliary and pancreatic tumors, neuroendocrine neoplasms, nasopharyngeal carcinoma and urothelial carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JS-001. CAS No. 1924598-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9978. | |
| Torkinib | Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM[1]. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PP 242. CAS No. 1092351-67-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10474. | |
| Torsemide | Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis[1][1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Torasemide. CAS No. 56211-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0247. | |
| Torsemide-d7 | Torsemide-d7 is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis[1][1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Torasemide-d7. CAS No. 1189375-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B0247S. | |
| Torsemide (Standard) | Torsemide (Standard) is the analytical standard of Torsemide. This product is intended for research and analytical applications. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis[1][1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Torasemide (Standard). CAS No. 56211-40-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0247R. | |
| Torudokimab | Torudokimab is a humanized antibody expressed in CHO, targeting IL-33. Torudokimab has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.22 kDa. The isotype control for Torudokimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003). Uses: Scientific research. Category: Signaling pathways. CAS No. 2241728-76-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990669. | |
| Torvutatug | Torvutatug is an anti-FOLR1 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD5335 Antibody; INT-019. CAS No. 2975630-15-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991164. | |
| Tosedostat | Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CHR-2797. CAS No. 238750-77-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14807. | |
| Tos-Gly-Pro-Arg-ANBA-IPA acetate | Tos-Gly-Pro-Arg-ANBA-IPA (tos-GPR-ANBA-IPA) acetate is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA acetate can be used for luminescence measurement[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: tos-GPR-ANBA-IPA acetate. CAS No. 2070009-46-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0020A. | |
| Tositumomab | Tositumomab (Anti-Human CD20 Recombinant Antibody) is a mouse-derived IgG2a monoclonal antibody, targeting to human CD20. Tositumomab can deplete B cells. Tositumomab can be used for the research of cancer, such as lymphoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human CD20 Recombinant Antibody; V10XA53. CAS No. 192391-48-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99326. | |
| Tosposertib | Tosposertib (TU2218 free base) is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM). Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TU2218 free base. CAS No. 1418305-55-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172240. | |
| Tosylate-DPA-714 | Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 958233-17-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-400882. | |
| (+)-Totarol | (+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 511-15-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N1136. | |
| Tovecimig | HY-P991033 is an VEGFA/DLL4-targeting G1-scFvlh_L-κ type bispecific antibody[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CTX-009. CAS No. 2923284-73-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991033. | |
| Tovinontrine | Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMR-687. CAS No. 2062661-53-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109193. | |
| Tovorafenib | Tovorafenib (TAK-580, MLN 2480) is an orally active and selective inhibitor of pan-Raf kinase. Tovorafenib can be used for the study of glioma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-580; MLN 2480; BIIB-024. CAS No. 1096708-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15246. | |
| Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) | Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a T cell proliferation activator. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) promotes the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can be used in research on inflammatory and immunity, as well as cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137593-46-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4984. | |
| Toyocamycin | Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vengicide. CAS No. 606-58-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103248. | |
| Tozasertib | Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX 680; MK-0457. CAS No. 639089-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-10161. | |
| Tozorakimab | Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-3506. CAS No. 2376858-66-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99550. | |
| TP003 | TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 628690-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-103512. | |
| TP-004 | TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454299-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120868. | |
| TP-008 | TP-008, a chemical probe, is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1976038-41-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125851. | |
| TP-021 | TP-021 (BCL6-IN-8c), a chemical probe, is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCL6-IN-8c. CAS No. 2130878-25-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119402. | |
| TP-024 | TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM[1]. TP-024 has antipsychotic and procognitive properties[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FTBMT. CAS No. 1358575-02-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101787. | |
| TP-030-2 | TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095514-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148239. | |
| TP0463518 | TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 (IC50=18 nM), PHD2 (Ki=5.3 nM), and PHD3 (IC50=63 nM), and targets monkey PHD2 with an IC50 of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFα, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1558021-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112144. | |
| TP0628103 TFA | TP0628103 (Compound 18) TFA is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2865106-78-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-161169A. | |
| TP-064 | TP-064, a chemical probe, is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC50 <10 nM). TP-064 inhibits dimethylation of BAF155 (IC50 of 340 nM) and MED12 (IC50 of 43 nM). TP-064 is inactive against the other family members except for PRMT6 (IC50 of 1.3 μM). TP-064 has anticancer activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2080306-20-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114965. | |
| TP-10 | TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 898563-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14550. | |
| TP-1287 | TP-1287, a prodrug of Alvocidib (HY-10005), is an orally active CDK9 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2044686-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153260. | |
| TP-3654 | TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1361951-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101126. | |
| TP-472 | TP-472, a chemical probe, is a selective BRD9/7 inhibitor, with Kds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7[1][2]. TP-472 induces apoptosis of melanoma cells[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2079895-62-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100517. | |
| TP4 (Nile tilapia piscidin) | TP4 (Nile tilapia piscidin) is an orally active amphipathic α-helical cationic antimicrobial peptide. TP4 (Nile tilapia piscidin) exerts broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria by disrupting cell membrane structures, and also exhibits certain hemolytic activity. TP4 (Nile tilapia piscidin) regulates the innate immune system and enhances the expression of lysozymes, cytokines and antioxidant enzymes to resist bacterial infection. TP4 (Nile tilapia piscidin) also stimulates the proliferation of keratinocytes and fibroblasts, and significantly promotes the healing of wounds infected with MRSA. TP4 (Nile tilapia piscidin) can be used in research related to bacterial infection, peritonitis, wound healing and other fields[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429184-62-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5557. | |
| TP-5801 | TP-5801 is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2574474-81-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-147316. | |
| TPA 023 | TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 252977-51-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101640. | |
| TPA-023B | TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 425377-76-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19505. | |
| TPC2-A1-N | TPC2-A1-N is a powerful and Ca2+-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136186-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131614. | |
| TPC2-A1-P | TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2804595-86-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131615. | |
| TPCA-1 | TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation. Uses: Scientific research. Category: Signaling pathways. CAS No. 507475-17-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10074. | |
| TPCK-treated Trypsin | TPCK-treated Trypsin is a trypsin whose activity is inhibited by tosyl phenylalanyl chloromethyl ketone. TPCK-treated Trypsin reduces autolysis and nonspecific proteolysis during experiments, exhibits stability in storage and handling. TPCK-treated trypsin can be used in proteomics research[1]. TPCK-treated Trypsin renders the virus hemagglutinin active, which allows multicycle replication of the virus. TPCK-treated Trypsin can be used for the study of influenza virus[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-7-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129047C. | |
| TPE-MI | TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tetraphenylethene maleimide. CAS No. 1245606-71-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143218. | |
| TPEN | TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TPEDA. CAS No. 16858-02-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100202. | |
| TPh A | TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3-pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Triphenyl Compound A. CAS No. 21306-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14454. | |
| TPI-1 | TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 79756-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100463. | |
| TPI-287 | TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849213-15-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126899. | |
| Tpl2 Kinase Inhibitor 1 | Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 871307-18-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12358. | |
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