MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Trypsin Inhibitor, soybean | Trypsin Inhibitor, soybean is a potent and reversible inhibitor of trypsin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9035-81-8. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-126388. |  |
| Trypsin (MS grade) | Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation[1][2][3][4][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-7-7. Pack Sizes: 100 μg. Product ID: HY-129047A. | |
| Trypsin, porcine pancreas (Cell culture grade) | Trypsin, porcine pancreas (Cell culture grade) is a serine protease that hydrolyzes proteins at the carboxyl side of lysine or arginine residues. Trypsin, porcine pancreas (Cell culture grade) exhibits excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) removes cellular components while preserving extracellular matrix structures to achieve uniform decellularization of porcine pancreas[1][2][3]. . Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-7-7. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-129047E. | |
| Tryptamine | Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine. CAS No. 61-54-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-B2132. | |
| Tryptamine-d4 hydrochloride | Tryptamine-d4 (hydrochloride) is the deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride, a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter[1]. Uses: Scientific research. Category: Isotope-labeled compounds. CAS No. 340257-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B2132S1. | |
| Tryptamine hydrochloride | Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries. Uses: Scientific research. Category: Signaling pathways. CAS No. 343-94-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W014971. | |
| Tryptone | Tryptone is a peptide-rich bacterial culture medium component that can regulate bacterial cell surface proteins and biofilm-related genes. Tryptone promotes the expression and assembly of bacterial adhesion proteins (such as LapA and LapF) by providing peptide substances as structural factors, enhancing cell surface hydrophobicity and intercellular adhesion, thereby stabilizing the biofilm matrix and supporting the maturation and maintenance of bacterial biofilms. The peptide mixture contained in Tryptone can specifically regulate the transcription of bacterial adhesion-related genes (such as activating LapA and inhibiting LapF), affecting the synthesis and localization of biofilm structural proteins[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73049-73-7. Pack Sizes: 25 g; 50 g. Product ID: HY-W133898. | |
| Tryptophan-cholic acid | Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-conjugated bile acid that acts as an endogenous ligand and agonist (EC50=9.6 μM) for the orphan G protein-coupled receptor (GPCR) MRGPRE (Mas-related G protein-coupled receptor family member E). Tryptophan-cholic acid is orally effective but has poor oral absorption and does not cross the blood-brain barrier. Tryptophan-cholic acid promotes the secretion of glucagon-like peptide GLP-1, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid improves glucose tolerance, promotes insulin secretion, and alleviates high-fat diet-induced hepatic steatosis without causing pruritus side effects. Tryptophan-cholic acid is primarily used in research on type 2 diabetes (T2D)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trp-CA. CAS No. 1630745-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N15721. | |
| Tryptophol | Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy[1][2][3][4][5][6][7][8][9][10][11][12]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indole-3-ethanol. CAS No. 526-55-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-W010155. | |
| Tryptophol (Standard) | Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indole-3-ethanol (Standard). CAS No. 526-55-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W010155R. | |
| TS-002266 | TS-002266 is a small molecule TUT4/7 inhibitor with anti-leukemic effects. TS-002266 is promising for research of cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2702325-64-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-169091. | |
| TSHR antagonist S37a | TSHR antagonist S37a is a highly selective thyrotropin receptor (TSHR) antagonist, with potential for the treatment of Graves' orbitopathy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143452-20-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129995A. | |
| TSI-01 | TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s=0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). 60 μM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore. Uses: Scientific research. Category: Signaling pathways. CAS No. 704878-75-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112825. | |
| TSLP-IN-1 | TSLP-IN-1 is a potent thymic stromal lymphopoietin (TSLP) inhibitor. TSLP-IN-1 disrupts TSLP-TSLPR protein-protein interaction, and downregulates IL-4 and IL-13. TSLP-IN-1 can be used for the research of inflammation diseases, such as skin disease, asthma, and allergies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 512837-95-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-207120. | |
| TSQ | TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λmax ~470 nm). TSQ can combine with Zn2+ in the presence of Ca2+ and Mg2+ to produce blue fluorescence (Ex/Em = 334/495 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 109628-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119287. | |
| TT-012 | TT-012 is a MITF inhibitor with a human MITF C50 of 13.1 nM and a human MITF Kd value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164471-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156483. | |
| TT-10 | TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAZ-K. CAS No. 2230640-94-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125016. | |
| TT3 | TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1821214-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148049. | |
| TTA-A2 | TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 953778-63-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111828. | |
| TTA-P2 | TTA-P2 (T-Type calcium channel inhibitor) is a selective, orally active, and BBB-penetrant T-type calcium channel blocker (IC50 = 22 nM). TTA-P2 reduces mechanical hypersensitivity and alleviates acute as well as chronic pain. TTA-P2 significantly reduces firing rates in temporal lobe epilepsy (TLE) neurons to control levels and suppresses synaptically evoked burst firing. TTA-P2 can be studied in research for neurological diseases such as tremor and absence epilepsy[1][2][3]< sup>[4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T-Type calcium channel inhibitor. CAS No. 1072018-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-10035. | |
| TTBK1-IN-2 | TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 μM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765453-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145313. | |
| TTK21 | TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood-brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory[1].CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function[2]. CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 709676-56-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116673. | |
| TTNPB | TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 13-7410; Arotinoid acid; AGN191183. CAS No. 71441-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15682. | |
| TTP-6171 | TTP-6171 is a non-covalent inhibitor of Monkeypox virus I7L protease, and it can be used for research on poxvirus infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 825647-78-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147036. | |
| TTT-28 | TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609138-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101511. | |
| TTX-030 | TTX-030 is a humanized antibody expressed in CHO cells, targeting ENTPD1/CD39. TTX-030 contains huIgG4SP heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for TTX-030 can refer to Human IgG4 kappa, Isotype Control (HY-P99003). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: Eltivutabart. CAS No. 2935496-38-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990670. | |
| Tubacin | Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2). Uses: Scientific research. Category: Signaling pathways. CAS No. 537049-40-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13428. | |
| Tubastatin A | Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2). Uses: Scientific research. Category: Signaling pathways. CAS No. 1252003-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13271A. | |
| Tubastatin A Hydrochloride | Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tubastatin A HCl; TSA HCl. CAS No. 1310693-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13271. | |
| Tubeimoside I | Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and IL-1β) production. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tubeimoside-1; Lobatoside-H. CAS No. 102040-03-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0890. | |
| Tubercidin | Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Deazaadenosine. CAS No. 69-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100126. | |
| Tubulin inhibitor 30 | Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2873383-67-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151879. | |
| Tubulysin | Tubulysin is a microtubule destabilizer that binds to the β-tubulin peptide site adjacent to the vinca alkaloid binding site and inhibits tubulin polymerization. Tubulysin induces apoptosis and exhibits antiproliferative activity against a variety of human cancer cells, including multidrug-resistant strains. Tubulysin can be conjugated to antibodies via a disulfide-containing quaternary ammonium linker for ADC synthesis. Tubulysin is applicable to tumor-related research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1943604-24-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128914. | |
| Tubulysin A | Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC Cytotoxin[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TubA. CAS No. 205304-86-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15995. | |
| Tubulysin M | Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 936691-46-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7053. | |
| Tucaresol | Tucaresol is an orally bioavailable immunopotentiatory drug that show to enhance T-helper-cell activity, with the induction of increased IL-2 and IFN-γ levels in mice and humans. Tucaresol has anti-HIV effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BWA589C. CAS No. 84290-27-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106755. | |
| Tucatinib | Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Irbinitinib; ARRY-380; ONT-380. CAS No. 937263-43-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16069. | |
| Tucatinib hemiethanolate | Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Irbinitinib hemiethanolate; ARRY-380 hemiethanolate; ONT-380 hemiethanolate. CAS No. 1429755-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16069A. | |
| Tucidinostat | Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chidamide; HBI-8000; CS 055. CAS No. 1616493-44-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-109015. | |
| Tucotuzumab celmoleukin | Tucotuzumab celmoleukin (EMD 273066) is an immunocytokine. Tucotuzumab celmoleukin consists of the following components: an IgG1 monoclonal antibody targeting human EpCAM antigen, and two molecules of IL2. Tucotuzumab celmoleukin binds to EpCAM. Tucotuzumab celmoleukin exerts anti-tumor effects on colon adenocarcinoma in synergy with radiofrequency ablation. Tucotuzumab celmoleukin can be used in research related to colon adenocarcinoma and colon cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD 273066; huKS-IL2. CAS No. 339986-90-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991214. | |
| Tuftsin | Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator. Uses: Scientific research. Category: Signaling pathways. CAS No. 9063-57-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0240. | |
| TUG-1375 | TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247372-59-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112813. | |
| TUG-424 | TUG-424 is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100 nM. TUG-424 may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity[1]. TUG-424 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1082058-99-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-14363. | |
| TUG-770 | TUG-770 is a potent, selective and orally active GPR40/FFA1 agonist with an EC50 of 6 nM for human FFA1. TUG-770 shows a high selectivity for FFA1 over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, and enzymes. TUG-770 can be uesd for type 2 diabetes research[1]. TUG-770 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1402601-82-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15697. | |
| TUG-891 | TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1374516-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100881. | |
| Tulathromycin A | Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 μM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tulathromycin; CP 472295. CAS No. 217500-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15662. | |
| Tulisokibart | Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PRA023. CAS No. 2648504-55-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990007. | |
| Tulmimetostat | Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor that targets and inhibits the EZH2 enzyme.Tulmimetostat has antitumor activity and is used in a variety of solid tumor studies[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CPI-0209. CAS No. 2567686-02-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145602. | |
| Tulobuterol | Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C-78 free base. CAS No. 41570-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B1810. | |
| Tulrampator | Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimers disease and in major depressive disorder[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CX-1632; S-47445. CAS No. 1038984-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109046. | |
| Tumulosic acid | Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1]. Uses: Scientific research. Category: Natural products. CAS No. 508-24-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9366. | |
| Tunicamycin | Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity[1][2][3].Tunicamycin increases exosome release in cervical cancer cells[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 11089-65-9. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0098. | |
| Tunlametinib | Tunlametinib is a highly selective, orally active MEK1/2 inhibitor (IC50=1.9 nM, MEK1). Tunlametinib blocks the RAS-RAF-MEK-ERK signaling pathway, arrests tumor cell cycle and promotes apoptosis. Tunlametinib potently inhibits the proliferation of RAS/RAF mutant cancer cells (such as BRAF V600E, KRAS G12C mutant cells). Tunlametinib shows synergistic anti-tumor effects with BRAF/KRASG12C/SHP2 inhibitors, Docetaxel (HY-B0011). Tunlametinib can be used to study targeted therapy for RAS/RAF mutation-driven malignancies (such as melanoma, colorectal cancer, and non-small cell lung cancer)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HL-085. CAS No. 1801756-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-132844. | |
| Turanose | Turanose is an isomer of Sucrose that naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect. Turanose has potential for obesity and related chronic diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 547-25-1. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-113334. | |
| Turkesterone | Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems[1]. Uses: Scientific research. Category: Natural products. CAS No. 41451-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2548. | |
| Turmetabart | Turmetabart (Anti-SEZ6 Antibody (SC17)) is a humanized anti-SEZ6 IgG1 monoclonal antibody. Anti-SEZ6 Antibody (SC17) can be used to synthesize antibody-drug conjugates (ADC) product, ABBV-011. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-SEZ6 Antibody (SC17); ABBV-011 antibody; ABBV-706 antibody. CAS No. 2650574-80-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P991041. | |
| Turofexorate isopropyl | Turofexorate isopropyl (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FXR-450; XL335; WAY-362450. CAS No. 629664-81-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50911. | |
| Tusamitamab | Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR-408377; PF-08046050 Antibody; SAR445953 Antibody. CAS No. 2349294-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99054. | |
| Tusamitamab ravtansine | Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR-408701; HuMAb2-3-SPDB-DM4. CAS No. 2254086-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99542. | |
| Tuspetinib | Tuspetinib (HM43239) is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HM43239. CAS No. 2294874-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145015. | |
| Tussilagone | Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 104012-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1388. | |
| Tuvusertib | Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M1774; ATR inhibitor 1. CAS No. 1613200-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111451. | |
| Tuxobertinib | Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BDTX-189. CAS No. 2414572-47-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136789. | |
| TVB-3166 | TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1533438-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120394. | |
| TVB-3664 | TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2097262-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120062. | |
| TW-37 | TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 877877-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12020. | |
| Tween 20 | Tween 20 (Polysorbate 20) is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polysorbate 20. CAS No. 9005-64-5. Pack Sizes: 100 mL; 500 mL. Product ID: HY-141415. | |
| Tween 80 | Tween 80 (Polysorbate 80), a surfactant, has been widely used as a solvent for pharmacological experiments. Tween 80 can also reduce bacterial attachment and inhibit biofilm formation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polysorbate 80. CAS No. 9005-65-6. Pack Sizes: 50 mL; 100 mL. Product ID: HY-Y1891. | |
| TWS119 | TWS119 is an inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway. Uses: Scientific research. Category: Signaling pathways. CAS No. 601514-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10590. | |
| TX1-85-1 | TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1603845-32-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-100848. | |
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