MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| TFEB activator 1 | TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39777-61-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135825. |  |
| TFEB activator 2 | TFEB activator 2 is an orally active compound that can cross the blood-brain barrier. TFEB activator 2 can bind to the dopamine transporter (DAT). TFEB activator 2 promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway. TFEB activator 2 has neuroprotective activity and can be used in the research of Alzheimer's disease and other diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3027414-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161724. | |
| TFEB activator 3 | TFEB activator 3 (compound 45) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 3 has effect on TFEB nuclear translocation with 44% (10μM 3h) and 97 % (30 μM 3h). TFEB activator 3 plays an important role in Alzheimers disease (AD). TFEB activator 3 can pass blodd brain barrier[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3027413-48-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161725. | |
| TFLLR-NH2 | TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 197794-83-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0226. | |
| TFLLR-NH2TFA | TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1313730-19-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0226A. | |
| TFMB-(R)-2-HG | TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG and acute myeloid leukemia (AML) oncogenic factor. TFMB-(R)-2-HG competitively inhibits α-ketoglutarate-dependent dioxygenases such as KDM2B and FTO. TFMB-(R)-2-HG impairs cell differentiation in response to Estrogen withdrawal. TFMB-(R)-2-HG is used in acute myeloid leukemia and glioma research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1445700-01-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129079. | |
| TfR-T12 | TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 344618-30-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2297. | |
| TG003 | TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 719277-26-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15338. | |
| TG100-115 | TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 677297-51-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10111. | |
| TG 100572 Hydrochloride | TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 867331-64-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10185. | |
| TG 100801 | TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 867331-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10186. | |
| TG2-179-1 | TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1135023-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-158774. | |
| TG4-155 | TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM[1][2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1[1]. TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164462-05-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18971. | |
| TGFβ-IN-5 | TGFβ-IN-5 is a type I transforming growth factor-β receptor (TGF-β R1) kinase inhibitor with an IC50 value of 0.0485 μM. TGFβ-IN-5 reverses the effect of TGF-β-mediated cell activation on the expression of fibrosis-related genes. TGFβ-IN-5 can be used in the research of fibroproliferative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 259870-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128437. | |
| TGFβRI-IN-3 | TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2763602-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132290. | |
| TGFBR1-IN-2 | TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 733806-89-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164793. | |
| TGN-020 | TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51987-99-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W008574. | |
| TGN-020 sodium | TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1313731-99-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W008574A. | |
| TGN-073 | TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 877459-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W176557. | |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14229. | |
| TGX-115 | TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 351071-62-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-124535. | |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Category: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. | |
| TH1020 | TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1841460-82-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116961. | |
| TH10785 | TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1002801-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147313. | |
| TH1834 | TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108830-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604. | |
| TH1834 dihydrochloride | TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108830-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604A. | |
| TH287 | TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609960-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16965. | |
| TH588 | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1609960-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12814. | |
| TH9619 | TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2379556-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155950. | |
| Thailanstatin A | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker-less ADC[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1426953-21-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129589. | |
| Thalidomide | Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ?250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg. Product ID: HY-14658. | |
| Thalidomide 4-chloro | Thalidomide 4-chloro is a chlorinated E3 ligase activator. Thalidomide 4-chloro may be used for further derivitization by substitution of chlorine. Uses: Scientific research. Category: Signaling pathways. CAS No. 244057-36-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-W460141. | |
| Thalidomide 4-fluoride | Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon ligand 4; E3 ligase Ligand 4. CAS No. 835616-60-9. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-41547. | |
| Thalidomide-4-O-C5-NH2 hydrochloride | Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2419145-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-138848A. | |
| Thalidomide-4-O-C6-NH2 hydrochloride | Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245697-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-135250B. | |
| Thalidomide 5-fluoride | Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%,>20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 835616-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W087383. | |
| Thalidomide-5-O-C4-NH2 hydrochloride | Thalidomide-5-O-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2694727-93-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-149561. | |
| Thalidomide-5-OH | Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 64567-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g. Product ID: HY-23095. | |
| Thalidomide-5-propargyne-NH2 hydrochloride | Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2490402-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139546. | |
| Thalidomide-CH2NH2 hydrochloride | Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions. Uses: Scientific research. Category: Signaling pathways. CAS No. 444287-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44249. | |
| Thalidomide-NH-amido-C4-NH2 | Thalidomide-NH-amido-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2093388-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134984. | |
| Thalidomide-NH-C6-NH2 hydrochloride | Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375194-37-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-129704B. | |
| Thalidomide-NH-PEG1-NH2 hydrochloride | Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2154342-56-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131867. | |
| Thalidomide-NH-PEG3-propionic acid | Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2138440-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-136166. | |
| Thalidomide-O-amido-C4-N3 | Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18. CAS No. 2098488-36-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103615. | |
| Thalidomide-O-amido-C4-NH2 hydrochloride | Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245697-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 100 mg. Product ID: HY-107438A. | |
| Thalidomide-O-amido-C8-NH2 TFA | Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon Ligand -Linker Conjugates 2 TFA; E3 Ligase Ligand-Linker Conjugates 20 TFA. CAS No. 1950635-16-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-103614. | |
| Thalidomide-O-amido-PEG3-C2-NH2 TFA | Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA. CAS No. 1957236-21-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103611. | |
| Thalidomide-O-C3-azide | Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2758432-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg. Product ID: HY-157510. | |
| Thalidomide-O-C6-azide | Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411389-65-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148556. | |
| Thalidomide-O-COOH | Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon ligand 3; E3 ligase Ligand 3. CAS No. 1061605-21-7. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-103597. | |
| Thalidomide-O-PEG4-NHS ester | Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411681-88-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-141012. | |
| Thalidomide-PEG2-NH2 hydrochloride | Thalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2891597-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-133484B. | |
| Thalidomide-PEG4-COOH | Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2828438-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-138774. | |
| Thalidomide-PEG5-COOH | Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2688100-28-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-138773. | |
| Thalidomide-piperazine hydrochloride | Thalidomide-piperazine hydrochloride is a synthetic E3 ligase ligand-linker conjugate, comprising a cereblon ligand based on Thalidomide (HY-14658) and one linker. Thalidomide-piperazine hydrochloride can be used in studies related to PROTAC synthesis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2228029-82-9. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg. Product ID: HY-132971. | |
| Thalidomide-Piperazine-Piperidine hydrochloride | Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2599846-44-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138783A. | |
| THAL-SNS-032 | THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2139287-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123937. | |
| THAM | THAM (Tris) is a low-toxicity amino alcohol buffer, a specific CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tris; Tris(hydroxymethyl)aminomethane. CAS No. 77-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 100 g; 500 g. Product ID: HY-D0227. | |
| THAM hydrochloride | THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tris HCl; Tris(hydroxymethyl)aminomethane hydrochloride. CAS No. 1185-53-1. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 100 g; 500 g. Product ID: HY-D0227A. | |
| Thanatin | Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 μM, 0.6-40 μM and 0.6-20 μM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 214542-43-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P5601. | |
| Thapsigargin | Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67526-95-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13433. | |
| Theaflavin | Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase. Uses: Scientific research. Category: Signaling pathways. CAS No. 4670-5-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0243. | |
| Theaflavin 3,3'-digallate | Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1[1]. Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TF-3; ZP10. CAS No. 30462-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1992. | |
| Theaflavin-3-gallate | Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through p53-dependent pathways. Theaflavin-3-gallate induces DNA damage through ATM/Chk/p53 pathway[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 30462-34-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0245. | |
| Theaflavin-3'-gallate | Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC50 of 7.6 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28543-07-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0244. | |
| Theliatinib | Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases[1]. Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Xiliertinib; HMPL-309. CAS No. 1353644-70-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104066. | |
| Theobromine | Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,7-Dimethylxanthine. CAS No. 83-67-0. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N0138. | |
| Theodrenaline hydrochloride | Theodrenaline hydrochloride is a cardiac stimulant, also acts as an anti-hypotensive agent together with Cafedrine. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)?-Theodrenaline hydrochloride. CAS No. 2572-61-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00344A. | |
| Theogallin | Theogallin (3-Galloylquinic acid) is an active ingredient in decaffeinated green tea extract. Theogallin has antidepressive and cognition enhancing effect[1]. Uses: Scientific research. Category: Natural products. Alternative Names: 3-Galloylquinic acid. CAS No. 17365-11-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-122924. | |
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