MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Aristolochic acid A | Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Aristolochic acid I; TR 1736. CAS No. 313-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0510. |  |
| Aristolochic acid B | Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aristolochic acid II. CAS No. 475-80-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N0511. | |
| Aristololactam II | Aristololactam II is an aristololactam-related blue-fluorescent compound found in the callus tissue of Stephania cepharantha[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55610-00-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11562. | |
| Arjunetin | Arjunetin, isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor[1]. Uses: Scientific research. Category: Natural products. CAS No. 31297-79-7. Pack Sizes: 10 mM * 1 mL in Methanol; 5 mg. Product ID: HY-N7592. | |
| Arjungenin | Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58880-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4294. | |
| Arjunic acid | Arjunic acid (Arjuntriterpenic acid) (compound 13) is a triterpenoid compound isolated from Sanguisorba officinalis L[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Arjuntriterpenic acid. CAS No. 31298-06-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2895. | |
| Arjunolic acid | Arjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-κB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohn's disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohn's disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 465-00-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2896. | |
| ARL67156 trisodium | ARL67156 (FPL 67156) trisodium is a selective small molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12?μM, respectively. ARL67156 trisodium can be used in the research of calcific aortic valve disease, asthma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FPL 67156 trisodium. CAS No. 1021868-83-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103265. | |
| ARN 077 | ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: URB913. CAS No. 1373625-34-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120813. | |
| ARN14494 | ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimers disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1037837-27-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115498. | |
| ARN1468 | ARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1381459-14-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150514. | |
| ARN14974 | ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644158-57-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103592. | |
| ARN14988 | ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC50=12.8 nM for the human enzyme)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1502027-70-4. Pack Sizes: 1 mg. Product ID: HY-124927. | |
| ARN19702 | ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1971937-18-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145339. | |
| ARN19874 | ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2190502-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118994. | |
| ARN22089 | ARN22089 is a oral active novel class of trisubstituted pyrimidine, blocks the interaction of CDC42 GTPases with specific downstream effectors. ARN22089 blocks tumor growth in BRAF mutant mouse melanoma model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2248691-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149464. | |
| ARN25068 | ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2649882-80-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144290. | |
| ARN2966 | ARN2966 is a potent, orally active and cross the blood-brain barrier amyloid precursor protein (APP) translation modulator. Uses: Scientific research. Category: Signaling pathways. CAS No. 102212-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18292. | |
| ARN-3236 | ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613710-01-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-120856. | |
| ARN726 | ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 μM. ARN726 decreases alcohol self-administration in a dose-dependent manner[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628343-77-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124597. | |
| Arnidiol | Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F.[1]. Uses: Scientific research. Category: Natural products. CAS No. 6750-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N4165. | |
| Aromadendrene | Aromadendrene can be isolated from Eucalyptus globulus. Aromadendrene has antimicrobial activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Aromadendrene. CAS No. 489-39-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N8411. | |
| ARP-100 | ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1? pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 704888-90-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103444. | |
| ARP101 | ARP101 is a potent and selective inhibitor matrix metalloproteinase-2 (MMP-2). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 is effective in inducing the formation of autophagosome and conversion of LC3I into LC3II[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849773-63-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101535. | |
| ARQ 621 | ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity[1]. ARQ 621 is a kinesin inhibitor[2]. ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1095253-39-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16062. | |
| ARS-1323-alkyne | ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2436544-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128522. | |
| ARS-1620 | ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics. Uses: Scientific research. Category: Induced disease models products. CAS No. 1698055-85-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00418. | |
| ARS-1630 | ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1. Uses: Scientific research. Category: Signaling pathways. CAS No. 1698055-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00417. | |
| ARS-853 | ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1629268-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19706. | |
| ART0380 | ART0380 is a potent, selective and orally active ATR kinase inhibitor. ART0380 potently inhibits human ATR-ATRIP complex with an IC50 of 51.7 nM. ART0380 binds the ATP pocket of the ATR-ATRIP complex, blocks ATR-dependent Chk1 serine 345 phosphorylation, and induces cell cycle disorder and DNA damage. ART0380 demonstrates potent and selective antitumor activity in preclinical models with varying types of ataxia-telangiectasia mutated (ATM) gene aberrancy. ART0380 can be used for the research of cancer, such as colorectal cancer and prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2267316-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157941. | |
| ART558 | ART558 is a potent, selective and allosteric DNA polymerase theta (Polθ) inhibitor (IC50=7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer, such as breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2603528-97-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141520. | |
| ART5803 | ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3058434-76-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991611. | |
| ART615 | ART615 is the related isomer of ART558. ART615, the inactive of ART558, elicits <10% Polθ inhibition at 12?μM, thus serving as a control for ART558 (IC50=7.9 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031765-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-145056. | |
| ART812 | ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2607138-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-139289. | |
| Arteannuin B | Arteannuin B, No. 2000 can be jointly submitted with the blue material. Arteannuin B had anti-SARS-CoV-2 activity, EC50=10.28 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50906-56-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2016. | |
| Artefenomel | Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OZ439. CAS No. 1029939-86-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16762. | |
| Artemether | Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224. CAS No. 71963-77-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-N0402. | |
| Artemether-d3 | Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dihydroqinghaosu methyl ether-d3; Dihydroartemisinin methyl ether-d3; SM224-d3. CAS No. 93787-85-0. Pack Sizes: 1 mg. Product ID: HY-N0402S. | |
| Artemisinin | Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Qinghaosu; NSC 369397. CAS No. 63968-64-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0094. | |
| Artemisitene | Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 101020-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-122550. | |
| Artemitin | Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 479-90-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N3017. | |
| Arterolane | Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OZ 277; RBx 11160. CAS No. 664338-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10852. | |
| Artesunate | Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Uses: Scientific research. Category: Signaling pathways. CAS No. 88495-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0193. | |
| Artesunate (Standard) | Artesunate (Standard) is the analytical standard of Artesunate. This product is intended for research and analytical applications. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Uses: Scientific research. Category: Signaling pathways. CAS No. 88495-63-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0193R. | |
| ARUK2001607 | ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924824-56-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-152155. | |
| ARUK3001185 | ARUK3001185 is a potent, selective, orally active and brain-penetrant inhibitor of Notum (IC50 = 6.7 nM). ARUK3001185 can restore Wnt signaling in the presence of Notum in vitro. ARUK3001185 is selective against serine hydrolases, kinases, and drug targets. ARUK3001185 can be used to research the role of Notum plays in diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411969-39-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147519. | |
| Arundic Acid | Arundic Acid is an orally effective astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of the astrocytic glutamate transporter EAAT1 by activating the ERK, Akt and NF-κB pathways. Arundic Acid attenuates retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid is a S100β protein synthesis inhibitor that prevents neurological deficits and brain tissue damage after intracerebral hemorrhage in rats. Arundic Acid downregulates neuroinflammation and astrocytic dysfunction after status epilepticus in immature rats. Arundic Acid is applicable to research related to Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage and epilepsy[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONO-2506; (R)-2-Propyloctanoic acid. CAS No. 185517-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107661. | |
| ARV-393 | ARV-393 is a potent and orally active BCL6 PROTAC degrader. ARV-393 induces ubiquitination of BCL6 and its subsequent degradation by the proteasome. ARV-393 has the potential for the research of advanced non-hodgkin lymphoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851885-95-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158105. | |
| ARV-771 | ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1949837-12-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100972. | |
| Ar-V7-IN-1 | Ar-V7-IN-1 is a potent inhibitor of Ar-V7. Ar-V7-IN-1 inhibits the transcriptional activity of androgen receptor (AR) and the secretion of prostate-specific antigen (PSA) with an eGFP IC50 of 1232 nM and the PSA IC50 of 1391 μM. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230880-25-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145709. | |
| ARV-825 | ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1818885-28-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-16954. | |
| Arvanil | Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Vanillylarachidonamide. CAS No. 128007-31-8. Pack Sizes: 5 mg (113.73 mM * 100 μL in Ethanol); 10 mg (113.73 mM * 200 μL in Ethanol). Product ID: HY-103333. | |
| Arylomycin A2 | Arylomycin A2, an antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 459844-20-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3884. | |
| Arzoxifene hydrochloride | Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY353381 hydrochloride; SERM III hydrochloride. CAS No. 182133-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-13556A. | |
| AS1134900 | AS1134900 is a highly selective uncompetitive allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1) with an IC50 of 0.73 μM. AS1134900 can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 149760-98-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150621. | |
| AS-136A | AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC50 of 2 μM for measles virus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 949898-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-134909. | |
| AS 1411 | AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGRO-100. CAS No. 301636-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147081. | |
| AS1517499 | AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 919486-40-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100614. | |
| AS1810722 | AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 909561-15-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134772. | |
| AS1842856 | AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 836620-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-100596. | |
| AS1842856 (Standard) | AS1842856 (Standard) is the analytical standard of AS1842856 (HY-100596). This product is intended for research and analytical applications. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 836620-48-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100596R. | |
| AS1949490 | AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 μM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1203680-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18686. | |
| AS-252424 | AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 900515-16-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-13532. | |
| AS-254s | AS-254s is the inhibitor for absent, small, or homeotic-like 1 protein (ASH1L) with an IC50 of 94 nM (FP assay). AS-254s exhibits antiproliferative activity against MLL1-rearranged leukemic cells with GI50 <1 μM. AS-254s induces the differentiation of MLL1-r leukemic cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3096805-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-170494. | |
| AS2717638 | AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3). AS2717638 can be used in the research of pain and neuroinflammation-related diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2148339-28-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114379. | |
| AS2863619 | AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241300-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126675A. | |
| AS2863619 free base | AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241300-50-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-126675. | |
| As48 | As48 is a selective TREM2 agonist with a KD value of 12.48 μM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1214405-38-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-182702. | |
| AS601245 | AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 345987-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11010. | |
| AS-605240 | AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC50 of 8 nM, and a Ki of 7.8 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 648450-29-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10109. | |
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