MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| APX-115 | APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ewha-18278. CAS No. 1395946-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120801. |  |
| APX2009 | APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1415030-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-120069. | |
| APX2039 | APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2342606-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147110. | |
| APY0201 | APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production. Uses: Scientific research. Category: Signaling pathways. CAS No. 1232221-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15982. | |
| Apyrase | Apyrase is an Nucleoside triphosphate diphosphohydrolase (NTPDase). Apyrase can hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP). Apyrase can inhibit Stx2 toxin release of enterohemorrhagic Escherichia coli (EHEC) infection and protect the intestinal barrier function. Apyrase can be used for the research of infection and inflammation, such as hemorrhagic colitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-95-7. Pack Sizes: 10 U; 100 U. Product ID: HY-P2764. | |
| AQC | AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate. CAS No. 148757-94-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-117695. | |
| AqF026 | AqF026 is an aquaporin 1 (AQP1) agonist. AqF026 enhances the channel activity of human AQP1 in the Xenopus laevis oocyte system. AqF026 enhances the osmotic transport of water across the peritoneum in a mouse model of peritoneal dialysis. AqF026 can be used in studies related to ultrafiltration failure in peritoneal dialysis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1021869-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174166. | |
| AQX-016A | AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849669-54-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-115620. | |
| AR03 | AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 μM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMH-23. CAS No. 510721-85-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-119993. | |
| AR-13503 | AR-13503 (AR-13324 M1 metabolite) is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR-13324 M1 metabolite. CAS No. 2309668-15-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12798C. | |
| AR 231453 | AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 733750-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-15564. | |
| AR-42 | AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan-HDAC inhibitor (IC50=16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HDAC-42; OSU-HDAC42. CAS No. 935881-37-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13265. | |
| AR420626 | AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3) (IC50=117 nM). AR420626 has anti-inflammatory, anticancer and antidiabetic activities. AR420626 improves neurogenic diarrhea by inhibiting nAChR mediated neural pathways. AR420626 inhibits the growth of HepG2 xenografts and inhibits the proliferation of hepatoma cells by inducing apoptosis. AR420626 also suppresses allergic asthma and eczema and has the ability to activate GPR41 to increase Ca2+ signal-mediated glucose uptake and improve diabetes[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1798310-55-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116522. | |
| AR7 | AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80306-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101106. | |
| AR-9281 | AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APAU. CAS No. 913548-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111151. | |
| AR-A014418 | AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR 0133418; GSK 3β inhibitor VIII; AR 014418. CAS No. 487021-52-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10512. | |
| (+)-Arabinogalactan,from larch wood, 80% | (+)-Arabinogalactan, from larch wood, 80% (Polyarabinogalactan, 80%) can be used in glycobiology research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyarabinogalactan, 80%. CAS No. 9036-66-2. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g; 500 g. Product ID: HY-W350004. | |
| Arabinose | Arabinose is a pentose sugar commonly found in plants. Arabinose alleviates immune dysregulation and inflammation by promoting balanced immune responses and reducing inflammation. Arabinose induces cytotoxicity, autophagy (Autophagy), and cell cycle arrest in breast cancer cells through the p38-MAPK signaling pathway. Arabinose activates the ACSS2-PPARγ/TFEB-AMPK axis in neuroblastoma cells, thereby exerting neuromodulatory/antidepressant effects. Arabinose can also be used as an intermediate in compound synthesis. Arabinose may be applied in research related to immune inflammation, depression, breast cancer, and other diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)?-Arabinose; DL-Arabinose; dl-Arabinose. CAS No. 147-81-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-N2353. | |
| Arabinoxylan (Medium viscosity) | Arabinoxylan Medium viscosity is an orally active Dectin-1 splice variant modulator, glucose absorption inhibitor, and chyme viscosity enhancer. Arabinoxylan Medium viscosity inhibits particulate β-glucan-induced Dectin-1A activation and mildly suppresses Dectin-1B activation. In human dendritic cells stimulated with particulate β-glucan, Arabinoxylan Medium viscosity reduces the production of IL-10 and TNF-α, and increases the production of IL-4 and IL-23. Arabinoxylan Medium viscosity also supports antifungal immune responses without activating TLR2, TLR4 or TLR5, and does not induce cytokine production when used to stimulate human dendritic cells alone. Arabinoxylan Medium viscosity increases small intestinal chyme viscosity, gets degraded in the large intestine to produce short-chain fatty acids, reduces glucose absorption and insulin response, and improves glucose homeostasis. Arabinoxylan Medium viscosity supports microbial fermentation and the growth of beneficial microbiota in the gastrointestinal tract, prevents bile acid reabsorption, and delays starch digestion. Arabinoxylan Medium viscosity can be used in research related to type 2 diabetes, impaired glucose tolerance, and metabolic syndrome[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9040-27-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N15135. | |
| Arachidic acid | Arachidic acid is an orally bioavailable membrane fluidity modulator and receptor/ion channel effector. Arachidic acid does not activate arachidonic acid-sensitive K+ channels in rat midbrain and hypothalamic neurons. Arachidic acid alleviates age-related spatial cognitive impairment. Arachidic acid is applicable for research related to age-related spatial cognitive impairment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Eicosanoic acid. CAS No. 506-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W004260. | |
| Arachidonic acid-alkyne | Arachidonic acid-alkyne is aω - alkynyl lipid surrogates for polyunsaturated fatty acid. Arachidonic acid-alkyne has low rates of oxidation. Arachidonic acid-alkyne can be used for tracking the polyunsaturated fatty acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219038-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139285. | |
| Arachidonic acid-d8 | Arachidonic acid-d8 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Immunocytophyt-d8. CAS No. 69254-37-1. Pack Sizes: 1 mg (32.00 mM * 100 μL in Methyl acetate). Product ID: HY-109590S. | |
| Arachidonic acid sodium salt | Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Immunocytophyt sodium salt. CAS No. 6610-25-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109590A. | |
| Arachidonylcyclopropylamide | Arachidonylcyclopropylamide (ACPA) is a potent and selective CB1 receptors agonist. Arachidonylcyclopropylamide inhibits forskolin-stimulated cAMP production in CHO cells transfected with human cannabinoid CB1 receptors (IC50=2 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACPA. CAS No. 229021-64-1. Pack Sizes: 5 mg (145.54 mM * 100 μL in Ethanol). Product ID: HY-110003. | |
| Araloside V | Araloside V (Congmunoside V) is a triterpenoid saponin isolated from Aralia elata[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Congmunoside V. CAS No. 340963-86-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6970. | |
| Araloside X | Araloside X (Congmunoside X) is a triterpenoid saponin isolated from Aralia elata[1]. Uses: Scientific research. Category: Natural products. CAS No. 344911-90-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2001. | |
| Aranidipine | Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MPC1304. CAS No. 86780-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00212. | |
| ARB-272572 | ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2368182-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142221. | |
| Arbemnifosbuvir | Arbemnifosbuvir is a nidovirus DdRp-associated nucleotidyltransferase (NiRAN) domain of non-structural protein 12 (nsp12)-interfering drugs. Arbemnifosbuvir can be used for SARS-CoVs infection research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT-752 free base. CAS No. 1998705-63-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-156597. | |
| AR/BRD4 RIPTAC-1 | AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3083307-42-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-176521. | |
| Arbutin | Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-Arbutin. CAS No. 497-76-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g; 50 g. Product ID: HY-N0192. | |
| AR-C118925XX | AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 216657-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110126. | |
| AR-C155858 | AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 496791-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13248. | |
| ARCC-4 | ARCC-4 is a low-nanomolar Androgen Receptor (AR) degrader based on PROTAC, with a DC50 of 5?nM. ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1973403-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130492. | |
| Arcotatug | Arcotatug (IBI-343 antibody) is a CLDN18.2 targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IBI-343 antibody; HB37A6; TAK-921 Antibody. CAS No. 3031170-61-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991564. | |
| Arctigenin | Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Arctigenin. CAS No. 7770-78-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0035. | |
| Arctiin | Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in ammatory cytokines levels. Arctiin can used in study glomerulonephritis[4][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Arctii; NSC 315527; Arctigenin-4-glucoside. CAS No. 20362-31-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N0034. | |
| ARD-1676 | ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2632305-36-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156111. | |
| ARD-2051 | ARD-2051 is a selective and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 exhibits effective anti-tumor activity in VCaP xenograft mice model. ARD-2051 can be used for the research of prostate cancer (Pink: AR ligand (HY-400666), Blue: CRBN Ligand (HY-14658), Black: Linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2632305-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149862. | |
| ARD-2128 | ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2222111-87-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132292. | |
| ARD-2585 | ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2757422-79-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139436. | |
| ARD-61 | ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice[1]. ARD-61 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2316837-08-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-139659. | |
| ARD-69 | ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study of castration-resistant prostate cancer (mCRPC)[1][2][3].ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625). Uses: Scientific research. Category: Signaling pathways. CAS No. 2316837-10-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114402. | |
| Ardisiacrispin B | Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112766-96-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N8198. | |
| Arecaidine | Arecaidine is a GABA transport system inhibitor. Arecaidine inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1. Arecaidine inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats. Arecaidine inhibits hPAT1-mediated L-[3H]proline uptake in cells. Arecaidine can be used in research related to neurological diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 499-04-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-N2368. | |
| Arecaidine hydrochloride | Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6018-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2368A. | |
| Arecaidine propargyl ester hydrobromide | Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 116511-28-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-134061. | |
| Arecoline | Arecoline, a naturally brain-penetrant and orally active occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N2364. | |
| Arecoline hydrobromide | Arecoline hydrobromide, a naturally brain-penetrant and orally active occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide. CAS No. 300-08-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-B0489. | |
| Arenicin-1 | Arenicin-1 is an antimicrobial peptide that can be isolated from coelomocytes of the marine polychaeta lugworm Arenicola marina. Arenicin-1 displays potent antimicrobial activity, with MIC values ranging from 2.0 to 8.0 μM. Arenicin-1 can be used for antibacterial research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 808102-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P11190. | |
| Arformoterol tartrate | Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R,R)-Formoterol tartrate. CAS No. 200815-49-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0010D. | |
| Arg-AMS | Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 301351-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112862. | |
| Arg-Glu | Arg-Glu is a polypeptide identified through polypeptide screening. Arg-Glu is a small peptide generated from protein degradation or metabolism[1]. Uses: Scientific research. Category: Peptides. CAS No. 15706-89-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P4256. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RGDS peptide; Fibronectin tetrapeptide. CAS No. 91037-65-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12290. | |
| Arginase inhibitor 1 | Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1345808-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15775. | |
| Argininic acid | Argininic acid is an α-amino acid that is used in the biosynthesis of proteins. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Argininic Acid. CAS No. 157-07-3. Pack Sizes: 1 mg. Product ID: HY-113079. | |
| Argininosuccinic acid disodium | Argininosuccinic acid disodium is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid disodium can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid disodium can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid disodium can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 918149-29-8. Pack Sizes: 1 mg. Product ID: HY-113149A. | |
| Argipressin | Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Arg8-vasopressin; AVP. CAS No. 113-79-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0049. | |
| Argipressin acetate | Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Arg8-vasopressin acetate; AVP acetate. CAS No. 129979-57-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W539944. | |
| Argireline | Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetyl hexapeptide-3; Acetyl hexapeptide-8. CAS No. 616204-22-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-P0033. | |
| ARI-1 | ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38. ARI-1 induces Apoptosis. ARI-1 has anticancer activity against non-small cell lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3078120-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-139534. | |
| ARI-3099 | ARI-3099 is an oral fibroblast activation protein (FAP) inhibitor. ARI-3099 specifically inhibits the proteolytic activity of FAP and blocks the cleavage of human FGF-21 between residues P171 and S172. ARI-3099 extends the half-life of circulating human FGF-21 in mice. ARI-3099 can be used in the research of type 2 diabetes and metabolic disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1432499-49-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125366. | |
| ARI-3144 | ARI-3144 is an excellent and specific substrate for fibroblast activation protein (FAP). ARI-3144 is usually coupled with the fluorophore 7-Amino-4-methylcoumarin (HY-D0027) (AMC) for detection and quantification of FAP[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1426305-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160289. | |
| Arimoclomol | Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann-Pick disease type C. Arimoclomol can cross the blood-brain barrier and can be used in research on Niemann-Pick disease type C[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRX-220 free base. CAS No. 289893-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-106443. | |
| Arimoclomol citrate | Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2]. Arimoclomol citrate can be used for the study of Niemann-Pick disease type C. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRX-220 citrate. CAS No. 368860-21-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106443B. | |
| Arimoclomol maleate | Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].Arimoclomol maleate can be used for the study of Niemann-Pick disease type C. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRX-220. CAS No. 289893-26-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106443A. | |
| Aripiprazole | Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-14597. CAS No. 129722-12-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-14546. | |
| Aripiprazole-d8-1 | Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-14597-d8. CAS No. 1089115-04-7. Pack Sizes: 500 μg; 1 mg. Product ID: HY-14546S1. | |
| Aripiprazole Lauroxil | Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by bodys enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259305-29-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108751. | |
| Aristeromycin | Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19186-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112639. | |
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