MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| AMG7703 | AMG7703 is a selective and allosteric agonists of FFA2 (GPR43), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1103523-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114011. |  |
| AMG 900 | AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 945595-80-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13253. | |
| AMG 925 | AMG 925 is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1401033-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15889. | |
| AMG9810 | AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 545395-94-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101736. | |
| Amgen-23 | Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448706-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147282. | |
| AMG PERK 44 | AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883548-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12661A. | |
| AMG-Tie2-1 | AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870223-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13023. | |
| AMI-1 | AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20324-87-2. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18962. | |
| Amifampridine | Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4-Diaminopyridine. CAS No. 54-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g; 100 g. Product ID: HY-14946. | |
| Amifostine | Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WR2721. CAS No. 20537-88-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0639. | |
| Amifostine thiol dihydrochloride | Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer agents and activate p53 through a JNK-dependent signaling pathway. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WR-1065 dihydrochloride. CAS No. 14653-77-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg. Product ID: HY-103640. | |
| Amikacin | Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 41-6551. CAS No. 37517-28-5. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-B0509A. | |
| Amikacin disulfate | Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 41-6551 disulfate. CAS No. 39831-55-5. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g. Product ID: HY-B0509B. | |
| Amikacin sulfate | Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 41-6551 sulfate. CAS No. 149022-22-0. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-107813. | |
| Amiloride | Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-870. CAS No. 2609-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0285. | |
| Amiloride hydrochloride | Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-870 hydrochloride. CAS No. 2016-88-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0285A. | |
| Amine-PEG3-Biotin | Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 359860-27-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-111377. | |
| Aminoadipic acid | Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 542-32-5. Pack Sizes: 500 mg; 1 g. Product ID: HY-113328. | |
| Aminocaproyl-Val-Cit-PABC-Exatecan TFA | Aminocaproyl-Val-Cit-PABC-Exatecan TFA is a drug-linker conjugate for ADC, consiting of a cleavable linker (Aminocaproyl-Val-Cit-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Aminocaproyl-Val-Cit-PABC-Exatecan TFA can be used for ADC molecues synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029114-40-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171931A. | |
| Aminoglutethimide | Aminoglutethimide (DL-Aminoglutethimide) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC50 values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide reduces cortisol levels. Aminoglutethimide can be used in research on Cushing's syndrome, breast cancer, and other conditions[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-Aminoglutethimide. CAS No. 125-84-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0237. | |
| Aminoguanidine hydrochloride | Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride. CAS No. 1937-19-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B1041. | |
| Aminohippurate sodium | Aminohippurate sodium is a renal tubular transport inhibitor and a substrate for organic anion transporters. Aminohippurate sodium inhibits renal tubular reabsorption of phosphate and promotes increased urinary phosphate excretion. Aminohippurate sodium inhibits renal tubular reabsorption of vitamin C as well as the transport of glucose[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium p-aminohippurate; p-Aminohippuric acid sodium salt. CAS No. 94-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-A0080. | |
| Aminomethyltrioxsalen hydrochloride | Aminomethyltrioxsalen hydrochloride is a psoralen derivative and nucleic acid intercalator. Aminomethyltrioxsalen hydrochloride can penetrate intact cells and react with nucleic acid secondary structures in vivo without disrupting the tissue structure of natural nucleoproteins. Aminomethyltrioxsalen hydrochloride inactivates viruses by crosslinking nucleic acid pyrimidine residues after exposure to UV-A radiation. Aminomethyltrioxsalen hydrochloride can be used in research related to dengue virus infection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62442-61-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137265. | |
| (Aminooxy)acetamide-Val-Cit-PAB-MMAE | (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2446645-88-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153263. | |
| Aminooxyacetic acid hemihydrochloride | Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride. CAS No. 2921-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-107994. | |
| Aminooxy-PEG3-azide | Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1306615-51-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126949. | |
| Aminooxy-PEG4-azide | Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2100306-61-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-126950. | |
| Aminooxy-PEG5-azide | Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1919045-02-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-130507. | |
| Amino-PEG12-acid | Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1415408-69-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140177. | |
| Amino-PEG24-acid | Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2563873-76-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-140182. | |
| Amino-PEG2-CH2CH2-SH hydrochloride | Amino-PEG2-CH2CH2-SH (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3037676-58-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132120. | |
| Amino-PEG2-NH-Boc | Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127828-22-2. Pack Sizes: 1 g; 5 g; 10 g; 25 g. Product ID: HY-W008279. | |
| Amino-PEG3-C2-acid | Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 784105-33-5. Pack Sizes: 250 mg; 1 g; 5 g. Product ID: HY-W040165. | |
| Amino-PEG3-C2-Azido | Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. Amino-PEG3-C2-Azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 134179-38-7. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-W021401. | |
| Amino-PEG3-C2-sulfonic acid | Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1817735-43-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140001. | |
| Amino-PEG4-alcohol | Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 86770-74-3. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W008005. | |
| Amino-PEG4-Boc | Amino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 581065-95-4. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-140193. | |
| Amino-PEG4-GGFG-Dxd | Amino-PEG4-GGFG-Dxd (Compound 13-7) is a drug-linker conjugate for ADC. Amino-PEG4-GGFG-Dxd is composed of Dxd (HY-13631D) and a linker. Amino-PEG4-GGFG-Dxd can be used for synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2879227-88-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-158768. | |
| Amino-PEG4-Val-Cit-PAB-MMAE | Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1492056-71-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-141154. | |
| Amino-PEG6-alcohol | Amino-PEG6-alcohol is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG6-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39160-70-8. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-126942. | |
| Amino-PEG8-amine | Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 82209-36-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-130659. | |
| Amino-PEG8-Boc | Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG8-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 756526-06-4. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W019799. | |
| Aminopotentidine | Aminopotentidine is a histamine H2 receptor antagonist with KB values of 220 nM and 280 nM for human and guinea pig H2 receptors, respectively. It can also serve as a precursor for the synthesis of [125I] iodo derivatives[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 140873-26-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-101167. | |
| Aminopterin | Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Aminofolic acid; APGA. CAS No. 54-62-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14518. | |
| Amino Tadalafil | Amino Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor analog and tadalafil structural analog. Amino Tadalafil can be specifically detected by anti-tadalafil polyclonal antibodies, with a cross-reactivity of 105.2% with tadalafil. Amino Tadalafil can be incorporated into dietary supplements[1][2][3]. . Uses: Scientific research. Category: Signaling pathways. CAS No. 385769-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117109. | |
| Amino-Tri-(carboxyethoxymethyl)-methane | Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174362-95-9. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-117519. | |
| Aminoxyacetamide-PEG3-azide | Aminoxyacetamide-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminoxyacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1379761-16-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-133434. | |
| Aminoxyacetic acid | Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carboxymethoxylamine; Aminooxyacetate. CAS No. 645-88-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-107994A. | |
| Amiodarone | Amiodarone, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC50 of ?45 nM[1]. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone can be used in the research of both supraventricular and ventricular arrhythmias[1]. Uses: Scientific research. Category: Induced disease models products. CAS No. 1951-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14187. | |
| Amiodarone hydrochloride | Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC50 of ?45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1]. Uses: Scientific research. Category: Induced disease models products. CAS No. 19774-82-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-14188. | |
| Amiselimod hydrochloride | Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MT-1303 hydrochloride. CAS No. 942398-84-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16734A. | |
| Amisulpride | Amisulpride ((Rac)-Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Rac)-Aramisulpride; (Rac)-Esamisulpride; DAN 2163. CAS No. 71675-85-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-14545. | |
| Amitriptyline | Amitriptyline is an orally active tricyclic antidepressant (TCA). Amitriptyline mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline can reduce inflammation, angiogenesis and fibrosis. Amitriptyline binds to DAT (with Ki = 2.58 μM). Amitriptyline has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-48-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0527. | |
| Amitriptyline hydrochloride | Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with Ki = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 549-18-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g. Product ID: HY-B0527A. | |
| Amitriptyline N-β-D-glucuronide | Amitriptyline N-β-D-glucuronide is an ammonium glucuronide and an urinary excretion metabolite of amitriptyline[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112806-33-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137339. | |
| Amivantamab | Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-61186372. CAS No. 2171511-58-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P9977. | |
| Amlexanox | Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AA673; Amoxanox; CHX3673. CAS No. 68302-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0713. | |
| Amlitelimab | Amlitelimab () is an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb). Amlitelimab inhibits OX40-OX40L interaction, and can be used in the research of atopic dermatitis[1][2][3]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: KY1005; SAR445229. CAS No. 2378692-15-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99434. | |
| Amlodipine | Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88150-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0317. | |
| Amlodipine besylate | Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Amlodipine benzenesulfonate. CAS No. 111470-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0317B. | |
| Amlodipine-d4 | Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1185246-14-3. Pack Sizes: 5 mg. Product ID: HY-B0317S1. | |
| Ammonium bicarbonate,AR,99% | Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1066-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g. Product ID: HY-W093399. | |
| Ammonium chloride, AR, 99.5% | Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 12125-02-9. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g; 5 g; 10 g. Product ID: HY-Y1269. | |
| Ammonium chloride, for cell culture | Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Salmiac, for cell culture. CAS No. 12125-02-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-Y1269C. | |
| Ammonium iron(III) citrate | Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ammonium ferric citrate; FAC. CAS No. 1185-57-5. Pack Sizes: 1 g. Product ID: HY-B1645. | |
| Ammonium polyphosphate, n90 g/100 mL | Ammonium polyphosphate, n<20, water solubility>90 g/100 mL, a low-polymerization-degree ammonium polyphosphate (APP), is an important raw material in chelated, and controlled-release fertilizers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 68333-79-9. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-109536B. | |
| Ammonium sulfamate | Ammonium sulfamate (Sulfamic acid ammonium) is a kind of biological materials or organic compounds that are widely used in life science research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sulfamic acid ammonium. CAS No. 7773-06-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 g; 500 g; 1 k g. Product ID: HY-W040155. | |
| Ammonium sulphate,≥99.0%,AR | Ammonium sulphate,≥99.0%,AR is an inorganic sulfate salt used for molecular biology[1]. Ammonium sulphate,≥99.0%,AR can be used to precipitate proteins, separate antibodies, and enhance antigen-antibody reactions. Ammonium sulphate,≥99.0%,AR can serve as a nitrogen source in plant fertilizers and has developmentally toxicity to freshwater snails, but increases the number of Anopheles africanus and Culex mosquito larvae in rice paddies. Ammonium sulphate,≥99.0%,AR also inhibits the conversion of glucose to ascorbic acid in plants[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7783-20-2. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-Y0261A. | |
| Ammonium trifluoroacetate | Ammonium trifluoroacetate is an additive for regulating and calibrating new liquid/mass spectrometry systems[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trifluoroacetic acid amine. CAS No. 3336-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g. Product ID: HY-W105853. | |
| AMN082 | AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 97075-46-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103565. | |
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