MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| ALC-0315 analogue-4 | ALC-0315 analogue-4 is an ALC-0315 analog used in drug delivery. Uses: Scientific research. Category: Signaling pathways. CAS No. 2036273-14-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-173292. |  |
| Alcian Blue 8GX | Alcian Blue 8GX is a commonly used phthalocyanine dye that binds to glycoproteins and glycosaminoglycans. Alcian Blue 8GX has a wide range of applications in biological staining, including proteins in brain tumors and DNA in cells and tissues[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33864-99-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-D0001. | |
| Alclofenac | Alclofenac (Allopydin) is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Allopydin; W-7320. CAS No. 22131-79-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W009706. | |
| Alcohol dehydrogenase, Saccharomyces cerevisiae | Alcohol dehydrogenase, Saccharomyces cerevisiae is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EC 1.1.1.1. CAS No. 9031-72-5. Pack Sizes: 25 KU. Product ID: HY-P2740. | |
| Alcohol oxidase | Alcohol oxidase is a functional enzyme of methanol utilization pathway and can be isolated from yeast peroxisome[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AO; AOX. CAS No. 9073-63-6. Pack Sizes: 50 U; 250 U. Product ID: HY-P2756. | |
| Alda-1 | Alda-1 is a potent and selective ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2. Uses: Scientific research. Category: Signaling pathways. CAS No. 349438-38-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-18936. | |
| Aldafermin | Aldafermin (NGM282) is an analog of fibroblast growth factor 19. Aldafermin can be used for the research of nonalcoholic steatohepatitis (NASH)[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: NGM282. CAS No. 1616639-03-2. Pack Sizes: 500 μg; 1 mg. Product ID: HY-P99428. | |
| Aldehyde reactive probe TFA | Aldehyde reactive probe TFA is an aldehyde reactive probe. Aldehyde reactive probe TFA specifically labels the AP site in DNA with biotin residues. Aldehyde reactive probe TFA can detect RNA oxidation-induced debasement sites. Aldehyde reactive probe TFA can be used to quantify AP sites or detect other aldehyde-containing DNA damage and RNA oxidation-induced debasement sites[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 627090-10-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-135136. | |
| ALDH | ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aldehyde dehydrogenase (NAD(P)). CAS No. 9028-88-0. Pack Sizes: 25 U. Product ID: HY-P2947. | |
| ALDH1A1-IN-2 | ALDH1A1-IN-2 (compound 297) is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2231081-18-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126003. | |
| ALDH1A3-IN-1 | ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 μM and a Ki of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1695970-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144667. | |
| ALDH2 activator 1 | ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2988020-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176716. | |
| ALDH3A1-IN-1 | ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with an IC50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination research with docetaxel[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1039855-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144670. | |
| ALDH3A1-IN-3 | ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM. ALDH3A1-IN-3 has no inhibitory potential on the in vitro activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2. ALDH3A1-IN-3 can be used in cellular oxidation and cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315239-63-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125085. | |
| Aldometanib | Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LXY-05-029. CAS No. 2904601-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-148189. | |
| Aldosterone | Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-113313. | |
| Aldoxorubicin | Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INNO-206; DOXO-EMCH. CAS No. 1361644-26-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16261. | |
| Aldumastat | Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GLPG1972; S201086. CAS No. 1957278-93-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137430. | |
| Alectinib | Alectinib (CH5424802; RO5424802; RG7853) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802; RO5424802; RG7853. CAS No. 1256580-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13011. | |
| Alectinib-d8 | Alectinib-d8 is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802-d8; RO5424802-d8; AF802-d8. CAS No. 1256585-15-5. Pack Sizes: 1 mg. Product ID: HY-13011S. | |
| Alectinib Hydrochloride | Alectinib (CH5424802; RO5424802; RG7853) Hydrochloride is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride. CAS No. 1256589-74-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13011A. | |
| Alectinib Hydrochloride (Standard) | Alectinib (Hydrochloride) (Standard) is the analytical standard of Alectinib (Hydrochloride). This product is intended for research and analytical applications. Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802 Hydrochloride (Standard); RO5424802 Hydrochloride (Standard); AF-802 Hydrochloride (Standard). CAS No. 1256589-74-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13011AR. | |
| Alefacept | Alefacept (BG 9273) is a human lymphocyte function-associated antigen 3/immunoglobulin 1 fusion protein. Alefacept can be used for the research of chronic plaque psoriasis[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: BG 9273; Human LFA 3IgG fusion protein; LFA 3TIP. CAS No. 222535-22-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99429. | |
| Alemtuzumab | Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Campath-IH. CAS No. 216503-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9948. | |
| Alendronate sodium | Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alendronic acid monosodium salt. CAS No. 129318-43-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-108685. | |
| Alendronate sodium hydrate | Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alendronate; MK 217; G-704650 Adronat. CAS No. 121268-17-5. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-11101. | |
| Alendronic acid | Alendronate acid is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate acid induces skeletal alterations in the chicken embryonic development model. Alendronate acid can be used for osteoporosis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 66376-36-1. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0631. | |
| Aleniglipron | Aleniglipron (GSBR-1290) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist, with an EC50 value of less than 0.1 nM in HDB cell lines in cAMP stimulation assays. Aleniglipron selectively activates the Gαs-cAMP signaling pathway of GLP-1R without β-arrestin recruitment. Aleniglipron induces insulin release, promotes glucose clearance, reduces food intake and decreases body weight. Aleniglipron is applicable to research related to type 2 diabetes and obesity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSBR-1290. CAS No. 2685823-26-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160734. | |
| Aleplasinin | Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PAZ-417. CAS No. 481629-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14759. | |
| Alexa fluor 488 azide ditriethylamine | Alexa fluor 488 azide ditriethylamine is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 1006592-64-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1304. | |
| Alexa Fluor 594 azide | Alexa Fluor 594 azide is an azide-modified fluorescent dye and also a FRET acceptor reactant. Owing to its negligible direct absorption under 488 nm excitation light, excellent photostability, and the ability of its azide group to participate in the CuAAC reaction, Alexa Fluor 594 azide can be paired with a donor dye for single-molecule imaging via TIRFM, thereby enabling the visual monitoring of CuNP-catalyzed click reactions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1872449-19-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W800703. | |
| Alexa fluor 647 maleimide | Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1825332-75-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-D2906. | |
| Alexa fluor 647 NHS ester | Alexa fluor 647 NHS ester can be used to label Alexa fluor 647 to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620475-28-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D2096. | |
| Alexidine dihydrochloride | Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1715-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108547. | |
| Alfacalcidol | Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3. CAS No. 41294-56-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10003. | |
| ALFA-tag | ALFA-tag is a small and stable α-helical structure composed of 15 amino acids. ALFA-tag is highly hydrophilic and can be placed at the N-terminus, C-terminus, or between two independently folded domains of the target protein without affecting the function of the protein. ALFA-tag is widely used as an epitope tag and is used for the detection and manipulation of proteins in living cells[1]. Uses: Scientific research. Category: Peptides. CAS No. 2413353-86-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P10531. | |
| ALG-000184 | ALG-000184 is an orally effective inhibitor of hepatitis B virus (HBV), and it is also a prodrug of ALG-001075 (HY-177022). ALG-000184 can inhibit the production of HBV DNA in liver cells. ALG-000184 can be used in the research of chronic hepatitis B[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2495324-72-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169993. | |
| ALG-001075 | ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2495324-66-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-177022. | |
| ALG-055009 | ALG-055009 is a selective and orally active Thyroid Hormone Receptor Beta (THR-β) agonist with an EC50 of 0.063 μM. ALG-055009 binds to the T3 hormone pocket of human THR-β, forming polar interactions with protein residues. ALG-055009 can lower total cholesterol levels in rats on a high-fat diet. ALG-055009 exhibits high metabolic stability, good permeability, a long in vivo half-life, and limited drug-drug interaction liability. ALG-055009 can be used in studies related to metabolic dysfunction-associated fatty liver disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2542029-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168046. | |
| Alginate lyase | Alginate lyase is a polysaccharide lyase that catalyzes the degradation of alginate. Alginate lyase can be used for the research of cystic fibrosis by degrading the polysaccharide biofilm of Pseudomonas aeruginosa[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9024-15-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2835. | |
| Alglucosidase alfa | Alglucosidase alfa (rhGAA) is a hydrolytic lysosomal glycogen-specific recombinant human α-glucosidase. Alglucosidase alfa can be used for Pompe disease research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: rhGAA. CAS No. 420784-05-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108828. | |
| Alicapistat | Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD)[1]. Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-957. CAS No. 1254698-46-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109001. | |
| Alirinetide | Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases[1]. Uses: Scientific research. Category: Peptides. Alternative Names: GM604. CAS No. 725715-18-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107130. | |
| Alirocumab | Alirocumab is an anti-PCSK9 human monoclonal antibody. Alirocumab inhibits PCSK9. Alirocumab reduces NLRP3 inflammasome, regulates Nrf2/HO-1, HMGB1/NF-κB and Fractalkine/CX3CR1. Alirocumab increases the ability of the liver to bind LDL-cholesterol (LDL-C) and reduces levels of LDL-C in blood. Alirocumab improves atherosclerosis and inflammation[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN 727; SAR 236553. CAS No. 1245916-14-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9928. | |
| Alirocumab (anti-PCSK9) | Alirocumab (anti-PCSK9) is an anti-PCSK9 human monoclonal antibody. Alirocumab (anti-PCSK9) inhibits PCSK9. Alirocumab (anti-PCSK9) reduces NLRP3 inflammasome, regulates Nrf2/HO-1, HMGB1/NF-κB and Fractalkine/CX3CR1. Alirocumab (anti-PCSK9) increases the ability of the liver to bind LDL-cholesterol (LDL-C) and reduces levels of LDL-C in blood. Alirocumab (anti-PCSK9) improves atherosclerosis and inflammation[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN 727(anti-PCSK9); SAR 236553(anti-PCSK9). CAS No. 1245916-14-6. Pack Sizes: 1 mg; 2 mg; 5 mg. Product ID: HY-P9928A. | |
| Alisertib | Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MLN 8237. CAS No. 1028486-01-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10971. | |
| Aliskiren | Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGP 60536; CGP60536B; SPP 100. CAS No. 173334-57-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12176. | |
| Alisol B 23-acetate | Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma[1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate. CAS No. 26575-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0805. | |
| Alisol C | Alisol C is a triterpenoid that can be found in the tuber of Alisma orientale (Sam.) Juzep[1]. Uses: Scientific research. Category: Natural products. CAS No. 30489-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-N6570. | |
| Alisporivir | Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Debio-025; DEB-025. CAS No. 254435-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12559. | |
| Alisporivir intermediate-1 | Alisporivir intermediate-1 is an intermediate in the synthesis of Alisporivir. Alisporivir is used for the treatment of inflammatory and viral diseases. Uses: Scientific research. Category: Signaling pathways. CAS No. 882506-05-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1358. | |
| Alixorexton | Alixorexton (ALKS 2680) is an orally bioavailable, blood-brain barrier-permeable OX2R-selective activator and wake-promoting agent. Alixorexton can be used for the research of narcolepsy and idiopathic hypersomnia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALKS 2680. CAS No. 2648347-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172412. | |
| Alizapride hydrochloride | Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59338-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-A0125A. | |
| Alizarin Red S Indicator (4.3-6.3), IND | Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection), and can be used in osteoporosis and metabolic disease research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W110927. | |
| ALK2-IN-2 | ALK2-IN-2 is an orally active and selective inhibitor of ALK2 (ACVR1), with an IC50 value of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 can inhibit oxidative stress and protect endothelial cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2254409-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112815. | |
| ALK4290 | ALK4290 (AKST4290) is a potent, orally active and selective CCR3 inhibitor with a Ki of 3.2 nM. ALK4290 blocks CCR3-mediated signaling, abrogates macrophage supernatant-driven mesothelial-to-mesenchymal transition, and decreases p38 phosphorylation. ALK4290 inhibits CCL26-CCR3 axis-driven GPX2-mediated B-cell activation, and targets B cells to inhibit activation by GPX2-overexpressing tumor cells. ALK4290 can be used for the research of hepatocellular carcinome and Parkinsons disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AKST4290; BI144807. CAS No. 1251528-23-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136788. | |
| ALK5-IN-34 | ALK5-IN-34 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 can inhibit the activity of ALK5-IN-34 with an IC50 value of ≤10 nM. ALK5-IN-34 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2785430-90-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151289. | |
| ALK5-IN-8 | ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2705900-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144043. | |
| Alkaline phosphatase, Bovine intestine | Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Apase. CAS No. 9001-78-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2818. | |
| Alkaline Phosphatase, Calf intestinal | Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase, Calf intestinal is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline Phosphatase, Calf intestinal reduces myeloperoxidase activity and bacterial translocation. Alkaline Phosphatase, Calf intestinal improves survival rate of mice infected with E. coli. Alkaline Phosphatase, Calf intestinal improves TNBS-induced colon inflammation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Apase, Calf intestinal. CAS No. 9001-78-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P2818E. | |
| Alkaline phosphatase, Escherichia coli | Alkaline Phosphatase (Apase), Escherichia coli is an alkaline phosphatase from Escherichia coli, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Escherichia coli is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Escherichia coli reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Escherichia coli improves survival rate of mice infected with E. coli. Alkaline phosphatase, Escherichia coli improves TNBS-induced colon inflammation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Apase, Escherichia coli. CAS No. 9001-78-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P2818A. | |
| (-)-Alkannin | (-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 517-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6012. | |
| ALKBH1-IN-3 prodrug | ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of a DNA N6-methyladenine demethylase ALKBH1 inhibitor that significantly increases the abundance of 6mA in cells and upregulates the AMPK signaling pathway, thereby inhibiting the viability of gastric cancer cells. ALKBH1-IN-4 prodrug exhibits excellent cellular activity and favorable metabolic exposure in vivo, and holds promise for research in gastric cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3056005-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-169131. | |
| ALKBH5-IN-3 | ALKBH5-IN-3 is a selective, cell active ALKBH5 inhibitor with an IC50 of 0.021 μM. ALKBH5-IN-3 stabilizes ALKBH5 in HepG2 cells, and increases m6A level in intact cells. ALKBH5-IN-3 can be used as a versatile chemical probe to explore the biological function of ALKBH5. ALKBH5-IN-3 can be used for the research of Cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1505579-77-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-165422. | |
| ALKBH5-IN-5 | ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 μM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 140481-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172158. | |
| ALK-IN-1 | ALK-IN-1 is an orally active, blood-brain barrier-permeable ALK and EGFR inhibitor. ALK-IN-1 binds to and inhibits ALK kinase, ALK fusion proteins, and wild-type and mutant EGFR variants, thereby disrupting their corresponding signaling pathways. ALK-IN-1 can suppress the growth and proliferation of tumor cells and exhibits potential inhibitory activity against mutant EGFR. ALK-IN-1 can be used in the research of non-small-cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Brigatinib analog. CAS No. 1197958-12-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13464. | |
| ALK inhibitor 2 | ALK inhibitor 2 (compound 18) is a potent pyrimidin ALK inhibitor. ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 761438-38-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-15358. | |
| Alkyne Cholesterol | Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1631985-09-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-151705. | |
| Alkyne-cRGD | Alkyne-cRGD is an integrin ligand. Alkyne-cRGD can be used in the study of degraders. Alkyne-cRGD undergoes copper-catalyzed azide-alkyne cycloaddition reaction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2665674-77-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P6438. | |
| Alkyne-PEG4-maleimide | Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkyne-PEG4-maleimide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609651-90-2. Pack Sizes: 100 mg. Product ID: HY-133399. | |
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