MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| α-Zearalenol | α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER),α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36455-72-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N6710. |  |
| Alpidem | Alpidem, an anxiolytic agent, is an orally active and brain-penetrant GABAA receptor ligand, binds to α1β2γ2 subunit-containing GABAA receptors (IC50 of 17 nM) over α5β2γ2 subunit-containing GABAA receptors (IC50 of >10 μM). Alpidem modulates calcium-induced mitochondrial permeability transition, induces glutathione depletion and hepatocyte necrosis, potentiates TNF-α toxicity, inhibits marble-burying and locomotor activity, enhances stressed rodent feeding behavior, and exerts anticonvulsant effects. Alpidem can be used for the research of anxiety, anxiety disorders, and convulsions[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. CAS No. 82626-01-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W013150. | |
| Alpitatug | Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMC 3C5; JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6). CAS No. 2921676-05-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990608. | |
| Alprenolol | Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (RS)-Alprenolol; dl-Alprenolol. CAS No. 13655-52-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-B1517. | |
| Alprenolol hydrochloride | Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride. CAS No. 13707-88-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B1517A. | |
| Alrizomadlin | Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APG-115; AA-115. CAS No. 1818393-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101518. | |
| ALS-8112 | ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1445379-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12983. | |
| Alsevalimab | Alsevalimab is a humanized, afucosylated IgG1 monoclonal antibody against B7-H4. Alsevalimab blocks the binding of the B7-H4 protein to the receptors on the surface of T cells, reversing the immunosuppressive state in the tumor microenvironment, thereby activating the killing effect of T cells on cancer cells. Alsevalimab can be used in combination with Pembrolizumab (HY-P9902), and shows good safety profiles[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2254029-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99242. | |
| ALS-I | ALS-I, an acid-Liable surfactant, is adopted for in-solution enzymatic digestions, can help to solubilize hydrophobic proteins. ALS-I is significantly enhanced peptide recovery for mass spectrometry (MS) mapping in the study of the proteomes of regenerating rat retina and mouse brain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 308818-13-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-44157. | |
| Alsterpaullone | Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders[1]. Alsterpaullone induces apoptosis in leukemia cell line[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 9-Nitropaullone; NSC 705701. CAS No. 237430-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108359. | |
| ALT-007 | ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2035010-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170794. | |
| Altanserin | Altanserin can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 76330-71-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119156. | |
| Altenuene | Altenuene is a heptaketide isolated from an endolichenic fungal strain Nigrospora sphaerica[1]. Uses: Scientific research. Category: Natural products. CAS No. 29752-43-0. Pack Sizes: 1 mg. Product ID: HY-N6713A. | |
| Alteplase | Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters[1][2][3][4].The product size below only indicate the effective content of Alteplase. The ratio of Alteplase effective content : total content = 1:46-1:50. The actual ratio depends on the batch.). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Actilyse; Activase. CAS No. 105857-23-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108865. | |
| Alternariol | Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 641-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N6714. | |
| Altertoxin I | Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Dihydroalterperylenol. CAS No. 56258-32-3. Pack Sizes: 1 mg. Product ID: HY-N6724. | |
| Altiratinib | Altiratinib (DCC-2701) is a multi-targeted kinase inhibitor with IC50s of 2.7, 8, 9.2, 9.3, 0.85, 4.6, 0.83 nM for MET, TIE2, VEGFR2, FLT3, Trk1, Trk2, and Trk3 respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCC-2701. CAS No. 1345847-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0791. | |
| Altretamine | Altretamine is an alkylating antineoplastic agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ENT-50852; RB-1515; WR-95704. CAS No. 645-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0181. | |
| Aluminum Hydroxide | Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21645-51-2. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1521. | |
| ALV1 | ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of regulatory T cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2438124-79-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-145776. | |
| Alvelestat | Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD9668. CAS No. 848141-11-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15651. | |
| Alvespimycin | Alvespimycin (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-DMAG; KOS-1022; NSC 707545. CAS No. 467214-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10389. | |
| Alvespimycin hydrochloride | Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-DMAG hydrochloride; KOS-1022 hydrochloride; BMS 826476. CAS No. 467214-21-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 100 mg; 200 mg. Product ID: HY-12024. | |
| Alvimopan | Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ADL 8-2698; LY 246736. CAS No. 156053-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13243. | |
| ALW-II-41-27 | ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Eph receptor tyrosine kinase inhibitor. CAS No. 1186206-79-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18007. | |
| ALW-II-49-7 | ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC50 value of 40 nM in cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1135219-23-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18833. | |
| AM095 | AM095 is a selective LPA1 receptor antagonist. The IC50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells is 0.025 and 0.023 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1345614-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-16039. | |
| AM095 free acid | AM095 (free acid) is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1228690-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-16040. | |
| AM-1638 | AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1142214-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13467. | |
| AM-2099 | AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7. Uses: Scientific research. Category: Signaling pathways. CAS No. 1443373-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-100727. | |
| AM251 | AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC50 of 39 nM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 183232-66-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15443. | |
| AM-5308 | AM-5308 is the inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2410796-89-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144894. | |
| AM580 | AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CD336; NSC608001; Ro 40-6055. CAS No. 102121-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10475. | |
| AM6545 | AM6545 is a highly selective, brain-free (peripherally active) CB1 receptor antagonist (Ki=1.7 nM). AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment (such as proteinuria, fibrosis) and insulin resistance. AM6545 can be used in the study of obesity and its complications[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1245626-05-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110206. | |
| AM-9022 | AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2446872-46-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162110. | |
| AM9053 | AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease (NAAA) (IC50 = 30 nM). The effect of AM9053 on FAAH activity is limited (IC50 > 100 nM). AM9053 inhibits the proliferation of colorectal cancer cells by activating the PPAR-α and TRPV1 dependent mechanisms and induces S-phase cell cycle arrest. AM9053 alleviates intestinal fibrosis by regulating macrophage activity and inhibiting the IL-23 signaling pathway. AM9053 leads to an increase in NAE levels, especially PEA and OEA. AM9053 can be used for the study of colorectal cancer and intestinal fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 157469-21-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-185011. | |
| AM966 | AM966 is a high affinity, selective, oral LPA1-antagonist, inhibits LPA-stimulated intracellular calcium release (IC50=17 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1228690-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15277. | |
| Amantadine | Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Adamantanamine; 1-Aminoadamantane. CAS No. 768-94-5. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0402. | |
| Amantadine-d15 | Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Adamantanamine-d15; 1-Aminoadamantane-d15. CAS No. 33830-10-3. Pack Sizes: 10 mg. Product ID: HY-B0402S. | |
| Amantadine-d6 | Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Adamantanamine-d6; 1-Aminoadamantane-d6. CAS No. 1219805-53-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0402S1. | |
| Amantadine hydrochloride | Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride. CAS No. 665-66-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 50 g. Product ID: HY-B0402A. | |
| Amarogentin | Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21018-84-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N2447. | |
| Amastatin hydrochloride | Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 100938-10-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-115194. | |
| Amatuximab | Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MORab-009. CAS No. 931402-35-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99006. | |
| AMB639752 | AMB639752 is a potent DGKα inhibitor. AMB639752 restores restimulation induced cell death (RICD) in SAP deficient lymphocytes by inhibiting DGKα in intact cells. AMB639752 can be used for X-linked lymphoproliferative disease 1(XLP-1) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 371210-26-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156567. | |
| Ambenonium chloride | Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WIN 8077 chloride. CAS No. 115-79-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-100919. | |
| Ambrettolide | Ambrettolide is a natural macrolide compound that possesses a warm and delicate musk aroma, with a hint of animal fragrance[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7779-50-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W744618. | |
| Ambrisentan | Ambrisentan is a selective ET type A receptor (ETAR) antagonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BSF 208075; LU 208075. CAS No. 177036-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13209. | |
| Ambroxol | Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NA-872. CAS No. 18683-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B1039. | |
| Ambroxol hydrochloride | Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NA-872 hydrochloride. CAS No. 23828-92-4. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B1039A. | |
| Amcasertib | Amcasertib (BBI503) is an orally activate cancer stemness kinase inhibitor that enhances apoptosis. Amcasertib inhibits the expression of NANOG and CD133 and cell viability in PC-9/GR cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BBI503. CAS No. 1129403-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17602. | |
| Amcenestrant | SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC50 of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER+ breast cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR439859. CAS No. 2114339-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133017. | |
| AMD 3465 | AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GENZ-644494. CAS No. 185991-24-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-15971A. | |
| AMDE-1 | AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 478043-30-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119137. | |
| Amdiglurax | Amdiglurax (NSI-189) is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax holds potential for psychiatric disorder research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSI-189. CAS No. 1270138-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13999. | |
| Amelenodor | NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NX-13. CAS No. 2389235-01-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-141521. | |
| Amelubant | Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIIL 284. CAS No. 346735-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19304. | |
| Amenamevir | Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC50 of 14 ng/mL. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASP2151. CAS No. 841301-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14809. | |
| Amentoflavone | Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Didemethyl-ginkgetin. CAS No. 1617-53-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0662. | |
| Amezalpat | Amezalpat is the antagonist for PPARα with IC50 of 58 nM. Amezalpat exhibits antineoplastic activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TPST-1120. CAS No. 1616372-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172413. | |
| AMG131 | AMG131 (INT131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 is promising for research of type-2 diabetes mellitus[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INT131. CAS No. 315224-26-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117103. | |
| AMG-193 | AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC50=0.107 μM), thereby protecting normal cells with wild-type MTAP[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2790567-82-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-153390. | |
| AMG2850 | AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1470018-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104059. | |
| AMG-337 | AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173699-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18696. | |
| AMG410 | AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 shows greater than 100-fold selectivity against both HRAS and NRAS. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. AMG410 can be used for the study of colorectal, pancreatic, and lung cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3040175-17-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173632. | |
| AMG 487 | AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 473719-41-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15319. | |
| AMG 517 | AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 659730-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10634. | |
| AMG-548 | AMG-548, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM)[1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 864249-60-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108642. | |
| AMG-548 dihydrochloride | AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM)[1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2518299-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108642B. | |
| AMG 579 | AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1227067-61-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12913. | |
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