MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| AGG-523 | AGG-523 (PF-5212371) is an orally active, reversible, non-hydroxamate, zinc-binding selective inhibitor of ADAMTS4 and ADAMTS5 with IC50 of <0.03 and 0.04 μM. AGG-523 also inhibits MMP-2, -8, 12 activity AGG-523 attenuates release of aggrecanase-generated ARG-aggrecan fragments into synovial fluid, reduces surgery-induced ARG-aggrecan release in rat joint models, and inhibits aggrecanase activity to slow cartilage degradation. AGG-523 can be used for the research of osteoarthritis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-5212371. CAS No. 920289-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160822. |  |
| AGI-24512 | AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2201066-53-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-112130. | |
| AGI-41998 | AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2377492-26-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145778. | |
| AGI-5198 | AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IDH-C35. CAS No. 1355326-35-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-18082. | |
| AGI-6780 | AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50 of 190±8.1 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1432660-47-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15734. | |
| AGK2 | AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 μM. AGK2 inhibits SIRT1 and SIRT3 with IC50s of 30 and 91 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 304896-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100578. | |
| Agmatine sulfate | Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 2482-00-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-101238. | |
| AGN 192403 hydrochloride | AGN 192403 (BRD4780) hydrochloride is a potent and selective imidazoline-1 receptor antagonist with a Ki value of 42 nM. AGN 192403 hydrochloride is also a TMED9 inhibitor. AGN 192403 hydrochloride shows protective effects on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. AGN 192403 hydrochloride mitigates the proliferation and migration of differentiated glioma tumor cells. AGN 192403 hydrochloride can be used for glioma tumor and neurological diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-BRD4780. CAS No. 1021868-90-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-101374A. | |
| AGN 193109 | AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity. Uses: Scientific research. Category: Signaling pathways. CAS No. 171746-21-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00449. | |
| AGN194204 | AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRX4204; NRX194204; VTP 194204. CAS No. 220619-73-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13717. | |
| AGN-195183 | AGN-195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRX-5183; VTP-195183; NRX-195183. CAS No. 367273-07-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16684. | |
| AGN 196996 | AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 958295-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16682. | |
| AGN 205728 | AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 can inhibit abnormal proliferation of leukemia cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 859498-05-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16683. | |
| Agnuside | Agnuside is used in the study of asthma, inflammation, and angiogenic diseases. Agnuside is an orally active compound that can be extracted from Vitex negundo[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Agnoside. CAS No. 11027-63-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N2518. | |
| Agomelatine | Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-20098. CAS No. 138112-76-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17038. | |
| Agomelatine-d6 | Agomelatine-d6 is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-20098-d6. CAS No. 1079389-42-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-17038S. | |
| Agomelatine (Standard) | Agomelatine (Standard) is the analytical standard of Agomelatine. This product is intended for research and analytical applications. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-20098 (Standard). CAS No. 138112-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17038R. | |
| AGPS-IN-1 | AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2316782-88-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-153910. | |
| Agrimol B | Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55576-66-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0704. | |
| AGX51 | AGX51 is the first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and viability reduction. AGX51 can inhibit TNBC and has an IC50 of about 25 nM. AGX51 can be used in cancer research. Uses: Scientific research. Category: Signaling pathways. CAS No. 330834-54-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129241. | |
| AH078 | AH078 is a PROTAC-based CK1δ/ε degrader (DC50=0.55 μM, Dmax=70%) that lacks subtype selectivity between CK1δ and CK1ε. AH078 induces target protein degradation either by recruiting the CUL4-CRBN E3 ligase complex and proteasome, or via the VHL- and ubiquitin-dependent pathway. AH078 also exhibits selectivity for CK1α, and is widely applicable to research related to colon cancer, pancreatic cancer, breast cancer, ovarian cancer, chronic lymphocytic leukemia, acute myeloid leukemia, glioma, and metastatic breast adenocarcinoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3110370-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-170859. | |
| AH1 | AH1 is an immunodominant MHC class I-restricted nonamer peptide recognized by CD8+ cytotoxic T lymphocytes. AH1 derives from the envelope protein (gp70) of an endogenous ecotropic murine leukemia virus and is presented by the MHC class I Ld molecule. AH1 can be used for the research of colorectal carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 181272-91-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4193. | |
| AH2-14c | AH2-14c is an inhibitor for DNA demethylase ALKBH2. AH2-14c inhibits the cell viability (IC50 is 4.56 μM) and migration of GBM U87. AH2-14c regulates the expression of apoptosis-related genes, and induces apoptosis in GBM U87 cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099231-05-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168708. | |
| AH3960 | AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 862907-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15103. | |
| AH 6809 | AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33458-93-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10418. | |
| AH-7614 | AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6326-6-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19996. | |
| AI-10-104 | AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1881276-00-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122657. | |
| AI-10-49 | AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC50 value of 0.26 μM. AI-10-49 can be used for the research of leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1256094-72-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16786. | |
| AICAR | AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity[1][2][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acadesine; AICA Riboside. CAS No. 2627-69-2. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13417. | |
| AICA-riboside, 5-phosphate | AICA-riboside, 5-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AICAR-5'-MP. CAS No. 3031-94-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-134356. | |
| AICAR phosphate | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acadesine phosphate; AICA Riboside phosphate. CAS No. 681006-28-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13417A. | |
| AICAR (Standard) | AICAR (Standard) is the analytical standard of AICAR. This product is intended for research and analytical applications. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acadesine (Standard); AICA Riboside (Standard). CAS No. 2627-69-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13417R. | |
| Ailanthone | Ailanthone (Δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69?nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309?nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Δ13-Dehydrochaparrinone. CAS No. 981-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1943. | |
| AIM-100 | AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873305-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15290. | |
| AIM4 | AIM4 is a compound that can inhibit the aggregation of TDP-43. AIM4 has good biocompatibility and anti-inflammatory activity. AIM4 can be used in the research of diseases such as amyotrophic lateral sclerosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1841140-38-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-172450. | |
| AJ2-30 | AJ2-30 is a SLCl5A4 inhibitor. AJ2-30 inhibits endolysosomal TLR7-9-mediated mTOR activation. AJ2-30 blocks endogenous NOD signaling. AJ2-30 can be used in inflammation studies[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2700322-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155864. | |
| Ajmalicine | Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Raubasine. CAS No. 483-04-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1919. | |
| Ajmaline | Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cardiorythmine; (+)-Ajmaline. CAS No. 4360-12-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B1167. | |
| Ajoene | Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92285-01-3. Pack Sizes: 1 mg (21.33 mM * 200 μL in Ethyl acetate). Product ID: HY-106784. | |
| Ajugol | Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52949-83-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0914. | |
| AK-068 | AK-068 is a high-affinity and selective STAT6 ligand, with a Ki of 6 nM. AK-068 demonstrates at least >150- and >85-fold binding selectivity over STAT5A (Ki >1 μM) and STAT5B (Ki >500 μM) proteins, respectively. AK-068 is a ligand for target protein for PROTAC, can be used for synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2982851-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169182. | |
| AK-1690 | AK-1690 is a selective PROTAC degrader targeting STAT6 (DC50=1 nM) with a Ki of 6 nM against human STAT6. AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc.[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2984505-88-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169179. | |
| AK-2292 | AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models[1][2]. AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2984506-77-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148813. | |
| AK 295 | AK 295 (CX 295) is a selective calpain inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CX 295. CAS No. 160399-35-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119378. | |
| AK-7 | AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 420831-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16691. | |
| AkaLumine hydrochloride | AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (λmax=677?nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2558205-28-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112641A. | |
| Akardite II | Akardite II (AK-II) is a stabilizer for nitrocellulose (NC) propellants as it scavenges NOx. Akardite II helps control a variety of plant pathogens and weeds, which can be used as fungicides and herbicides[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AK-II. CAS No. 13114-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W004643. | |
| AKB-6899 | AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1007377-55-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113649. | |
| AKR1B10-IN-1 | AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2136579-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139696. | |
| AKT-IN-23 | AKT-IN-23 is an AKT inhibitor. AKT-IN-23 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226801-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161704. | |
| AKT inhibitor VIII | AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AKTi-1/2. CAS No. 612847-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10355. | |
| AKT Kinase Inhibitor | AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 842148-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10249A. | |
| AKU-005 | AKU-005 is a FAAH and MAGL dual inhibitor with IC50 values of 63, 389 nM for rat and human FAAH, respectively. AKU-005 has the potential for the research of trigeminal hyperalgesia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1515855-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163733. | |
| AL 082D06 | AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D06; D-06. CAS No. 256925-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15709. | |
| AL-8810 | AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 246246-19-5. Pack Sizes: 1 mg. Product ID: HY-100449. | |
| AL-9 | AL-9 is a inhibitor of PI4KIIIα, with the IC50 of 0.57 μM, that can inhibit HCV replication[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 869218-90-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118525. | |
| Alacepril | Alacepril (Cetapril) is an orally active angiotensin converting enzyme (ACE) inhibitor with long lasting antihypertensive effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cetapril; DU-1219. CAS No. 74258-86-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107318. | |
| Alagebrium chloride | Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALT711. CAS No. 341028-37-3. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg. Product ID: HY-106024B. | |
| Alamandine | Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1176306-10-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3108. | |
| Alamethicin | Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27061-78-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6708. | |
| Alanine aminotransferase, Porcine heart | Alanine aminotransferase, Porcine heart is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-86-6. Pack Sizes: 200 U. Product ID: HY-P2985. | |
| Alantolactone | Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Alantolactone; Alant camphor; Inula camphor. CAS No. 546-43-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0038. | |
| Ala-Phe-Lys-AMC | Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 120928-02-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P4339. | |
| Alarelin Acetate | Alarelin acetate is a synthetic GnRH agonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alarelin. CAS No. 79561-22-1. Pack Sizes: 5 mg; 10 mg; 100 mg. Product ID: HY-17405. | |
| Albendazole | Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKF-62979. CAS No. 54965-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0223. | |
| Albendazole sulfone | Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 75184-71-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W019773. | |
| Albiflorin | Albiflorin, a major constituent contained in peony root, is a brain-penetrant monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39011-90-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0037. | |
| Albiglutide fragment | Albiglutide fragment (GLP-1 (7-36) analog) is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GLP-1-Gly8; GLP-1 (7-36) analog. CAS No. 224638-84-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108795. | |
| ALC-0159 | ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1849616-42-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138300. | |
| ALC-0315 | ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2036272-55-4. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-138170. | |
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