MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Alkyne-phenol | Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins[1]. Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alkyne tyramide; Alk-Ph. CAS No. 1694495-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-131442. |  |
| Alkynyl myristic acid | Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkynyl myristic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 82909-47-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140335. | |
| Alkynyl Palmitic Acid | Alkynyl Palmitic Acid (Alk-C16) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkynyl Palmitic Acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alk-C16. CAS No. 99208-90-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W040304. | |
| Allantoin | Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Ureidohydantoin. CAS No. 97-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 5 g; 10 g; 25 g. Product ID: HY-N0543. | |
| Allantoin-13C2,15N4 | Allantoin-13C2,15N4 is the 13C and 15N labeled Allantoin[1]. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Ureidohydantoin-13C2,15N4. CAS No. 1219402-51-3. Pack Sizes: 500 μg; 1 mg. Product ID: HY-N0543S. | |
| Allicin | Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Diallyl thiosulfinate. CAS No. 539-86-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N0315. | |
| Alliin | Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 556-27-4. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N0661. | |
| (±)-Alliin | (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-L-Alliin. CAS No. 17795-26-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126085. | |
| Allithiamine | Allithiamine is a thiamin derivative with absorption characteristics similar to fat-soluble vitamins. Allithiamine acts as a cofactor precursor for thiamin pyrophosphate (TPP), which participates in carbohydrate metabolism by supporting the pyruvate dehydrogenase (PDH) complex to facilitate pyruvate entry into the tricarboxylic acid (TCA) cycle as acetyl CoA. Allithiamine can be used for researching thiamin metabolism[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Allithiamin. CAS No. 554-44-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W754527. | |
| Allitinib tosylate | Allitinib tosylate (AST-1306 (TsOH)) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib tosylate also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib tosylate is an anilino-quinazoline compound and has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AST-1306 (TsOH). CAS No. 1050500-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13427. | |
| ALLM | ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calpain inhibitor II. CAS No. 110115-07-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-118355. | |
| Allo-aca | Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3109368-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3212. | |
| Alloferon 1 | Alloferon 1 is an antiviral and antitumoral peptide. Alloferon 1 stimulates natural cytotoxicity of human peripheral blood lymphocytes. Alloferon 1 also induces IFN synthesis, and enhances antiviral and antitumor resistance in mice. Alloferon 1 also shows anti-inflammatory activity in λ-carrageenan-induced paw edema model. Alloferon 1 can be isolated from the blood of the blow fly Calliphora vicina (Diptera)[1][2][3]. Uses: Scientific research. Category: Peptides. CAS No. 347884-61-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5581. | |
| Allolithocholic acid | Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2276-94-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-143712. | |
| Allopurinol | Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315-30-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0219. | |
| Allopurinol riboside | Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites. Uses: Scientific research. Category: Signaling pathways. CAS No. 16220-07-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-101397. | |
| Allosecurinine | Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from Phyllanthus glaucus [1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phyllochrysine. CAS No. 884-68-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2377. | |
| Alloxan hydrate | Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 2244-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g. Product ID: HY-W017227. | |
| Alloxazine | Alloxazine is a selective A2b antagonist. Alloxazine completely block 5N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isoalloxazine. CAS No. 490-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-123085. | |
| all-trans-4-Oxoretinoic acid | all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: all-trans 4-Keto Retinoic Acid. CAS No. 38030-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107494A. | |
| all-trans-Anhydro Retinol | all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anhydrovitamin A. CAS No. 1224-78-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N7495. | |
| All-trans-retinal | All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 116-31-4. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W004500. | |
| All-trans-retinal (Standard) | All-trans-retinal (Standard) is the analytical standard of All-trans-retinal. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. CAS No. 116-31-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W004500R. | |
| Allura Red AC | Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FD&C RED NO. 40; CI 16035. CAS No. 25956-17-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-123630. | |
| Allylic-SAM | Allylic-SAM is an S-adenosyl methionine (SAM) analog. Allylic-SAM can be for the enrichment and detection of methyltransferase target sites in RNA[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 875155-64-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148904. | |
| Allylpalladium(II) chloride dimer | Allylpalladium(II) chloride dimer is an organometallic Pd complexe that can be used as a protein scaffold[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 12012-95-2. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W020940. | |
| Allyl-PEG2-OH | Allyl-PEG2-OH (Acryloyl-PEG2-OH) is a PEG derivative that can be used for drug delivery and other research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acryloyl-PEG2-OH. CAS No. 15075-50-0. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W047691. | |
| Almonertinib | Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-10296. CAS No. 1899921-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112823. | |
| Almonertinib hydrochloride | Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-10296 hydrochloride. CAS No. 2134096-03-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112823B. | |
| Almorexant | Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACT 078573. CAS No. 871224-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10805. | |
| Almorexant hydrochloride | Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACT 078573 hydrochloride. CAS No. 913358-93-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10805A. | |
| Alnuctamab | Alnuctamab (EM901) is a bispecific T-cell engager targeting BCMA and CD3, belonging to an asymmetric two-armed humanized IgG1 antibody. Alnuctamab can simultaneously bind to BCMA expressed on the surface of myeloma cells and CD3 molecules on the surface of T cells, recruiting T cells to kill tumors. Alnuctamab is used for the research of multiple myeloma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EM901; CC-93269. CAS No. 2296827-07-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99430. | |
| Aloe emodin | Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis[1]. Aloe emodin also exhibits antiviral activity that against influenza A virus[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rhabarberone; 3-Hydroxymethylchrysazine. CAS No. 481-72-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-N0189. | |
| Aloe emodin (Standard) | Aloe emodin (Standard) is the analytical standard of Aloe emodin. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rhabarberone (Standard); 3-Hydroxymethylchrysazine (Standard). CAS No. 481-72-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0189R. | |
| Aloenin | Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aloenin A. CAS No. 38412-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0495. | |
| Aloeresin A | Aloeresin A is the main ingredient in aloe vera and its related products[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 74545-79-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7219. | |
| Aloesin | Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aloeresin. CAS No. 30861-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2460. | |
| Aloesone | Aloesone is a phenolic compound. Aloesone can inhibit the production of ROS, the release of NO, M1 polarization, and apoptosis in RAW264.7 cells stimulated by LPS (HY-D1056). Aloesone has anti-inflammatory and antioxidant activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 40738-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N8559. | |
| Alofanib | Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RPT835. CAS No. 1612888-66-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17601. | |
| Alogabat | Alogabat is a positive allosteric modulator (PAM) and agonist (Ki <100 nM) of the GABAA α5 receptor, targeting the α5β3γ2 subunit with a Ki of 8.7 nM. Alogabat increases the expression level of α5β3γ2 in oocytes (1.97-fold). GABAA has been implicated in cognitive impairment associated with central nervous system (CNS) disorders, brain cancer (including brain tumors such as medulloblastoma), and can be used in the study of mild cognitive impairment (MCI), amnestic MCI (aMCI), age-associated memory impairment (AAMI), age-related cognitive decline (ARCD), dementia, Alzheimer's disease (AD), prodromal AD, post-traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cognitive impairment associated with cancer treatment, mental retardation, Parkinson's disease (PD), autism spectrum disorder, fragile X, Rett syndrome, obsessive-compulsive behavior, and substance addiction[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG-7816; RO-7017773. CAS No. 2230009-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132806. | |
| Aloin-A | Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI)[1][2][3][4]. Uses: Scientific research. Category: Natural products. Alternative Names: Barbaloin-A. CAS No. 1415-73-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N0123. | |
| Aloin-A (Standard) | Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Barbaloin-A (Standard). CAS No. 1415-73-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0123R. | |
| Aloin B | Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isobarbaloin. CAS No. 28371-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0886. | |
| Aloinoside A | 56645-88-6. Uses: Scientific research. Category: Signaling pathways. CAS No. 56645-88-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N12450. | |
| Aloinoside B | 11006-91-0. Uses: Scientific research. Category: Natural products. CAS No. 11006-91-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N12449. | |
| Alosetron | Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR 68755; GR 68755X. CAS No. 122852-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70050A. | |
| Alovudine | Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3'-Fluoro-3'-deoxythymidine; 3-Deoxy-3-fluorothymidine; FLT. CAS No. 25526-93-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1516. | |
| ALOX15-IN-1 | ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2764818-24-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143787. | |
| Aloxistatin | Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E64d; E64c ethyl ester. CAS No. 88321-09-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100229. | |
| Alpelisib | Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BYL-719. CAS No. 1217486-61-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15244. | |
| Alpelisib hydrochloride | Alpelisib (BYL-719) hydrochloride is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib hydrochloride also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib hydrochloride not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib hydrochloride can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BYL-719 hydrochloride. CAS No. 1584128-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15244A. | |
| Alpelisib (Standard) | Alpelisib (Standard) is the analytical standard of Alpelisib. This product is intended for research and analytical applications. Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BYL-719 (Standard). CAS No. 1217486-61-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15244R. | |
| α-1-2 Fucosidase, bifidobacterium longum | α1-2 Fucosidase (EC 3.2.1.51) is a highly specific exoglycosidase that catalyzes the hydrolysis of linear α1-2 linked fucose residues from oligosaccharides[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9037-65-4. Pack Sizes: 1 KU. Product ID: HY-132177A. | |
| alpha-1,3-Galactosyltransferase (a1,3GalT) | alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GGTA1. CAS No. 128449-51-4. Pack Sizes: 1 U; 5 U. Product ID: HY-E70052. | |
| alpha-1,4-Galactosyltransferase (LgtC) | alpha-1,4-Galactosyltransferase (LgtC) (A4GALT) is a glycosphingolipid-specific glycosyltransferase. alpha-1,4-Galactosyltransferase (LgtC) transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide. alpha-1,4-Galactosyltransferase (LgtC) can be used for the synthesis of P1 blood group antigens[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A4GALT. CAS No. 52725-57-2. Pack Sizes: 5 U; 25 U. Product ID: HY-E70047. | |
| α2-3,6 Neuraminidase, Bifidobacterium infantis | α2-3,6 Neuraminidase, Bifidobacterium infantis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal α2-3 and α2-6 unbranched sialic acid residues from complex carbohydrates and glycoproteins. α2-3,6 Neuraminidase does not exhibit activity on α2-8 or branched sialic acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-67-6. Pack Sizes: 100 U; 1000 U. Product ID: HY-P2988A. | |
| α2,3-Sialyltransferase, Pasteurella multocida (P-1059) | α2,3-Sialyltransferase, Pasteurella multocida (P-1059) (PmST1(M144D)), a sialyltransferase, can be isolated from Pasteurella multocida. alpha-2,3-Sialyltransferase (PmST1) can be converted into regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PmST1(M144D). CAS No. 71124-51-1. Pack Sizes: 100 U. Product ID: HY-E70056. | |
| α-2,6-Sialyltransferase, pasteurella multocida (P-1059) | alpha-2,6-Sialyltransferase (Pd26ST) (EC 2.4.99.1) is capable of sialylating both terminal and internal galactose and N-acetylgalactosamine, which producing terminal α2,6-sialosides[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9075-81-4. Pack Sizes: 10 U. Product ID: HY-E70055. | |
| α2β1 Integrin Ligand Peptide | α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DGEA peptide. CAS No. 134580-64-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1868. | |
| α5β1 integrin agonist-2 | α5β1 integrin agonist-2 (Compound 2) is a selective α5β1 integrin agonist (EC50 = 45.98 nM). α5β1 integrin agonist-2 induces integrin activation. α5β1 integrin agonist-2 is applicable to the research of leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3115530-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-175287. | |
| α5IA | α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-822179. CAS No. 215874-86-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116622. | |
| α7 nAchR-JAK2-STAT3 agonist 1 | α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108714-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146066. | |
| α,α-Trehalose 6-phosphate potassium | α,α-Trehalose 6-phosphate (Tre6P) potassium is a glucose analogue with potent anti-hyperglcaemic activity. α,α-Trehalose 6-phosphate potassium is rapidly converted to the end product, α,α-trehalose, through the action of α,α-Trehalose 6-phosphate phosphatase (T6PP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tre6P potassium. CAS No. 136632-28-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131368. | |
| α-Amanitin | α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-Amatoxin. CAS No. 23109-05-9. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-19610. | |
| α-Amylase | α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-90-2. Pack Sizes: 500 mg; 1 g. Product ID: HY-B2193. | |
| α-Amylase from Aspergillus oryzae | α-Amylase from Aspergillus oryzae is an amylase. α-Amylase from Aspergillus oryzae can be used for various biochemical studies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-19-8. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-P2762. | |
| α-Amylase, Human Saliva | α-Amylase, Human Saliva (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from human saliva. α-Amylase, Human Saliva catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Saliva can be used in life science research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,4-alpha-D-Glucan-glucanohydrolase, ptyalin. CAS No. 9000-90-2. Pack Sizes: 1 KU; 5 KU. Product ID: HY-B2193A. | |
| α-Amyrin | α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin shows anti-bacterial and anti-inflammation activity. α-Amyrin can reduce blood glucose level. α-Amyrin can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 638-95-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N8423. | |
| α-Amyrin acetate | α-Amyrin acetate is a pentacyclic triterpenoid compound with oral activity. α-Amyrin acetate can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin acetate can reduce blood glucose level. α-Amyrin acetate can be used for the researches of cancer and metabolic disease, such as breast cancer and diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 863-76-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2842. | |
| α-Arbutin | α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Hydroxyphenyl α-D-glucopyranoside. CAS No. 84380-01-8. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-N3002. | |
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