MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Androgen receptor antagonist 1 | Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM[1]. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338812-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130992. |  |
| Andrographidine A | Andrographidine A is a natural product[1]. Uses: Scientific research. Category: Natural products. CAS No. 113963-37-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N13477. | |
| Andrographolide | Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Andrographis. CAS No. 5508-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0191. | |
| Andropanolide | Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages[1]. Uses: Scientific research. Category: Natural products. CAS No. 869807-57-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1912. | |
| Androsin | Androsin is an active compound isolated from Picrorhiza Kurroa Royle ex Benth. Androsin activates AMPKα/PI3K/Beclin1/LC3 signaling pathway, inhibits SREBP1c/FASN signaling pathway. Androsin can be used in research of asthma and non-alcoholic fatty liver disease (NAFLD). Androsin is orally active[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 531-28-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1399. | |
| Aneratrigine | Aneratrigine is a selective Nav1.7 inhibitor with an IC50 of 19 nM. Aneratrigine is applicable for pain-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2097163-74-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156596. | |
| Anethole trithione | Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 532-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B1223. | |
| Anetumab | Anetumab (Anti-MSLN Antibody) is a fully humanized anti mesothelin (MSLN) IgG1 antibody. Anetumab (Anti-MSLN Antibody) can be used to synthesize the ADC molecule Anetumab ravtansine (HY-141606). Anetumab (Anti-MSLN Antibody) can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-MSLN Antibody. CAS No. 1954758-84-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99352. | |
| ANG1005 | ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GRN1005; Paclitaxel trevatide. CAS No. 1075214-55-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4073. | |
| Angelicin | Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isopsoralen. CAS No. 523-50-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N0763. | |
| Angiopep-2-Cys | Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine. Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 906480-09-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1351. | |
| Angiotensin I (human, mouse, rat) | Angiotensin I is a decapeptide hormone. Angiotensin I is the precursor of Angiotensin II (HY-13948). Angiotensin I can be used in the study of cardiovascular diseases such as hypertension and vasospasm[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 484-42-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1032. | |
| Angiotensin II human | Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Angiotensin II; Ang II; DRVYIHPF. CAS No. 4474-91-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13948. | |
| Angiotensin II human acetate | Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate. CAS No. 68521-88-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13948A. | |
| Angiotensin III, human, mouse | Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 13602-53-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1540. | |
| Angiotensin III, human, mouse TFA | Angiotensin III, human, mouse (TFA) is an angiotensin. Uses: Scientific research. Category: Signaling pathways. CAS No. 2938960-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1540A. | |
| Angoline | Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21080-31-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N7674. | |
| Angoroside C (Standard) | Angoroside C (Standard) is the analytical standard of Angoroside C. This product is intended for research and analytical applications. Angoroside C, a phenylpropanoid glycoside isolated from Scrophularia ningpoensis, has beneficial effects against ventricular remodeling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115909-22-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0062R. | |
| Angstrom6 | Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A6 Peptide. CAS No. 220334-14-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2230. | |
| Anhydroleucovorin | Anhydroleucovorin is a form of tetrahydrofolate and serves as a substrate for cyclohydrolase, which converts it to 10-formyltetrahydrofolate. Anhydroleucovorin can be used in oncology research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7444-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-153039. | |
| Anhydrotetracycline | Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5a(6)-Anhydrotetracycline. CAS No. 1665-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142052. | |
| Anhydrotetracycline hydrochloride | Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression systems in eukaryotic cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13803-65-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118660. | |
| Anhydrous sodium dihydrogen phosphate | Dihydrogen monosodium phosphate (Monosodium phosphate) is an inorganic salt compound commonly used in industry and laboratories. It can be used as a buffer, nutritional supplement, cleaning agent, etc., and plays a role in certain metal processing, pharmaceutical and chemical industries. In addition, Dihydrogen monosodium phosphate can also be used in the field of water treatment and environmental protection, for example as a purifying agent or precipitating agent for solutions. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium phosphate monobasic; Monosodium dihydrogen orthophosphate; Monosodium phosphate. CAS No. 7558-80-7. Pack Sizes: 10 mM * 1 mL in Water; 100 g; 500 g. Product ID: HY-B2243. | |
| Anhydrous sodium dihydrogen phosphate, for HPLC | Anhydrous sodium dihydrogen phosphate, for HPLC is widely used in molecular biology, biochemistry and chromatography[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium phosphate monobasic for HPLC; Monosodium dihydrogen orthophosphate for HPLC; Monosodium phosphate for HPLC. CAS No. 7558-80-7. Pack Sizes: 10 mM * 1 mL in Water; 10 g; 50 g. Product ID: HY-B2243A. | |
| Ani9 | Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 356102-14-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119981. | |
| Anidulafungin | Anidulafungin is a new semisynthetic echinocandin with antifungal potency. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY303366. CAS No. 166663-25-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13553. | |
| Anifrolumab | Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDX-1333; MEDI-546. CAS No. 1326232-46-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99168. | |
| Aniline Blue sodium | Aniline Blue sodium is a water-soluble dye commonly used as a biological stain for the detection of nucleic acids and proteins in various laboratory procedures such as electrophoresis and microscopy. Aniline Blue sodium has unique chemical properties that allow it to bind to specific cellular components, producing a color change that facilitates their visualization and analysis. Uses: Scientific research. Category: Signaling pathways. CAS No. 28631-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g. Product ID: HY-W133919. | |
| Aniracetam | Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 13-5057. CAS No. 72432-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-10932. | |
| Anisatin | Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10?μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5230-87-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N9506. | |
| Anisindione | Anisindione is an oral indandione anticoagulant. Anisindione inhibits the formation of active procoagulant factors II, VII, IX and X. Anisindione can be used in anticoagulation-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117-37-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0924. | |
| Anisodamine | Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Hydroxyhyoscyamine. CAS No. 55869-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N0584. | |
| Anisomycin | Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Flagecidin; Wuningmeisu C. CAS No. 22862-76-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18982. | |
| Anisomycin (Standard) | Anisomycin (Standard) is the analytical standard of Anisomycin. This product is intended for research and analytical applications. Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Flagecidin (Standard); Wuningmeisu C (Standard). CAS No. 22862-76-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18982R. | |
| Annonacin | Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 111035-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2877. | |
| ANO1-IN-4 | ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 μM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098490-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-153508. | |
| ANP [Des18-22] 4-23 amide (rat) | ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 111863-73-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1526. | |
| Anrukinzumab | Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMA-638. CAS No. 910649-32-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99439. | |
| Ansamitocin P-3 | Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Antibiotic C 15003P3; Maytansinol isobutyrate. CAS No. 66584-72-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15739. | |
| Anselamimab | Anselamimab (CAEL-101) is a chimeric monoclonal antibody for systemic light chain (AL) amyloidosis. Anselamimab can promote phagocytic destruction and subsequent clearance of amyloid deposits. Anselamimab can be used in the research of amyloidosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAEL-101. CAS No. 2414866-63-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99105. | |
| Anserine | Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine has blood-brain barrier permeability, and improves memory functions in Alzheimer's disease (AD)-model mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 584-85-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-113354. | |
| Ansuvimab | Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ansuvimab-zyk; mAb114. CAS No. 2375952-29-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99337. | |
| Antalarmin hydrochloride | Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220953-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103377. | |
| Antcin A | Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 163597-24-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9921. | |
| Anthraflavic acid | Anthraflavic acid specifically inhibits the activity of cytochrome P-448 without affecting phenobarbital-induced cytochrome P-450 or NADPH-dependent cytochrome c reduction. Anthraflavic acid inhibits cytosolic metabolic pathways, blocks the microsomal and cytosolic activation of IQ, and reduces the metabolic activation level of Glu-P-I. Anthraflavic acid may exert anticancer activity by inhibiting the metabolic activation of chemical carcinogens. Anthraflavic acid is applicable to cancer-related research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84-60-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W006230. | |
| Anticancer agent 126 | Anticancer agent 126 (compound 12) is a WDR5 inhibitor with anticancer effects. Anticancer agent 126 disrupts WDR5-MYC interaction in cells and reduce MYC target gene expression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033748-20-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149873. | |
| Anticancer agent 188 | Anticancer agent 188 (compound D43) inhibits DNA synthesis in TNBC cells, leading to cell cycle arrest at the G2/M phase. Anticancer agent 188 has anti-cancer viability by inducing ROS-mediated apoptosis and DNA damage[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1207377-56-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162276. | |
| Anticancer agent 73 | Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124811-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147918. | |
| Antide | Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-21074; ORF 23541. CAS No. 112568-12-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0013. | |
| Antidepressant agent 10 | Antidepressant agent 10 (Compound 4) is an orally active compound. Antidepressant agent 10 has IC50 values of 190 nM and 110 nM for 5-HT1A and 5-HT2, respectively. Antidepressant agent 10 can be used in the research of mental disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 87691-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g. Product ID: HY-W009754. | |
| Antifungal agent 18 | Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2572713-30-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139903. | |
| Antihistamine-1 | Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1186430-60-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100238. | |
| Anti-inflammatory agent 49 | nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 851471-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155656. | |
| Anti-Influenza agent 11 | Anti-Influenza agent 11 (compound L08) is an inhibitor of Influenza Virus and can be used in the research of influenza virus infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3118478-63-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-185307. | |
| Antimicrobial agent-44 | Antimicrobial agent-44 (Compound 7C) is an antibacterial agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2009354-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176969. | |
| Antimicrobial agent-45 | Antimicrobial agent-45 (Compound 16) is a broad-spectrum antibacterial agent. Antimicrobial agent-45 exhibits MICs against Cr. neoformans, S. aureus, MRSA and My. intracellulare of 9.25, 74.04, 74.04 and 74.04 μM respectively. Antimicrobial agent-45 can be used for the study of cryptococcal infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2043299-21-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176970. | |
| Antimycin A2 | Antimycin A2 is a selective inhibitor of the cytochrome b-c1 complex in the mitochondrial electron transport chain. Antimycin A2 disrupts mitochondrial membrane potential and produces reactive oxygen species (ROS) by inhibiting electron transfer between cytochrome b and c. Antimycin A2 has bactericidal and piscicidal activity, as well as tumor cell growth inhibitory effects, and can induce S-phase cell cycle arrest and apoptosis in HeLa cells. Antimycin A2 is suitable for research of cervical cancer and fisheries management. Antimycin A2 can be naturally isolated from the fermentation products of Streptomyces sp. strains[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27220-57-1. Pack Sizes: 500 μg. Product ID: HY-N12257. | |
| Antiproliferative agent-61 | Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613078-24-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-123656. | |
| Antipyrine | Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenazone; Phenazon. CAS No. 60-80-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0171. | |
| Antipyrine-d3 | Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenazone-d3; Phenazon-d3. CAS No. 65566-62-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0171S. | |
| Antisauvagine-30 | Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: aSvg-30. CAS No. 220673-95-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1107. | |
| Anti-virus agent 1 | Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Remdesivir isopropyl ester analog. CAS No. 1911578-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131233. | |
| Antrafenine | Antrafenine (Stakane) is a non-narcotic analgesic. Antrafenine demonstrates central analgesic effects in acetic acid writhing test and mouse hot plate test experiments. Antrafenine significantly alleviates the pain of osteoarthritis. Antrafenine exhibits mild anti-inflammatory activity in a rat toe edema model. Antrafenine can be used in pain and anti-inflammatory research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stakane. CAS No. 55300-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0235. | |
| Antroquinonol | Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects[1]. Antroquinonol can be used for the research of colon cancer[2]. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Antroquinonol. CAS No. 1010081-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19893. | |
| Anzurstobart | Anzurstobart is a CD47/SIRPα inhibitor with human SIRPα Kd of 0.0541 nM and human SIRPα IC50 of 100 nM. Anzurstobart binds SIRPα at a CD47-overlapping site, blocks CD47-SIRPα interactions, inhibits CD47-SIRPα axis signaling, and binds across 6 prevalent human SIRPα haplotypes. Anzurstobart binds SIRPγ and inhibits CD47-SIRPγ interactions. Anzurstobart can be used for the research of non-Hodgkin's lymphoma, colorectal cancer, squamous cell carcinoma of the head and neck, diffuse large B-cell lymphoma, and advanced solid and hematologic malignancies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-95251; BMS-986351. CAS No. 2543693-10-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990033. | |
| AO-365/43472821 | AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor (IC50 = 0.29 μM) and shows a significant inhibitory effect on (CDC-like kinase 1) CLK1 (IC50 = 0.08 μM). AO-365/43472821 could protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid (HY-N6785) (OA)-induced injury. AO-365/43472821 decreased tau (pSer396)/tau and Aβ1-42 protein expression. AO-365/43472821 can be used for the study of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1081122-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-179177. | |
| AP-18 | AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55224-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W014421. | |
| AP1867 | AP1867 is a synthetic FKBP12F36V-directed ligand[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 195514-23-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114434. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC FKBP12-binding moiety 2. CAS No. 2230613-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-114420. | |
| AP20187 | AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. Uses: Scientific research. Category: Signaling pathways. Alternative Names: B/B Homodimerizer. CAS No. 195514-80-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13992. | |
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