Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| 10058-F4 | 10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 promotes a caspase-3-dependent apoptosis and modulates autophagy. Group: Inhibitors. CAS No. 403811-55-2. Pack Sizes: 25mg. Product ID: S7153. Formula: C12H11NOS2. Smiles: CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| 17β-Estradiol | Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway. Group: Inhibitors. Alternative Names: 17β-estradiol, β-Estradiol, E2, 17β-Oestradiol. CAS No. 50-28-2. Pack Sizes: 50mg. Product ID: S1709. Formula: C18H24O2. Smiles: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 2',3'-cGAMP Sodium Salt | 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM. Group: Inhibitors. Alternative Names: 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium. CAS No. 2734858-36-5. Pack Sizes: 1mg. Product ID: S7904. Formula: C20H22N10Na2O13P2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| 2-Bromohexadecanoic acid (2-BP) | 2-BP (2-Bromohexadecanoic acid) is a nonmetabolisable analogue of palmitate and acts as a palmitoylation inhibitor, which inhibits multiple palmitoyl-acyl transferase (PAT) activity towards MyrGCK(NBD) and FarnCNRas(NBD) with identical IC50s of approx. 4 μM. 2-Bromohexadecanoic acid can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins. Group: Inhibitors. Alternative Names: 2-bromopalmitate. CAS No. 18263-25-7. Pack Sizes: 5mg. Product ID: E0120. Formula: C16H31BrO2. Smiles: CCCCCCCCCCCCCCC(Br)C(O)=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| 2-DG (2-Deoxy-D-glucose) | 2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression. Group: Inhibitors. Alternative Names: 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose. CAS No. 154-17-6. Pack Sizes: 500mg. Product ID: S4701. Formula: C6H12O5. Smiles: C(C=O)C(C(C(CO)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 2x M-PCR OPTI Mix (Dye Plus) | The Mouse Direct PCR Kit provides a fast preparation and PCR amplIFication that is specIFically designed for mouse genotyping. Buffer L and Protease Plus rapidly digests mouse tissue to release intact genomic DNA that can be used directly as the template for PCR amplIFication. Group: Kits. Pack Sizes: 1ml*5 (500 rxns). Product ID: B45012. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| 2x SYBR Green qPCR Master Mix | Bimake 2x SYBR Green qPCR master mix performs qPCR with highest sensitivity, specIFicity and reliability compared with Roche, Abi and Takara. offered at lowest price on the market. Group: Kits. Pack Sizes: 25 mL. Product ID: B21203. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| 2x SYBR Green qPCR Master Mix | Bimake 2x SYBR Green qPCR master mix performs qPCR with highest sensitivity, specIFicity and reliability compared with Roche, Abi and Takara. offered at lowest price on the market. Group: Kits. Pack Sizes: 5 mL. Product ID: B21202. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| 2x SYBR Green qPCR Master Mix (Low ROX) | 2x SYBR Green qPCR Master Mix (Low ROX). Group: Kits. Pack Sizes: 5 ml. Product ID: B21702. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| 2x SYBR Green qPCR Master Mix (Low ROX) | 2x SYBR Green qPCR Master Mix (Low ROX). Group: Kits. Pack Sizes: 25 ml. Product ID: B21703. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| 3-Deazaneplanocin A (DZNep) Hydrochloride | DZNeP (3-deazaneplanocin A) HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM in a cell-free assay. Group: Inhibitors. Alternative Names: NSC 617989 HCl. CAS No. 120964-45-6. Pack Sizes: 1mg. Product ID: S7120. Formula: C12H14N4O3.HCl. Smiles: C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 3-Hydroxybutyric acid (BHB acid) | 3-Hydroxybutyric acid (BHB) is a small molecule metabolite that is elevated in type I diabetes.. Group: Inhibitors. Alternative Names: 3-hydroxybutanoic acid, β-Hydroxybutyric acid. CAS No. 300-85-6. Pack Sizes: 25mg. Product ID: S1031. Formula: C4H8O3. . Storage Conditions: 2 years -20°C(in the dark). | United States; Europe |
| 3-Methyladenine (3-MA) | 3-MA (3-Methyladenine) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: NSC 66389. CAS No. 5142-23-4. Pack Sizes: 50mg. Product ID: S2767. Formula: C6H7N5. Smiles: CN1C=NC(=N)C2=C1N=CN2. | United States; Europe |
| 3-TYP | 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively. Group: Inhibitors. Alternative Names: 3-(1H-1,2,3-triazol-4-yl) pyridine. CAS No. 120241-79-4. Pack Sizes: 5mg. Product ID: S8628. Formula: C7H6N4. Smiles: C1=CC(=CN=C1)C2=NNN=C2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 4-HNE (4-Hydroxynonenal) | 4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress. Group: Inhibitors. Alternative Names: HNE, 4-hydroxy Nonenal, 4-hydroxy-2-nonenal. CAS No. 75899-68-2. Pack Sizes: 5mg. Product ID: S9793. Formula: C9H16O2. Storage Conditions: 2 years -20°C liquid. | United States; Europe |
| 4-Hydroxytamoxifen (Afimoxifene) | 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants. Group: Inhibitors. Alternative Names: Afimoxifene. CAS No. 68392-35-8. Pack Sizes: 10mg. Product ID: S7827. Formula: C26H29NO2. Smiles: CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 4μ8C | 4μ8C (IRE1 Inhibitor III) is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. Group: Inhibitors. Alternative Names: IRE1 Inhibitor III. CAS No. 14003-96-4. Pack Sizes: 10mg. Product ID: S7272. Formula: C11H8O4. Smiles: CC1=CC(=O)OC2=C1C=CC(=C2C=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 4-PBA (4-Phenylbutyric acid) | 4-PBA (4-Phenylbutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models. Group: Inhibitors. Alternative Names: Benzenebutyric acid. CAS No. 1821-12-1. Pack Sizes: 100mg. Product ID: S3592. Formula: C10H12O2. Smiles: OC(=O)CCCC1=CC=CC=C1. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| 53BP1 Antibody [M24M17] | 53BP1,TP53BP1. Group: Antibodies. Alternative Names: 53BP1,TP53BP1. Pack Sizes: 20uL. Product ID: F2158. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| 5-Azacytidine (5-Aza, Azacitidine) | Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy. Group: Inhibitors. Alternative Names: 5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine. CAS No. 320-67-2. Pack Sizes: 200mg. Product ID: S1782. Formula: C8H12N4O5. Smiles: C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 5-Fluorouracil (5-FU) | 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. Group: Inhibitors. Alternative Names: Fluorouracil, NSC 19893. CAS No. 51-21-8. Pack Sizes: 200mg. Product ID: S1209. Formula: C4H3FN2O2. Smiles: C1=C(C(=O)NC(=O)N1)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 6-OHDA (Oxidopamine hydrobromide) | 6-OHDA (Oxidopamine hydrobromide) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity. 6-OHDA (Oxidopamine hydrobromide) can be used to induce animal models of Parkinson's Disease.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: 6-hydroxydopamine; 2,4,5-trihydroxyphenethylamine. CAS No. 636-00-0. Pack Sizes: 25mg. Product ID: S5324. Formula: C8H11NO3.HBr. Smiles: C1=C(C(=CC(=C1O)O)O)CCN.Br. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| 740 Y-P (PDGFR 740Y-P) | 740 Y-P (PDGFR 740Y-P, 740YPDGFR) is a cell-permeable phosphopeptide activator of PI3K. Group: Inhibitors. Alternative Names: 740YPDGFR. CAS No. 1236188-16-1. Pack Sizes: 1mg. Product ID: S7865. Formula: C141H222N43O39PS3. Smiles: CCC(C)C(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NCC(=O)NC(CC6=CC=C(C=C6)OP(=O)(O)O)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CCSC)C(=O)NC(CO)C(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| 8-Bromo-cAMP (8-Br-cAMP) Sodium Salt | 8-Bromo-cAMP sodium salt is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator. Group: Inhibitors. Alternative Names: 8-Br-Camp sodium salt. CAS No. 76939-46-3. Pack Sizes: 25mg. Product ID: S7857. Formula: C10H10BrN5NaO6P. Smiles: C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-].[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| A-1331852 | A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases. Group: Inhibitors. CAS No. 1430844-80-6. Pack Sizes: 5mg. Product ID: S7801. Formula: C38H38N6O3S. Smiles: CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=C(C6)C(=CC=C7)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| A-485 | A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets. Group: Inhibitors. CAS No. 1889279-16-6. Pack Sizes: 2mg. Product ID: S8740. Formula: C25H24F4N4O5. Smiles: CC(C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)C3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| A-769662 | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase / FBPase activity. Group: Inhibitors. CAS No. 844499-71-4. Pack Sizes: 5mg. Product ID: S2697. Formula: C20H12N2O3S. Smiles: C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| A-83-01 | A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin / nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. CAS No. 909910-43-6. Pack Sizes: 5mg. Product ID: S7692. Formula: C25H19N5S. Smiles: CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| A-922500 (DGAT-1 Inhibitor 4a) | A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. Group: Inhibitors. Alternative Names: DGAT-1 Inhibitor 4a. CAS No. 959122-11-3. Pack Sizes: 5mg. Product ID: S2674. Formula: C26H24N2O4. Smiles: C1CC(C(C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Abemaciclib (LY2835219) | Abemaciclib is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Group: Inhibitors. Alternative Names: LY2835219. CAS No. 1231929-97-7. Pack Sizes: 5mg. Product ID: S5716. Formula: C27H32F2N8. Smiles: CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| ABL001 (Asciminib) | Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of?0.5-0.8?nM and selectivity to the myristoyl pocket of ABL1. Group: Inhibitors. CAS No. 1492952-76-7. Pack Sizes: 2mg. Product ID: S8555. Formula: C20H18ClF2N5O3. Smiles: C1CN(CC1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)Cl)C4=CC=NN4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ABT-199 (Venetoclax) | Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of 4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3. Group: Inhibitors. Alternative Names: GDC-0199. CAS No. 1257044-40-8. Pack Sizes: 5mg. Product ID: S8048. Formula: C45H50ClN7O7S. Smiles: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ABT-494 (Upadacitinib) | Upadacitinib is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM), with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1. Group: Inhibitors. Alternative Names: ABT-494. CAS No. 1310726-60-3. Pack Sizes: 5mg. Product ID: S8162. Formula: C17H19F3N6O. Smiles: CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| ABT-737 | ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2. Group: Inhibitors. CAS No. 852808-04-9. Pack Sizes: 5mg. Product ID: S1002. Formula: C42H45ClN6O5S2. Smiles: CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Acalabrutinib (ACP-196) | Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR. Group: Inhibitors. CAS No. 1420477-60-6. Pack Sizes: 5mg. Product ID: S8116. Formula: C26H23N7O2. Smiles: CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) | ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV). Group: Inhibitors. Alternative Names: Ac-CoA Synthase Inhibitor1. CAS No. 508186-14-9. Pack Sizes: 5mg. Product ID: S8588. Formula: C20H18N4O2S2. Smiles: COCCNC(=O)NC1=CC2=C(C=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ac-DEVD-CHO | Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. Group: Inhibitors. Alternative Names: Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO. CAS No. 169332-60-9. Pack Sizes: 2mg. Product ID: S7901. Formula: C20H30N4O11. Smiles: CC(C)C(C(=O)NC(CC(=O)O)C=O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Acetyl-CoA Carboxylase Antibody [N24C17] | Acetyl-CoA carboxylase 1, Acetyl-Coenzyme A carboxylase alpha, ACC1, ACC-alpha, ACC α, ACACA, ACAC, ACCA, ACC-beta, ACC β, ACACB, ACC2, ACCB, Acetyl-CoA carboxylase 2. Group: Antibodies. Alternative Names: ACC1, ACC α, ACCA, ACC2, ACC β, ACCB. Pack Sizes: 20ul. Product ID: F0270. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Acetyl-Histone H3 (Lys27) Antibody [L2M16] | Acetyl Histone H3 (Lys27),Acetyl-Histone H3 (Lys27),Histone H3 (acetyl K27). Group: Antibodies. Alternative Names: Acetyl-Histone H3 (Lys27),Histone H3 (acetyl K27). Pack Sizes: 20ul. Product ID: F0271. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Acetyl-Histone H3 (Lys 9) Antibody [F7J15] | Acetyl-Histone H3 (Lys9),Ac-Histone H3,Histone H3 (acetyl K9). Group: Antibodies. Alternative Names: Acetyl-Histone H3 (Lys9),Ac-Histone H3,Histone H3 (acetyl K9). Pack Sizes: 20ul. Product ID: F0319. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Actin Antibody [A24J5] | Actin,Actin Ab-5,pan Actin,Pan-Actin. Group: Antibodies. Alternative Names: Actin,Pan-Actin. Pack Sizes: 20ul. Product ID: F0082. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Actinomycin D (Dactinomycin) | Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an RNA and protein synthesis inhibitor that can suppress bacterial protein synthesis. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity / flammable / skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. Group: Inhibitors. Alternative Names: Act D, RASP-101. CAS No. 50-76-0. Pack Sizes: 10mg. Product ID: S8964. Formula: C62H86N12O16. | United States; Europe |
| Adagrasib (MRTX849) | Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling. Group: Inhibitors. CAS No. 2326521-71-3. Pack Sizes: 2mg. Product ID: S8884. Formula: C32H35ClFN7O2. Smiles: CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN(C(C6)CC#N)C(=O)C(=C)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Adalimumab (anti-TNF-alpha) | Adalimumab (anti-TNF-alpha) is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD. Group: Antibodies. Alternative Names: LU200134, D2E7. CAS No. 331731-18-1. Pack Sizes: 5mg. Product ID: A2010. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Adavosertib (AZD1775, MK-1775) | Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2. Group: Inhibitors. Alternative Names: AZD1775. CAS No. 955365-80-7. Pack Sizes: 5mg. Product ID: S1525. Formula: C27H32N8O2. Smiles: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ademetionine (S-Adenosylmethionine) | Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals. Group: Inhibitors. Alternative Names: AdoMet, S-Adenosylmethionine, SAMe. CAS No. 29908-03-0. Pack Sizes: 25mg. Product ID: S5109. Formula: C15H22N6O5S. Smiles: C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Afatinib (BIBW2992) | Afatinib inhibits EGFR / ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy. Group: Inhibitors. Alternative Names: BIBW2992. CAS No. 850140-72-6. Pack Sizes: 1g. Product ID: S1011. Formula: C24H25ClFN5O3. Smiles: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AG-120 (Ivosidenib) | Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Group: Inhibitors. CAS No. 1448347-49-6. Pack Sizes: 5mg. Product ID: S8206. Formula: C28H22ClF3N6O3. Smiles: C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AG-1478 | AG-1478 is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA). Group: Inhibitors. Alternative Names: Tyrphostin AG-1478, NSC 693255. CAS No. 153436-53-4,175178-82-2. Pack Sizes: 5mg. Product ID: S2728. Formula: C16H14ClN3O2. Smiles: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AICAR (Acadesine) | AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3. Group: Inhibitors. Alternative Names: NSC105823, AICA Riboside. CAS No. 2627-69-2. Pack Sizes: 1g. Product ID: S1802. Formula: C9H14N4O5. Smiles: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Akt1 Antibody [C19L11] | Akt1 Antibody [C19L11]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0217. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Akt (pan) Antibody [E16N17] | RAC-beta serine / threonine-protein kinase, Protein kinase Akt-2, PKB beta 1, RAC-PK-beta, RAC-gamma serine / threonine-protein kinase, Akt-3, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG, RAC-alpha serine / threonine-protein kinase, PKB, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1. Group: Antibodies. Alternative Names: AKT1, AKT2, AKT3. Pack Sizes: 20ul. Product ID: F0004. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Alectinib (CH5424802) | Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429. Group: Inhibitors. Alternative Names: AF-802, RG-7853,CH5424802. CAS No. 1256580-46-7. Pack Sizes: 5mg. Product ID: S2762. Formula: C30H34N4O2. Smiles: CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Alisertib (MLN8237) | Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3. Group: Inhibitors. CAS No. 1028486-01-2. Pack Sizes: 5mg. Product ID: S1133. Formula: C27H20ClFN4O4. Smiles: COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Aloxistatin (E-64d) | Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%. Group: Inhibitors. Alternative Names: E-64d. CAS No. 88321-09-9. Pack Sizes: 2mg. Product ID: S7393. Formula: C17H30N2O5. Smiles: CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Alpelisib (BYL719) | Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2. Group: Inhibitors. CAS No. 1217486-61-7. Pack Sizes: 5mg. Product ID: S2814. Formula: C19H22F3N5O2S. Smiles: CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| α smooth muscle Actin / α-SMA Antibody [J14M24] | Actin, alpha-Smooth Muscle,Actin, α-Smooth Muscle,alpha smooth muscle Actin,Alpha-Smooth Muscle Actin,Smooth Muscle Actin,α-Actin,α-Smooth Muscle Actin. Group: Antibodies. Alternative Names: α-Smooth Muscle,Smooth Muscle Actin,α-Actin,α-Smooth Muscle Actin. Pack Sizes: 20uL. Product ID: F2514. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| α-Smooth Muscle Actin Antibody [L19D14] | Actin, alpha-Smooth Muscle,Actin, α-Smooth Muscle,alpha smooth muscle Actin,Alpha-Smooth Muscle Actin,Smooth Muscle Actin,α-Actin,α-Smooth Muscle Actin, α-SMA, a-SMA. Group: Antibodies. Alternative Names: α-SMA, ACTA2. Pack Sizes: 20uL. Product ID: F0017. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| α-Tubulin Antibody [A15C7] | alpha Tubulin,alpha-Tubulin,TUBA1B,α-Tubulin. Group: Antibodies. Alternative Names: TUBA1B. Pack Sizes: 20ul. Product ID: F0063. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| AM580 | AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. Group: Inhibitors. Alternative Names: CD336; NSC608001; Ro 40-6055. CAS No. 102121-60-8. Pack Sizes: 5mg. Product ID: S2933. Formula: C22H25NO3. Smiles: CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| AMD3100 (Plerixafor) | Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication. Group: Inhibitors. Alternative Names: JM 3100, SID791. CAS No. 110078-46-1. Pack Sizes: 10mg. Product ID: S8030. Formula: C28H54N8. Smiles: C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AMG 487 | AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively. Group: Inhibitors. CAS No. 473719-41-4. Pack Sizes: 5mg. Product ID: S8682. Formula: C32H28F3N5O4. Smiles: CCOC1=CC=C(C=C1)N2C(=O)C3=CC=CN=C3N=C2C(C)N(CC4=CC=CN=C4)C(=O)CC5=CC=C(OC(F)(F)F)C=C5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| AMG 510 (Sotorasib) | Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound. Group: Inhibitors. CAS No. 2296729-00-3. Pack Sizes: 2mg. Product ID: S8830. Formula: C30H30F2N6O3. Smiles: CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| AMPK α1 Antibody [A7G1] | AMPK α1 Antibody [A7G1]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2859. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| AMPKα Antibody [G6M15] | 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1, PRKAA1, AMPK1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, PRKAA2, AMPK2. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0269. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| ANA-12 | ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively. Group: Inhibitors. CAS No. 219766-25-3. Pack Sizes: 5mg. Product ID: S7745. Formula: C22H21N3O3S. Smiles: C1CCNC(=O)C(C1)NC(=O)C2=CC=CC=C2NC(=O)C3=CC4=CC=CC=C4S3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Angiotensin II human | Angiotensin II human is a potent vasoconstrictor that induces angiogenesis by activating angiotensin II type 1 (AT1) receptor, which increases the production of vascular endothelial growth factor (VEGF) in a redox-sensitive manner and promotes the formation of capillaries from endothelial cells through the LOX-1-dependent redox-sensitive pathway. Group: Inhibitors. CAS No. 4474-91-3. Pack Sizes: 5mg. Product ID: E1015. Formula: C50H71N13O12. | United States; Europe |
| Angiotensin II Human Acetate (DRVYIHPF) | Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes. Group: Peptides. CAS No. 68521-88-0. Pack Sizes: 5mg. Product ID: P1085. Formula: C52H75N13O14. Storage Conditions: 3 years-20°C powder. | United States; Europe |
| Anisomycin (Flagecidin) | Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis. Group: Inhibitors. Alternative Names: Flagecidin, Wuningmeisu C. CAS No. 22862-76-6. Pack Sizes: 10mg. Product ID: S7409. Formula: C14H19NO4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Anlotinib (AL3818) Dihydrochloride | Anlotinib (AL3818) is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. It has broad-spectrum antitumor potential in clinical trials. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation. Group: Inhibitors. CAS No. 1360460-82-7. Pack Sizes: 5mg. Product ID: S8726. Formula: C23H22FN3O3.2HCl. Smiles: CC1=CC2=C(N1)C=CC(=C2F)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC.Cl.Cl. Storage Conditions: 3 years -20°C powder. | United States; Europe |
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