Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| AZD5363 (Capivasertib) | Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2. Group: Inhibitors. CAS No. 1143532-39-1. Pack Sizes: 5mg. Product ID: S8019. Formula: C21H25ClN6O2. Smiles: C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| AZD6244 (Selumetinib) | Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3. Group: Inhibitors. Alternative Names: ARRY-142886. CAS No. 606143-52-6. Pack Sizes: 200mg. Product ID: S1008. Formula: C17H15BrClFN4O3. Smiles: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AZD7648 | AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases. Group: Inhibitors. CAS No. 2230820-11-6. Pack Sizes: 5mg. Product ID: S8843. Formula: C18H20N8O2. Smiles: CC1=CC2=NC=NN2C=C1NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCOCC5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| AZD8055 | AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (?1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1. Group: Inhibitors. CAS No. 1009298-09-2. Pack Sizes: 1g. Product ID: S1555. Formula: C25H31N5O4. Smiles: CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AZD9291 (Osimertinib) | Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3. Group: Inhibitors. Alternative Names: Mereletinib. CAS No. 1421373-65-0. Pack Sizes: 5mg. Product ID: S7297. Formula: C28 H33 N7 O2. Smiles: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bafilomycin A1 (Baf-A1) | Bafilomycin A1(Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis. Group: Inhibitors. CAS No. 88899-55-2. Pack Sizes: 1mg. Product ID: S1413. Formula: C35H58O9. Smiles: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. Group: Inhibitors. CAS No. 126150-97-8. Pack Sizes: 10mg. Product ID: S7534. Formula: C34H40N2O18. Smiles: CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Barasertib-HQPA (AZD2811) | Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1. Group: Inhibitors. Alternative Names: AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib. CAS No. 722544-51-6. Pack Sizes: 5mg. Product ID: S1147. Formula: C26H30FN7O3. Smiles: CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bardoxolone Methyl (RTA 402) | Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells. Group: Inhibitors. Alternative Names: RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me. CAS No. 218600-53-4. Pack Sizes: 25mg. Product ID: S8078. Formula: C32H43NO4. Smiles: CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Baricitinib (LY3009104) | Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3. Group: Inhibitors. Alternative Names: INCB028050, LY3009104. CAS No. 1187594-09-7. Pack Sizes: 5mg. Product ID: S2851. Formula: C16H17N7O2S. Smiles: CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bax Antibody [L6B9] | Bax, NT. Group: Antibodies. Alternative Names: Bax, NT. Pack Sizes: 20ul. Product ID: F0037. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| BAY 11-7082 (BAY 11-7821) | BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells. Group: Inhibitors. Alternative Names: BAY 11-7821. CAS No. 19542-67-7. Pack Sizes: 10mg. Product ID: S2913. Formula: C10H9NO2S. Smiles: CC1=CC=C(C=C1)S(=O)(=O)C=CC#N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BAY-3827 | BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration. Group: Inhibitors. CAS No. 2377576-35-5. Pack Sizes: 5mg. Product ID: S9833. Formula: C27H25FN6O. Smiles: CCC1=CC=CC=C1C(=O)NC2=N[NH]C3=C2C=C(C4C(=C(C)N(C)C(=C4C#N)C)C#N)C(=C3C)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| BAY-876 | BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4. Group: Inhibitors. CAS No. 1799753-84-6. Pack Sizes: 5mg. Product ID: S8452. Formula: C24H16F4N6O2. Smiles: CC1=C(C(=NN1CC2=CC=C(C=C2)C#N)C(F)(F)F)NC(=O)C3=CC(=NC4=C3C=CC(=C4)F)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bay K 8644 | Bay K 8644 is a racemate. Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. Group: Inhibitors. CAS No. 71145-03-4. Pack Sizes: 5mg. Product ID: S7924. Formula: C16H15F3N2O4. Smiles: CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bcl-2 Antibody [D6K15] | Bcl2,Bcl-2. Group: Antibodies. Alternative Names: Apoptosis regulator Bcl-2. CAS No. Pack Sizes: 20uL. Product ID: F2515. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Bcl-2 Antibody [H20N17] | Bcl2,Bcl-2. Group: Antibodies. Alternative Names: Bcl-2. Pack Sizes: 20uL. Product ID: F0125. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Bcl-xL Antibody [D4A3] | Bcl-xL Antibody [D4A3]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0129. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| BDNF Antibody [E17G19] | BDNF Antibody [E17G19]. Group: Antibodies. CAS No. Pack Sizes: 20uL. Product ID: F1591. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Beclin 1 Antibody [A2D9] | Beclin,Beclin 1,Beclin-1,BECN1 / Beclin-1. Group: Antibodies. Alternative Names: Beclin,Beclin-1,BECN1 / Beclin-1. CAS No. Pack Sizes: 20ul. Product ID: F0038. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Belinostat (PXD101) | Belinostat is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy. Group: Inhibitors. Alternative Names: PXD101,NSC726630, PX-105684. CAS No. 866323-14-0. Pack Sizes: 10mg. Product ID: S1085. Formula: C15H14N2O4S. Smiles: C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Belnacasan (VX-765) | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2. Group: Inhibitors. CAS No. 273404-37-8. Pack Sizes: 10mg. Product ID: S2228. Formula: C24H33ClN4O6. Smiles: CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bemcentinib (R428) | Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective). Group: Inhibitors. Alternative Names: BGB324. CAS No. 1037624-75-1. Pack Sizes: 1mg. Product ID: S2841. Formula: C30H34N8. Smiles: C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Berzosertib (VE-822) | Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells. Group: Inhibitors. Alternative Names: VX970, M6620. CAS No. 1232416-25-9. Pack Sizes: 10mg. Product ID: S7102. Formula: C24H25N5O3S. Smiles: CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| β-Actin Antibody [C21N23] | ACTB,beta Actin,beta Actin Loading Control,beta-Actin,β-Actin. Group: Antibodies. Alternative Names: ACTB, β Actin Loading Control. CAS No. Pack Sizes: 20ul. Product ID: F0012. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| β-Catenin Antibody [M7A19] | beta Catenin,beta-Catenin,CTNNB1,β-Catenin. Group: Antibodies. Alternative Names: beta-Catenin,CTNNB1,β-Catenin. CAS No. Pack Sizes: 20uL. Product ID: F2521. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| β-nicotinamide mononucleotide (NMN) | Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase. Group: Inhibitors. Alternative Names: β-NM, NMN. CAS No. 1094-61-7. Pack Sizes: 25mg. Product ID: S5259. Formula: C11H15N2O8P. Smiles: C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| β-Tubulin Antibody [C23L2] | beta Tubulin,beta Tubulin Loading Control,beta-Tubulin,β-Tubulin. Group: Antibodies. Alternative Names: β Tubulin Loading Control. Pack Sizes: 20ul. Product ID: F0167. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Bevacizumab (anti-VEGF) | Bevacizumab (anti-VEGF, Avastin) is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments, MW:149 KD. Group: Antibodies. Alternative Names: rhuMab VEGF. CAS No. 216974-75-3. Pack Sizes: 5mg. Product ID: A2006. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| BGJ398 (Infigratinib) | Infigratinib (BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. Group: Inhibitors. Alternative Names: NVP-BGJ398. CAS No. 872511-34-7. Pack Sizes: 5mg. Product ID: S2183. Formula: C26H31Cl2N7O3. Smiles: CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BI-10773 (Empagliflozin) | Empagliflozin is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3. Group: Inhibitors. Alternative Names: BI 10773. CAS No. 864070-44-0. Pack Sizes: 25mg. Product ID: S8022. Formula: C23H27ClO7. Smiles: C1COCC1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)C4C(C(C(C(O4)CO)O)O)O)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BI 2536 | BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2. Group: Inhibitors. CAS No. 755038-02-9. Pack Sizes: 1g. Product ID: S1109. Formula: C28H39N7O3. Smiles: CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BIBF 1120 (Nintedanib) | Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3. Group: Inhibitors. Alternative Names: BIBF 1120, Intedanib. CAS No. 656247-17-5. Pack Sizes: 1g. Product ID: S1010. Formula: C31H33N5O4. Smiles: CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Biotin (Vitamin B7) | Biotin(Vitamin B7) is a B-vitamin and acts as a necessary coenzyme for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. Biotin is covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. Group: Inhibitors. CAS No. 58-85-5. Pack Sizes: 10mM/1mL. Product ID: S3130. Formula: C10H16N2O3S. Smiles: C1C2C(C(S1)CCCCC(=O)O)NC(=O)N2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Birabresib (OTX015) | Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. Group: Inhibitors. Alternative Names: MK 8628. CAS No. 202590-98-5. Pack Sizes: 2mg. Product ID: S7360. Formula: C25H22ClN5O2S. Smiles: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Birinapant (TL32711) | Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of apoptosis in latent HIV-1-infected cells. Phase 2. Group: Inhibitors. Alternative Names: TL32711. CAS No. 1260251-31-7. Pack Sizes: 5mg. Product ID: S7015. Formula: C42H56F2N8O6. Smiles: CCC(C(=O)N1CC(CC1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)CC6CC(CN6C(=O)C(CC)NC(=O)C(C)NC)O)O)NC(=O)C(C)NC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Blasticidin S Hydrochloride | Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation. It is used to select transfected cells carrying bsr or BSD resistance genes. Group: Inhibitors. CAS No. 3513-3-9. Pack Sizes: 25mg. Product ID: S7419. Formula: C17H27ClN8O5. Smiles: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| (-)-Blebbistatin | (-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Group: Inhibitors. Alternative Names: (S)-(-)-Blebbistatin. CAS No. 856925-71-8. Pack Sizes: 10mg. Product ID: S7099. Formula: C18H16N2O2. Smiles: CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Bleomycin sulfate | Bleomycin sulfate is a DNA synthesis inhibitor and a glycopeptide antibiotic, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. This chemical can be used to induce animal models of pulmonary fibrosis. Group: Inhibitors. Alternative Names: NSC125066 sulfate. CAS No. 9041-93-4. Pack Sizes: 10mg. Product ID: S1214. Formula: C55H85N17O25S4. Smiles: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BMH-21 | BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. Group: Inhibitors. CAS No. 896705-16-1. Pack Sizes: 10mg. Product ID: S7718. Formula: C21H20N4O2. Smiles: CN(C)CCNC(=O)C1=CC=CN2C1=NC3=CC4=CC=CC=C4C=C3C2=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BMN-673 (Talazoparib) | Talazoparib (BMN 673, LT-673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3. Group: Inhibitors. Alternative Names: LT-673. CAS No. 1207456-01-6. Pack Sizes: 10mg. Product ID: S7048. Formula: . C19H14F2N6O. . Smiles: CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BMS-345541 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively. Group: Inhibitors. CAS No. 445430-58-0. Pack Sizes: 5mg. Product ID: S8044. Formula: C14H17N5. Smiles: CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BMS-927711 (Rimegepant) | Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM. Group: Inhibitors. Alternative Names: BHV-3000. CAS No. 1289023-67-1. Pack Sizes: 5mg. Product ID: S6659. Formula: C28H28F2N6O3. Smiles: C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| BMS-986165 (Deucravacitinib) | Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of Tyk2 with a Ki value of 0.02 nM for binding to the Tyk2 pseudokinase domain. It is highly selective against a panel of 265 kinases and pseudokinases. Group: Inhibitors. CAS No. 1609392-27-9. Pack Sizes: 2mg. Product ID: S8879. Formula: C20H19D3N8O3. Smiles: CNC(=O)C1=NN=C(C=C1NC2=CC=CC(=C2OC)C3=NN(C=N3)C)NC(=O)C4CC4. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Bortezomib | Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors. Group: Inhibitors. Alternative Names: LDP-341, MLM341, NSC 681239,PS-341, BTZ. CAS No. 179324-69-7. Pack Sizes: 1g. Product ID: S1013. Formula: C19H25BN4O4. Smiles: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| BPTES | BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity. Group: Inhibitors. CAS No. 314045-39-1. Pack Sizes: 10mg. Product ID: S7753. Formula: C24H24N6O2S3. Smiles: C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Brd4 Antibody [D15J2] | Brd4 Antibody [D15J2]. Group: Antibodies. CAS No. Pack Sizes: 20ul. Product ID: F1076. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| BrdU (Bromodeoxyuridine, 5-BrdU) | BrdU (Bromodeoxyuridine) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells. Group: Inhibitors. Alternative Names: 5-Bromo-2'-deoxyuridine, BUdR. CAS No. 59-14-3. Pack Sizes: 200mg. Product ID: S7918. Formula: C9H11BrN2O5. Smiles: C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Brefeldin A (BFA chemical) | Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy. Group: Inhibitors. Alternative Names: Cyanein, Decumbin. CAS No. 20350-15-6. Pack Sizes: 5mg. Product ID: S7046. Formula: C16H24O4. Smiles: CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Brigatinib | Brigatinib is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. Group: Inhibitors. Alternative Names: AP26113. CAS No. 1197953-54-0. Pack Sizes: 5mg. Product ID: S8229. Formula: C29H39ClN7O2P. Smiles: CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Busulfan | Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.Busulfan (NSC-750) can be used to induce animal models of Anemia. Group: Inhibitors. Alternative Names: NSC-750. CAS No. 55-98-1. Pack Sizes: 50mg. Product ID: S1692. Formula: C6H14O6S2. Smiles: CS(=O)(=O)OCCCCOS(=O)(=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Butyzamide | Butyzamide is a non-peptidyl thrombopoietin receptor, activator of Mpl. It also augments the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. It has potential for treatment of thrombocytopenia. Group: Inhibitors. CAS No. 1110767-45-7. Pack Sizes: 1mg. Product ID: E1352. Formula: C29H32Cl2N2O5S. | United States; Europe |
| BV6 | BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor. Group: Inhibitors. CAS No. 1001600-56-1(freebase). Pack Sizes: 5mg. Product ID: S7597. Formula: C70H96N10O8.xCF3COOH. Smiles: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCCCCCNC(=O)C(C(C5=CC=CC=C5)C6=CC=CC=C6)NC(=O)C7CCCN7C(=O)C(C8CCCCC8)NC(=O)C(C)NC)NC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| BX-795 | BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively. Group: Inhibitors. CAS No. 702675-74-9. Pack Sizes: 10mg. Product ID: S1274. Formula: C23H26IN7O2S. Smiles: C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| C-176 | STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway. Group: Inhibitors. CAS No. 314054-00-7. Pack Sizes: 5mg. Product ID: S6575. Formula: C11H7IN2O4. Smiles: C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| C188-9 (TTI-101) | C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Group: Inhibitors. Alternative Names: TTI 101. CAS No. 432001-19-9. Pack Sizes: 5mg. Product ID: S8605. Formula: C27H21NO5S. Smiles: COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| C646 | C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy. Group: Inhibitors. CAS No. 328968-36-1. Pack Sizes: 10mg. Product ID: S7152. Formula: C24H19N3O6. Smiles: CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| CA-074 methyl ester (CA-074 Me) | CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. Group: Inhibitors. Alternative Names: Cathepsin B Inhibitor IV. CAS No. 147859-80-1. Pack Sizes: 5mg. Product ID: S7420. Formula: C19H31N3O6. Smiles: CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| CA3 (CIL56) | CA3 (CIL56) has potent inhibitory effects on YAP1 / Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). Group: Inhibitors. CAS No. 300802-28-2. Pack Sizes: 5mg. Product ID: S8661. Formula: C23H27N3O5S2. Smiles: C1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)N5CCCCC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Cabozantinib (XL184) | Cabozantinib (XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway. Group: Inhibitors. Alternative Names: BMS-907351. CAS No. 849217-68-1. Pack Sizes: 5mg. Product ID: S1119. Formula: C28H24FN3O5. Smiles: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Caerulein (Cerulein, FI-6934) | Caerulein (Ceruletide, Cerulein, FI-6934), a cholecystokinin (CCK) receptor agonist, is a safe and effective cholecystokinetic agent and small bowel and exocrine pancreatic stimulant. Caerulein (FI-6934) can be used to induce animal models of acute pancreatitis. Group: Inhibitors. Alternative Names: Ceruletide, Cerulein. CAS No. 17650-98-5. Pack Sizes: 5mg. Product ID: S9690. Formula: C58H73N13O21S2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| CAL-101 (Idelalisib) | Idelalisib (CAL-101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy. Group: Inhibitors. Alternative Names: GS-1101. CAS No. 870281-82-6. Pack Sizes: 10mg. Product ID: S2226. Formula: C22H18FN7O. Smiles: CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Calcitriol (1,25-Dihydroxyvitamin D3) | Calcitriol is a nonselective vitamin D receptor activator / agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: RO215535, Topitriol, 1,25-Dihydroxyvitamin D3. CAS No. 32222-06-3. Pack Sizes: 2mg. Product ID: S1466. Formula: C27H44O3. Smiles: CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C. Storage Conditions: 1 year -80°C powder (in dark and seal) . | United States; Europe |
| Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells. Group: Inhibitors. CAS No. 117591-20-5. Pack Sizes: 10mg. Product ID: S7396. Formula: C20H30N2O4. Smiles: CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Calreticulin Antibody [G16N21] | CRT. Group: Antibodies. Alternative Names: CRT, CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP, grp60, CALR, CRTC. CAS No. Pack Sizes: 20uL. Product ID: F0472. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| CaMKII Antibody [K10C12] | CaM Kinase II,CaMKII,CaMKII (pan),CaMKIIα/β/γ/δ. Group: Antibodies. Alternative Names: CaM Kinase II,CaMKII (pan),CaMKIIα/β/γ/δ. CAS No. Pack Sizes: 20ul. Product ID: F1032. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Camptothecin (CPT) | Camptothecin (CPT) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2. Group: Inhibitors. Alternative Names: Campathecin, (S)-(+)-Camptothecin,NSC-100880. CAS No. 7689-3-4. Pack Sizes: 250mg. Product ID: S1288. Formula: C20H16N2O4. Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Canagliflozin (JNJ-28431754) | Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. Group: Inhibitors. Alternative Names: TA 7284. CAS No. 842133-18-0. Pack Sizes: 5mg. Product ID: S2760. Formula: C24H25FO5S. Smiles: CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Capecitabine | Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis. Group: Inhibitors. Alternative Names: RO 09-1978. CAS No. 154361-50-9. Pack Sizes: 200mg. Product ID: S1156. Formula: C15H22FN3O6. Smiles: CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Capmatinib (INC280) | Capmatinib is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1. Group: Inhibitors. Alternative Names: INC280, NVP-INC280, INCB28060. CAS No. 1029712-80-8. Pack Sizes: 10mg. Product ID: S2788. Formula: C23H17FN6O. Smiles: CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
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