Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Cyclopamine (11-Deoxojervine) | Cyclopamine (11-deoxojervine) is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells. Group: Inhibitors. Alternative Names: 11-deoxojervine. CAS No. 4449-51-8. Pack Sizes: 5mg. Product ID: S1146. Formula: C27H41NO2. Smiles: CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Cyclophosphamide | Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group. Group: Inhibitors. Alternative Names: NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane. CAS No. 50-18-0. Pack Sizes: 100mg. Product ID: S1217. Formula: C7H15Cl2N2O2P. Smiles: ClCCN(CCCl)[P]1(=O)NCCCO1. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Cyclophosphamide Monohydrate | Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.Cyclophosphamide (NSC-26271) Monohydrate can be used to induce animal models of Anemia. Group: Inhibitors. Alternative Names: NSC-26271 Monohydrate. CAS No. 6055-19-2. Pack Sizes: 50mg. Product ID: S2057. Formula: C7H15Cl2N2O2P.H2O. Smiles: C1CNP(=O)(OC1)N(CCCl)CCCl.O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Cyclosporin A | Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation. Group: Inhibitors. Alternative Names: Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193. CAS No. 59865-13-3. Pack Sizes: 50mg. Product ID: S2286. Formula: C62H111N11O12. Smiles: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Cytarabine | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. Group: Inhibitors. Alternative Names: Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459,U-19920A. CAS No. 147-94-4. Pack Sizes: 50mg. Product ID: S1648. Formula: C9H13N3O5. Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Cytochalasin D | Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap. Group: Inhibitors. Alternative Names: Zygosporin A, NSC 209835. CAS No. 22144-77-0. Pack Sizes: 1mg. Product ID: S8184. Formula: C30H37NO6. Smiles: CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Dabrafenib (GSK2118436) | Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively. Group: Inhibitors. Alternative Names: GSK2118436, GSK2118436A. CAS No. 1195765-45-7. Pack Sizes: 5mg. Product ID: S2807. Formula: C23H20F3N5O2S2. Smiles: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Dapagliflozin (BMS-512148) | Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4. Group: Inhibitors. Alternative Names: BMS-512148. CAS No. 461432-26-8. Pack Sizes: 50mg. Product ID: S1548. Formula: C21H25ClO6. Smiles: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| DAPT | DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy. Group: Inhibitors. Alternative Names: GSI-IX, LY-374973. CAS No. 208255-80-5. Pack Sizes: 5mg. Product ID: S2215. Formula: C23H26F2N2O4. Smiles: CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Daraxonrasib (RMC-6236) | Daraxonrasib (RMC-6236) is a RAS(ON) multi-selective noncovalent inhibitor of the active, GTP-bound state of both mutant and wild-type variants of canonical RAS isoforms with broad therapeutic potential. RMC-6236 exhibits strong anticancer efficacy in RAS-addicted cell lines, especially those with mutations at codon 12 of KRAS. Group: Inhibitors. Alternative Names: RAS-IN-2. CAS No. 2765081-21-6. Pack Sizes: 1mg. Product ID: E1597. Formula: C44H58N8O5S. | United States; Europe |
| Dasatinib (BMS-354825) | Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of autophagy and apoptosis with anti-tumor activity. Group: Inhibitors. Alternative Names: BMS-354825. CAS No. 302962-49-8. Pack Sizes: 1g. Product ID: S1021. Formula: C22H26ClN7O2S. Smiles: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Datopotamab deruxtecan | Datopotamab deruxtecan (DS-1062, DS-1062A, Anti-TRP2/dxd) is an antibody-drug conjugate (ADC) composed of a humanized anti-TROP2 monoclonal antibody, conjugated to topoisomerase I inhibitor, via a tetrapeptide-based linker. Datopotamab deruxtecan has the potential for use in solid tumors mainly in advanced unresectable advanced NSCLC. Alternative Names: DS-1062, DS-1062A, Anti-TRP2/dxd. CAS No. 2238831-60-0. Pack Sizes: 1mg. Product ID: D4050. Formula: 4.2. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Daunorubicin Hydrochloride (Daunomycin) | Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.Daunorubicin (RP 13057) HCl can be used to induce animal models of Kidney Disease. Group: Inhibitors. Alternative Names: Rubidomycin HCl, RP 13057 HCl. CAS No. 23541-50-6. Pack Sizes: 10mg. Product ID: S3035. Formula: C27H29NO10. HCl. Smiles: CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| dBET6 | dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis. Group: Inhibitors. CAS No. 1950634-92-0. Pack Sizes: 5mg. Product ID: S8762. Formula: C42H45ClN8O7S. Smiles: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Decitabine | Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines. Group: Peptides. Alternative Names: Deoxycytidine, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716. CAS No. 2353-33-5. Pack Sizes: 25mg. Product ID: S1200. Formula: C8H12N4O4. Smiles: C1C(C(OC1N2C=NC(=NC2=O)N)CO)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Defactinib (VS-6063) | Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2. Group: Inhibitors. Alternative Names: PF-04554878. CAS No. 1073154-85-4. Pack Sizes: 5mg. Product ID: S7654. Formula: C20H21F3N8O3S. Smiles: CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Deferiprone | Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III), binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. Group: Inhibitors. Alternative Names: CP20. CAS No. 30652-11-0. Pack Sizes: 50mg. Product ID: S4067. Formula: C7H9NO2. Smiles: CC1=C(C(=O)C=CN1C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Deferoxamine mesylate | Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur. Group: Inhibitors. Alternative Names: Ba 33112, Desferrioxamine B, DFOM, NSC 644468, DFO. CAS No. 138-14-7. Pack Sizes: 25mg. Product ID: S5742. Formula: C26H52N6O11S. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Denifanstat (TVB-2640) | Denifanstat (TVB-2640) is an orally bioavailable, pharmacological fatty acid synthase (FAS / FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis. Group: Inhibitors. Alternative Names: ASC-40, FASN-IN-2. CAS No. 1399177-37-7. Pack Sizes: 5mg. Product ID: S9714. Formula: C27H29N5O. Smiles: CC1=NN=C([NH]1)C2=C(C=C(C)C(=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N)C5CCC5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Dexamethasone | Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients. Group: Inhibitors. Alternative Names: NSC 34521, Hexadecadrol, Prednisolone F,MK-125. CAS No. 50-02-2. Pack Sizes: 10g. Product ID: S1322. Formula: C22H29FO5. Smiles: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C. Storage Conditions: 2 years 4°C, in dark and seal. | United States; Europe |
| DFNA5 / GSDME Antibody [G9F19] | cleaved N-terminal DFNA5 / GSDME,DFNA5 / GSDME,Gasdermin E. Group: Antibodies. Alternative Names: cleaved N-terminal DFNA5,DFNA5 / GSDME,Gasdermin E. CAS No. Pack Sizes: 20uL. Product ID: F1701. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| DHA (Dihydroartemisinin) | DHA (Dihydroartemisinin) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation. Group: Inhibitors. Alternative Names: Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol. CAS No. 71939-50-9. Pack Sizes: 100mg. Product ID: S2290. Formula: C15H24O5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| diABZI STING agonist-1 (tautomerism) | diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: diABZI STING agonist-1, Tautomerism. CAS No. 2138498-18-5. Pack Sizes: 2mg. Product ID: S8796. Formula: C42H51N13O7. Smiles: CCN1C(=CC(=N1)C)C(=O)NC2=NC3=C(N2CC=CCN4C5=C(C=C(C=C5OCCCN6CCOCC6)C(=O)N)N=C4NC(=O)C7=CC(=NN7CC)C)C(=CC(=C3)C(=O)N)OC. | United States; Europe |
| Dibenzazepine (YO-01027) | DBZ (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. Group: Inhibitors. Alternative Names: YO-01027. CAS No. 209984-56-5. Pack Sizes: 2mg. Product ID: S2711. Formula: C26H23F2N3O3. Smiles: CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Dibutyryl cAMP (db cAMP / Bucladesine) sodium | Bucladesine sodium is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor. Group: Inhibitors. Alternative Names: DBcAMP sodium salt. CAS No. 16980-89-5. Pack Sizes: 100mg. Product ID: S7858. Formula: C18H23N5NaO8P. Smiles: CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Dinaciclib (SCH 727965) | Dinaciclib is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3. Group: Inhibitors. Alternative Names: SCH727965, PS-095760. CAS No. 779353-01-4. Pack Sizes: 5mg. Product ID: S2768. Formula: C21H28N6O2. Smiles: CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| DL-Lactic acid | Lactate (Lactic acid) is the product of glycolysis, produced due to lack of oxygen in contracting skeletal muscle in vivo, and can be utilised under fully aerobic conditions. It plays a key role as a metabolic intermediate and can be used as hemodynamic marker and resuscitation endpoint in several cohorts of critically ill patients. Group: Inhibitors. Alternative Names: Lactic acid. CAS No. 50-21-5. Pack Sizes: 100mg. Product ID: E4473. Formula: C3H6O3. Storage Conditions: 2 years -20°C liquid. | United States; Europe |
| DMF (Dimethyl Fumarate) | DMF (Dimethyl Fumarate) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression. Group: Inhibitors. Alternative Names: BG-12. CAS No. 624-49-7. Pack Sizes: 1g. Product ID: S2586. Formula: C6H8O4. Smiles: COC(=O)C=CC(=O)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| DMH1 | DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy. Group: Inhibitors. CAS No. 1206711-16-1. Pack Sizes: 10mg. Product ID: S7146. Formula: C24 H20 N4 O. Smiles: CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| DMOG (Dimethyloxallyl Glycine) | DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: Dimethyloxalylglycine. CAS No. 89464-63-1. Pack Sizes: 20mg. Product ID: S7483. Formula: C6H9NO5. Smiles: COC(=O)CNC(=O)C(=O)OC. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| DNase I, Bovine pancreas | DNase I, Bovine pancreas is a Ca²?/Mg²?-dependent endonuclease that cleaves phosphodiester bonds double-stranded DNA, classified under EC 3.1.21.1 as a hydrolase. It binds to the minor groove of DNA, with key amino acids like R111, Y211, and N170 interacting with the DNA backbone to facilitate catalysis, while residues N74 and S206 in the active site are crucial for substrate binding and DNA recognition. DNase I is essential for DNA degradation, chromatin research, and is widely used to generate smaller DNA fragments for genomic studies and to examine DNA-protein interactions in chromatin remodeling research. Group: Inhibitors. CAS No. 9003-98-9. Pack Sizes: 50mg. Product ID: E7018. | United States; Europe |
| Docetaxel | Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. Group: Inhibitors. Alternative Names: NSC 628503,RP56976. CAS No. 114977-28-5. Pack Sizes: 10mg. Product ID: S1148. Formula: C43H53NO14. Smiles: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Doramapimod (BIRB 796) | Doramapimod (BIRB 796) is a pan-p38 MAPK inhibitor with IC50 of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2. Group: Inhibitors. CAS No. 285983-48-4. Pack Sizes: 5mg. Product ID: S1574. Formula: C31H37N5O3. Smiles: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Dorsomorphin (Compound C) | Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For cell testing, the water-soluble S7306 Dorsomorphin 2HCl is recommended. Group: Inhibitors. Alternative Names: BML-275,Compound C. CAS No. 866405-64-3. Pack Sizes: 5mg. Product ID: S7840. Formula: C24H25N5O. Smiles: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Dorsomorphin Dihydrochloride | Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type 1 BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line. Group: Inhibitors. Alternative Names: BML-275 2HCl,Compound C 2HCl. CAS No. 1219168-18-9. Pack Sizes: 10mg. Product ID: S7306. Formula: C24H25N5O.2HCl. Smiles: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Doxorubicin | Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis. Group: Inhibitors. Alternative Names: Adriamycin,Hydroxydaunorubicin,DOX. CAS No. 23214-92-8. Pack Sizes: 5mg. Product ID: E2516. Formula: C27H29NO11. Smiles: COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| Doxorubicin (Adriamycin) Hydrochloride | Doxorubicin Hydrochloride is an antibiotic agent and DNA Topoisomerase II Inhibitor with IC50 of 2.67 μM against human DNA topoisomerase II. This compound reduces basal phosphorylation of AMPK and is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation. This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution. It can be used to induce animal models of kidney disease. Group: Inhibitors. Alternative Names: Adriamycin, NSC 123127, Hydroxydaunorubicin HCl. CAS No. 25316-40-9. Pack Sizes: 10mg. Product ID: S1208. Formula: C27H29NO11.HCl. Smiles: CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Doxycycline | Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor. Group: Inhibitors. Alternative Names: Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum. CAS No. 564-25-0. Pack Sizes: 25mg. Product ID: S5159. Formula: C22H24N2O8. Smiles: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Doxycycline Hyclate | Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP). Group: Inhibitors. Alternative Names: WC2031. CAS No. 24390-14-5. Pack Sizes: 1g. Product ID: S4163. Formula: C22H24N2O8.1/2C2H6O.HCl.1/2H2O. Smiles: CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| DPI (Diphenyleneiodonium chloride) | DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS / eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). Group: Inhibitors. CAS No. 4673-26-1. Pack Sizes: 10mg. Product ID: S8639. Formula: C12H8I.Cl. Smiles: C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| DRP1 Antibody [H2B5] | DLP1,DNM1L,DRP1. Group: Antibodies. Alternative Names: DLP1,DNM1L,DRP1. Pack Sizes: 20ul. Product ID: F0328. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| dTAG-13 | dTAG-13(FKBP12 PROTAC dTAG-13) is an ortho-substituted, heterobifunctional selective degrader of FKBP12F36V that effectively engage FKBP12F36V and CRBN leading to rapid and selective CRBN-mediated degradation of FKBP12F36V.It can useful for target validation in the context of drug discovery. Group: Inhibitors. Alternative Names: FKBP12 PROTAC dTAG-13. CAS No. 2064175-41-1. Pack Sizes: 5mg. Product ID: S9813. Formula: C57H68N4O15. | United States; Europe |
| Dupilumab (anti-IL-4Rα) | Dupilumab (anti-IL-4Rα) is a fully human anti-interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit. Group: Antibodies. Alternative Names: REGN-668, SAR-231893. CAS No. 1190264-60-8. Pack Sizes: 1mg. Product ID: A2038. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Durvalumab (anti-PD-L1) | Durvalumab (anti-PD-L1) is a selective, high affinity human IgG1 mAb that blocks programmed cell death ligand-1 (PD-L1) binding to PD-1 (IC50=0.1 nM) and CD80 (IC50=0.04 nM). MW=146.3 kDa. Group: Antibodies. Alternative Names: MEDI4736. CAS No. 1428935-60-7. Pack Sizes: 5mg. Product ID: A2013. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| DYKDDDDK Tag Antibody [C19M9] | DDDDK tag (Binds to FLAG tag sequence),DYKDDDDK (FLAG(R) epitope tag),DYKDDDDK Epitope Tag,DYKDDDDK Tag,FLAG,Flag tag,FLAG(R),FLAG(R) M2,OctA-Probe. Group: Antibodies. Alternative Names: DDK; FLAG; Flag tag; tag. Pack Sizes: 20uL. Product ID: F3506. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| DYKDDDDK Tag Antibody [L24H1] | DDDDK tag,DYKDDDDK,DYKDDDDK Epitope Tag,DYKDDDDK Tag,OctA-Probe,Flag. Group: Antibodies. Alternative Names: DDDDK tag,DYKDDDDK Epitope Tag,DYKDDDDK Tag,OctA-Probe. Pack Sizes: 20ul. Product ID: F0973. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Dynasore | Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV). Group: Inhibitors. CAS No. 304448-55-3. Pack Sizes: 10mg. Product ID: S8047. Formula: C18H14N2O4. Smiles: C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Dyngo-4a (Hydroxy-Dynasore) | Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1?μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. Group: Inhibitors. Alternative Names: Hydroxy-Dynasore. CAS No. 1256493-34-1. Pack Sizes: 10mg. Product ID: S7163. Formula: C18H14N2O5. Smiles: C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3O)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite. Group: Inhibitors. CAS No. 66701-25-5. Pack Sizes: 10mg. Product ID: S7379. Formula: C15H27N5O5. Smiles: CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| E7080 (Lenvatinib) | Lenvatinib is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3. Group: Inhibitors. Alternative Names: E7080. CAS No. 417716-92-8. Pack Sizes: 2mg. Product ID: S1164. Formula: C21H19ClN4O4. Smiles: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| E-Cadherin Antibody [P11M9] | E Cadherin,E-Cadherin,Uvomorulin/E-Cadherin. Group: Antibodies. Alternative Names: Cadherin-1, CAM 120/80, Epithelial cadherin (E-cadherin), Uvomorulin, CDH1, CDHE, UVO. Pack Sizes: 20uL. Product ID: F3517. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| E-Cadherin Antibody [P6M3] | E Cadherin,E-Cadherin,Uvomorulin/E-Cadherin. Group: Antibodies. Alternative Names: Cadherin-1, CAM 120/80, Epithelial cadherin (E-cadherin), Uvomorulin, CDH1, CDHE, UVO. Pack Sizes: 20ul. Product ID: F0005. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Eflornithine (DFMO) Hydrochloride Hydrate | Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours. Group: Inhibitors. Alternative Names: Difluoromethylornithine hydrochloride hydrate, MDL-71782 hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate. CAS No. 96020-91-6. Pack Sizes: 100mg. Product ID: S4582. Formula: C6H12F2N2O2.HCl.H2O. Smiles: C(CC(C(F)F)(C(=O)O)N)CN.O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Eganelisib (IPI-549) | Eganelisib (IPI-549) is a potent inhibitor of PI3K-γ with >100-fold selectivity over other lipid and protein kinases. The biochemical IC50 for PI3K-γ is 16 nM. Group: Inhibitors. CAS No. 1693758-51-8. Pack Sizes: 5mg. Product ID: S8330. Formula: C30H24N8O2. Smiles: CC(C1=CC2=C(C(=CC=C2)C#CC3=CN(N=C3)C)C(=O)N1C4=CC=CC=C4)NC(=O)C5=C6N=CC=CN6N=C5N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| EGCG ((-)-Epigallocatechin Gallate) | EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. Group: Inhibitors. CAS No. 989-51-5. Pack Sizes: 50mg. Product ID: S2250. Formula: C22H18O11. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| EGF Receptor Antibody [K22M8] | EGF Receptor,EGFR,Epidermal Growth Factor Receptor. Group: Antibodies. Alternative Names: EGF Receptor,EGFR,Epidermal Growth Factor Receptor. Pack Sizes: 20ul. Product ID: F0053. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| eIF2α Antibody [C14N24] | EIF2S1,eIF2α. Group: Antibodies. Alternative Names: EIF2S1,eIF2α. Pack Sizes: 20ul. Product ID: F0316. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| EIPA (L593754) | EIPA (L593754; MH 12-43) acts as an inhibitor of macropinocytosis and sodium-hydrogen exchangers(NHE) (IC50=0.033μg/mL). EIPA blocks the activity of Na(+)/H(+) exchanger, which are plasma membrane proteins implicated in all forms of macropinocytosis. Group: Inhibitors. Alternative Names: L593754; MH 12-43. CAS No. 1154-25-2. Pack Sizes: 5mg. Product ID: S9849. Formula: C11H18ClN7O. Smiles: CCN(C(C)C)C1=C(Cl)N=C(C(=N1)N)C(=O)NC(N)=N. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Elacridar (GF120918) | Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor. Group: Inhibitors. Alternative Names: GW120918, GG918, GW0918. CAS No. 143664-11-3. Pack Sizes: 10mg. Product ID: S7772. Formula: C34H33N3O5. Smiles: COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Elamipretide (SS-31, MTP-131) | Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Group: Inhibitors. Alternative Names: D-Arg-Dmt-Lys-Phe-NH2. CAS No. 736992-21-5. Pack Sizes: 5mg. Product ID: S9803. Formula: C32H49N9O5. Smiles: CC1=C(CC(NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(N)=O)C(=CC(=C1)O)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Elesclomol (STA-4783) | Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.Elesclomol (STA-4783) is a potent copper ionophore and can be used in the research of copper-dependent cell death (cuproptosis). Group: Inhibitors. CAS No. 488832-69-5. Pack Sizes: 5mg. Product ID: S1052. Formula: C19H20N4O2S2. Smiles: CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Emricasan (IDN-6556) | Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. Group: Inhibitors. Alternative Names: PF 03491390, PF-03491390. CAS No. 254750-02-2. Pack Sizes: 5mg. Product ID: S7775. Formula: C26H27F4N3O7. Smiles: CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| EN6 | EN6 is a novel covalent autophagy activator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein. Group: Inhibitors. CAS No. 1808714-73-9. Pack Sizes: 5mg. Product ID: S6650. Formula: C19H14F2N4O2. Smiles: C=CC(=O)NC1=C(C=CC(=C1)NC(=O)C2=CN(N=C2)C3=CC=CC=C3F)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Enfortumab (Anti-Nectin-4) | Enfortumab (Anti-Nectin-4) is a monoclonal antibody targeting Nectin-4 and has potential for research into urothelial cancer. MW: 145.44 kD. Group: Antibodies. CAS No. 1448664-46-7. Pack Sizes: 1mg. Product ID: A2392. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Enfortumab vedotin-ejfv | Enfortumab vedotin-ejfv (Padcev) is an antibody-drug conjugate (ADC) composed of an fully human anti-Nectin-4 IgG1 kappa monoclonal antibody (AGS-22C3), conjugated to Monomethyl Auristatin E (MMAE), via a protease-cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl. Enfortumab vedotin-ejfv has the potential for use in research of urothelial carcinoma. Alternative Names: Padcev. CAS No. 1346452-25-2. Pack Sizes: 1mg. Product ID: D4053. Formula: 3.6. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Entinostat (MS-275) | Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3. Group: Inhibitors. Alternative Names: SNDX-275. CAS No. 209783-80-2. Pack Sizes: 200mg. Product ID: S1053. Formula: C21H20N4O3. Smiles: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Entrectinib (Rxdx-101) | Entrectinib is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2. Group: Inhibitors. Alternative Names: RXDX-101, NMS-E628. CAS No. 1108743-60-7. Pack Sizes: 5mg. Product ID: S7998. Formula: C31H34F2N6O2. Smiles: CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Epacadostat (INCB024360) | Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Group: Inhibitors. CAS No. 1204669-58-8. Pack Sizes: 5mg. Product ID: S7910. Formula: C11H13BrFN7O4S. Smiles: C1=CC(=C(C=C1N=C(C2=NON=C2NCCNS(=O)(=O)N)NO)Br)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Epirubicin HCl | Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin induces apoptosis. Group: Inhibitors. Alternative Names: IMI 28 HCl, NSC 256942 HCl, 4'-epidoxorubicin HCl. CAS No. 56390-09-1. Pack Sizes: 5mg. Product ID: S1223. Formula: C27H29NO11.HCl. Smiles: CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| EPZ004777 | EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis. Group: Inhibitors. CAS No. 1338466-77-5. Pack Sizes: 5mg. Product ID: S7353. Formula: C28H41N7O4. Smiles: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
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