Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Ivacaftor (VX-770) | Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively. Group: Inhibitors. Alternative Names: VX-770. CAS No. 873054-44-5. Pack Sizes: 5mg. Product ID: S1144. Formula: C24H28N2O3. Smiles: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| IWP-2 | IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ. Group: Inhibitors. CAS No. 686770-61-6. Pack Sizes: 10mg. Product ID: S7085. Formula: C22H18N4O2S3. Smiles: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| IWR-1-endo | IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Group: Inhibitors. Alternative Names: endo-IWR 1, IWR-1. CAS No. 1127442-82-3. Pack Sizes: 10mg. Product ID: S7086. Formula: C25H19N3O3. Smiles: C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JAK2 Antibody [J11G12] | JAK2 Antibody [J11G12]. Group: Antibodies. Alternative Names: Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2; JAK2. CAS No. Pack Sizes: 20uL. Product ID: F2850. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| JAK2 Antibody [K5N8] | JAK2 Antibody [K5N8]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0231. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| JNK1 + JNK2 + JNK3 Antibody [M18P18] | Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, PRKM8, SAPK1, SAPK1C, Mitogen-activated protein kinase 9, MAP kinase 9; MAPK 9, JNK-55, Stress-activated protein kinase 1a, SAPK1a, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, MAPK9, JNK2, PRKM9, SAPK1A, Mitogen-activated protein kinase 10, MAP kinase 10; MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3. Group: Antibodies. Alternative Names: MAPK 8, MAPK 9, MAPK 10. CAS No. Pack Sizes: 20uL. Product ID: F1574. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line. Group: Inhibitors. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 5mg. Product ID: S4901. Formula: C29H29N7O2. Smiles: CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JPH203 (Nanvuranlat) | Nanvuranlat (JPH203, KYT-0353), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 μM) and cell growth (IC50=4.1 μM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. Group: Inhibitors. Alternative Names: KYT-0353. CAS No. 1037592-40-7. Pack Sizes: 5mg. Product ID: S8667. Formula: C23H19Cl2N3O4. Smiles: C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| (+)-JQ1 | (+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. Group: Inhibitors. CAS No. 1268524-70-4. Pack Sizes: 10mg. Product ID: S7110. Formula: C23H25ClN4O2S. Smiles: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JSH-23 | JSH-23 is an inhibitor of NF-κB transcriptional activity, which inhibits LPS-stimulated nuclear factor (NF)-κB transcriptional activity in RAW 264.7 cells with an IC50 value of 7.1 μM, and interferes with LPS-induced NF-κB nuclear translocation without affecting IκB degradation. Group: Inhibitors. CAS No. 749886-87-1. Pack Sizes: 5mg. Product ID: S7351. Formula: C16H20N2. Smiles: CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| K-975 | K-975 is a potent, selective and orally active TEAD inhibitor that directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma. Group: Inhibitors. CAS No. 2563855-03-6. Pack Sizes: 5mg. Product ID: E1329. Formula: C16H14CINO2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| KD025 (Belumosudil) | Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2. Group: Inhibitors. Alternative Names: SLx-2119. CAS No. 911417-87-3. Pack Sizes: 5mg. Product ID: S7936. Formula: C26H24N6O2. Smiles: CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| KEAP1 Antibody [L11G24] | KEAP1,KEAP1 (P586). Group: Antibodies. Alternative Names: KEAP1,P586. Pack Sizes: 20uL. Product ID: F0484. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Ki67 Antibody [J16J15] | Ki67,Ki-67,Ki67/MKI67,Mki67,Proliferating Cell Protein Ki-67. Group: Antibodies. Alternative Names: Proliferation marker protein Ki-67; Antigen identified by monoclonal antibody Ki-67; Antigen KI-67; Antigen Ki67; MKI67. CAS No. Pack Sizes: 20uL. Product ID: F0126. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Ko143 | KO143 is a potent and relatively selective ATP-binding cassette sub-family G member 2 (ABCG2 / BCRP) inhibitor. KO143 decreases the ATPase activity of ABCG2 with IC50 of 9.7 nM. Group: Inhibitors. CAS No. 461054-93-3. Pack Sizes: 5mg. Product ID: S7043. Formula: C26H35N3O5. Smiles: CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| KU-55933 | KU-55933 is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU - 55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy - initiating kinase ULK1 and results in a significant decrease of autophagy. Group: Inhibitors. Alternative Names: ATM Kinase Inhibitor. CAS No. 587871-26-9. Pack Sizes: 5mg. Product ID: S1092. Formula: C21H17NO3S2. Smiles: C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| KU-60019 | KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer. Group: Inhibitors. CAS No. 925701-49-1. Pack Sizes: 10mg. Product ID: S1570. Formula: C30H33N3O5S. Smiles: CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Laduviglusib (CHIR-99021) Hydrochloride | Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt / beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins. Group: Inhibitors. Alternative Names: CT99021 HCl. CAS No. 1797989-42-4. Pack Sizes: 5mg. Product ID: S2924. Formula: C22H18Cl2N8.HCl. Smiles: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Lamin A/C Antibody [D9G3] | Lamin A + Lamin C,Lamin A/C. Group: Antibodies. Alternative Names: Lamin A/C. Pack Sizes: 20ul. Product ID: F0287. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Lamin B1 Antibody [E7B10] | Lamin B1 Antibody [E7B10]. Group: Antibodies. CAS No. Pack Sizes: 20ul. Product ID: F0523. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Lamivudine (3TC, BCH-189) | Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV / AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. Group: Inhibitors. Alternative Names: GR109714X, BCH-189. CAS No. 134678-17-4. Pack Sizes: 10mg. Product ID: S1706. Formula: C8H11N3O3S. Smiles: C1C(OC(S1)CO)N2C=CC(=NC2=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LAMP1 Antibody [C20P18] | LAMP1 Antibody [C20P18]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2872. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| LAMP1 Antibody [L9J5] | LAMP1 Antibody [L9J5]. Group: Antibodies. Alternative Names: Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP1. Pack Sizes: 20uL. Product ID: F4075. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Lanifibranor (IVA-337) | Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively. Group: Inhibitors. CAS No. 927961-18-0. Pack Sizes: 5mg. Product ID: S8770. Formula: C19H15ClN2O4S2. Smiles: C1=CC2=C(C=C1S(=O)(=O)N3C4=C(C=C(C=C4)Cl)C=C3CCCC(=O)O)SC=N2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Lapatinib (GW572016) | Lapatinib is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death. Group: Inhibitors. Alternative Names: GSK572016, GW2016. CAS No. 231277-92-2. Pack Sizes: 25mg. Product ID: S2111. Formula: C29H26ClFN4O4S. Smiles: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| L-Ascorbic Acid (Vitamin C) | Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy. Group: Inhibitors. Alternative Names: L-Ascorbic acid. CAS No. 50-81-7. Pack Sizes: 50mg. Product ID: S3114. Formula: C6H8O6. Smiles: C(C(C1C(=C(C(=O)O1)O)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LB-100 | LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. Group: Inhibitors. CAS No. 1632032-53-1. Pack Sizes: 5mg. Product ID: S7537. Formula: C13H20N2O4. Smiles: CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| L-Buthionine-(S,R)-sulfoximine (L-BSO) | BSO is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively. Group: Inhibitors. Alternative Names: L-Buthionine sulfoximine, l-BSO. CAS No. 83730-53-4. Pack Sizes: 5mg. Product ID: S9728. Formula: C8H18N2O3S. Smiles: CCCC[S](=N)(=O)CCC(N)C(O)=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| LC3A/B Antibody [M18P1] | Microtubule-associated proteins 1A/1B light chain 3A, Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, MAP1A/MAP1B light chain 3A , MAP1A/MAP1B LC3 A, Microtubule-associated protein 1 light chain 3 alpha, MAP1LC3A, Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta, MAP1LC3B, MAP1ALC3. Group: Antibodies. Alternative Names: MAP1A/MAP1B LC3 A, MAP1A/MAP1B LC3 B. Pack Sizes: 20ul. Product ID: F0144. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| LC3B Antibody [G7J7] | LC3B Antibody [G7J7]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0145. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| LDN-193189 | LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For cell testing, the water-soluble S7507 LDN-193189 2HCl is recommended.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! Group: Inhibitors. Alternative Names: DM3189. CAS No. 1062368-24-4. Pack Sizes: 2mg. Product ID: S2618. Formula: C25H22N6. Smiles: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LDN-193189 Dihydrochloride | LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. Group: Inhibitors. Alternative Names: DM-3189 2HCl. CAS No. 1435934-00-1. Pack Sizes: 5mg. Product ID: S7507. Formula: C25H24Cl2N6. Smiles: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Lecanemab (Anti-Amyloid Beta) | Lecanemab (Anti-Amyloid Beta) is a humanized IgG1 monoclonal antibody targeting soluble aggregated amyloid beta (Aβ). It can be used for the research of Alzheimer's Disease. MW :147.06 KD. Group: Antibodies. Alternative Names: BAN-2401. CAS No. 1260393-98-3. Pack Sizes: 1mg. Product ID: A3112. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| LEE011 (Ribociclib) | Ribociclib is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3. Group: Inhibitors. Alternative Names: LEE011. CAS No. 1211441-98-3. Pack Sizes: 5mg. Product ID: S7440. Formula: C23H30N8O. Smiles: CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Leptomycin B (LMB) | Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM-10 nM. Group: Inhibitors. Alternative Names: LMB, CI 940, Elactocin, Mantuamycin, NSC 364372. CAS No. 87081-35-4. Pack Sizes: 5mg. Product ID: S7580. Formula: C33H48O6. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Letrozole | Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy. Group: Inhibitors. Alternative Names: CGS 20267. CAS No. 112809-51-5. Pack Sizes: 25mg. Product ID: S1235. Formula: C17H11N5. Smiles: C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Leucovorin Calcium Pentahydrate (Folinic acid) | Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: NSC-3590 Calcium Pentahydrate, Calcium Folinatc, Citrovorum Factor. CAS No. 6035-45-6. Pack Sizes: 250mg. Product ID: S1236. Formula: C20H31CaN7O12. Smiles: C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]. Storage Conditions: 4°C (in the dark). | United States; Europe |
| Leupeptin Hemisulfate | Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin. Group: Inhibitors. CAS No. 103476-89-7. Pack Sizes: 10mg. Product ID: S7380. Formula: C20H38N6O4.1/2H2SO4. Smiles: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LGK974 (WNT974) | LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1. Group: Inhibitors. Alternative Names: NVP-LGK974, WNT974. CAS No. 1243244-14-5. Pack Sizes: 5mg. Product ID: S7143. Formula: C23H20N6O. Smiles: CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LGX818 (Encorafenib) | Encorafenib is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3. Group: Inhibitors. Alternative Names: LGX818. CAS No. 1269440-17-6. Pack Sizes: 1mg. Product ID: S7108. Formula: C22 H27 Cl F N7 O4 S. Smiles: CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Linsitinib (OSI-906) | Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3. Group: Inhibitors. CAS No. 867160-71-2. Pack Sizes: 5mg. Product ID: S1091. Formula: C26H23N5O. Smiles: CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Liothyronine (Triiodothyronine, T3) | T3 (Triiodothyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. 0.1 M NaOH is recommended as a stock solution. Group: Inhibitors. Alternative Names: 3,3',5-Triiodo-L-thyronine. CAS No. 6893-2-3. Pack Sizes: 25mg. Product ID: S5726. Formula: C15H12I3NO4. Smiles: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Lipopolysaccharides (LPS) | Lipopolysaccharides (LPSs, Endotoxin,LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. Lipopolysaccharides induces secretion of cell migrasome. Group: Inhibitors. Alternative Names: LPSs, Endotoxin,LPS. CAS No. 93572-42-0. Pack Sizes: 1mg. Product ID: S7850. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Liproxstatin-1 | Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. Group: Inhibitors. CAS No. 950455-15-9. Pack Sizes: 5mg. Product ID: S7699. Formula: C19H21ClN4. Smiles: C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Liraglutide | Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist. Group: Inhibitors. Alternative Names: NN2211, Liraglutida, Liraglutidum. CAS No. 204656-20-2. Pack Sizes: 1mg. Product ID: S8256. Formula: C172H265N43O51. Smiles: CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC6=CN=CN6)N)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LL37 (Human cathelicidin) | LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties. Group: Peptides. Alternative Names: Ropocamptide. CAS No. 154947-66-7. Pack Sizes: 5mg. Product ID: P1201. Formula: C205H340N60O53. Storage Conditions: 3 years-20°Cpowder. | United States; Europe |
| Lorlatinib (PF-6463922) | Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of apoptosis. Phase 1. Group: Inhibitors. CAS No. 1454846-35-5. Pack Sizes: 5mg. Product ID: S7536. Formula: C21H19FN6O2. Smiles: CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Lovastatin (Mevinolin, MK-803) | Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy. Group: Inhibitors. Alternative Names: Mevinolin, MK-803. CAS No. 75330-75-5. Pack Sizes: 50mg. Product ID: S2061. Formula: C24H36O5. Smiles: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LOXO-292 (Selpercatinib) | Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET (c-RET) inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively. Group: Inhibitors. Alternative Names: ARRY-192. CAS No. 2152628-33-4. Pack Sizes: 5mg. Product ID: S8781. Formula: C29H31N7O3. Smiles: CC(C)(COC1=CN2C(=C(C=N2)C#N)C(=C1)C3=CN=C(C=C3)N4CC5CC(C4)N5CC6=CN=C(C=C6)OC)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| LY2090314 | LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases. Group: Inhibitors. CAS No. 603288-22-8. Pack Sizes: 5mg. Product ID: S7063. Formula: C28H25FN6O3. Smiles: C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY2109761 | LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis. Group: Inhibitors. CAS No. 700874-71-1. Pack Sizes: 5mg. Product ID: S2704. Formula: C26H27N5O2. Smiles: C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY2835219 (Abemaciclib) Mesylate | Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3. Group: Inhibitors. Alternative Names: LY2835219 mesylate. CAS No. 1231930-82-7. Pack Sizes: 5mg. Product ID: S7158. Formula: C27H32F2N8.CH4O3S. Smiles: CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY294002 | LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis. Group: Inhibitors. Alternative Names: SF 1101, NSC 697286. CAS No. 154447-36-6. Pack Sizes: 10mg. Product ID: S1105. Formula: C19H17NO3. Smiles: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY411575 | LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane / cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells. LY411575 induces apoptosis. Group: Inhibitors. CAS No. 209984-57-6. Pack Sizes: 5mg. Product ID: S2714. Formula: C26H23F2N3O4. Smiles: CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MAP2 Antibody [G20G3] | MAP2,MAP-2,Microtubule-Associated Protein 2 (MAP2). Group: Antibodies. Alternative Names: MAP2,Microtubule-Associated Protein 2. Pack Sizes: 20ul. Product ID: F0548. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Maraviroc (UK-427857) | Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection. Group: Inhibitors. Alternative Names: UK-427857. CAS No. 376348-65-1. Pack Sizes: 5mg. Product ID: S2003. Formula: C29H41F2N5O. Smiles: CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MC903 (Calcipotriene) | Calcipotriene (MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: Calcipotriol. CAS No. 112965-21-6. Pack Sizes: 5mg. Product ID: S3739. Formula: C27H40O3. Smiles: CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C. Storage Conditions: 2 years -80 in solvent (in dark and seal) . | United States; Europe |
| MCC950 | MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. Group: Inhibitors. Alternative Names: CP-456773, CRID3. CAS No. 210826-40-7. Pack Sizes: 5mg. Product ID: S8930. Formula: C20H24N2O5S. Smiles: CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| MCC950 Sodium | MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes. Group: Inhibitors. Alternative Names: CP-456773 Sodium, CRID3 Sodium. CAS No. 256373-96-3. Pack Sizes: 10mg. Product ID: S7809. Formula: C20H23N2O5S.Na. Smiles: CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Mdivi-1 | Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis. Group: Inhibitors. Alternative Names: Mitochondrial division inhibitor 1. CAS No. 338967-87-6. Pack Sizes: 20mg. Product ID: S7162. Formula: C15H10Cl2N2O2S. Smiles: COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MDV3100 (Enzalutamide) | Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. Enzalutamide is shown to increase autophagy. Group: Inhibitors. Alternative Names: MDV3100. CAS No. 915087-33-1. Pack Sizes: 5mg. Product ID: S1250. Formula: C21H16F4N4O2S. Smiles: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Medroxyprogesterone Acetate (MPA) | MPA (Medroxyprogesterone acetate) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding. Group: Inhibitors. Alternative Names: NSC-26386, Medroxyprogesterone 17-acetate, Farlutin. CAS No. 71-58-9. Pack Sizes: 50mg. Product ID: S2567. Formula: C24H34O4. Smiles: CC1CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MEK1/2 Antibody [J11P23] | Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MAP2K2, MKK2, PRKMK2, Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1 MAPK/ERK kinase 1, MAP2K1, PRKMK1. Group: Antibodies. Alternative Names: MAPKK 1, MAPKK 2, MKK1, MKK2. Pack Sizes: 20ul. Product ID: F0334. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MEK162 (Binimetinib, ARRY-162) | Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3. Group: Inhibitors. Alternative Names: ARRY-162,ARRY-438162. CAS No. 606143-89-9. Pack Sizes: 10mg. Product ID: S7007. Formula: C17H15BrF2N4O3. Smiles: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Melphalan | Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.This product is a hazardous chemical (acute toxicity / flammable / skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. Group: Inhibitors. Alternative Names: Alkeran, Sarcolysin, L-PAM. CAS No. 148-82-3. Pack Sizes: 100mg. Product ID: S8266. Formula: C13H18Cl2N2O2. Smiles: C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Menadione (Vitamin K3) | Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. Group: Inhibitors. Alternative Names: NSC 4170. CAS No. 58-27-5. Pack Sizes: 50mg. Product ID: S1949. Formula: C11H8O2. Smiles: CC1=CC(=O)C2=CC=CC=C2C1=O. Storage Conditions: 3 years-20°C(in the dark) powder. | United States; Europe |
| Metformin (1,1-Dimethylbiguanide) | Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. Group: Inhibitors. Alternative Names: 1,1-Dimethylbiguanide. CAS No. 657-24-9. Pack Sizes: 25mg. Product ID: S5958. Formula: C4H11N5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Metformin Hydrochloride | Metformin Hydrochloride (1,1-Dimethylbiguanide Hydrochloride) is a highly effective Antihyperglycemic Agent, which primarily decreases hyperglycemia in hepatocytes by suppressing hepatic gluconeogenesis (glucose production by the liver). It also promotes mitophagy in mononuclear cells and induces apoptosis of lung cancer cells through activating the JNK/p38 MAPK pathway and GADD153. Group: Inhibitors. Alternative Names: 1,1-Dimethylbiguanide HCl. CAS No. 1115-70-4. Pack Sizes: 5g. Product ID: S1950. Formula: C4H11N5.HCl. Smiles: CN(C)C(=N)N=C(N)N.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Methotrexate | Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. Group: Inhibitors. Alternative Names: NCI-C04671, Amethopterin, CL14377, WR19039. CAS No. 59-05-2. Pack Sizes: 100mg. Product ID: S1210. Formula: C20H22N8O5. Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| Methyl-β-cyclodextrin (MβCD) | Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities. Group: Inhibitors. Alternative Names: Methyl-beta-cyclodextrin, M-β-CyD, Methyl-β-CD. CAS No. 128446-36-6. Pack Sizes: 100mg. Product ID: S6827. Storage Conditions: 3 years -20°C powder. | United States; Europe |
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