Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Phospho-JAK1 (Tyr1034/1035)/JAK2 (Tyr1007/1008) Antibody [L3G19] | Phospho-JAK1 (Tyr1034/1035)/JAK2 (Tyr1007/1008) Antibody [L3G19]. Group: Antibodies. Alternative Names: Tyrosine-protein kinase JAK2; Janus kinase 2 (JAK-2); JAK2 Tyrosine-protein kinase; JAK1 Janus kinase 1 (JAK-1); JAK1; JAK1A JAK1B. Pack Sizes: 20uL. Product ID: F2644. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| Phospho-JNK1/2/3 (T183/183/221) Antibody [D17M9] | Phospho-JNK1/2/3 (T183/183/221) Antibody [D17M9]. Group: Antibodies. Alternative Names: Phospho JNK1 + JNK2 + JNK3 (Thr 183+Thr 183+The 221). Pack Sizes: 20uL. Product ID: F1572. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-MEK1/2 (Ser217/221) Antibody [G6P21] | Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MAP2K2, MKK2, PRKMK2, Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1 MAPK/ERK kinase 1, MAP2K1, PRKMK1. Group: Antibodies. Alternative Names: PhosphoMEK1 (Ser217/221), MEK2 (Ser222/226). Pack Sizes: 20ul. Product ID: F0345. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-mTOR (Ser2448) Antibody [H1M6] | mTOR (phospho S2448),Phospho-mTOR (Ser2448),p-mTOR. Group: Antibodies. Alternative Names: mTOR (phospho S2448),Phospho-mTOR (Ser2448),p-mTOR. Pack Sizes: 20ul. Product ID: F0158. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-mTOR (Ser2448) Antibody [P18P17] | mTOR (phospho S2448),Phospho-mTOR (Ser2448),p-mTOR. Group: Antibodies. Alternative Names: mTOR (phospho S2448),Phospho-mTOR (Ser2448),p-mTOR. Pack Sizes: 20uL. Product ID: F2584. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-NF-κB p65 (Ser536) Antibody [M4C8] | NF-kB p65 (phospho S536),Phospho-NFkB p65 (Ser536),Phospho-NF-κB p65 (Ser536),p-RELA/NFκB p65. Group: Antibodies. Alternative Names: NF-kB p65 (phospho S536),Phospho-NFkB p65 (Ser536),p-RELA/NFκB p65. Pack Sizes: 20ul. Product ID: F0155. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Nrf2 (Ser40) Antibody [N4G2] | Phospho-Nrf2 (Ser40) Antibody [N4G2]. Group: Antibodies. Alternative Names: Phospho Nrf2 (Ser 40). CAS No. Pack Sizes: 20uL. Product ID: F1552. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-p38 MAPK (Thr180/Tyr182) Antibody [M21L8] | Mitogen-activated protein kinase 14 , MAP kinase 14, MAPK 14, CSAID-binding protein, CSBP,MAP kinase MXI2, MAX-interacting protein 2, MAP kinase p38 alpha, MAP kinase p38 α, SAPK2a, MAP kinase 12, MAPK 12, ERK-6, MAP kinase p38 gamma, Stress-activated protein kinase 3, MAPK12, SAPK3, MAP kinase 11; MAPK 11, MAP kinase p38 beta, p38b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B, MAP kinase 13, MAPK 13, MAP kinase p38 delta, Stress-activated protein kinase 4, MAPK13, PRKM13, SAPK4, MAP kinase p38 δ, MAP kinase p38 γ. Group: Antibodies. Alternative Names: MAPK 14, MAPK12, MAPK11, SAPK, MAPK13. Pack Sizes: 20uL. Product ID: F0159. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-p44/42 MAPK (Erk1/2) (T202/Y204) Antibody [D13L13] | Mitogen-activated protein kinase 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, ERK1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, ERK2, PRKM1, PRKM2. Group: Antibodies. Alternative Names: Phospho p44 MAPK (Thr 202), Phospho p42 MAPK (Thr 204), Phospho p44 ERK1 (Thr 202), Phospho p42 ERK2 (Tyr 204). Pack Sizes: 20ul. Product ID: F0007. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-p53 (Ser15) Antibody [K22F18] | p53 (phospho S15),Phospho-p53 (Ser15). Group: Antibodies. Alternative Names: p53 (phospho S15),Phospho-p53 (Ser15). Pack Sizes: 20ul. Product ID: F0355. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-PERK (Thr982) Antibody [A3P5] | Phospho-PERK (Thr982) Antibody [A3P5]. Group: Antibodies. Alternative Names: PEK; WRS; PERK; Phospho-PERK-T982. CAS No. Pack Sizes: 20uL. Product ID: F3893. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-S6 Ribosomal Protein (S235/236) Antibody [G7G11] | Phospho-S6 Ribosomal Protein (Ser235/236),RPS6 (phospho S235 + S236). Group: Antibodies. Alternative Names: Phospho-S6 Ribosomal Protein (Ser235/236),RPS6 (phospho S235 + S236). Pack Sizes: 20ul. Product ID: F0198. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Smad3 (Ser423/Ser425) Antibody [L3N2] | Phospho-Smad3 (Ser423/425),Smad3 (phospho S423 + S425), Smad5 (463/465), Smad1 (Ser 463/465), Smad2 (Ser 465/467)d5 (Se. Group: Antibodies. Alternative Names: Phospho-Smad3 (Ser 423/425)+Smad5 (Ser 463/465)+Smad1 (Ser 463/465)+Smad2 (Ser 465/467). Pack Sizes: 20uL. Product ID: F2846. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Src Family (Tyr416) Antibody [H4N15] | Tyrosine-protein kinase Yes, Proto-oncogene c-Yes, p61-Yes, YES1, YES, Tyrosine-protein kinase Lyn, Lck/Yes-related novel protein tyrosine kinase, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn, LYN, JTK8, Tyrosine-protein kinase Lck, LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK, Tyrosine-protein kinase HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, p60-Src, SRC, SRC1, Tyrosine-protein kinase Fyn, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, p59-Fyn. Group: Antibodies. Alternative Names: YES, LYN, LSK, HCK,SRC, SLK. Pack Sizes: 20uL. Product ID: F0304. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-STAT1 (Tyr701) Antibody [N19D1] | Phospho-Stat1 (Tyr701),p-Stat1,STAT1 (phospho Y701). Group: Antibodies. Alternative Names: Phospho-Stat1 (Tyr701),p-Stat1,STAT1 (phospho Y701). Pack Sizes: 20uL. Product ID: F0199. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-STAT3 (Ser727) Antibody [B8F21] | Phospho-Stat3 (Ser727),STAT3 (phospho S727). Group: Antibodies. Alternative Names: Phospho STAT3 (Ser 727), STAT3. CAS No. Pack Sizes: 20ul. Product ID: F1212. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-STAT3 (Tyr705) Antibody [B17F7] | Phospho-Stat3 (Tyr705),p-Stat3,STAT3 (phospho Y705). Group: Antibodies. Alternative Names: Phospho-Stat3 (Tyr705),p-Stat3,STAT3 (phospho Y705), STAT3. CAS No. Pack Sizes: 20uL. Product ID: F0157. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-STAT6 (Tyr641) Antibody [A16N6] | Phospho-Stat6 (Tyr641),STAT6 (phospho Y641). Group: Antibodies. Alternative Names: Phospho-Stat6 (Tyr641),STAT6 (phospho Y641). Pack Sizes: 20uL. Product ID: F0555. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-TBK1/NAK (Ser172) Antibody [H16A23] | NAK/TBK1 (phospho S172),Phospho-TBK1/NAK (Ser172). Group: Antibodies. Alternative Names: Phospho NAK (Ser172). Pack Sizes: 20ul. Product ID: F0255. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-YAP (Ser127) Antibody [K8E8] | Phospho-YAP (Ser127),YAP1 (phospho S127). Group: Antibodies. Alternative Names: Hippo; P-YAP; Yes; Yes-associated. Pack Sizes: 20uL. Product ID: F0352. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody [L15L21] | Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK, Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK. Group: Antibodies. Alternative Names: Phospho Zap-70 (Tyr319), Phospho Syk (Tyr 352). Pack Sizes: 20uL. Product ID: F0556. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PI-103 | PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma. Group: Inhibitors. CAS No. 371935-74-9. Pack Sizes: 5mg. Product ID: S1038. Formula: C19H16N4O3. Smiles: C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PI3 Kinase p85α Antibody [K4G2] | PI 3 Kinase p85 alpha,PI 3-kinase p85α,PI3 Kinase p85α. Group: Antibodies. Alternative Names: PI3K p85α. Pack Sizes: 20uL. Product ID: F1720. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PI3 Kinase p85 Antibody [A5E17] | PI3 Kinase,PI3 Kinase p85. Group: Antibodies. Alternative Names: PI3 Kinase p85, Phosphatidylinositol 3-kinase regulatory subunit alpha, PIK3R1, GRB1. Pack Sizes: 20ul. Product ID: F0294. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Picropodophyllin (AXL1717) | Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity. Group: Inhibitors. Alternative Names: AXL1717. CAS No. 477-47-4. Pack Sizes: 5mg. Product ID: S7668. Formula: C22H22O8. Smiles: COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Pictilisib (GDC-0941) | Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2. Group: Inhibitors. Alternative Names: RG7321. CAS No. 957054-30-7. Pack Sizes: 1g. Product ID: S1065. Formula: C23H27N7O3S2. Smiles: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Pifithrin-α (PFTα) Hhydrobromide | Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR). Group: Inhibitors. Alternative Names: Pifithrin-α hydrobromide. CAS No. 63208-82-2. Pack Sizes: 25mg. Product ID: S2929. Formula: C16H18N2OS.HBr. Smiles: CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PINK1 Antibody [M4A21] | PINK1 Antibody [M4A21]. Group: Antibodies. Alternative Names: BRPK; PTEN-induced putative kinase protein 1; PINK1. CAS No. Pack Sizes: 20uL. Product ID: F3247. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Pinometostat (EPZ5676) | Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1. Group: Inhibitors. CAS No. 1380288-87-8. Pack Sizes: 10mg. Product ID: S7062. Formula: C30H42N8O3. Smiles: CC(C)N(CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Pirfenidone | Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3. Group: Inhibitors. Alternative Names: S-7701, AMR-69. CAS No. 53179-13-8. Pack Sizes: 10mg. Product ID: S2907. Formula: C12H11NO. Smiles: CC1=CN(C(=O)C=C1)C2=CC=CC=C2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Pitavastatin (NK-104) Calcium | Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis. Group: Inhibitors. Alternative Names: NK-104 calcium. CAS No. 147526-32-7. Pack Sizes: 50mg. Product ID: S1759. Formula: C50H46CaF2N2O8. Smiles: C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Pitstop 2 | Pitstop 2 is an inhibitor of the interaction of amphiphysin with the amino terminal domain of clathrin that inhibits both clathrin-dependent endocytosis (CDE) and clathrin independent endocytosis (CIE). Group: Inhibitors. CAS No. 1332879-52-3. Pack Sizes: 5mg. Product ID: S9670. Formula: C20H13BrN2O3S2. Smiles: BrC1=CC=C(C=C1)\C=C2/SC(=NC2=O)N[S](=O)(=O)C3=CC=CC4=C3C=CC=C4. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| PKM2 Antibody [F23E18] | PKM2 Antibody [F23E18]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0295. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PKM2-IN-1 (Compound 3k) | PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. Group: Inhibitors. Alternative Names: PKM2-IN-1. CAS No. 94164-88-2. Pack Sizes: 5mg. Product ID: S8616. Formula: C18H19NO2S2. Smiles: CC1=C(C(=O)C2=CC=CC=C2C1=O)CSC(=S)N3CCCCC3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Plerixafor (AMD3100) 8HCl | Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent. Group: Inhibitors. Alternative Names: JM 3100 8HCl,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride. CAS No. 155148-31-5. Pack Sizes: 5mg. Product ID: S3013. Formula: C28H54N8.8HCl. Smiles: C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PLX4032 (Vemurafenib) | Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy. Group: Inhibitors. Alternative Names: RG7204, RO5185426,PLX4032. CAS No. 918504-65-1. Pack Sizes: 10mg. Product ID: S1267. Formula: C23H18ClF2N3O3S. Smiles: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| PLX5622 | PLX5622 is a highly selective CSF-1R inhibitor (IC50 ?20-fold selectivity over KIT and FLT3. Group: Inhibitors. CAS No. 1303420-67-8. Pack Sizes: 2mg. Product ID: S8874. Formula: C21H19F2N5O. Smiles: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| PMA chemical (Phorbol 12-myristate 13-acetate) | PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way. Group: Inhibitors. Alternative Names: 12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 5mg. Product ID: S7791. Formula: C36H56O8. Smiles: CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C. | United States; Europe |
| Polybrene (Hexadimethrine Bromide) | Polybrene (Hexadimethrine bromide) is a cationic polymer which is widely used as supplement for retroviral and lentiviral transduction. Group: Inhibitors. CAS No. 28728-55-4. Pack Sizes: 5mg. Product ID: E1299. Formula: (C13H30N2)n.2Br. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Poly(I:C) (Polyinosinic-Polycytidylic Acid) | Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer. Group: Inhibitors. Alternative Names: Polyinosinic acid-polycytidylic acid. CAS No. 24939-03-5. Pack Sizes: 5mg. Product ID: E0518. Formula: C19H27N7O16P2. Smiles: NC1=NC(=O)N(C=C1)C2OC(CO[P;v5](O)(O)=O)C(O)C2O.OC3C(O)C(OC3CO[P;v5](O)(O)=O)[N]4C=NC5=C4NC=NC5=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Pomalidomide (CC-4047) | Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest. Group: Inhibitors. Alternative Names: CC-4047. CAS No. 19171-19-8. Pack Sizes: 50mg. Product ID: S1567. Formula: C13H11N3O4. Smiles: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ponatinib (AP24534) | Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy. Group: Inhibitors. Alternative Names: AP24534. CAS No. 943319-70-8. Pack Sizes: 10mg. Product ID: S1490. Formula: C29H27F3N6O. Smiles: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PP2 (AGL 1879) | PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA. Group: Inhibitors. Alternative Names: AG 1879,AGL 1879. CAS No. 172889-27-9. Pack Sizes: 1mg. Product ID: S7008. Formula: C15H16ClN5. Smiles: CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PPARα Antibody [P17E1] | PPARα Antibody [P17E1]. Group: Antibodies. Alternative Names: Peroxisome proliferator-activated receptor alpha; PPAR-alpha; Nuclear receptor subfamily 1 group C member 1; PPARA; NR1C1; PPAR. Pack Sizes: 20uL. Product ID: F4266. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PR-171 (Carfilzomib) | Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of autophagy and induces cell apoptosis. Group: Inhibitors. CAS No. 868540-17-4. Pack Sizes: 5mg. Product ID: S2853. Formula: C40H57N5O7. Smiles: CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PR-619 | PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy. Group: Inhibitors. CAS No. 2645-32-1. Pack Sizes: 25mg. Product ID: S7130. Formula: C7H5N5S2. Smiles: C1=C(C(=NC(=C1SC#N)N)N)SC#N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Prexasertib (LY2606368) Dihydrochloride | Prexasertib(LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. Group: Inhibitors. CAS No. 1234015-54-3. Pack Sizes: 2mg. Product ID: S7178. Formula: C18H19N7O2.2HCl. Smiles: COC1=C(C(=CC=C1)OCCCN)C2=CC(=NN2)NC3=NC=C(N=C3)C#N.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Progesterone | Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. Group: Inhibitors. Alternative Names: NSC 64377, Pregn-4-ene-3,20-dione,NSC 9704. CAS No. 57-83-0. Pack Sizes: 25mg. Product ID: S1705. Formula: C21H30O2. Smiles: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Propranolol HCl | Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor. Group: Inhibitors. Alternative Names: AY-64043, ICI-45520, NCS-91523. CAS No. 318-98-9. Pack Sizes: 50mg. Product ID: S4076. Formula: C16H21NO2.HCl. Smiles: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Prostaglandin E2 (PGE2) | Prostaglandin E2 (PGE2, Dinoprostone) plays important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. It is easy to discolor when stored in liquid environment for a long time. It is recommended to store it in powder form and try to use it as soon as possible! Group: Inhibitors. Alternative Names: Dinoprostone. CAS No. 363-24-6. Pack Sizes: 5mg. Product ID: S3003. Formula: C20H32O5. Smiles: CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Protease Inhibitor Cocktail comprehensively protects proteins from degradation by a variety of proteases. Provided at 100X in an EDTA-free, DMSO solution, it is ready to use. Group: Kits. Pack Sizes: 1 mL x 10. Product ID: B14002. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Protease Inhibitor Cocktail comprehensively protects proteins from degradation by a variety of proteases. Provided at 100X in an EDTA-free, DMSO solution, it is ready to use. Group: Kits. Pack Sizes: 1 mL. Product ID: B14001. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| Protein A/G Magnetic Beads for IP | Protein A/G Magnetic Beads for IP. Group: Kits. Pack Sizes: 5 ml. Product ID: B23202. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| Protein A/G Magnetic Beads for IP | Protein A/G Magnetic Beads for IP. Group: Kits. Pack Sizes: 1 ml. Product ID: B23201. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| PSD95 Antibody [F17C8] | Post Synaptic Density Protein 95,PSD95,PSD-95. Group: Antibodies. Alternative Names: Post Synaptic Density Protein 95,PSD95. Pack Sizes: 20ul. Product ID: F0240. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PSD-95 Antibody [H11A14] | Post Synaptic Density Protein 95,PSD95,PSD-95. Group: Antibodies. Alternative Names: Post Synaptic Density Protein 95,PSD95. CAS No. Pack Sizes: 20uL. Product ID: F3124. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Purmorphamine | Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy. Group: Inhibitors. Alternative Names: Shh Signaling Antagonist VI. CAS No. 483367-10-8. Pack Sizes: 5mg. Product ID: S3042. Formula: C31H32N6O2. Smiles: C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Puromycin | Puromycin (CL13900, Puromycine) is an antibiotic, analog of the 3' end of aminoacyl-tRNA and an inhibitor of protein synthesis that mimics tyrosyl-tRNA, causing premature termination of translation. It blocks translation by labeling and releasing elongating polypeptide chains from ribosomes and has been widely used in molecular biology research. Group: Inhibitors. Alternative Names: CL13900, Puromycine. CAS No. 53-79-2. Pack Sizes: 1mg. Product ID: E4996. Formula: C22H29N7O5. | United States; Europe |
| Puromycin Dihydrochloride | Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation. Group: Inhibitors. Alternative Names: CL13900 2HCl. CAS No. 58-58-2. Pack Sizes: 50mg. Product ID: S7417. Formula: C22H29N7O5.2HCl. Smiles: CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PX-478 Dihydrochloride | PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1. Group: Inhibitors. CAS No. 685898-44-6. Pack Sizes: 5mg. Product ID: S7612. Formula: C13H20Cl4N2O3. Smiles: C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PY-60 | PY-60 is a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP) with EC50 of 1.6 μM, which acts by inhibiting a central scaffolding protein in the Hippo pathway, Annexin A2. It promotes the regenerative repair of cutaneous wounds in pig and human models. Group: Inhibitors. CAS No. 2765218-56-0. Pack Sizes: 5mg. Product ID: S9861. Formula: C16H15N3O2S. | United States; Europe |
| QNZ (EVP4593) | QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively. Group: Inhibitors. CAS No. 545380-34-5. Pack Sizes: 5mg. Product ID: S4902. Formula: C22H20N4O. Smiles: C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Quercetin (Sophoretin) | Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4. Group: Inhibitors. Alternative Names: Sophoretin, C.I. 75720, NSC 9221. CAS No. 117-39-5. Pack Sizes: 100mg. Product ID: S2391. Formula: C15H10O7. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Quizartinib (AC220) | Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3. Group: Inhibitors. CAS No. 950769-58-1. Pack Sizes: 10mg. Product ID: S1526. Formula: C29H32N6O4S. Smiles: CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Q-VD-Oph | Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection. Group: Inhibitors. Alternative Names: Quinoline-Val-Asp-Difluorophenoxymethylketone. CAS No. 1135695-98-5. Pack Sizes: 1mg. Product ID: S7311. Formula: C26H25F2N3O6. Smiles: CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| R406 | R406(R406 besylate) is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 induces apoptosis. Phase 1. Group: Inhibitors. Alternative Names: R406 besylate. CAS No. 841290-81-1. Pack Sizes: 5mg. Product ID: S2194. Formula: C22H23FN6O5.C6H6O3S. Smiles: CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RAB7 Antibody [D12B20] | Rab 7,Rab7. Group: Antibodies. Alternative Names: Rab7. Pack Sizes: 20ul. Product ID: F0357. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| (Rac)-Shikonin | (±)-Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition. Group: Inhibitors. Alternative Names: C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844. CAS No. 54952-43-1. Pack Sizes: 20mg. Product ID: S8279. Formula: C16H16O5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RAD001 (Everolimus) | Everolimus is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation. Group: Inhibitors. Alternative Names: RAD001,SDZ-RAD. CAS No. 159351-69-6. Pack Sizes: 1g. Product ID: S1120. Formula: C53H83NO14. Smiles: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Rad51 Antibody [H22D22] | Rad51. Group: Antibodies. Alternative Names: Rad51. CAS No. Pack Sizes: 20ul. Product ID: F1110. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
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