Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Raleukin | Anakinra (Raleukin, AMG-719) is an exogenous antagonist of recombinant human interleukin-1 receptor that also inhibits caspase-1 and caspase-9 activity with Ki of 0.201 μM and 0.31 μM respectively. It is used in research to study IL-1 blockade in inflammation, tumor growth, islet transplantation, and cardiac injury models. Group: Peptides. Alternative Names: AMG-719; Anakinra. CAS No. 143090-92-0. Pack Sizes: 1mg. Product ID: P1235. Storage Conditions: 2 years -20°C liquid. |  United States; Europe |
| Rapamycin (Sirolimus) | Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM in HEK293 cells.Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator and an immunosuppressant. Group: Inhibitors. Alternative Names: Sirolimus, AY-22989, NSC-2260804. CAS No. 53123-88-9. Pack Sizes: 5mg. Product ID: S1039. Formula: C51H79NO13. Smiles: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Rat IgG1 isotype control-InVivo | Rat IgG1 isotype control-InVivo monoclonal antibody (Clone:HRPN) reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2119. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Rat IgG2a isotype control-InVivo | Rat IgG2a isotype control-InVivo can be used as an isotype-matched control for rat IgG2a antibodies. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2123. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Rat IgG2b isotype control-InVivo | Rat IgG2b isotype control-InVivo monoclonal antibody (Clone:LTF-2) reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2116. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Ravoxertinib (GDC-0994) | Ravoxertinib (GDC-0994) is a potent, orally available and highly selective ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1. Group: Inhibitors. CAS No. 1453848-26-4. Pack Sizes: 5mg. Product ID: S7554. Formula: C21H18ClFN6O2. Smiles: CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)C(CO)C4=CC(=C(C=C4)Cl)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Regorafenib (BAY 73-4506) | Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy. Group: Inhibitors. Alternative Names: Fluoro-Sorafenib, BAY 73-4506. CAS No. 755037-03-7. Pack Sizes: 5mg. Product ID: S1178. Formula: C21H15ClF4N4O3. Smiles: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Relacorilant (CORT125134) | Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. Group: Inhibitors. CAS No. 1496510-51-0. Pack Sizes: 5mg. Product ID: E1091. Formula: C27H22F4N6O3S. Smiles: C[N]1C=C(C=N1)[S;v6](=O)(=O)N2CCC3=CC4=C(CC3(C2)C(=O)C5=CC(=CC=N5)C(F)(F)F)C=N[N]4C6=CC=C(F)C=C6. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Remodelin Hydrobromide | Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor. Group: Inhibitors. Alternative Names: Remodelin HBr. CAS No. 1622921-15-6. Pack Sizes: 10mg. Product ID: S7641. Formula: C15H15BrN4S. Smiles: C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RepSox (E-616452) | RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively. Group: Inhibitors. Alternative Names: SJN 2511,ALK5 Inhibitor II. CAS No. 446859-33-2. Pack Sizes: 25mg. Product ID: S7223. Formula: C17H13N5. Smiles: CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Resatorvid (TAK-242) | Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy. Group: Inhibitors. Alternative Names: CLI-095. CAS No. 243984-11-4. Pack Sizes: 5mg. Product ID: S7455. Formula: C15H17ClFNO4S. Smiles: CCOC(=O)C1=CCCCC1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Resiquimod (R-848) | Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2. Group: Inhibitors. Alternative Names: S28463. CAS No. 144875-48-9. Pack Sizes: 20mg. Product ID: S8133. Formula: C17H22N4O2. Smiles: CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Resveratrol (trans-Resveratrol) | Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases (LOX, IC50=2.7 μM) , kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy / autophagy and autophagy-dependent apoptosis. Group: Inhibitors. Alternative Names: SRT501. CAS No. 501-36-0. Pack Sizes: 200mg. Product ID: S1396. Formula: C14H12O3. Smiles: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Retatrutide (LY3437943) | Retatrutide (LY3437943) acts as a triple agonist peptide of the glucagon receptor (GCGR), glucagon-like peptide-1 receptor (GLP-1R) and glucosedependent insulinotropic polypeptide receptor (GIPR). Retatrutide binds to human GCGR, GLP-1R, and GIPR with EC50 values of 5.79, 0.775 nM, and 0.0643, respectively. Retatrutide has the potential for use in research on obesity. Group: Peptides. Alternative Names: LY3437943. CAS No. 2381089-83-2. Pack Sizes: 1mg. Product ID: P1230. Formula: C221H342N46O68. | United States; Europe |
| Retinoic acid (Tretinoin, Vitamin A acid) | Retinoic acid (Tretinoin) is a natural agonist of RAR agonist, it can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. Tretinoin (NSC 122758) can be used to induce animal models of osteoporosis. Group: Inhibitors. Alternative Names: All-trans Retinoic Acid, ATRA, Vitamin A acid,NSC 122758. CAS No. 302-79-4. Pack Sizes: 50mg. Product ID: S1653. Formula: C20H28O2. Smiles: CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C. Storage Conditions: 3 years -20°C(in the dark) powder. | United States; Europe |
| RGD peptide (Arg-Gly-Asp) | RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. Group: Inhibitors. CAS No. 99896-85-2. Pack Sizes: 10mg. Product ID: S8008. Formula: C12H22N6O6. Smiles: C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RGFP966 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC. Group: Inhibitors. CAS No. 1396841-57-8. Pack Sizes: 10mg. Product ID: S7229. Formula: C21H19FN4O. Smiles: C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| (R)-GNE-140 | (R)-GNE-140 is an inhibitory agent for LDHA, LDHB, and LDHC, with IC50 values ??of 3 nM and 5 nM for LDHA and LDHB, respectively. (R)-GNE-140 is 18 times more potent than its S isomer. Group: Inhibitors. CAS No. 2003234-63-5. Pack Sizes: 2mg. Product ID: S6675. Formula: C25H23ClN2O3S2. Smiles: C1COCCN1C2=CC=C(C=C2)C3(CC(=C(C(=O)N3)SC4=CC=CC=C4Cl)O)C5=CSC=C5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Rituximab (anti-CD20) | Rituximab (anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD. Group: Antibodies. Alternative Names: IDEC-C2B8. CAS No. 174722-31-7. Pack Sizes: 5mg. Product ID: A2009. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| RMC-7977 | RMC-7977 is a potent, reversible, tri-complex oral inhibitor that selectively targets active (GTP-bound) forms of KRAS, HRAS, and NRAS, which exhibits broad-spectrum activity against both mutant and wild-type variants (a RASMULTI (ON) inhibitor). It also exhibits significant anti-tumor efficacy in pancreatic ductal adenocarcinoma (PDAC). Group: Inhibitors. CAS No. 2765082-12-8. Pack Sizes: 1mg. Product ID: E1858. Formula: C47H60N8O6S. | United States; Europe |
| Ro-3306 | RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis. Group: Inhibitors. CAS No. 872573-93-8. Pack Sizes: 10mg. Product ID: S7747. Formula: C18H13N3OS2. Smiles: C1=CC2=C(C=CC(=C2)C=C3C(=O)NC(=NCC4=CC=CS4)S3)N=C1. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RO4929097 (RG-4733) | RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2. Group: Inhibitors. Alternative Names: RG-4733. CAS No. 847925-91-1. Pack Sizes: 5mg. Product ID: S1575. Formula: C22H20F5N3O3. Smiles: CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Romidepsin (FK228) | Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228 / depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells. Group: Inhibitors. Alternative Names: FK228, Depsipeptide, FR 901228, NSC 630176. CAS No. 128517-07-7. Pack Sizes: 10mg. Product ID: S3020. Formula: C24H36N4O6S2. Smiles: CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Roscovitine (Seliciclib) | Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6. Phase 2. Group: Inhibitors. Alternative Names: CYC202, Seliciclib, R-roscovitine. CAS No. 186692-46-6. Pack Sizes: 10mg. Product ID: S1153. Formula: C19H26N6O. Smiles: CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Rosiglitazone (BRL 49653) | Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis. Group: Inhibitors. Alternative Names: BRL 49653. CAS No. 122320-73-4. Pack Sizes: 25mg. Product ID: S2556. Formula: C18H19N3O3S. Smiles: CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Roxadustat (FG-4592) | Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3. Group: Inhibitors. Alternative Names: ASP1517. CAS No. 808118-40-3. Pack Sizes: 10mg. Product ID: S1007. Formula: C19H16N2O5. Smiles: CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RSL3 | RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. Group: Inhibitors. CAS No. 1219810-16-8. Pack Sizes: 5mg. Product ID: S8155. Formula: C23H21ClN2O5. Smiles: COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| RU.521 (RU320521) | RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS / dsDNA complex with Kd of 36.2 nM. Group: Inhibitors. Alternative Names: RU320521. CAS No. 2262452-06-0. Pack Sizes: 5mg. Product ID: S6841. Formula: C19H12Cl2N4O3. Smiles: CC1=C(C(=O)N(N1)C2=NC3=C(N2)C=CC(=C3Cl)Cl)C4C5=CC=CC=C5C(=O)O4. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| RUNX2 Antibody [F19J12] | RUNX2 Antibody [F19J12]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2885. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Ruxolitinib (INCB18424) | Ruxolitinib (INCB18424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. This compound kills tumor cells through toxic mitophagy. It induces autophagy and enhances apoptosis. Group: Inhibitors. Alternative Names: INCB018424. CAS No. 941678-49-5. Pack Sizes: 5mg. Product ID: S1378. Formula: C17H18N6. Smiles: C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3. Storage Conditions: 3 years-20°C(in the dark) powder. | United States; Europe |
| Ruxolitinib (INCB18424) Phosphate | Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis. Group: Inhibitors. Alternative Names: INCB018424, INC424. CAS No. 1092939-17-7. Pack Sizes: 25mg. Product ID: S5243. Formula: C17H18N6.H3O4P. Smiles: C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| S100 β Antibody [K11H13] | S-100 (beta-Subunit),S100 beta,S100B. Group: Antibodies. Alternative Names: S-100 (β-Subunit), S100B. Pack Sizes: 20uL. Product ID: F1617. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| S63845 | S63845 is a new, selective MCL-1 inhibitor with the Kd value of 0.19 nM and has no discernible binding to the other BCL-2 members, BCL-2 or BCL-XL. Group: Inhibitors. CAS No. 1799633-27-4. Pack Sizes: 1mg. Product ID: S8383. Formula: C39H37ClF4N6O6S. Smiles: CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)OC(CC5=CC=CC=C5OCC6=CC=NN6CC(F)(F)F)C(=O)O)C7=CC=C(O7)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sacituzumab (anti-Trop-2) | Sacituzumab (anti-Trop-2) is a fully humanized IgG1 kappa monoclonal antibody that binds Trop-2. Group: Antibodies. CAS No. 1796566-95-4. Pack Sizes: 1mg. Product ID: A2031. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Sacituzumab govitecan | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution. Alternative Names: IMMU-132. CAS No. 1491917-83-9 (Sacituzumab govitecan). Pack Sizes: 1mg. Product ID: D4002. Formula: 7.6. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| SAG (Smoothened Agonist) | SAG (Smoothened Agonist) is a potent agonist of Smoothened (Smo). Smoothened Agonist induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM. Group: Inhibitors. CAS No. 912545-86-9. Pack Sizes: 5mg. Product ID: S6384. Formula: C28H28ClN3OS. Smiles: CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(Cl)C5=CC=CC=C5S4. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SAG (Smoothened Agonist) Hydrochloride | SAG (Smoothened Agonist) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. Group: Inhibitors. CAS No. 2095432-58-7. Pack Sizes: 2mg. Product ID: S7779. Formula: C28H29Cl2N3OS. Smiles: CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SANT-1 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. Group: Inhibitors. CAS No. 304909-07-7. Pack Sizes: 10mg. Product ID: S7092. Formula: C23H27N5. Smiles: CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SAR405 | SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells. Group: Inhibitors. CAS No. 1523406-39-4. Pack Sizes: 5mg. Product ID: S7682. Formula: C19H21ClF3N5O2. Smiles: CC1COCCN1C2=CC(=O)N3CCC(N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Saracatinib (AZD0530) | Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3. Group: Inhibitors. CAS No. 379231-04-6. Pack Sizes: 10mg. Product ID: S1006. Formula: C27H32ClN5O5. Smiles: CN1CCN(CC1)CCOC2=CC3=C(C(=C2)OC4CCOCC4)C(=NC=N3)NC5=C(C=CC6=C5OCO6)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SB202190 | SB202190 is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. Group: Inhibitors. Alternative Names: FHPI. CAS No. 152121-30-7. Pack Sizes: 25mg. Product ID: S1077. Formula: C20H14N3OF. Smiles: C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SB203580 (Adezmapimod) | Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy. Group: Inhibitors. Alternative Names: RWJ 64809, PB 203580. CAS No. 152121-47-6. Pack Sizes: 25mg. Product ID: S1076. Formula: C21H16FN3OS. Smiles: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F. Storage Conditions: 3 years-20°C (in the dark) powder. | United States; Europe |
| SB 225002 | SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. Group: Inhibitors. CAS No. 182498-32-4. Pack Sizes: 10mg. Product ID: S7651. Formula: C13H10BrN3O4. Smiles: C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SB431542 | SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases. Group: Inhibitors. CAS No. 301836-41-9. Pack Sizes: 10mg. Product ID: S1067. Formula: C22H16N4O3. Smiles: C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5. | United States; Europe |
| SB505124 | SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. Group: Inhibitors. CAS No. 694433-59-5. Pack Sizes: 10mg. Product ID: S2186. Formula: C20H21N3O2. Smiles: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SB-525334 | SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. Group: Inhibitors. CAS No. 356559-20-1. Pack Sizes: 5mg. Product ID: S1476. Formula: C21H21N5. Smiles: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SB590885 | SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases. Group: Inhibitors. CAS No. 405554-55-4. Pack Sizes: 10mg. Product ID: S2220. Formula: C27H27N5O2. Smiles: CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)C(=NO)CC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SBE-β-CD | SBE-β-CD is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. Group: Inhibitors. Alternative Names: Sulfobutylether-β-Cyclodextrin. CAS No. 182410-00-0. Pack Sizes: 100mg. Product ID: S4592. Formula: C42H70-nO35.nNa.n(C4H8O3S). Smiles: [Na+].[Na+].OCC1OC2OC3C(O)C(O)C(OC3CO)OC4C(O)C(O)C(OC4CO)OC5C(O)C(OCCCC[S]([O-])(=O)=O)C(OC5COCCCC[S]([O-])(=O)=O)OC6=C(CO)OC(OC7C(O)C(O)C(OC7CO)OC8C(O)C(O)C(OC8CO)OC1C(O)C2O)C(O)C6O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SBFI-26 | SBFI-26 competitively inhibits the activities of FABP5 and FABP7. Group: Inhibitors. CAS No. 1541209-75-9. Pack Sizes: 5mg. Product ID: S9957. Formula: C28H22O4. Smiles: OC(=O)C1C(C(C1C2=CC=CC=C2)C(=O)OC3=C4C=CC=CC4=CC=C3)C5=CC=CC=C5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SBI-0206965 | SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells. Group: Inhibitors. CAS No. 1884220-36-3. Pack Sizes: 5mg. Product ID: S7885. Formula: C21H21BrN4O5. Smiles: CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SC79 | SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation. Group: Inhibitors. CAS No. 305834-79-1. Pack Sizes: 10mg. Product ID: S7863. Formula: C17H17ClN2O5. Smiles: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SCD1 Antibody [H13N22] | SCD1. Group: Antibodies. Alternative Names: FADS5; SCD1; SCDOS; SCD; Stearoyl-CoA desaturase; hSCD1; Acyl-CoA desaturase; Delta(9)-desaturase; Fatty acid desaturase; Delta-9 desaturase. CAS No. Pack Sizes: 20uL. Product ID: F3395. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SCH772984 | SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay, respectively, And show robust efficacy in RAS- or BRAF-mutant cancer cells. Group: Inhibitors. CAS No. 942183-80-4. Pack Sizes: 5mg. Product ID: S7101. Formula: C33H33N9O2. Smiles: C1CN(CC1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SCR7 | SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos. Group: Inhibitors. CAS No. 14892-97-8. Pack Sizes: 5mg. Product ID: S7742. Formula: C18H12N4OS. Smiles: C1=CC=C(C=C1)C2=NC3=C(NC(=S)NC3=O)N=C2C4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Selinexor (KPT-330) | Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2. Group: Inhibitors. Alternative Names: ATG-010. CAS No. 1393477-72-9. Pack Sizes: 5mg. Product ID: S7252. Formula: C17H11F6N7O. Smiles: C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Selisistat (EX-527) | Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2. Group: Inhibitors. Alternative Names: SEN0014196. CAS No. 49843-98-3. Pack Sizes: 5mg. Product ID: S1541. Formula: C13H13ClN2O. Smiles: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Semaglutide | Semaglutide is an oral agonist of glucagon-like peptide-1 receptor (GLP1R), used for treating type 2 diabetes and obesity by enhancing insulin secretion, reducing glucagon levels, and promoting weight loss. It is available in subcutaneous and oral formulations. Group: Inhibitors. CAS No. 910463-68-2. Pack Sizes: 1mg. Product ID: S9697. | United States; Europe |
| Semaglutide Sodium | Semaglutide Sodium (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM). Group: Inhibitors. Alternative Names: Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217. CAS No. 910463-68-2(free base). Pack Sizes: 1mg. Product ID: E7333. Formula: C187H291N45O59. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Semaxanib (SU5416) | Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.Semaxanib (SU5416) can be used to induce animal models of chronic intermittent hypoxia. Group: Inhibitors. Alternative Names: semaxinib. CAS No. 204005-46-9. Pack Sizes: 5mg. Product ID: S2845. Formula: C15H14N2O. Smiles: CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Serotonin Hydrochloride (5-HT HCl) | Serotonin (5-HT) HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist. Group: Inhibitors. CAS No. 153-98-0. Pack Sizes: 50mg. Product ID: S4244. Formula: C10H12N2O.HCl. Smiles: C1=CC2=C(C=C1O)C(=CN2)CCN.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Setanaxib (GKT137831) | Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis. Group: Inhibitors. Alternative Names: GKT831. CAS No. 1218942-37-0. Pack Sizes: 5mg. Product ID: S7171. Formula: C21H19ClN4O2. Smiles: CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Setidegrasib (ASP3082) | ASP3082 (Setidegrasib; KRAS G12D inhibitor 17) is a PROTAC degrader targeting KRAS(G12D) with a DC50 of 38 nM. It effectively inhibits growth in various KRAS(G12D)-mutated cancer cell lines, including pancreatic (PK-59, HPAC) and colorectal (GP2d, GP5d) with IC50 values ranging from 3.6 to 29 nM. Group: Inhibitors. Alternative Names: ASP-3082; KRAS G12D inhibitor 17. CAS No. 2821793-99-9. Pack Sizes: 1mg. Product ID: E4757. Formula: C60H65FN12O7S. Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)C)N4C=C(N=N4)C5=CC=C(C=C5)COC6=[C@]([C@]7=C(C(F)=CC8=C7C=NN8)C)C(C9CC9)=CC%10=C6N=C(N=C%10N%11C[C@@H]%12C[C@H]%11CN%12)OC%13CCOCC%13)=O)O)=O)CO. | United States; Europe |
| Setmelanotide (RM-493) | Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM. Group: Inhibitors. Alternative Names: BIM-22493, CAM 4072. CAS No. 920014-72-8. Pack Sizes: 5mg. Product ID: E1002. Formula: C49H68N18O9S2. Smiles: CC1NC(=O)C(CSSCC(NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=C[NH]5)NC1=O)C(N)=O)NC(=O)C(CCCN=C(N)N)NC(C)=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SGC-CBP30 | SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Group: Inhibitors. CAS No. 1613695-14-9. Pack Sizes: 10mg. Product ID: S7256. Formula: C28H33ClN4O3. Smiles: CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)CC(C)N5CCOCC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Shield-1 (Shld1) | Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP). Shield-1 reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 stabilizes the entire fusion protein. Group: Inhibitors. Alternative Names: Shld1. CAS No. 914805-33-7. Pack Sizes: 5mg. Product ID: S3469. Formula: C42H56N2O10. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SHP099 Hydrochloride | SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50?value of?0.071?μM and shows no activity against SHP1. Group: Inhibitors. CAS No. 2200214-93-1. Pack Sizes: 5mg. Product ID: S8278. Formula: C16H20Cl3N5. Smiles: Cl.CC1(N)CCN(CC1)C2=CN=C(C(=N2)N)C3=CC=CC(=C3Cl)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Silmitasertib (CX-4945) | Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2. Group: Inhibitors. CAS No. 1009820-21-6. Pack Sizes: 2mg. Product ID: S2248. Formula: C19H12ClN3O2. Smiles: C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)O)C4=C2C=CN=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Simvastatin (MK-733) | Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Group: Inhibitors. Alternative Names: MK 733. CAS No. 79902-63-9. Pack Sizes: 25mg. Product ID: S1792. Formula: C25H38O5. Smiles: CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SIRT1 Antibody [N11B23] | SirT1,Sirt1(Sir2). Group: Antibodies. Alternative Names: SirT1,Sir2. CAS No. Pack Sizes: 20ul. Product ID: F0526. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SIS3 Hydrochloride | SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. Group: Inhibitors. CAS No. 521984-48-5. Pack Sizes: 2mg. Product ID: S7959. Formula: C28H27N3O3.HCl. Smiles: CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
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