Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Sitagliptin | Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes. Group: Inhibitors. Alternative Names: MK-0431. CAS No. 486460-32-6. Pack Sizes: 25mg. Product ID: S5079. Formula: C16H15F6N5O. Smiles: C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| SKI-606 (Bosutinib) | Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT / mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. Group: Inhibitors. Alternative Names: SKI-606. CAS No. 380843-75-4. Pack Sizes: 1g. Product ID: S1014. Formula: C26H29Cl2N5O3. Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SKL2001 | SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction. Group: Inhibitors. CAS No. 909089-13-0. Pack Sizes: 10mg. Product ID: S8320. Formula: C14H14N4O3. Smiles: C1=COC(=C1)C2=CC(=NO2)C(=O)NCCCN3C=CN=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Smad2/3 Antibody [M18H19] | Mothers against decapentaplegic homolog 3, MAD homolog 3, Mothers against DPP homolog 3, Mad3, JV15-2, SMAD 3, Smad3, hSMAD3, hMAD-3, MADH3, SMAD family member 3, Mothers against decapentaplegic homolog 2, MAD homolog 2, JV18-1, hMAD-2, SMAD 2, Smad2, hSMAD2, Mothers against DPP homolog 2, Mad-related protein 2, SMAD family member 2. Group: Antibodies. Alternative Names: hSMAD2, hSMAD3. Pack Sizes: 20ul. Product ID: F0363. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Smad3 Antibody [J9N13] | Smad3 Antibody [J9N13]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0364. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SN-38 | SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy. Group: Inhibitors. Alternative Names: NK012. CAS No. 86639-52-3. Pack Sizes: 10mg. Product ID: S4908. Formula: C22H20N2O5. Smiles: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Snail Antibody [K14K14] | SNAI 1,Snail. Group: Antibodies. Alternative Names: SNAI 1,Snail. Pack Sizes: 20ul. Product ID: F0164. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SNDX-5613 (Revumenib) | Revumenib(SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM. Group: Inhibitors. CAS No. 2169919-21-3. Pack Sizes: 5mg. Product ID: S8996. Formula: C32H47FN6O4S. Smiles: CCN(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](=O)(=O)CC)C3)C=CC(=C1)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SOD2 Antibody [B16G13] | Mn-SOD,SOD2,SOD2 / MnSOD,SOD2/Mn-SOD,Superoxide Dismutase 2/SOD2. Group: Antibodies. Alternative Names: Mn-SOD,SOD2,Superoxide Dismutase 2/SOD2. Pack Sizes: 20ul. Product ID: F0508. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Sodium butyrate | Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells. Group: Inhibitors. Alternative Names: NaB, Butanoic acid sodium salt. CAS No. 156-54-7. Pack Sizes: 1g. Product ID: S1999. Formula: C4H7NaO2. Smiles: CCCC(=O)[O-].[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sodium Dichloroacetate (DCA) | DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth. Group: Inhibitors. Alternative Names: Dichloroacetic acid, bichloroacetic acid, BCA. CAS No. 2156-56-1. Pack Sizes: 100mg. Product ID: S8615. Formula: C2HCl2O2.Na. Smiles: C(C(=O)[O-])(Cl)Cl.[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sodium L-Ascorbyl-2-Phosphate (SAP) | Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production. Group: Inhibitors. Alternative Names: Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate. CAS No. 66170-10-3. Pack Sizes: 25mg. Product ID: S5115. Formula: C6H6O9P.3Na. Smiles: C(C(C1C(=C(C(=O)O1)OP(=O)([O-])[O-])O)O)O.[Na+].[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sodium L-lactate | Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent. Group: Inhibitors. CAS No. 867-56-1. Pack Sizes: 25mg. Product ID: S6010. Formula: C3H5NaO3. Smiles: CC(C(=O)[O-])O.[Na+]. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Sodium oxamate | Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH - A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1 / cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation. Group: Inhibitors. Alternative Names: SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt. CAS No. 565-73-1. Pack Sizes: 100mg. Product ID: S6871. Formula: C2H2NNaO3. Smiles: C(=O)(C(=O)[O-])N.[Na+]. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Sodium Potassium ATPase Antibody [F11L6] | alpha 1 Sodium Potassium ATPase,alpha 1 Sodium Potassium ATPase/ATP1A1,Na,K-ATPase,Na,K-ATPase α1,Na+/K+ ATPase (alpha Subunit),Na+/K+ ATPase alpha-1,Sodium Potassium ATPase,Sodium Potassium ATPase Alpha 1. Group: Antibodies. Alternative Names: alpha 1 Sodium Potassium ATPase,ATP1A1,Na,K-ATPase α1,Na+/K+ ATPase (alpha Subunit), ATPase. CAS No. Pack Sizes: 20uL. Product ID: F2192. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Solutol HS-15 (Polyethylene glycol 12-hydroxystearate) | Solutol HS-15(Polyethylene glycol 12-hydroxystearate) is a Macrogol 15 hydroxy stearate, which improves permeability by disrupting the membrane structure / fluidity change. Note: Due to its chemical properties, this product will be semi-solid and solid at room temperature and low temperature. Group: Inhibitors. Alternative Names: Polyethylene glycol 12-hydroxystearate. CAS No. 70142-34-6. Pack Sizes: 10g. Product ID: E1708. Formula: C2H6O2*C18H36O3. Storage Conditions: 2 years 4°C liquid. | United States; Europe |
| Sonidegib (NVP-LDE225, Erismodegib) | Sonidegib is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3. Group: Inhibitors. Alternative Names: NVP-LDE225, Erismodegib. CAS No. 956697-53-3. Pack Sizes: 5mg. Product ID: S2151. Formula: C26H26F3N3O3. Smiles: CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sorafenib (BAY 43-9006) | Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. Group: Inhibitors. Alternative Names: NSC-724772,BAY 43-9006. CAS No. 284461-73-0. Pack Sizes: 20mg. Product ID: S7397. Formula: C21H16ClF3N4O3. Smiles: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sox2 Antibody [C21B1] | Sox2,SOX-2. Group: Antibodies. Alternative Names: Sox2. Pack Sizes: 20uL. Product ID: F0310. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SOX9 Antibody [J19L1] | SOX9 Antibody [J19L1]. Group: Antibodies. CAS No. Pack Sizes: 20uL. Product ID: F1113. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SP600125 | SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad?spectrum inhibitor of serine / threonine kinases including Aurora kinase A, FLT3 and TRKA with of IC50 of 60?nM, 90?nM and 70?nM. SP600125 inhibits autophagy and activates apoptosis. Group: Inhibitors. Alternative Names: Nsc75890. CAS No. 129-56-6. Pack Sizes: 10mg. Product ID: S1460. Formula: C14H8N2O. Smiles: C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SQ22536 | SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets. Group: Inhibitors. Alternative Names: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine. CAS No. 17318-31-9. Pack Sizes: 10mg. Product ID: S8283. Formula: C9H11N5O. Smiles: C1CC(OC1)N2C=NC3=C(N=CN=C32)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SQSTM1 / p62 Antibody [D16H4] | p62 (Sequestosome-1),p62 Ick ligand,p62/SQSTM1,SQSTM1,SQSTM1 / p62,SQSTM1/p62. Group: Antibodies. Alternative Names: p62 (Sequestosome-1),p62 Ick ligand,p62,SQSTM1. Pack Sizes: 20ul. Product ID: F0106. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Src Antibody [H13N7] | Src,v-Src. Group: Antibodies. Alternative Names: Src,v-Src. Pack Sizes: 20ul. Product ID: F0262. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SREBP1 Antibody [J19N8] | SREBP1 Antibody [J19N8]. Group: Antibodies. CAS No. Pack Sizes: 20uL. Product ID: F1581. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SRI-011381 (C381) | SRI-011381 (C381) is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage. Group: Inhibitors. Alternative Names: C381. CAS No. 1629138-41-5. Pack Sizes: 5mg. Product ID: S6654. Formula: C20H31N3O. . Smiles: C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SRT 1720 Hydrochloride | SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy. Group: Inhibitors. CAS No. 1001645-58-4. Pack Sizes: 5mg. Product ID: S1129. Formula: C25H23N7OS.HCl. Smiles: C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Stat1 Antibody [J19A4] | Stat1 Antibody [J19A4]. Group: Antibodies. Alternative Names: Signal Transducer and Activator of Transcription 1. Pack Sizes: 20ul. Product ID: F0263. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Stat3 Antibody [J18A23] | Stat3 Antibody [J18A23]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0200. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Stattic | Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis. Group: Inhibitors. CAS No. 19983-44-9. Pack Sizes: 25mg. Product ID: S7024. Formula: C8H5NO4S. Smiles: C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Staurosporine (STS) | Staurosporine (STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3. Group: Inhibitors. Alternative Names: AM-2282, Antibiotic AM-2282. CAS No. 62996-74-1. Pack Sizes: 2mg. Product ID: S1421. Formula: C28H26N4O3. Smiles: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Stemregenin 1 (SR1) | SR1 (StemRegenin 1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay. Group: Inhibitors. CAS No. 1227633-49-9. Pack Sizes: 10mg. Product ID: S2858. Formula: C24H23N5OS. Smiles: CC(C)N1C=NC2=C(N=C(N=C21)C3=CSC4=CC=CC=C43)NCCC5=CC=C(C=C5)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| STING Antibody [F1N19] | STING Antibody [F1N19]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2884. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| STING Antibody [N23J24] | STING,STING/TMEM173. Group: Antibodies. Alternative Names: STING,STING/TMEM173. CAS No. Pack Sizes: 20uL. Product ID: F0361. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| STM2457 | STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases. Group: Inhibitors. CAS No. 2499663-01-1. Pack Sizes: 5mg. Product ID: S9870. Formula: C25H28N6O2. Smiles: O=C(NCC1=C[N]2C=C(CNCC3CCCCC3)C=CC2=N1)C4=CC(=O)N5C=CC=CC5=N4. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Streptozotocin (STZ) | STZ (Streptozotocin) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Streptozotocin (STZ) can be used to induce animal models of diabetes. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: NSC-85998, Streptozocin, U 9889,STZ. CAS No. 18883-66-4. Pack Sizes: 1g. Product ID: S1312. Formula: C8H15N3O7. Smiles: CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| SU 5402 | SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively. Group: Inhibitors. CAS No. 215543-92-3. Pack Sizes: 10mg. Product ID: S7667. Formula: C17H16N2O3. Smiles: CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Subasumstat (TAK-981) | Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities. Group: Inhibitors. CAS No. 1858276-04-6. Pack Sizes: 5mg. Product ID: S8829. Formula: C25H28ClN5O5S2. Smiles: CC1=C(C=C(S1)C(=O)C2=CN=CN=C2NC3CC(C(C3)O)COS(=O)(=O)N)C4C5=C(CCN4)C=CC(=C5)Cl. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Sulforaphane | Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.. Group: Inhibitors. CAS No. 4478-93-7. Pack Sizes: 1mg. Product ID: S5771. Formula: C6H11NOS2. Storage Conditions: 2 years -20°C(in the dark) liquid. | United States; Europe |
| Sulfosuccinimidyl Oleate Sodium (SSO) | Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain with IC50 of 4 μM. It inhibits CD36 mediated LCFA transport. It exhibits anti-inflammatory effect. Group: Inhibitors. Alternative Names: Sulfo-N-succinimidyl oleate sodium. CAS No. 1212012-37-7. Pack Sizes: 5mg. Product ID: E2988. Formula: C22H37NO7S.Na. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Sunitinib (SU-11248) | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis. Group: Inhibitors. Alternative Names: SU11248. CAS No. 557795-19-4. Pack Sizes: 50mg. Product ID: S7781. Formula: C22H27FN4O2. Smiles: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Sunitinib (SU11248) Malate | Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis. Group: Inhibitors. Alternative Names: SU11248 malate. CAS No. 341031-54-7. Pack Sizes: 50mg. Product ID: S1042. Formula: C22H27FN4O2.C4H6O5. Smiles: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Synaptophysin Antibody [J5G22] | Synaptophysin,SYP / Synaptophysin. Group: Antibodies. Alternative Names: Synaptophysin,SYP. CAS No. Pack Sizes: 20uL. Product ID: F1215. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| T0070907 | T0070907 is a potent inhibitor of PPARγ (peroxisome proliferator activator receptor γ ) that induces G2/M arrest and enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. It also acts as an antagonist of PPARγ that suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms. Group: Inhibitors. CAS No. 313516-66-4. Pack Sizes: 5mg. Product ID: S2871. Formula: C12H8ClN3O3. Smiles: C1=CC(=C(C=C1[N+](=O)[O-])C(=O)NC2=CC=NC=C2)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| T-5224 | T-5224 is a selective inhibitor of transcription factor c-Fos / activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription. Group: Inhibitors. CAS No. 530141-72-1. Pack Sizes: 5mg. Product ID: S8966. Formula: C29H27NO8. Smiles: C1CCC(C1)OC2=CC(=C(C=C2)C(=O)C3=CC(=C(C=C3)OCC4=CC5=C(C=C4)C(=O)NO5)CCC(=O)O)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Tagtociclib (PF-07104091) | Tagtociclib (PF-07104091) inhibits CDK2, which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Group: Inhibitors. CAS No. 2460249-19-6. Pack Sizes: 5mg. Product ID: S9878. Formula: C19H28N6O4. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| TAK-243 (MLN7243) | TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NFκB pathway activation and promotes apoptosis. Group: Inhibitors. CAS No. 1450833-55-2. Pack Sizes: 2mg. Product ID: S8341. Formula: C19H20F3N5O5S2. Smiles: N[S;v6](=O)(=O)OCC1CC(NC2=CC=NC3=CC(=N[N]23)C4=CC(=CC=C4)SC(F)(F)F)C(O)C1O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Talabostat (Val-boroPro, PT-100) Mesylate | Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities. Group: Inhibitors. Alternative Names: Val-boroPro. CAS No. 150080-09-4. Pack Sizes: 5mg. Product ID: S8455. Formula: C10H23BN2O6S. Smiles: B(C1CCCN1C(=O)C(C(C)C)N)(O)O.CS(=O)(=O)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Tamoxifen | Tamoxifen is an orally active, selective estrogen receptor modulator (SERM) which exhibits both estrogenic agonist and antagonist effects. It blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Group: Inhibitors. Alternative Names: ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen. CAS No. 10540-29-1. Pack Sizes: 1g. Product ID: S1238. Formula: C26H29NO. Smiles: CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3. Storage Conditions: 2 years 4°C, in dark and seal. | United States; Europe |
| Tanespimycin (17-AAG) | Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3. Group: Inhibitors. Alternative Names: CP127374, NSC-330507, KOS 953. CAS No. 75747-14-7. Pack Sizes: 25mg. Product ID: S1141. Formula: C31H43N3O8. Smiles: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TAS-116 (Pimitespib) | Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L). Group: Inhibitors. CAS No. 1260533-36-5. Pack Sizes: 5mg. Product ID: S7716. Formula: C25H26N8O. Smiles: CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Tauroursodeoxycholic Acid (TUDCA) | Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD). Group: Inhibitors. CAS No. 14605-22-2. Pack Sizes: 25mg. Product ID: S3654. Formula: C26H45NO6S. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TBK1/NAK Antibody [K6D9] | NAK/TBK1,TBK1,TBK1/NAK. Group: Antibodies. Alternative Names: NAK/TBK1,TBK1. Pack Sizes: 20uL. Product ID: F0525. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| TDI-011536 | TDI-011536 is a potent Lats kinase inhibitor that interrupts Hippo-Yap signaling and promotes proliferation of lesioned cardiac muscle cells. Group: Inhibitors. CAS No. 2687970-96-1. Pack Sizes: 5mg. Product ID: E1314. Formula: C19H16N4O2S. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Telaglenastat (CB-839) | Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1. Group: Inhibitors. CAS No. 1439399-58-2. Pack Sizes: 5mg. Product ID: S7655. Formula: -C26H24F3N7O3S. Smiles: C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Temsirolimus (CCI-779) | Temsirolimus is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis. Group: Inhibitors. Alternative Names: NSC 683864,CCI-779. CAS No. 162635-04-3. Pack Sizes: 10mg. Product ID: S1044. Formula: C56H87NO16. Smiles: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tepotinib (EMD-1214063) | Tepotinib is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib (EMD 1214063) induces autophagy. Phase 1. Group: Inhibitors. Alternative Names: EMD 1214063, MSC2156119. CAS No. 1100598-32-0. Pack Sizes: 5mg. Product ID: S7067. Formula: C29H28N6O2. Smiles: CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TEPP-46 (ML265) | TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL. Group: Inhibitors. Alternative Names: CID-44246499, NCGC00186528. CAS No. 1221186-53-3. Pack Sizes: 5mg. Product ID: S7302. Formula: C17H16N4O2S2. Smiles: CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tetraethylthiuram disulfide (Disulfiram) | Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD). Group: Inhibitors. Alternative Names: NSC 190940, Tetraethylthiuram disulfide, TETD. CAS No. 97-77-8. Pack Sizes: 50mg. Product ID: S1680. Formula: C10H20N2S4. Smiles: CCN(CC)C(=S)SSC(=S)N(CC)CC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tezacaftor (VX-661) | Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2. Group: Inhibitors. CAS No. 1152311-62-0. Pack Sizes: 5mg. Product ID: S7059. Formula: C26H27F3N2O6. Smiles: CC(C)(CO)C1=CC2=CC(=C(C=C2N1CC(CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TGF β1 Antibody [P22B16] | TGF beta 1,Transforming Growth Factor-beta1. Group: Antibodies. Alternative Names: Transforming Growth Factor-β1, TGFB1, TGFB. CAS No. Pack Sizes: 20uL. Product ID: F1624. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Thapsigargin | Thapsigargin is a potent, non-competitive inhibitor of the sarco / endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell apoptosis. Thapsigargin is extracted from a plant, Thapsia garganica. Group: Inhibitors. CAS No. 67526-95-8. Pack Sizes: 1mg. Product ID: S7895. Formula: C34H50O12. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Thiamet G | Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal -hexosaminidase. Group: Inhibitors. CAS No. 1009816-48-1. Pack Sizes: 5mg. Product ID: S7213. Formula: C9H16N2O4S. Smiles: CCN=C1NC2C(C(C(OC2S1)CO)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Thiazovivin (TZV) | Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. Group: Inhibitors. CAS No. 1226056-71-8. Pack Sizes: 5mg. Product ID: S1459. Formula: C15H13N5OS. Smiles: C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Thrombospondin 1 Antibody [E9P21] | Thrombospondin 1 Antibody [E9P21]. Group: Antibodies. Alternative Names: Glycoprotein G, Thrombospondin-1, thrombospondin-1p180, thrombospondin-p50, ThrombospondinTHBS1, tbsp1, THBS, THBS-1, THBS1, TSP, TSP-1, TSP1. CAS No. Pack Sizes: 20uL. Product ID: F1912. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Thymidine | Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. Group: Inhibitors. Alternative Names: NSC 21548, Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd. CAS No. 50-89-5. Pack Sizes: 25mg. Product ID: S4803. Formula: C10H14N2O5. Smiles: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| THZ1 2HCl | THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Group: Inhibitors. CAS No. 2095433-94-4. Pack Sizes: 5mg. Product ID: S7549. Formula: C31H30Cl3N7O2. Smiles: CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TIC10 (ONC201) | TIC10 (ONC201) inactivates Akt and ERK to induce TNF-related apoptosis-inducing ligand (TRAIL) through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Group: Inhibitors. Alternative Names: Dordaviprone. CAS No. 1616632-77-9. Pack Sizes: 10mg. Product ID: S7963. Formula: C24H26N4O. Smiles: CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tirzepatide (LY3298176) sodium | Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively. Group: Peptides. CAS No. 2023788-19-2 (free base). Pack Sizes: 1mg. Product ID: P1206. Formula: C225H348N48O68• XNa. Storage Conditions: 3 years-20°C powder. | United States; Europe |
| TLR2-IN-C29 | TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling. Group: Inhibitors. Alternative Names: C29. CAS No. 363600-92-4. Pack Sizes: 5mg. Product ID: S6597. Formula: C16H15NO4. Smiles: CC1=C(C=CC=C1N=CC2=C(C(=CC=C2)OC)O)C(=O)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.