Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| MG132 | MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM). MG132 can be used to induce animal models of Parkinsons disease. Group: Inhibitors. Alternative Names: (S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al. CAS No. 1211877-36-9. Pack Sizes: 5mg. Product ID: S2619. Formula: C26H41N3O5. Smiles: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| MG132 SSS | MG132 SSS(Z-Leu-Leu-Leu-al, MG132) is a potent proteasome and calpain inhibitor with IC50 of 100 nM and 1.2 μM, respectively. Group: Inhibitors. Alternative Names: Z-Leu-Leu-Leu-al, MG132. CAS No. 133407-82-6. Pack Sizes: 5mg. Product ID: E2899. Formula: C26H41N3O5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| MGL-3196 (Resmetirom) | Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay. Group: Inhibitors. Alternative Names: VIA-3196. CAS No. 920509-32-6. Pack Sizes: 5mg. Product ID: S6663. Formula: C17H12Cl2N6O4. Smiles: CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| MHY1485 | MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy. Group: Inhibitors. CAS No. 326914-06-1. Pack Sizes: 10mg. Product ID: S7811. Formula: C17H21N7O4. Smiles: C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Mifepristone (RU-486) | Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion. Group: Inhibitors. Alternative Names: C-1073, RU 38486. CAS No. 84371-65-3. Pack Sizes: 50mg. Product ID: S2606. Formula: C29H35NO2. Smiles: CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Minocycline Hydrochloride | Minocycline HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. Group: Inhibitors. Alternative Names: CL 59806. CAS No. 13614-98-7. Pack Sizes: 50mg. Product ID: S4226. Formula: C23H27N3O7.HCl. Smiles: CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Mirin | Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. Mirin inhibits MRN-dependent activation of ATM. Group: Inhibitors. CAS No. 1198097-97-0. Pack Sizes: 10mg. Product ID: S8096. Formula: C10H8N2O2S. Smiles: OC1=CC=C(C=C1)\C=C2/SC(=N)NC2=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Mitofusin 2 Antibody [J12N7] | MFN2,Mfn2 / Mitofusin 2,Mitofusin 2,Mitofusin-2. Group: Antibodies. Alternative Names: MFN2,Mitofusin-2. Pack Sizes: 20uL. Product ID: F0566. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Mitomycin C | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity / flammable / skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. Group: Inhibitors. Alternative Names: Ametycine. CAS No. 50-07-7. Pack Sizes: 10mg. Product ID: S8146. Formula: C15H18N4O5. Smiles: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MitoQ (Mitoquinone) Mesylate | MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid. Group: Inhibitors. Alternative Names: MitoQ10 mesylate, Mitoubiquinone mesylate. CAS No. 845959-50-4. Pack Sizes: 5mg. Product ID: S8978. Formula: C38H47O7PS. Smiles: CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)[O-]. Storage Conditions: 2 years -20°C liquid. | United States; Europe |
| Mito-TEMPO | Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression. Group: Inhibitors. CAS No. 1334850-99-5. Pack Sizes: 5mg. Product ID: S9733. Formula: C29H35N2O2P.Cl. Smiles: [Cl-].CC1(C)CC(CC(C)(C)N1[O])NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4. | United States; Europe |
| MK-2206 Dihydrochloride | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2. Group: Inhibitors. CAS No. 1032350-13-2. Pack Sizes: 5mg. Product ID: S1078. Formula: C25H21N5O.2HCl. Smiles: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ML-210 | ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity. Group: Inhibitors. Alternative Names: CID 49766530. CAS No. 1360705-96-9. Pack Sizes: 5mg. Product ID: S0788. Formula: C22H20Cl2N4O4. Smiles: CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| ML385 | ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins. Group: Inhibitors. CAS No. 846557-71-9. Pack Sizes: 5mg. Product ID: S8790. Formula: C29H25N3O4S. Smiles: CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| ML792 | ML-792 is a potent and selective inhibitor of SUMO (small ubiquitin-like modifier)-activating enzyme (SAE). ML-792 inhibits SAE/SUMO1 and SAE/SUMO2 in ATP-inorganic pyrophosphate (PPi) exchange assays with IC50 of 3 nM and 11 nM, respectively. Group: Inhibitors. CAS No. 1644342-14-2. Pack Sizes: 5mg. Product ID: S8697. Formula: C21H23BrN6O5S. Smiles: C1C(CC(C1COS(=O)(=O)N)O)NC2=NC=NC=C2C(=O)C3=NN(C=C3)CC4=CC(=CC=C4)Br. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| MLN2238 (Ixazomib) | Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3. Group: Inhibitors. CAS No. 1072833-77-2. Pack Sizes: 5mg. Product ID: S2180. Formula: C14H19BCl2N2O4. Smiles: B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MLN4924 (Pevonedistat) | MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. Group: Inhibitors. CAS No. 905579-51-3. Pack Sizes: 2mg. Product ID: S7109. Formula: C21H25N5O4S. Smiles: C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MMAE (Monomethyl auristatin E) | MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent. Group: Inhibitors. Alternative Names: SGD-1010. CAS No. 474645-27-7. Pack Sizes: 1mg. Product ID: S7721. Formula: C39H67N5O7. . Smiles: CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC. Storage Conditions: -20°C power 3 years. | United States; Europe |
| MMP3 Antibody [N23A23] | MMP3,MMP-3. Group: Antibodies. Alternative Names: MMP3. Pack Sizes: 20ul. Product ID: F1042. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MMP9 Antibody [G4H21] | MMP9,MMP-9. Group: Antibodies. Alternative Names: MMP9. CAS No. Pack Sizes: 20ul. Product ID: F0008. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MMP9 Antibody [P1J16] | MMP9,MMP-9. Group: Antibodies. Alternative Names: MMP9. CAS No. Pack Sizes: 20uL. Product ID: F2867. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MNNG (1-Methyl-3-nitro-1-nitrosoguanidine) | 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. It acts as a carcinogen and mutagen among 3 human diploid lymphoblast lines, MIT-2, WI-L2, and GM 130.The product is a solid-liquid mixture.1-Methyl-3-nitro-1-nitrosoguanidine can be used to induce animal models of Gastric Carcinoma. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: N-Methyl-N-nitroso-N-nitroguanidine, Methylnitronitrosoguanidine, MNG. CAS No. 70-25-7. Pack Sizes: 100mg. Product ID: E0157. Formula: C2H5N5O3. Smiles: CN(N=O)C(=N)N[N](=O)=O. Storage Conditions: 3 years, -20°C. | United States; Europe |
| Mouse Direct PCR Kit (For Genotyping) | The Mouse Direct PCR Kit provides a fast preparation and PCR amplIFication that is specIFically designed for mouse genotyping. Buffer L and Protease Plus rapidly digests mouse tissue to release intact genomic DNA that can be used directly as the template for PCR amplIFication. Group: Kits. Pack Sizes: 200rxns. Product ID: B40013. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| Mouse Direct PCR Kit (For Genotyping) | The Mouse Direct PCR Kit provides a fast preparation and PCR amplIFication that is specIFically designed for mouse genotyping. Buffer L and Protease Plus rapidly digests mouse tissue to release intact genomic DNA that can be used directly as the template for PCR amplIFication. Group: Kits. Pack Sizes: 500rxns. Product ID: B40015. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| Mouse IgG1 isotype control-InVivo | The monoclonal mouse IgG1 K immunoglobulin is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2106. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Mouse IgG2a isotype control-InVivo | Mouse IgG2a isotype control-InVivo (Clone:C1.18.4) monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2117. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| MPTP Hydrochloride | MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.MPTP hydrochloride can be used to induce animal models of Parkinsons disease. Group: Inhibitors. CAS No. 23007-85-4. Pack Sizes: 20mg. Product ID: S4732. Formula: C12H15N·HCl. Smiles: CN1CCC(=CC1)C2=CC=CC=C2.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MRT68921 Hydrochloride | MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. Group: Inhibitors. CAS No. 2070014-87-6. Pack Sizes: 5mg. Product ID: S7949. Formula: C25H34N6O·xHCl. Smiles: CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MRTX1133 | MRTX1133 is a highly selective inhibitor of mutant KRAS G12D and can reversibly binds to the activated and inactivated KRAS G12D mutants and inhibit their activity. The specificity of MRTX1133 to KRAS G12D is more than 1000 times that of wild-type KRAS. Group: Inhibitors. CAS No. 2621928-55-8. Pack Sizes: 5mg. Product ID: E1051. Formula: C33H31F3N6O2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| mTOR Antibody [C15M14] | mTOR Antibody [C15M14]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0169. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MYCi975 | MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities. Group: Inhibitors. Alternative Names: NUCC-0200975. CAS No. 2289691-01-4. Pack Sizes: 5mg. Product ID: S8906. Formula: C25H16Cl2F6N2O2. Smiles: CN1C(=CC(=N1)C(F)(F)F)C2=C(C(=C(C=C2)OCC3=CC=C(C=C3)Cl)C4=CC(=C(C=C4)Cl)C(F)(F)F)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Myc tag Antibody [A14H15] | Myc tag Antibody [A14H15]. Group: Antibodies. Alternative Names: BHLHE39; MYC; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; Proto-oncogene c-Myc; Transcription factor p64; bHLHe39. Pack Sizes: 20uL. Product ID: F4919. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MyD88 Antibody [G4P20] | MyD88 Antibody [G4P20]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0289. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Myelin Basic Protein Antibody [K10K15] | MBP,Myelin Basic Protein. Group: Antibodies. Alternative Names: MBP,Myelin Basic Protein. Pack Sizes: 20ul. Product ID: F1098. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Myeloperoxidase Heavy Chain Antibody [G9M2] | MPO,MPO / Myeloperoxidase,Myeloperoxidase. Group: Antibodies. Alternative Names: Myeloperoxidase,MPO. CAS No. Pack Sizes: 20uL. Product ID: F1614. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| MYK-461 (Mavacamten) | Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders. Group: Inhibitors. Alternative Names: SAR439152. CAS No. 1642288-47-8. Pack Sizes: 5mg. Product ID: S8861. Formula: C15H19N3O2. Smiles: CC(C)N1C(=O)C=C(NC1=O)NC(C)C2=CC=CC=C2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Nab-Paclitaxel | Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Pack Sizes: 10mg. Product ID: E1068. Formula: C47H51NO14. Storage Conditions: Store at room temperature, 3 years. | United States; Europe |
| N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) | Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: N-acetylcysteine. CAS No. 616-91-1. Pack Sizes: 1g. Product ID: S1623. Formula: C5H9NO3S. Smiles: CC(=O)NC(CS)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| NAD+ (β-DPN) | NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. Group: Inhibitors. Alternative Names: β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide. CAS No. 53-84-9. Pack Sizes: 50mg. Product ID: S2518. Formula: C21H27N7O14P2. Smiles: C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Navitoclax (ABT-263) | Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. Group: Inhibitors. CAS No. 923564-51-6. Pack Sizes: 1g. Product ID: S1001. Formula: C47H55ClF3N5O6S3. Smiles: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| N-Cadherin Antibody [G6B2] | CD325,CD325 (N-Cadherin),N Cadherin,N-Cadherin. Group: Antibodies. Alternative Names: CDH2; Cadherin-2; CDw325; Neural cadherin (N-cadherin); CD325; CDHN; NCAD. Pack Sizes: 20uL. Product ID: F0147. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NCT-503 | NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with the IC50 value of 2.5 μM. It is inactive against a panel of other dehydrogenases and shows minimal cross-reactivity in a panel of 168 GPCRs. Group: Inhibitors. CAS No. 1916571-90-8. Pack Sizes: 5mg. Product ID: S8619. Formula: C20H23F3N4S. Smiles: CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Necrostatin-1 (Nec-1) | Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis. Group: Inhibitors. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10mg. Product ID: S8037. Formula: C13H13N3OS. Smiles: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Necrostatin 2 racemate (Nec-1s) | Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases. Group: Inhibitors. Alternative Names: 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S. CAS No. 852391-15-2. Pack Sizes: 5mg. Product ID: S8641. Formula: C13H12ClN3O2. Smiles: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Necrosulfonamide | Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL). Group: Inhibitors. CAS No. 1360614-48-7. Pack Sizes: 10mg. Product ID: S8251. Formula: C18H15N5O6S2. Smiles: COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Nedisertib (M3814) | Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM. Group: Inhibitors. Alternative Names: Peposertib, MSC2490484A. CAS No. 1637542-33-6. Pack Sizes: 5mg. Product ID: S8586. Formula: C24H21ClFN5O3. Smiles: COC1=NN=C(C=C1)C(C2=C(C=C(C(=C2)C3=NC=NC4=C3C=CC(=C4)N5CCOCC5)F)Cl)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Nerandomilast (BI 1015550) | Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with IC50 of 7.2 nM. It has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD). Group: Inhibitors. CAS No. 1423719-30-5. Pack Sizes: 5mg. Product ID: E1382. Formula: C20H25ClN6O2S. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Neratinib (HKI-272) | Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3. Group: Inhibitors. Alternative Names: HKI-272. CAS No. 698387-09-6. Pack Sizes: 5mg. Product ID: S2150. Formula: C30H29ClN6O3. Smiles: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| N-Ethylmaleimide (NEM) | NEM (N-Ethylmaleimide) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria. Group: Inhibitors. CAS No. 128-53-0. Pack Sizes: 25mg. Product ID: S3692. Formula: C6H7NO2. Smiles: CCN1C(=O)C=CC1=O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| NeuN Antibody [J1P15] | NeuN,NeuN (rabbit monoclonal),NeuN purified,RBFOX3 / NeuN. Group: Antibodies. Alternative Names: NeuN,RBFOX3 / NeuN. CAS No. Pack Sizes: 20ul. Product ID: F0103. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NF-κB p65 Antibody [G23D18] | NFkappaB,NFkappaB Antibody, p65 subunit, active subunit,NF-kB p65,NF-κB p65,RelA / NFkB p65,RELA/NFκB p65. Group: Antibodies. Alternative Names: NFkappaB, p65 subunit, active subunit,NF-kB p65,RELA/NFκB p65. Pack Sizes: 20ul. Product ID: F0006. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NIBR-LTSi | NIBR-LTSi is a selective small-molecule inhibitor of LATS kinase. It activates YAP signaling and promotes tissue regeneration in vitro and in vivo, supporting future research on the regenerative potential of the YAP / Hippo pathway. Group: Inhibitors. Pack Sizes: 5mg. Product ID: E4687. Formula: C18H20N4O. | United States; Europe |
| Nicotinamide (Niacinamide) | Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Group: Inhibitors. Alternative Names: Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128. CAS No. 98-92-0. Pack Sizes: 100mg. Product ID: S1899. Formula: C6H6N2O. Smiles: C1=CC(=CN=C1)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Nicotinamide Riboside Chloride (NR-Cl) | Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+. Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements. Group: Inhibitors. CAS No. 23111-00-4. Pack Sizes: 25mg. Product ID: S2935. Formula: C11H15ClN2O5. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| Nigericin sodium salt | Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. Group: Inhibitors. Alternative Names: NSC 292567. CAS No. 28643-80-3. Pack Sizes: 5mg. Product ID: S6653. Formula: C40H67NaO11. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Nilotinib (AMN-107) | Nilotinib is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition. Group: Inhibitors. Alternative Names: AMN-107. CAS No. 641571-10-0. Pack Sizes: 25mg. Product ID: S1033. Formula: C28H22F3N7O. Smiles: CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Niraparib (MK-4827) | Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3. Group: Inhibitors. CAS No. 1038915-60-4. Pack Sizes: 5mg. Product ID: S2741. Formula: C19H20N4O. Smiles: C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Nivolumab (anti-PD-1) | Nivolumab (anti-PD-1) is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD. Group: Antibodies. Alternative Names: BMS-936558, ONO-4538, MDX-1106. CAS No. 946414-94-4. Pack Sizes: 5mg. Product ID: A2002. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| NLRP3 Antibody [E13F14] | Cryopyrin/NALP3/NLRP3,NLRP3,NLRP3/NALP3. Group: Antibodies. Alternative Names: Cryopyrin/NALP3/NLRP3,NLRP3,NLRP3/NALP3. Pack Sizes: 20ul. Product ID: F0335. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NLRP3 Antibody [E14M24] | NLRP3 Antibody [E14M24]. Group: Antibodies. Alternative Names: NACHT, LRR and PYD domains-containing protein 3; Angiotensin / vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; NLRP3; C1orf7; CIAS1; NALP3; PYPAF1. Pack Sizes: 20uL. Product ID: F4415. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NLRP3 Antibody [K12J9] | Cryopyrin/NALP3/NLRP3,NLRP3,NLRP3/NALP3. Group: Antibodies. Alternative Names: Cryopyrin/NALP3/NLRP3,NLRP3,NLRP3/NALP3. Pack Sizes: 20uL. Product ID: F3229. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NMDA (N-Methyl-D-aspartic acid) | NMDA (N-Methyl-D-aspartic acid) is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4. Group: Inhibitors. CAS No. 6384-92-5. Pack Sizes: 50mg. Product ID: S7072. Formula: C5H9NO4. Smiles: CNC(CC(=O)O)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| NMS-873 | NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). Group: Inhibitors. CAS No. 1418013-75-8. Pack Sizes: 5mg. Product ID: S7285. Formula: C27H28N4O3S2. Smiles: CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Nocodazole | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis. Group: Inhibitors. Alternative Names: R17934, Oncodazole, NSC238159. CAS No. 31430-18-9. Pack Sizes: 10mg. Product ID: S2775. Formula: C14H11N3O3S. Smiles: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| (?)-Norepinephrine | (-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.(-)-Norepinephrine can be used to induce animal models of Cardiomyopathy. Group: Inhibitors. Alternative Names: Arterenol, Levarterenol, L-Noradrenaline. CAS No. 51-41-2. Pack Sizes: 25mg. Product ID: S9507. Formula: C8H11NO3. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| Novobiocin Sodium (Cathomycin, Albamycin) | Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria. Group: Inhibitors. Alternative Names: Albamycin,Cathomycin,NSC 2382. CAS No. 1476-53-5. Pack Sizes: 50mg. Product ID: S2492. Formula: C31H35N2O11.Na. Smiles: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| NRF2 Antibody [J1K11] | NRF2 Antibody [J1K11]. Group: Antibodies. Alternative Names: Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2 ; Nrf-2; Nuclear factor, erythroid derived 2, like 2 ; NFE2L2; NRF2. Pack Sizes: 20uL. Product ID: F4141. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| NSC 23766 Trihydrochloride | NSC 23766 trihydrochloride is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. Group: Inhibitors. CAS No. 1177865-17-6. Pack Sizes: 10mg. Product ID: S8031. Formula: C24H35N7.3ClH. Smiles: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C.Cl.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| NSC 74859 (S3I-201) | NSC 74859 (S3I-201) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5. Group: Inhibitors. CAS No. 501919-59-1. Pack Sizes: 5mg. Product ID: S1155. Formula: C16H15NO7S. Smiles: CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| NU7441 (KU-57788) | NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage. Group: Inhibitors. CAS No. 503468-95-9. Pack Sizes: 5mg. Product ID: S2638. Formula: C25H19NO3S. Smiles: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
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