Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Nutlin-3 | Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells. Group: Inhibitors. CAS No. 890090-75-2. Pack Sizes: 5mg. Product ID: S1061. Formula: C30H30Cl2N4O4. Smiles: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Nutlin-3a | Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner. Group: Inhibitors. Alternative Names: (-)-Nutlin-3. CAS No. 675576-98-4. Pack Sizes: 5mg. Product ID: S8059. Formula: C30H30Cl2N4O4. Smiles: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Occludin Antibody [F22C23] | Occludin Antibody [F22C23]. Group: Antibodies. Alternative Names: EMT; epithelial. Pack Sizes: 20uL. Product ID: F3044. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| ODM-201 (Darolutamide) | Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3. Group: Inhibitors. Alternative Names: BAY-1841788. CAS No. 1297538-32-9. Pack Sizes: 5mg. Product ID: S7559. Formula: C19H19ClN6O2. Smiles: CC(CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=NNC(=C3)C(C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ODN 1826 sodium (CpG 1826 sodium) | ODN 1826 sodium (CpG 1826 sodium) is a synthetic CpG oligodeoxynucleotide and agonist of TLR9 signaling pathway, that induces G1-phase arrest and apoptosis in A20 lymphoma cells while stimulating NO and iNOS production in mouse models, as part of its immunostimulatory activity. Group: Peptides. Alternative Names: CpG 1826 sodium. Pack Sizes: 1mg. Product ID: P1246. | United States; Europe |
| Oleic acid (cis-9-Octadecenoic acid) | Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.Oleic Acid can be used to induce animal models of Renal Failure. Group: Inhibitors. Alternative Names: Oleate, 9-Octadecenoic Acid, Elaidoic acid. CAS No. 112-80-1. Pack Sizes: 100mg. Product ID: S4707. Formula: C18H34O2. Storage Conditions: 2 years -20°C liquid. | United States; Europe |
| Oligomycin A (MCH 32) | Oligomycin A (MCH 32), a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase which inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria. It inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP. It also induces apoptosis in a variety of cell types. Group: Inhibitors. Alternative Names: MCH 32. CAS No. 579-13-5. Pack Sizes: 5mg. Product ID: S1478. Formula: C45H74O11. Smiles: CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| O-Propargyl-Puromycin | O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis. It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs. Group: Inhibitors. Alternative Names: OP-puro. CAS No. 1416561-90-4. Pack Sizes: 5mg. Product ID: E4666. Formula: C24H29N7O5. | United States; Europe |
| Oseltamivir Phosphate | Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza. Group: Inhibitors. Alternative Names: Tamiflu. CAS No. 204255-11-8. Pack Sizes: 250mg. Product ID: S2597. Formula: C16H28N2O4.H3PO4. Smiles: CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| OSMI-1 | OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 μM for full length human OGT (ncOGT). Group: Inhibitors. CAS No. 1681056-61-0. Pack Sizes: 5mg. Product ID: S9835. Formula: C28H25N3O6S2. Smiles: COC1=CC=CC=C1C(N[S](=O)(=O)C2=CC3=C(NC(=O)C=C3)C=C2)C(=O)N(CC4=CC=CO4)CC5=CC=CS5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Oxaliplatin | Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. Group: Inhibitors. Alternative Names: L-OHP,NSC 266046. CAS No. 61825-94-3. Pack Sizes: 50mg. Product ID: S1224. Formula: C8H14N2O4Pt. Smiles: C1CCC(C(C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| p21 Waf1/Cip1 Antibody [F7M18] | p21,p21 Waf1/Cip1,p21/CIP1/CDKN1A,p21/WAF1/Cip1,Waf1/Cip1/CDKN1A p21. Group: Antibodies. Alternative Names: p21,p21 Waf1/Cip1,p21/CIP1/CDKN1A,Waf1/Cip1/CDKN1A p21. Pack Sizes: 20ul. Product ID: F0170. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| p38 MAPK Antibody [N23C2] | Mitogen-activated protein kinase 14, MAP kinase 14; MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2,MAP kinase p38 alpha, MAP kinase p38 α, SAPK2a, MAP kinase 12; MAPK 12, ERK-6, ERK6, MAP kinase p38 gamma, MAPK12, SAPK3, MAP kinase 11; MAPK 11, MAP kinase p38 beta, p38b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B, CSBP, CSBP1, CSBP2, MXI2, MAP kinase p38 γ,MAP kinase p38 gamma, Stress-activated protein kinase 3, MAP kinase p38 β, MAP kinase p38 beta, p38b. Group: Antibodies. Alternative Names: MAPK 14, SAPK2a, MAPK12, SAPK3, MAPK11, SAPK2B. Pack Sizes: 20ul. Product ID: F0171. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| p44/42 MAPK (Erk1/2) Antibody [F1E12] | Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, ERK1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2,ERK2, PRKM1, PRKM2. Group: Antibodies. Alternative Names: MAPK3, ERK1, p44-MAPK, p42-MAPK, MAPK1, ERK2. Pack Sizes: 20uL. Product ID: F0002. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| p53 Antibody [F16A10] | p53,p53 (pantropic),TP53. Group: Antibodies. Alternative Names: p53,TP53. Pack Sizes: 20uL. Product ID: F0020. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| p70 S6 Kinase Antibody [D7E4] | p70 S6 Kinase,p70 S6 kinase α,p70 S6 kinase/S6K1,S6K1. Group: Antibodies. Alternative Names: p70 S6 Kinase,p70 S6 kinase α,p70 S6 kinase/S6K1,S6K1. Pack Sizes: 20uL. Product ID: F0011. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Paclitaxel | Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy. Group: Inhibitors. Alternative Names: NSC 125973, PTX. CAS No. 33069-62-4. Pack Sizes: 10mg. Product ID: S1150. Formula: C47H51NO14. Smiles: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Palbociclib (PD-0332991) | Palbociclib (PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.This product has poor solubility, animal in vivo experiments are available, cell experiments please choose carefully! Group: Inhibitors. Alternative Names: PD 0332991. CAS No. 571190-30-2. Pack Sizes: 5mg. Product ID: S4482. Formula: C24H29N7O2. Smiles: CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Palmitic acid | Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. This product is a fatty acid that is almost insoluble in water-soluble solvents such as culture medium. It needs to be emulsified before use in cell experiments. It is recommended to purchase it in powder form. Group: Inhibitors. Alternative Names: hexadecanoic acid, Cetylic acid. CAS No. 57-10-3. Pack Sizes: 25mg. Product ID: S3794. Formula: C16H32O2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Panitumumab (anti-EGFR) | Panitumumab (anti-EGFR, ABX-EGF) is a recombinant, fully human IgG2 monoclonal antibody that binds to the epidermal growth factor receptor (EGFR). Group: Antibodies. Alternative Names: ABX-EGF. CAS No. 339177-26-3. Pack Sizes: 1mg. Product ID: A2018. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Panobinostat (LBH589) | Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. Group: Inhibitors. Alternative Names: NVP-LBH589. CAS No. 404950-80-7. Pack Sizes: 10mg. Product ID: S1030. Formula: C21H23N3O2. Smiles: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Paquinimod (ABR-215757) | Paquinimod (ABR 25757), a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice. Group: Inhibitors. Alternative Names: ABR 25757, ABR-215757. CAS No. 248282-01-1. Pack Sizes: 5mg. Product ID: S9963. Formula: C21H22N2O3. Smiles: CCN(C(=O)C1=C(O)C2=C(CC)C=CC=C2N(C)C1=O)C3=CC=CC=C3. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Parkin Antibody [H15P18] | PARK2,Parkin. Group: Antibodies. Alternative Names: PARK2,Parkin. Pack Sizes: 20ul. Product ID: F0296. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PARP1 Antibody [N4A5] | PARP,PARP1. Group: Antibodies. Alternative Names: PARP,PARP1. Pack Sizes: 20ul. Product ID: F0148. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PCNA Antibody [N10L6] | PCNA,Proliferating Cell Nuclear Antigen. Group: Antibodies. Alternative Names: PCNA,Proliferating Cell Nuclear Antigen. Pack Sizes: 20ul. Product ID: F0018. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PD0325901 (Mirdametinib) | Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2. Group: Inhibitors. CAS No. 391210-10-9. Pack Sizes: 5mg. Product ID: S1036. Formula: C16H14F3IN2O4. Smiles: C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PD-0332991 (Palbociclib) Hydrochloride | Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. Group: Inhibitors. CAS No. 827022-32-2. Pack Sizes: 5mg. Product ID: S1116. Formula: C24H29N7O2.HCl. Smiles: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PD-0332991 (Palbociclib) Isethionate | Palbociclib Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. Group: Inhibitors. Alternative Names: PD0332991 Isethionate. CAS No. 827022-33-3. Pack Sizes: 50mg. Product ID: S1579. Formula: C24H29N7O2.C2H6O4S. Smiles: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PD173074 | PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells. Group: Inhibitors. CAS No. 219580-11-7. Pack Sizes: 5mg. Product ID: S1264. Formula: C28H41N7O3. Smiles: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PD-1 (Intracellular Domain) Antibody [G6H24] | PD-1 (Intracellular Domain) Antibody [G6H24]. Group: Antibodies. Alternative Names: Programmed cell death protein 1, Protein PD-1, Pdcd1, Pd1. Pack Sizes: 20uL. Product ID: F3016. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PD 98059 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist. Group: Inhibitors. CAS No. 167869-21-8. Pack Sizes: 10mg. Product ID: S1177. Formula: C16H13NO3. Smiles: COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PDD00017273 | PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with an IC50 of 26 nM. PDD00017273 exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Group: Inhibitors. CAS No. 1945950-21-9. Pack Sizes: 5mg. Product ID: S8862. Formula: C23H26N6O4S2. Smiles: CC1=NN(C(=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)NC4(CC4)C)C(=O)N(C2=O)CC5=CN=C(S5)C)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| PDGFR α Antibody [P1E17] | PDGF Receptor alpha / PDGFR-α,PDGF Receptor α,PDGFR alpha. Group: Antibodies. Alternative Names: Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor. CAS No. Pack Sizes: 20uL. Product ID: F3240. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PD-L1 Antibody [G4H2] | CD274 (PD-L1, B7-H1),PD-L1. Group: Antibodies. Alternative Names: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1; Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; hPD-L1; B7 homolog 1; B7-H1. CAS No. Pack Sizes: 20uL. Product ID: F2853. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PD-L1 Antibody [P4L19] | CD274 (PD-L1, B7-H1),PD-L1. Group: Antibodies. Alternative Names: Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; hPD-L1; B7 homolog 1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1. CAS No. Pack Sizes: 20uL. Product ID: F2670. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| PEG300 | PEG300 (Polyethylene glycol 300) is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. It serves as a kind of solubilizer, excipient, lubricant, and chemical reagent. PEG300 helps in the formation of hydrogels in situ upon mixing with silk. These PEG-silk hydrogels are of interest for many biomedical applications, such as anti-fouling and anti-adhesion. Group: Inhibitors. Alternative Names: Polyethylene glycol 300. CAS No. 25322-68-3. Pack Sizes: 100mL. Product ID: S6704. Formula: (C2H4O)nH2O. Storage Conditions: Store at room temperature, 3 years. | United States; Europe |
| PEG400 | PEG400b (Polyethylene glycol 400) is a commonly used co-solvent used in a variety of pharmaceutical formulations. It acts as a good solubilizer and surfactant and has the potential to improve the bioavailability of drugs. PEG400 significantly accelerates the metabolism of baicalein and increases the penetration of BG and B6G in Caco?2 cells. Group: Inhibitors. Alternative Names: Polyethylene glycol 400. CAS No. 25322-68-3. Pack Sizes: 100mL. Product ID: S6705. Formula: (C2H4O)nH2O. Storage Conditions: Store at room temperature, 3 years. | United States; Europe |
| Pembrolizumab (anti-PD-1) | Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD. Group: Antibodies. Alternative Names: MK-3475, lambrolizumab. CAS No. 1374853-91-4. Pack Sizes: 5mg. Product ID: A2005. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Pemetrexed | Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. Group: Inhibitors. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 25mg. Product ID: S5971. Formula: C20H21N5O6. Smiles: NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N1. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Pemigatinib (INCB054828) | Pemigatinib is an orally active and selective inhibitor of FGFR with IC50 of 0.4 nM, 0.5 nM, 1.2 nM and 30 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma. Group: Inhibitors. Alternative Names: INCB054828. CAS No. 1513857-77-6. Pack Sizes: 5mg. Product ID: S0088. Formula: C24H27F2N5O4. Smiles: CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Pepstatin A | Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases. Group: Inhibitors. Alternative Names: Pepstatin. CAS No. 26305-03-3. Pack Sizes: 10mg. Product ID: S7381. Formula: C34H63N5O9. Smiles: CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PERK Antibody [L1C15] | PERK,p-ERK. Group: Antibodies. Alternative Names: PERK. Pack Sizes: 20ul. Product ID: F0027. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Pertuzumab (anti-HER2) | Pertuzumab (anti-HER2), a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors, impairs the ability of HER2 to bind to other members of the HER family, MW: 148 KD. Group: Antibodies. Alternative Names: 2C4. CAS No. 380610-27-5. Pack Sizes: 5mg. Product ID: A2008. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Pexidartinib (PLX3397) | Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3. Group: Inhibitors. CAS No. 1029044-16-3. Pack Sizes: 10mg. Product ID: S7818. Formula: C20H15ClF3N5. Smiles: C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PF-02341066 (Crizotinib) | Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Group: Inhibitors. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 5mg. Product ID: S1068. Formula: C21H22Cl2FN5O. Smiles: CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PF-06424439 Methanesulfonate | PF-06424439 is a first orally bioavailable small-molecule inhibitor of DGAT2 with an IC50 of 14 nM. Group: Inhibitors. CAS No. 1469284-79-4. Pack Sizes: 5mg. Product ID: S9921. Formula: C23H30ClN7O4S. Smiles: C[S](O)(=O)=O.ClC1=C[N](N=C1)C2(CC2)C3=NC4=CC=C(N=C4[NH]3)N5CCCC(C5)C(=O)N6CCCC6. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| PF-07220060 (CDK4/6-IN-6) | PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4 / Cyclin D1 and CDK6 / Cyclin D3, respectively. Group: Inhibitors. Alternative Names: CDK4/6-IN-6. CAS No. 2380321-51-5. Pack Sizes: 5mg. Product ID: E1495. Formula: C22H27ClFN5O3. | United States; Europe |
| PF-573228 | PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis. Group: Inhibitors. CAS No. 869288-64-2. Pack Sizes: 10mg. Product ID: S2013. Formula: C22H20F3N5O3S. Smiles: CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| PGP9.5 Antibody [L3K10] | PGP9.5,Protein Gene Product 9.5,UCHL1,UCH-L1/PGP9.5. Group: Antibodies. Alternative Names: PGP9.5,Protein Gene Product 9.5,UCHL1. CAS No. Pack Sizes: 20ul. Product ID: F1137. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phenylephrine HCl | Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant. Group: Inhibitors. Alternative Names: NCI-C55641 HCl,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride. CAS No. 61-76-7. Pack Sizes: 50mg. Product ID: S2569. Formula: C9H13NO2.HCl. Smiles: CNCC(C1=CC(=CC=C1)O)O.Cl. Storage Conditions: 2 years -80 (in the dark) in solvent. | United States; Europe |
| Phospho-AKT1/2/3 (Ser473/474/472) Antibody [B6L18] | Phospho-AKT1/2/3 (Ser473/474/472) Antibody [B6L18]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F1644. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Akt1 (Ser473) Antibody [K10L8] | Phospho-Akt1 (Ser473) Antibody [K10L8]. Group: Antibodies. Alternative Names: RAC-alpha serine / threonine-protein kinase; Protein kinase B (PKB); Protein kinase B alpha (PKB alpha); Proto-oncogene c-Akt; RAC-PK-alpha; AKT1; PKB; RAC. Pack Sizes: 20uL. Product ID: F4087. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Akt (Ser473) Antibody [B19D19] | p-Akt1/2/3,phospho akt1 / pkbalpha (ser473),Phospho-Akt (Ser473). Group: Antibodies. Alternative Names: RAC-beta serine / threonine-protein kinase, Protein kinase Akt-2, Protein kinase B beta (PKB beta), RAC protein kinase beta, AKT2, RAC-gamma serine / threonine-protein kinase, Protein kinase Akt-3, Protein kinase B gamma (PKB gamma), RAC-PK-gamma, STK-2, AKT3, PKBG, RAC-alpha serine / threonine-protein kinase, Protein kinase B (PKB), Protein kinase B alp. Pack Sizes: 20uL. Product ID: F3507. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Akt (Ser473) Antibody [F14K15] | p-Akt1/2/3,phospho akt1 / pkbalpha (ser473),Phospho-Akt (Ser473). Group: Antibodies. Alternative Names: AKT1; AKT2; AKT3; AKT serine / threonine kinase 1; v - akt murine thymoma viral oncogene homolog 1; C - AKT; PRKBA; RAC - PKα; AKT serine / threonine kinase 2; RAC - β; PRKBB; AKT serine / threonine kinase 3; PRKBG; STK - 2. Pack Sizes: 20uL. Product ID: F0152. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Akt (Thr450) Antibody [J1B12] | RAC-beta serine / threonine-protein kinase, Protein kinase Akt-2, PKB beta 1, RAC-PK-beta, RAC-gamma serine / threonine-protein kinase, Akt-3, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG, RAC-alpha serine / threonine-protein kinase, PKB, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1. Group: Antibodies. Alternative Names: AKT1, AKT2, AKT3. Pack Sizes: 20uL. Product ID: F0699. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-AMPKα (Thr172) Antibody [E15N20] | Phospho-AMPKα (Thr172) Antibody [E15N20]. Group: Antibodies. Alternative Names: 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase (ACACA kinase), Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase), Tau-protein kinase PRKAA1 , AMPK1, PRKAA1. Pack Sizes: 20uL. Product ID: F3514. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-CaMKII (Thr286) Antibody [L21H4] | Calcium / calmodulin-dependent protein kinase type II subunit beta, Calcium / calmodulin-dependent protein kinase type II subunit delta, Calcium / calmodulin-dependent protein kinase type II subunit gamma, Calcium / calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit beta, CaMK-II subunit beta, CAMK2B, CAM2, CAMK2, CAMKB, CaM kinase II subunit delta; CaMK-II subunit delta, CAMK2D, CAMKD, CaM kinase II subunit gamma; CaMK-II subunit gamma, CAMK2G, CAMK, CAMK-II, CAMKG,CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968, CaMK-II β, CaMK-II δ, CaMK-II γ, CaMK-II α. Group: Antibodies. Alternative Names: CaMKII (phospho Thr 286),CaMKII α (phospho Thr 286). Pack Sizes: 20ul. Product ID: F0342. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-c-Jun (Ser63) Antibody [A1M19] | c-Jun (phospho S63),c-Jun (phospho S73),p-c-Jun,Phospho-c-Jun (Ser63),Phospho-c-Jun (Ser63) II,Phospho-c-Jun (Ser73). Group: Antibodies. Alternative Names: Transcription factor Jun; Activator protein 1 (AP1); Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUN. Pack Sizes: 20uL. Product ID: F1069. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-CREB (Ser133) Antibody [K11M21] | CREB (phospho S133),Phospho-CREB (Ser133). Group: Antibodies. Alternative Names: CREB (phospho S133),Phospho-CREB (Ser133). CAS No. Pack Sizes: 20uL. Product ID: F0154. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-CREB (Ser133) Antibody [M20D18] | CREB (phospho S133),Phospho-CREB (Ser133). Group: Antibodies. Alternative Names: CREB (phospho S133),Phospho-CREB (Ser133). CAS No. Pack Sizes: 20uL. Product ID: F2525. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-EGF Receptor (Tyr1068) Antibody [J6N1] | EGFR (phospho Y1068),Phospho-EGF Receptor (Tyr1068). Group: Antibodies. Alternative Names: Phospho EGFR (Tyr1068). Pack Sizes: 20uL. Product ID: F0298. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-eIF2α (Ser51) Antibody [F15N7] | EIF2S1 (phospho S51),Phospho-eIF2α (Ser51). Group: Antibodies. Alternative Names: EIF2S1 (phospho S51),Phospho-eIF2α (Ser51). Pack Sizes: 20ul. Product ID: F0257. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Erk1 (T 202/Y 204)/Erk2 (T 185/Y 187) Antibody [G4M7] | ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187),Erk1 (pT202/pY204) + Erk2 (pT185/pY187),MAP Kinase, Activated (Diphosphorylated ERK-1&2),phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187). Group: Antibodies. Alternative Names: ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187),MAP Kinase, Activated (Diphosphorylated ERK-1&2). Pack Sizes: 20uL. Product ID: F1555. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-FAK (Tyr397) Antibody [G24K11] | FAK (phospho Y397),FAK (Tyr397),p-FAK,Phospho-FAK (Tyr397). Group: Antibodies. Alternative Names: FAK; FAK1; PTK2; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; Protein phosphatase 1 regulatory subunit 71; Protein-tyrosine kinase 2; p125FAK; pp125FAK; FRNK; PPP1R71. CAS No. Pack Sizes: 20uL. Product ID: F2876. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-FoxO1 (Ser256) Antibody [E12L24] | FOXO1A (phospho S256),Phospho-FoxO1 (Ser256). Group: Antibodies. Alternative Names: FOXO1A (phospho S256),Phospho-FoxO1 (Ser256). Pack Sizes: 20uL. Product ID: F0800. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-GSK-3β (Ser9) Antibody [G1H24] | GSK3B (phospho S9),p-GSK3 beta,Phospho-GSK-3-beta (Ser9),Phospho-GSK-3β (Ser9). Group: Antibodies. Alternative Names: GSK3B (phospho Ser 9), p-GSK3 β. Pack Sizes: 20ul. Product ID: F0299. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-Histone H2A.X (Ser139) Antibody [E5F13] | gamma H2A.X (phospho S139),gamma H2AX [p Ser139],Histone H2A.X (Ser139),p-Histone H2A.X(Ser 139),phospho-H2A.X (Ser139),phospho-Histone H2A.X (Ser139). Group: Antibodies. Alternative Names: p-Histone H2A.X(Ser 139), gamma H2A.X, γ H2A.X. Pack Sizes: 20ul. Product ID: F0019. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-IκBα (Ser32/36) Antibody [F24N7] | IkB-alpha [p Ser32, p Ser36],Phospho-IκBα (Ser32/36). Group: Antibodies. Alternative Names: NF-kappa-B inhibitor alpha, I-kappa-B-alpha (IkB-alpha; IkappaBalpha), Major histocompatibility complex enhancer-binding protein MAD3, NFKBIA, IKBA, MAD3, NFKBI. Pack Sizes: 20uL. Product ID: F0197. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-IKB α (Ser36) Antibody [B13N13] | Phospho-IKB α (Ser36) Antibody [B13N13]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2237. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Phospho-IRF-3 (Ser386) Antibody [L20H23] | Phospho-IRF-3 (Ser386) Antibody [L20H23]. Group: Antibodies. Alternative Names: Interferon regulatory factor 3, IRF-3, IRF3. Pack Sizes: 20uL. Product ID: F4013. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
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